231 research outputs found
Techniques for single-shot volumetric fluorescence imaging
- Publication venue
- Publication date
- 19/01/2021
- Field of study
Rapid development of genetically encoded fluorescent indicators has provided a diverse chemical toolkit to probe complex biological systems, leading to the expansion of fluorescence microscopy for biological research and applications. However, the inherent constraints on resolution, speed and field of view have hindered the development of high speed, three dimensional fluorescence imaging over large spatial scales for biological microscopy. This thesis describes two strategies based on confocal microscopy to provide single-shot volumetric fluorescence imaging over large scales. In the first part, we describe a multiplane line-scan imaging strategy, which uses a series of axially distributed reflecting slits to probe different depths within a sample volume. Our technique, called line-scan multi-z confocal microscopy, enables the simultaneous imaging of an optically sectioned image stack with a single camera at frame rates of hundreds of hertz, without the need for axial scanning. We demonstrate the applicability of our system to monitor fast dynamics in biological samples by performing calcium imaging of neuronal activity in mouse brains and voltage imaging of cardiomyocytes in cardiac samples. In the second part, we describe a fiber bundle-based endomicroscopy technique, which provides pseudo-volumetric imaging over large field of views, without the need for axial scanning. Our technique uses a gradient refractive index lens to achieve an axially extended illumination and a series of reflecting pinholes of different diameters to simultaneously probe different number of fiber cores. The fluorophores are localized from the series of acquired images using a convolution neural network. We validate our system by localizing fluorescent beads distributed in a volume sample
Fast Micron-Scale 3D Printing with a Resonant-Scanning Two-Photon Microscope
- Publication venue
- Publication date
- 26/02/2018
- Field of study
3D printing allows rapid fabrication of complex objects from digital designs.
One 3D-printing process, direct laser writing, polymerises a light-sensitive
material by steering a focused laser beam through the shape of the object to be
created. The highest-resolution direct laser writing systems use a femtosecond
laser to effect two-photon polymerisation. The focal (polymerisation) point is
steered over the shape of the desired object with mechanised stages or
galvanometer-controlled mirrors. Here we report a new high-resolution direct
laser writing system that employs a resonant mirror scanner to achieve a
significant increase in printing speed over galvanometer- or piezo-based
methods while maintaining resolution on the order of a micron. This printer is
based on a software modification to a commerically available resonant-scanning
two-photon microscope. We demonstrate the complete process chain from hardware
configuration and control software to the printing of objects of approximately
400×400×350μm, and validate performance with objective
benchmarks. Released under an open-source license, this work makes micro-scale
3D printing available the large community of two-photon microscope users, and
paves the way toward widespread availability of precision-printed devices.Comment: Corresponding author: BWP ([email protected]). TJG and TMO contributed
equally to this work. TJG is an employee of Neuralink In
Cyclin A2 Mutagenesis Analysis: A New Insight into CDK Activation and Cellular Localization Requirements
- Author
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Cyclin A2 is essential at two critical points in the somatic cell cycle: during S phase, when it activates CDK2, and during the G2 to M transition when it activates CDK1. Based on the crystal structure of Cyclin A2 in association with CDKs, we generated a panel of mutants to characterize the specific amino acids required for partner binding, CDK activation and subcellular localization. We find that CDK1, CDK2, p21, p27 and p107 have overlapping but distinct requirements for association with this protein. Our data highlight the crucial importance of the N-terminal α helix, in conjunction with the α3 helix within the cyclin box, in activating CDK. Several Cyclin A2 mutants selectively bind to either CDK1 or CDK2. We demonstrate that association of Cyclin A2 to proteins such as CDK2 that was previously suggested as crucial is not a prerequisite for its nuclear localization, and we propose that the whole protein structure is involved
Towards an International Consensus on the Prevention, Treatment, and Management of High-Risk Substance Use and Overdose among Youth
- Author
- Azar Pouya
- Backmund Markus
- Cabanis Maurice
- Christie Grant
- Dürsteler Kenneth M
- Elsner Julie
- et al
- Farrell Michael
- Haltmayer Hans
- Ignaszewski Martha J
- Krausz Michael
- Köck Patrick
- Marian Calin
- Mathew Nickie
- Moe Jessica
- Moore Eva
- Muller Christian
- Orsolini Laura
- Post Marianne
- Rechberger Gerhard
- Röhrig Jeanette
- Spijkerman Renske
- Strasser Johannes
- Suen Janet
- Teesson Maree
- Trabi Thomas
- Tsang Vivian
- Vo Dzung
- Vogel Marc
- Westenberg Jean N
- Wladika Wolfgang
- Publication venue
- 'MDPI AG'
- Publication date
- 13/04/2022
- Field of study
Background and Objectives: Now more than ever, there is an obvious need to reduce the overall burden of disease and risk of premature mortality that are associated with mental health and substance use disorders among young people. However, the current state of research and evidence-based clinical care for high-risk substance use among youth is fragmented and scarce. The objective of the study is to establish consensus for the prevention, treatment, and management of high-risk substance use and overdose among youth (10 to 24 years old). Materials and Methods: A modified Delphi technique was used based on the combination of scientific evidence and clinical experience of a group of 31 experts representing 10 countries. A semi-structured questionnaire with five domains (clinical risks, target populations, intervention goals, intervention strategies, and settings/expertise) was shared with the panelists. Based on their responses, statements were developed, which were subsequently revised and finalized through three iterations of feedback. Results: Among the five major domains, 60 statements reached consensus. Importantly, experts agreed that screening in primary care and other clinical settings is recommended for all youth, and that the objectives of treating youth with high-risk substance use are to reduce harm and mortality while promoting resilience and healthy development. For all substance use disorders, evidence-based interventions should be available and should be used according to the needs and preferences of the patient. Involuntary admission was the only topic that did not reach consensus, mainly due to its ethical implications and resulting lack of comparable evidence. Conclusions: High-risk substance use and overdoses among youth have become a major challenge. The system’s response has been insufficient and needs substantial change. Internationally devised consensus statements provide a first step in system improvement and reform
Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector
- Author
- Aaboud Morad
- Aad Georges
- Abbott Brad
- Abdinov Ovsat
- Abeloos Baptiste
- Abidi Syed
- AbouZeid Ossama
- Abraham Nicola
- Abramowicz Halina
- Abreu Henso
- Abreu Ricardo
- Abulaiti Yiming
- Acharya Bobby
- Adachi Shunsuke
- Adamczyk Leszek
- Adelman Jahred
- Adersberger Michael
- Adye Tim
- Affolder Tony
- Afik Yoav
- Agatonovic-Jovin Tatjana
- Agheorghiesei Catalin
- Aguilar-Saavedra Juan
- Ahlen Steven
- Ahmadov Faig
- Aielli Giulio
- Akatsuka Shunichi
- Akerstedt Henrik
- Akilli Ece
- Akimov Andrei
- Alberghi Gian
- Albert Justin
- Albicocco Pietro
- Alconada Verzini Maria
- Alderweireldt Sara
- Aleksa Martin
- Aleksandrov Igor
- Alexa Calin
- Alexander Gideon
- Alexopoulos Theodoros
- Alhroob Muhammad
- Ali Babar
- Aliev Malik
- Alimonti Gianluca
- Alison John
- Alkire Steven
- Allbrooke Benedict
- Allen Benjamin
- Allport Phillip
- Aloisio Alberto
- Alonso Alejandro
- Alonso Francisco
- Alpigiani Cristiano
- Alshehri Azzah
- Alstaty Mahmoud
- Alvarez Gonzalez Barbara
- Alviggi Mariagrazia
- Amadio Brian
- Amaral Coutinho Yara
- Amelung Christoph
- Amidei Dante
- Amor Dos Santos Susana
- Amoroso Simone
- Anastopoulos Christos
- Ancu Lucian
- Andari Nansi
- Andeen Timothy
- Anders Christoph
- Anders John
- Anderson Kelby
- Andreazza Attilio
- Andrei George
- Angelidakis Stylianos
- Angelozzi Ivan
- Angerami Aaron
- Anisenkov Alexey
- Anjos Nuno
- Annovi Alberto
- Antel Claire
- Antonelli Mario
- Antonov Alexey
- Antrim Daniel
- Anulli Fabio
- Aoki Masato
- Aperio Bella Ludovica
- Arabidze Giorgi
- Arai Yasuo
- Araque Juan
- Araujo Ferraz Victor
- Arce Ayana
- Ardell Rose
- Arduh Francisco
- Arguin Jean-Francois
- Argyropoulos Spyridon
- Arik Metin
- Armbruster Aaron
- Armitage Lewis
- Arnaez Olivier
- Arnold Hannah
- Arratia Miguel
- Arslan Ozan
- Artamonov Andrei
- Artoni Giacomo
- Artz Sebastian
- Asai Shoji
- Asbah Nedaa
- Ashkenazi Adi
- Asquith Lily
- Assamagan Ketevi
- Astalos Robert
- Atkinson Markus
- Atlay Naim
- Augsten Kamil
- Avolio Giuseppe
- Axen Bradley
- Ayoub Mohamad
- Azuelos Georges
- Baas Alessandra
- Baca Matthew
- Bachacou Henri
- Bachas Konstantinos
- Backes Moritz
- Bagnaia Paolo
- Bahmani Marzieh
- Bahrasemani Sina
- Baines John
- Bajic Milena
- Baker Oliver
- Bakker Pepijn
- Baldin Evgenii
- Balek Petr
- Balli Fabrice
- Balunas William
- Banas Elzbieta
- Bandyopadhyay Anjishnu
- Banerjee Swagato
- Bannoura Arwa
- Barak Liron
- Barberio Elisabetta
- Barberis Dario
- Barbero Marlon
- Barillari Teresa
- Barisits Martin-Stefan
- Barkeloo Jason
- Barklow Timothy
- Barlow Nick
- Barnes Sarah
- Barnett Bruce
- Barnett Michael
- Barnovska-Blenessy Zuzana
- Baroncelli Antonio
- Barone Gaetano
- Barr Alan
- Barranco Navarro Laura
- Barreiro Guimarães da Costa João
- Barreiro Fernando
- Barros Vale Maria
- Bartoldus Rainer
- Barton Adam
- Bartos Pavol
- Basalaev Artem
- Bassalat Ahmed
- Bates Richard
- Batista Santiago
- Batley Richard
- Battaglia Marco
- Bauce Matteo
- Bauer Florian
- Bawa Harinder
- Beacham James
- Beattie Michael
- Beau Tristan
- Beauchemin Pierre-Hugues
- Bechtle Philip
- Beck Hans~Peter
- Beck Helge
- Becker Kathrin
- Becker Maurice
- Becot Cyril
- Beddall Andrew
- Beddall Ayda
- Bednyakov Vadim
- Bedognetti Matteo
- Bee Christopher
- Beermann Thomas
- Begalli Marcia
- Begel Michael
- Behr Janna
- Bell Andrew
- Bella Gideon
- Bellagamba Lorenzo
- Bellerive Alain
- Bellomo Massimiliano
- Belotskiy Konstantin
- Beltramello Olga
- Belyaev Nikita
- Benary Odette
- Benchekroun Driss
- Bender Michael
- Benekos Nektarios
- Benhammou Yan
- Benhar Noccioli Eleonora
- Benitez Jose
- Benjamin Douglas
- Benoit Mathieu
- Bensinger James
- Bentvelsen Stan
- Beresford Lydia
- Beretta Matteo
- Berge David
- Bergeaas Kuutmann Elin
- Berger Nicolas
- Bergsten Laura
- Beringer Jürg
- Berlendis Simon
- Bernard Nathan
- Bernardi Gregorio
- Bernius Catrin
- Bernlochner Florian
- Berry Tracey
- Berta Peter
- Bertella Claudia
- Bertoli Gabriele
- Bertram Iain
- Bertsche Carolyn
- Besjes Geert-Jan
- Bessidskaia Bylund Olga
- Bessner Martin
- Besson Nathalie
- Bethani Agni
- Bethke Siegfried
- Betti Alessandra
- Bevan Adrian
- Beyer Julien-christopher
- Bianchi Riccardo-Maria
- Biebel Otmar
- Biedermann Dustin
- Bielski Rafal
- Bierwagen Katharina
- Biesuz Nicolo
- Biglietti Michela
- Billoud Thomas
- Bilokon Halina
- Bindi Marcello
- Bingul Ahmet
- Bini Cesare
- Biondi Silvia
- Bisanz Tobias
- Bittrich Carsten
- Bjergaard David
- Black James
- Black Kevin
- Blair Robert
- Blazek Tomas
- Bloch Ingo
- Blocker Craig
- Blue Andrew
- Blumenschein Ulrike
- Blunier Sylvain
- Bobbink Gerjan
- Bobrovnikov Victor
- Bocchetta Simona
- Bocci Andrea
- Bock Christopher
- Boehler Michael
- Boerner Daniela
- Bogavac Danijela
- Bogdanchikov Alexander
- Bohm Christian
- Boisvert Veronique
- Bokan Petar
- Bold Tomasz
- Boldyrev Alexey
- Bolz Arthur
- Bomben Marco
- Bona Marcella
- Boonekamp Maarten
- Borisov Anatoly
- Borissov Guennadi
- Bortfeldt Jonathan
- Bortoletto Daniela
- Bortolotto Valerio
- Boscherini Davide
- Bosman Martine
- Bossio Sola Jonathan
- Boudreau Joseph
- Bouhova-Thacker Evelina
- Boumediene Djamel
- Bourdarios Claire
- Boutle Sarah
- Boveia Antonio
- Boyd James
- Boyko Igor
- Bozson Adam
- Bracinik Juraj
- Brandt Andrew
- Brandt Gerhard
- Brandt Oleg
- Braren Frued
- Bratzler Uwe
- Brau Benjamin
- Brau James
- Breaden Madden William
- Brendlinger Kurt
- Brennan Amelia
- Brenner Lydia
- Brenner Richard
- Bressler Shikma
- Briglin Daniel
- Bristow Timothy
- Britton Dave
- Britzger Daniel
- Brochu Frederic
- Brock Ian
- Brock Raymond
- Brooijmans Gustaaf
- Brooks Timothy
- Brooks William
- Brosamer Jacquelyn
- Brost Elizabeth
- Broughton James
- Bruckman de Renstrom Pawel
- Bruncko Dusan
- Bruni Alessia
- Bruni Graziano
- Bruni Lucrezia
- Bruno Salvatore
- Brunt Benjamin
- Bruschi Marco
- Bruscino Nello
- Bryant Patrick
- Bryngemark Lene
- Buanes Trygve
- Buat Quentin
- Buchholz Peter
- Buckley Andrew
- Budagov Ioulian
- Buehrer Felix
- Bugge Magnar
- Bulekov Oleg
- Bullock Daniel
- Burch Tyler
- Burdin Sergey
- Burgard Carsten
- Burger Angela
- Burghgrave Blake
- Burka Klaudia
- Burke Stephen
- Burmeister Ingo
- Burr Jonathan
- Bussey Peter
- Butler John
- Buttar Craig
- Butterworth Jonathan
- Butti Pierfrancesco
- Buttinger William
- Buzatu Adrian
- Buzykaev Aleksey
- Büscher Daniel
- Büscher Volker
- C-Q Changqiao
- Cabrera Urbán Susana
- Caforio Davide
- Cai Huacheng
- Cairo Valentina
- Cakir Orhan
- Calace Noemi
- Calafiura Paolo
- Calandri Alessandro
- Calderini Giovanni
- Calfayan Philippe
- Callea Giuseppe
- Caloba Luiz
- Calvente Lopez Sergio
- Calvet David
- Calvet Samuel
- Calvet Thomas
- Camacho Toro Reina
- Camarda Stefano
- Camarri Paolo
- Cameron David
- Caminal Armadans Roger
- Camincher Clement
- Campana Simone
- Campanelli Mario
- Camplani Alessandra
- Campoverde Angel
- Canale Vincenzo
- Cano Bret Marc
- Cantero Josu
- Cao Tingting
- Capeans Garrido Maria
- Caprini Irinel
- Caprini Mihai
- Capua Marcella
- Carbone Ryne
- Cardarelli Roberto
- Cardillo Fabio
- Carli Ina
- Carli Tancredi
- Carlino Gianpaolo
- Carlson Benjamin
- Carminati Leonardo
- Carney Rebecca
- Caron Sascha
- Carquin Edson
- Carrillo-Montoya German
- Carrá Sonia
- Casadei Diego
- Casado Maria
- Casha Albert
- Casolino Mirkoantonio
- Casper David
- Castelijn Remco
- Castillo Gimenez Victoria
- Castro Nuno
- Catinaccio Andrea
- Catmore James
- Cattai Ariella
- Caudron Julien
- Cavaliere Viviana
- Cavallaro Emanuele
- Cavalli Donatella
- Cavalli-Sforza Matteo
- Cavasinni Vincenzo
- Celebi Emre
- Ceradini Filippo
- Cerda Alberich Leonor
- Cerri Alessandro
- Cerrito Lucio
- Cerutti Fabio
- Cervelli Alberto
- Cetin Serkant
- Chafaq Aziz
- Chakraborty Dhiman
- Chan Stephen
- Chan Wing
- Chan Yat
- Chang Philip
- Chapman John
- Charlton Dave
- Chau Chav
- Chavez Barajas Carlos
- Che Siinn
- Cheatham Susan
- Chegwidden Andrew
- Chekanov Sergei
- Chekulaev Sergey
- Chelkov Gueorgui
- Chelstowska Magda
- Chen Cheng
- Chen Chunhui
- Chen Hucheng
- Chen Jing
- Chen Shenjian
- Chen Shion
- Chen Xin
- Chen Ye
- Cheng Hok
- Cheng Huajie
- Cheplakov Alexander
- Cheremushkina Evgeniya
- Cherkaoui El Moursli Rajaa
- Cheu Elliott
- Cheung Kingman
- Chevalier Laurent
- Chiarella Vitaliano
- Chiarelli Giorgio
- Chiodini Gabriele
- Chisholm Andrew
- Chitan Adrian
- Chiu Yu
- Chizhov Mihail
- Choi Kyungeon
- Chomont Arthur
- Chouridou Sofia
- Chow Yun
- Christodoulou Valentinos
- Chu Ming
- Chudoba Jiri
- Chuinard Annabelle
- Chwastowski Janusz
- Chytka Ladislav
- Ciftci Abbas
- Cinca Diane
- Cindro Vladimir
- Cioara Irina
- Ciocio Alessandra
- Cirotto Francesco
- Citron Zvi
- Citterio Mauro
- Ciubancan Mihai
- Clark Allan
- Clark Brian
- Clark Michael
- Clark Philip
- Clarke Robert
- Clement Christophe
- Coadou Yann
- Cobal Marina
- Coccaro Andrea
- Cochran James
- Colasurdo Luca
- Cole Brian
- Colijn Auke-Pieter
- Collot Johann
- Colombo Tommaso
- Conde Muiño Patricia
- Coniavitis Elias
- Connell Simon
- Connelly Ian
- Constantinescu Serban
- Conti Geraldine
- Conventi Francesco
- Cooke Mark
- Cooper-Sarkar Amanda
- Cormier Felix
- Cormier Kyle
- Corradi Massimo
- Corriveau Francois
- Cortes-Gonzalez Arely
- Costa Giuseppe
- Costa María
- Costanzo Davide
- Cottin Giovanna
- Cowan Glen
- Cox Brian
- Cranmer Kyle
- Crawley Samuel
- Creager Rachael
- Cree Graham
- Crescioli Francesco
- Cribbs Wayne
- Cristinziani Markus
- Croft Vince
- Crosetti Giovanni
- Crépé-Renaudin Sabine
- Cueto Ana
- Cuhadar Donszelmann Tulay
- Cukierman Aviv
- Cummings Jane
- Curatolo Maria
- Czekierda Sabina
- Czodrowski Patrick
- Cúth Jakub
- D'amen Gabriele
- D'Auria Saverio
- D'Eramo Louis
- D'Onofrio Monica
- Da Cunha Sargedas De Sousa Mario
- Da Via Cinzia
- Dabrowski Wladyslaw
- Dado Tomas
- Dai Tiesheng
- Dale Orjan
- Dallaire Frederick
- Dallapiccola Carlo
- Dam Mogens
- Dandoy Jeffrey
- Daneri Maria
- Dang Nguyen
- Daniells Andrew
- Dann Nicholas
- Danninger Matthias
- Dano Hoffmann Maria
- Dao Valerio
- Darbo Giovanni
- Darmora Smita
- Dassoulas James
- Dattagupta Aparajita
- Daubney Thomas
- Davey Will
- David Claire
- Davidek Tomas
- Davis Douglas
- Davison Peter
- Dawe Edmund
- Dawson Ian
- de Asmundis Riccardo
- De Benedetti Abraham
- De Castro Stefano
- De Cecco Sandro
- De Groot Nicolo
- De Jong Paul
- De la Torre Hector
- De Lorenzi Francesco
- De Maria Antonio
- De Pedis Daniele
- De Salvo Alessandro
- De Sanctis Umberto
- De Santo Antonella
- De Vasconcelos Corga Kevin
- De Vivie De Regie Jean-Baptiste
- De Kaushik
- Debbe Ramiro
- Debenedetti Chiara
- Dedovich Dmitri
- Dehghanian Nooshin
- Deigaard Ingrid
- Del Gaudio Michela
- Del Peso Jose
- Delgove David
- Deliot Frederic
- Delitzsch Chris
- Dell'Acqua Andrea
- Dell'Asta Lidia
- Dell'Orso Mauro
- Della Pietra Massimo
- della Volpe Domenico
- Delmastro Marco
- Delporte Charles
- Delsart Pierre-Antoine
- DeMarco David
- Demers Sarah
- Demichev Mikhail
- Demilly Aurelien
- Denisov Sergey
- Denysiuk Denys
- Derendarz Dominik
- Derkaoui Jamal
- Derue Frederic
- Dervan Paul
- Desch Klaus
- Deterre Cecile
- Dette Karola
- Devesa Maria
- Deviveiros Pier-Olivier
- Dewhurst Alastair
- Dhaliwal Saminder
- Di Bello Francesco
- Di Ciaccio Anna
- Di Ciaccio Lucia
- Di Clemente William
- Di Donato Camilla
- Di Girolamo Alessandro
- Di Girolamo Beniamino
- Di Micco Biagio
- Di Nardo Roberto
- Di Petrillo Karri
- Di Simone Andrea
- Di Sipio Riccardo
- Di Valentino David
- Diaconu Cristinel
- Diamond Miriam
- Dias Flavia
- Diaz Marco
- Dickinson Jennet
- Diehl Edward
- Dietrich Janet
- Dimitrievska Aleksandra
- Dingfelder Jochen
- Dita Petre
- Dita Sanda
- Dittus Fridolin
- Djama Fares
- Djobava Tamar
- Djuvsland Julia
- Dobos Daniel
- Dobre Monica
- Dodsworth David
- Doglioni Caterina
- Dolejsi Jiri
- Dolezal Zdenek
- Donadelli Marisilvia
- Donati Simone
- Dondero Paolo
- Donini Julien
- Dopke Jens
- Doria Alessandra
- Dova Maria-Teresa
- Doyle Tony
- Drechsler Eric
- Dris Manolis
- Du Yanyan
- Duarte-Campderros Jorge
- Dubinin Filipp
- Dubreuil Arnaud
- Duchovni Ehud
- Duckeck Guenter
- Ducourthial Audrey
- Ducu Otilia
- Duda Dominik
- Dudarev Alexey
- Dudder Andreas
- Duffield Emily
- Duflot Laurent
- Dulsen Carsten
- Dumancic Mirta
- Dumitriu Ana
- Duncan Anna
- Dunford Monica
- Duperrin Arnaud
- Duran Yildiz Hatice
- Durglishvili Archil
- Duschinger Dirk
- Dutta Baishali
- Duvnjak Damir
- Dyndal Mateusz
- Dziedzic Bartosz
- Díez Cornell Sergio
- Dührssen Michael
- Düren Michael
- Eckardt Christoph
- Ecker Katharina
- Edgar Ryan
- Eifert Till
- Eigen Gerald
- Einsweiler Kevin
- Ekelof Tord
- El Kacimi Mohamed
- El Kosseifi Rima
- Ellajosyula Venugopal
- Ellert Mattias
- Elles Sabine
- Ellinghaus Frank
- Elliot Alison
- Ellis Nicolas
- Elmsheuser Johannes
- Elsing Markus
- Emeliyanov Dmitry
- Enari Yuji
- Ennis Joseph
- Epland Matthew
- Erdmann Johannes
- Ereditato Antonio
- Ernst Michael
- Errede Steven
- Escalier Marc
- Escobar Carlos
- Esposito Bellisario
- Estrada Pastor Oscar
- Etienvre Anne-Isabelle
- Etzion Erez
- Evans Hal
- Ezhilov Alexey
- Ezzi Mohammed
- Fabbri Federica
- Fabbri Laura
- Fabiani Veronica
- Facini Gabriel
- Fakhrutdinov Rinat
- Falciano Speranza
- Falla Rebecca
- Faltova Jana
- Fang Yaquan
- Fanti Marcello
- Farbin Amir
- Farilla Addolorata
- Farina Christian
- Farina Edoardo
- Farooque Trisha
- Farrell Steven
- Farrington Sinead
- Farthouat Philippe
- Fassi Farida
- Fassnacht Patrick
- Fassouliotis Dimitrios
- Faucci Giannelli Michele
- Favareto Andrea
- Fawcett William
- Fayard Louis
- Fedin Oleg
- Fedorko Wojciech
- Feigl Simon
- Feligioni Lorenzo
- Feng Cunfeng
- Feng Eric
- Fenton Michael
- Fenyuk Alexander
- Feremenga Last
- Fernandez Martinez Patricia
- Ferrando James
- Ferrari Arnaud
- Ferrari Pamela
- Ferrari Roberto
- Ferreira de Lima Danilo
- Ferrer Antonio
- Ferrere Didier
- Ferretti Claudio
- Fiedler Frank
- Filipuzzi Marco
- Filipčič Andrej
- Filthaut Frank
- Fincke-Keeler Margret
- Finelli Kevin
- Fiolhais Miguel
- Fiorini Luca
- Fischer Adam
- Fischer Cora
- Fischer Julia
- Fisher Wade
- Flaschel Nils
- Fleck Ivor
- Fleischmann Philipp
- Fletcher Rob
- Flick Tobias
- Flierl Bernhard
- Flores Castillo Luis
- Flowerdew Michael
- Forcolin Giulio
- Formica Andrea
- Forti Alessandra
- Foster Andrew
- Fournier Daniel
- Fox Harald
- Fracchia Silvia
- Francavilla Paolo
- Franchini Matteo
- Franchino Silvia
- Francis David
- Franconi Laura
- Franklin Melissa
- Frate Meghan
- Fraternali Marco
- Freeborn David
- Fressard-Batraneanu Silvia
- Freund Benjamin
- Froidevaux Daniel
- Frost James
- Fukunaga Chikara
- Fusayasu Takahiro
- Fuster Juan
- Förster Fabian
- Gabizon Ofir
- Gabrielli Alessandro
- Gabrielli Andrea
- Gach Grzegorz
- Gadatsch Stefan
- Gadomski Szymon
- Gagliardi Guido
- Gagnon Louis
- Galea Cristina
- Galhardo Bruno
- Gallas Elizabeth
- Gallop Bruce
- Gallus Petr
- Galster Gorm
- Gan Kk
- Ganguly Sanmay
- Gao Yanyan
- Gao Yongsheng
- Garay Walls Francisca
- Garcia-Sciveres Maurice
- García Navarro José
- García Pascual Juan
- García Carmen
- Gardner Robert
- Garelli Nicoletta
- Garonne Vincent
- Gascon Bravo Alberto
- Gasnikova Ksenia
- Gatti Claudio
- Gaudiello Andrea
- Gaudio Gabriella
- Gavrilenko Igor
- Gay Colin
- Gaycken Goetz
- Gazis Evangelos
- Gee Norman
- Geisen Jannik
- Geisen Marc
- Geisler Manuel
- Gellerstedt Karl
- Gemme Claudia
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- Yamatani Masahiro
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- Zaitsev Alexander
- Zakharchuk Nataliia
- Zalieckas Justas
- Zaman Aungshuman
- Zambito Stefano
- Zanzi Daniele
- Zeitnitz Christian
- Zemaityte Gabija
- Zemla Andrzej
- Zeng Jian
- Zeng Qi
- Zenin Oleg
- Zerwas Dirk
- Zhang Dengfeng
- Zhang Dongliang
- Zhang Fangzhou
- Zhang Guangyi
- Zhang Huijun
- Zhang Jinlong
- Zhang Lei
- Zhang Liqing
- Zhang Matt
- Zhang Peng
- Zhang Rui
- Zhang Ruiqi
- Zhang Xueyao
- Zhang Yu
- Zhang Zhiqing
- Zhao Xiandong
- Zhao Yongke
- Zhao Zhengguo
- Zhemchugov Alexey
- Zhou Bing
- Zhou Chen
- Zhou Li
- Zhou Maosen
- Zhou Mingliang
- Zhou Ning
- Zhou You
- Zhu Cheng
- Zhu Hongbo
- Zhu Junjie
- Zhu Yingchun
- Zhuang Xuai
- Zhukov Konstantin
- Zibell Andre
- Zieminska Daria
- Zimine Nikolai
- Zimmermann Christoph
- Zimmermann Stephanie
- Zinonos Zinonas
- Zinser Markus
- Ziolkowski Michael
- Zobernig Georg
- Zoccoli Antonio
- Zou Rui
- zur Nedden Martin
- Zwalinski Lukasz
- Åkesson Torsten
- Šfiligoj Tina
- Ženiš Tibor
- Živković Lidija
- Άlvarez Piqueras Damián
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements
Canagliflozin and renal outcomes in type 2 diabetes and nephropathy
- Author
- A Kaldun Nossuli
- Aamir Jamal
- Adalbert Schiller
- Adam Cheifetz
- Adarsh Daswani
- Adeera Levin
- Adline Ghazi
- Adrian Guinsburg
- Adriana Cif
- Adriana Gabriela Onaca
- Adriana Ilavska
- Adriana Villarino
- Agarwal R.
- Agnieszka Starzec
- Ahmed Arif
- Ahmed Awad
- Aiping Yin
- Akimichi Asano
- Alan Jackson
- Alan McMahon
- Alan Perlman
- Alberto Di Carlo
- Alberto Esquenazi
- Alejandra Oviedo
- Alejandro Valdes Depeda
- Aleksandra Kendereski
- Alex Valenzuela
- Alexander Dreval
- Alexander Gonzalez
- Alexander Shinkov
- Alexander Turchin
- Alexandre Klein
- Alfonso Soto Gonzalez
- Alfred Penfornis
- Alfredo Chew Wong
- Alfredo Wassermann
- Ali Torshizi
- Alicia Chilito
- Alina Agafyina
- Alison Dawson
- Alva Hansraj
- Amer Al-Karadsheh
- Amorin Remus Popa
- Amrendra Kumar
- Amy Sprague
- Ana Limos
- Ana Maria Cusumano
- Ana Maria Elosegui
- Anabella Amigo
- Anatoliy Kazmirchuk
- Andrea Phillips
- Andrea Stella
- Andreas Maddux
- Andrej Dzupina
- Andres Alvarisqueta
- Andrew Johnson
- Andrew O'Shaughnessy
- Andrew Steele
- Andrian Yakov
- Andrzej Januszewicz
- Andrzej Madej
- Angelina Angelova
- Anibal Gastaldi
- Anil Gupta
- Anita Bhajan Manocha
- Anjanette Tan
- Anna Kaminska
- Anna Maria Veronelli
- Anna Strzelecka
- Anna Zateyshchikova
- Anselmo Bordonava
- Antanas Navickas
- Anthony Gunstone
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- Secundino Cigarran Guldris
- Senan Sultan
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- Shahabul Arfeen
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- Sophie Borot
- Souhila Ounadjela
- Sreedhar Mandayam
- Srikanth Bellary
- Stanislav Zemek
- Stanislaw Mazur
- Stefan Dimitrov
- Stephan Maxeiner
- Stephen Grubb
- Stephen Smith
- Steven Fishbane
- Stuart Handelsman
- Suely Keiko Kohara
- Sun Kim
- Sun-Hee Park
- Sunil Sheth
- Susumu Kashine
- Svetlana Goykhman
- Svitlana D Bilyk
- Swee Win Lam
- Sylvia Rosas
- Sylvia Shaw
- Szilard Vasas
- Sérgio Alberto Cunha Vêncio
- Sérgio Yamada
- Tadashi Iitsuka
- Takamoto Kodera
- Takashi Wada
- Takayuki Watanabe
- Tamara Malek Marin
- Tamas Oroszlan
- Tara Chang
- Tareq Nassar
- Tarissa Beatrice Zanata Petry
- Tatiana Koroleva
- Tatiana Morugova
- Tatiana Raskina
- Tatyana Zykova
- Te-Lin Hsia
- Terue Sakakibara
- Tetiana Zlova
- Tetsuji Niiya
- Tetyana Pertseva
- Tiago Schuch
- Timothy Hall
- Tom Christensen
- Tom Greene
- Tomas Drasnar
- Tomas Smith Casabella
- Tonatiu Diaz Escalante
- Toshihiko Yanase
- Toshio Kawada
- Vadym Vizir
- Vanassa Ratnasingam
- Venessa Tsang
- Venkata Behara
- Vera Klokocnikova
- Vera Krane
- Veronica Anghel
- Veselka Genadieva
- Vesna Popovic-Radinovic
- Viacheslav Marasaev
- Victor Commendatore
- Victor Saavedra Gajardo
- Vijayaraman Arutchelvam
- Viktor Margaritov
- Viktor Zaviriukha
- Viktoria Andreeva
- Vimladhevi Govender
- Vincent Pichette
- Vincent Woo
- Vira Tseluyko
- Virginia Esther Visco
- Vivek Sood
- Vivekan Jha
- Vladimir Dobronravov
- Vladimir Khirmanov
- Vladimir Tesar
- Vlado Perkovic
- Volker Burst
- Volodymyr Botsyurko
- Walter Guillermo Douthat
- Walter Pharr
- Wasim Hanif
- Wataru Yumita
- Wayne H-H Sheu
- Wayne Turner
- Wei Yen Kong
- Weihong Song
- Weiping Lu
- Wendy Lane
- Wenge Li
- Wheeler D. C.
- Wladmir Saporito
- Xuemei Li
- Xueqing Yu
- Yamil Canaan
- Yan Ren
- Yannick Le Meur
- Yaozhong Kong
- Yasuro Kumeda
- Yasushi Wakida
- Yavin Y.
- Yeong Hoon Kim
- Yevgeniya Svyshchenko
- Young Min Cho
- Yulia Samoylova
- Yung-Chuan Lu
- Yuriy Mostovoy
- Yuriy Shwartz
- Yvette Ethel Yap
- Zaynab Abejuela
- Zdravko Kamenov
- Zeid Khitan
- Zhang H.
- Zinman B.
- Zishan Ali
- Zuzana Ochodnicka
- Ângela Regina Nazario Sabbag
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
The development and validation of a scoring tool to predict the operative duration of elective laparoscopic cholecystectomy
- Author
- Aawsaj Yousif
- Abayomi Michael
- Acharya Vikas
- Aggarwal Smeer Kumar
- Ahmad Anwar
- Ahmed Irfan
- Ahmed Jamil
- Ahmed Javed
- Ahmed Talat
- Ainley Paul
- Akhtar Mansoor
- Al Amari Khalid
- Al-Abed Yahya A.
- Al-Akash Musallam
- Al-Bahrani Ahmed Z.
- Al-Khyatt Waleed
- Al-Muhktar Ahmed
- Al-Sarireh Bilal
- Al-Taan Omer
- Alagaratnam Swethan
- Alam Imran
- Alberts Justin
- Alderson Derek
- Aldridge Roland C.
- Aleksandrov Danail
- Ali Haythem
- Ali Shahda
- Amin Khalid
- Andrew David R.
- Appleton Shaun
- Arhi Chanpreet
- Aroori Somaiah
- Aryal Kamal
- Asad Mehek
- Aseem Rabiya
- Asprou Fotini M.
- Awan Altaf
- Ayaani Soofiyah
- Aymon null
- Babu Benoy I.
- Bajwa Dalvir S.
- Bajwa Farrukh M.
- Baker Andrew L.
- Balfe Paul
- Ball William R.
- Ballance Laura
- Banwell Victoria
- Barnes James
- Barrie Jenifer
- Bartlett Francis
- Basheer Mohammed
- Bashir Gareth
- Basra Melvinder
- Basu Sanjoy
- Basynat Pradeep
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- Tang Cheuk-Bong
- Tanner Nicola
- Tate Sophie
- Tayeh Salim
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- Teasdale Rebecca L.
- Templeton Alexa
- Terrace John
- Thakkar Rohan
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- Trevatt Alexander E. J.
- Trotter Martin
- Tsang Andrew
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- Ullah Muhammad Fahad
- Upchurch Emma A.
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- Varghase Joseph
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- Vijay Vardhini
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- Vijayanand Dhakshinamoorthy
- Villatoro Eduardo
- Virupaksha Suvi
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- Vohra Ravinder S.
- Wadley Martin
- Wainwright Denise
- Wajed Saj
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- Wardle Stacy
- Warren Conor
- Watkin Helen
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- Watson Nicholas F.
- Wayman John
- Weaver Simon
- Weber Beatrix
- Weber Beatrix
- Weerasinghe Chamindri
- Welbourn Hannah
- Wheatley Kevin
- White Timothy J.
- Wijetunga Imeshi
- Wild Jonathan R. L.
- Wilkinson Marc D.
- Williams Sophie V.
- Williamson Tracey K.
- Willson Peter D.
- Wilson Michael S. J.
- Wilson Timothy R.
- Winter Des C.
- Winter Hannah
- Wood Christopher P. J.
- Wood Peter
- Wood Simon
- Woodman Thomas
- Yahya Salama
- Yao Caroline
- Yeldham Geoffrey
- Yoganathan Thusidaran
- Youssef Haney
- Zafar Sara
- Zafrani Zakhi
- Zarsadias Prizzi
- Zeeshan Saquib
- Zhang Catherine
- Ziprin Paul
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: The ability to accurately predict operative duration has the potential to optimise theatre efficiency and utilisation, thus reducing costs and increasing staff and patient satisfaction. With laparoscopic cholecystectomy being one of the most commonly performed procedures worldwide, a tool to predict operative duration could be extremely beneficial to healthcare organisations.
Methods: Data collected from the CholeS study on patients undergoing cholecystectomy in UK and Irish hospitals between 04/2014 and 05/2014 were used to study operative duration. A multivariable binary logistic regression model was produced in order to identify significant independent predictors of long (> 90 min) operations. The resulting model was converted to a risk score, which was subsequently validated on second cohort of patients using ROC curves.
Results: After exclusions, data were available for 7227 patients in the derivation (CholeS) cohort. The median operative duration was 60 min (interquartile range 45–85), with 17.7% of operations lasting longer than 90 min. Ten factors were found to be significant independent predictors of operative durations > 90 min, including ASA, age, previous surgical admissions, BMI, gallbladder wall thickness and CBD diameter. A risk score was then produced from these factors, and applied to a cohort of 2405 patients from a tertiary centre for external validation. This returned an area under the ROC curve of 0.708 (SE = 0.013, p 90 min increasing more than eightfold from 5.1 to 41.8% in the extremes of the score.
Conclusion: The scoring tool produced in this study was found to be significantly predictive of long operative durations on validation in an external cohort. As such, the tool may have the potential to enable organisations to better organise theatre lists and deliver greater efficiencies in care
stairs and fire
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Acosta Darin
- Acosta Jhon Gabriel
- Adair Antony
- Adam Nadia
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Afanasiev Serguei
- Agostino Lorenzo
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Aguilo Ernest
- Ahmad Muhammad
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akgun Ugur
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Aldá Júnior Walter Luiz
- Alexander James
- Aliev Takhmasib
- Almeida Nuno
- Alver Burak
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anastassov Anton
- Anderson Jacob
- Anderson Michael
- Andrea Jeremy
- Andreev Valeri
- Andreev Vladimir
- Andreev Yuri
- Andrews Warren
- Anghel Ioana Maria
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Aranyi Attila
- Arce Pedro
- Arcidiacono Roberta
- Arenton Michael Wayne
- Arfaei Hessamaddin
- Argiro Stefano
- Arisaka Katsushi
- Arneodo Michele
- Arora Sanjay
- Asawatangtrakuldee Chayanit
- Asghar Muhammad Irfan
- Askew Andrew
- Assran Yasser
- Ata Metin
- Atac Muzaffer
- Atramentov Oleksiy
- Attikis Alexandros
- Auffray Etiennette
- Autermann Christian Tobias
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M.
- Babb John
- Bacchetta Nicola
- Bachtis Michail
- Baden Drew
- Baesso Paolo
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bai Yuting
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Bakken Jon Alan
- Balazs Michael
- Ball Austin
- Ball Gordon
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Banzuzi Kukka
- Barbagli Giuseppe
- Barberis Emanuela
- Barbone Lucia
- Bardak Cemile
- Barfuss Anne-Fleur
- Bargassa Pedrame
- Barge Derek
- Baringer Philip
- Barker Anthony
- Barnes Virgil E.
- Barnett Bruce Arnold
- Barney David
- Barone Luciano
- Barrett Matthew
- Bartalini Paolo
- Barth Christian
- Basegmez Suzan
- Basso Lorenzo
- Battilana Carlo
- Baty Clement
- Bauer Gerry
- Bauerdick Lothar A. T.
- Baumgartel Darin
- Baur Ulrich
- Bayshev Igor
- Bazterra Victor Eduardo
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beaupere Nicolas
- Bedjidian Marc
- Beernaert Kelly
- Behrenhoff Wolf
- Behrens Ulf
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- Beliy Nikita
- Belknap Donald
- Bell Alan James
- Bell Ken W.
- Bellan Paolo
- Bellan Riccardo
- Bellinger James Nugent
- Belotelov Ivan
- Belyaev Alexander
- Belyaev Andrey
- Benaglia Andrea
- Bencze Gyorgy
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- Bhat Pushpalatha C.
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- Chan Matthew
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- Chang You-Hao
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- Chang Yuan-Hann
- Chanon Nicolas
- Chao Yuan
- Charaf Otman
- Charlot Claude
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- Chasserat Julien
- Chatrchyan Serguei
- Chatterjee Avishek
- Chauhan Sushil
- Checchia Paolo
- Chen Guo-Ming
- Chen He-Sheng
- Chen Jie
- Chen Kai-Feng
- Chen Kuan-Hsin
- Chen Mingshui
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- Cherepanov Vladimir
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- Choudhary Brajesh C.
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- Christiansen Tim
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- Cossutti Fabio
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- Nespolo Massimo
- Nessi-Tedaldi Francesca
- Nesvold Erik
- Neu Christopher
- Neumeister Norbert
- Newbold Dave M.
- Newman Harvey B.
- Newman-Holmes Catherine
- Newsom Charles Ray
- Nguyen Duong
- Nguyen Harold
- Nguyen Matthew
- Nicolaou Charalambos
- Nicolas Kaufman Gala
- Niegel Martin
- Nikitenko Alexander
- Nirunpong Kachanon
- Nishu Nishu
- Nogima Helio
- Noonan Daniel
- Norbeck Edwin
- Nourbakhsh Shervin
- Novaes Sergio F.
- Nowack Andreas
- Nowak Friederike
- Ntomari Eleni
- Nuttens Claude
- Nuzzo Salvatore
- Nägeli Christoph
- Nürnberg Andreas
- O'Brien Christine
- O'Dell Vivian
- Oberst Oliver
- Obertino Maria Margherita
- Obraztsov Stepan
- Ocalan Kadir
- Ocampo Rios Alberto Andres
- Ochando Christophe
- Ochesanu Silvia
- Odell Nathaniel
- Odorici Fabrizio
- Oehler Andreas
- Ofierzynski Radoslaw Adrian
- Oguri Vitor
- Ojalvo Isabel
- Olaiya Emmanuel
- Olbrechts Annik
- Oliveros Sandra
- Olschewski Mark
- Olsen James
- Olson Jonathan
- Olzem Jan
- Onel Yasar
- Onengut Gulsen
- Oreshkin Vadim
- Organtini Giovanni
- Orimoto Toyoko
- Orsini Luciano
- Osipenkov Ilya
- Osorio Oliveros Andres Felipe
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- Ott Jochen
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- Palichik Vladimir
- Palinkas Jozsef
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- Panwalkar Shruti
- Paoletti Simone
- Paolucci Pierluigi
- Papacz Paul Jakob
- Papadopoulos Ioannis
- Papageorgiou Anastasios
- Pape Luc
- Paramatti Riccardo
- Paramesvaran Sudarshan
- Parashar Neeti
- Parida Bibhuti
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- Park Inkyu
- Park Michael
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- Park Sung Keun
- Pashenkov Anatoli
- Pastika Nathaniel
- Pastrone Nadia
- Patel Rishi
- Patras Vaios
- Patterson Juliet Ritchie
- Paulini Manfred
- Paus Christoph
- Pauss Felicitas
- Pavlov Borislav
- Pavlunin Viktor
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- Peiffer Thomas
- Pela Joao
- Pellett Dave
- Pelliccioni Mario
- Peltola Timo
- Penzo Aldo
- Perchalla Lars
- Perelygin Victor
- Perera Lalith
- Perez Emmanuelle
- Perfilov Maxim
- Perieanu Adrian
- Perloff Alexx
- Pernicka Manfred
- Perries Stephane
- Perrotta Andrea
- Perrozzi Luca
- Peruzzi Marco
- Pesaresi Mark
- Peterman Alison
- Petkov Peicho
- Petrakou Eleni
- Petridis Konstantinos
- Petrilli Achille
- Petrillo Gianluca
- Petrov Vladimir
- Petrucciani Giovanni
- Petrukhin Alexey
- Petrushanko Sergey
- Petyt David
- Pfeiffer Andreas
- Pi Haifeng
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- Pieri Marco
- Pierini Maurizio
- Pierro Giuseppe Antonio
- Pieta Holger
- Pietsch Niklas
- Pimiä Martti
- Pin Arnaud
- Pioppi Michele
- Piotrzkowski Krzysztof
- Piparo Danilo
- Piperov Stefan
- Piroué Pierre
- Pitzl Daniel
- Pivarski James
- Plager Charles
- Plestina Roko
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- Polatoz Ayse
- Polese Giovanni
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- Pordes Ruth
- Potenza Alberto
- Potenza Renato
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- Primavera Federica
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- Ptochos Fotios
- Puerta Pelayo Jesus
- Pugliese Gabriella
- Puigh Darren
- Puljak Ivica
- Qazi Shamona
- Qian Si-Jin
- Quan Xiaohang
- Quast Gunter
- Quertenmont Loic
- Rabbertz Klaus
- Racz Attila
- Radburn-Smith Benjamin Charles
- Radi Amr
- Ragazzi Stefano
- Rahatlou Shahram
- Rahbaran Babak
- Rahmat Rahmat
- Raics Peter
- Raidal Martti
- Rakness Gregory
- Ralph Duncan
- Ramirez Vargas Juan Eduardo
- Rander John
- Ranieri Riccardo
- Ranjan Kirti
- Rappoccio Salvatore
- Raspereza Alexei
- Ratnikov Fedor
- Ratnikova Natalia
- Ratti Sergio P.
- Raupach Frank Arthur
- Raval Amita
- Raymond David Mark
- Razis Panos A.
- Rebane Liis
- Rebassoo Finn
- Redaelli Nicola
- Redjimi Radia
- Redondo Ignacio
- Reece William
- Reid Ivan
- Reithler Hans
- Rekovic Vladimir
- Remington Ronald
- Renker Dieter
- Rennefeld Jörg
- Renz Manuel
- Reucroft Steve
- Reyes-Santos Marco A.
- Ribeiro Cipriano Pedro M.
- Ribeiro Pedro Quinaz
- Ribnik Jacob
- Riccardi Cristina
- Richards Alan
- Richman Jeffrey
- Rinkevicius Aurelijus
- Rizzi Andrea
- Ro Sang-Ryul
- Roberts Jay
- Robles Jorge
- Robmann Peter
- Rodenburg Marissa
- Rodozov Mircho
- Rodrigo Teresa
- Rodrigues Antunes Joao
- Rodriguez Jorge Luis
- Rodríguez-Marrero Ana Yaiza
- Roe Jeffrey
- Rogan Christopher
- Rogerson Samuel
- Roh Youn
- Rohe Tilman
- Rohlf James
- Rohringer Christine
- Rohringer Herbert
- Roland Benoit
- Roland Christof
- Roland Gunther
- Rolandi Gigi
- Romano Francesco
- Romanowska-Rybinska Katarzyna
- Romeo Francesco
- Romero Alessandra
- Romero Luciano
- Rommerskirchen Tanja
- Rompotis Nikolaos
- Ronchese Paolo
- Ronga Frederic Jean
- Rose Andrew
- Rose Keith
- Rosin Michele
- Rosowsky André
- Ross Ian
- Rossato Kenneth
- Rossi Antonio
- Rossin Roberto
- Rossini Marco
- Rougny Romain
- Rovelli Chiara
- Rovelli Tiziano
- Rovere Marco
- Ruchti Randy
- Rudolph Matthew
- Ruiz-Jimeno Alberto
- Rumerio Paolo
- Rusack Roger
- Rusakov Sergey V.
- Ruspa Marta
- Russ James
- Rutherford Britney
- Ryan Matthew John
- Ryckbosch Dirk
- Ryd Anders
- Ryu Geonmo
- Ryutin Roman
- Röcker Steffen
- Sabes David
- Sacchi Roberto
- Safarzadeh Batool
- Safonov Alexei
- Safronov Grigory
- Saha Anirban
- Saini Lovedeep Kaur
- Saka Halil
- Sakharov Alexandre
- Sakulin Hannes
- Sakuma Tai
- Sakumoto Willis
- Sala Leonardo
- Sala Silvano
- Salazar Ibarguen Humberto Antonio
- Salerno Roberto
- Salfeld-Nebgen Jakob
- Salur Sevil
- Salvati Emmanuele
- Sammet Jan
- Sanabria Juan Carlos
- Sanchez Ann - Karin
- Sander Christian
- Sanders David A.
- Sanders Stephen
- Sani Matteo
- Santanastasio Francesco
- Santaolalla Javier
- Santocchia Attilio
- Santoro Alberto
- Saoulidou Niki
- Saout Christophe
- Sarkar Subir
- Sarycheva Ludmila
- Sasseville Michael
- Sauerland Philip
- Savin Alexander
- Savrin Viktor
- Sawley Marie-Christine
- Scarborough Tara
- Schael Stefan
- Schettler Hannes
- Scheurer Armin
- Schieferdecker Philipp
- Schilling Frank-Peter
- Schlein Peter
- Schleper Peter
- Schlieckau Eike
- Schmanau Mike
- Schmidt Alexander
- Schmidt Ringo
- Schmitt Michael Henry
- Schmitt Michael Houston
- Schmitz Stefan Antonius
- Schnetzer Steve
- Schoerner-Sadenius Thomas
- Schott Gregory
- Schröder Matthias
- Schul Nicolas
- Schum Torben
- Schwarz Thomas
- Schwick Christoph
- Schäfer Christoph
- Schöfbeck Robert
- Scodellaro Luca
- Scurlock Bobby
- Searle Matthew
- Seez Christopher
- Segala Michael
- Segoni Ilaria
- Seitz Claudia
- Seixas Joao
- Sekmen Sezen
- Sellers Paul
- Selvaggi Giovanna
- Selvaggi Michele
- Semenov Sergey
- Sen Niladri
- Sen Sercan
- Senghi Soares Mara
- Sengupta Sinjini
- Senkin Sergey
- Seo Eunsung
- Seo Hyunkwan
- Serban Alin Titus
- Serin Meltem
- Sever Ramazan
- Sexton-Kennedy Elizabeth
- Sfiligoi Igor
- Sguazzoni Giacomo
- Shah Mehar Ali
- Sharma Archana
- Sharma Archana
- Sharma Seema
- Sharma Varun
- Sharma Vivek
- Sheldon Paul
- Shepherd-Themistocleous Claire H.
- Shi Xin
- Shipkowski Simon Peter
- Shipsey Ian
- Shiu Jing-Ge
- Shivpuri Ram Krishen
- Shmatov Sergey
- Shoaib Muhammad
- Shrestha Shruti
- Shreyber Irina
- Shukla Prashant
- Shumeiko Nikolai
- Sibille Jennifer
- Siegrist Patrice
- Sigamani Michael
- Sikler Ferenc
- Silkworth Christopher
- Sill Alan
- Sillou Daniel
- Silva Do Amaral Sheila Mara
- Silva Pedro
- Silvers David
- Silverwood Hamish
- Silvestre Catherine
- Silvestris Lucia
- Sim Kwang Souk
- Simon Michal
- Simon Sean
- Simonetto Franco
- Simonis Hans-Jürgen
- Singh Anil
- Singh Gurpreet
- Singh Jasbir
- Singh Supreet Pal
- Singovsky Alexander
- Sinthuprasith Tutanon
- Sirois Yves
- Siroli Gianni
- Sirunyan Albert M.
- Skhirtladze Nikoloz
- Skuja Andris
- Slaunwhite Jason
- Smirnov Igor
- Smirnov Vitaly
- Smith James
- Smith John
- Smith Kenneth
- Smith Vincent J.
- Smith Wesley H.
- Snigirev Alexander
- Snoek Hella
- Snook Benjamin
- Snow Gregory R.
- Snowball Matthew
- Soares Jorge Luana
- Sobol Andrei
- Sobron Sanudo Mar
- Soffi Livia
- Sogut Kenan
- Solano Ada
- Somalwar Sunil
- Son Dong-Chul
- Song Sanghyeon
- Sonmez Nasuf
- Sonnenschein Lars
- Sordini Viola
- Souza Dos Anjos Tiago
- Spagnolo Paolo
- Spalding William J.
- Spanier Stefan
- Sparrow Alex
- Speer Thomas
- Sperka David
- Sphicas Paraskevas
- Spiegel Leonard
- Spiga Daniele
- Spiridonov Alexander
- Spiropulu Maria
- Sprenger Daniel
- Squires Michael
- St John Jason
- Stadie Hartmut
- Stahl Achim
- Staiano Amedeo
- Starodumov Andrei
- Steggemann Jan
- Stein Matthias
- Steinbrück Georg
- Stenson Kevin
- Stephans George
- Stickland David
- Stieger Benjamin
- Stiliaris Efstathios
- Stober Fred-Markus Helmut
- Stolin Viatcheslav
- Stone Robert
- Stoye Markus
- Stoykova Stefka
- Stoynev Stoyan
- Strauss Josef
- Stringer Robert
- Strobbe Nadja
- Strom Derek
- Stuart David
- Sturdy Jared
- Stöckli Fabian
- Suarez Gonzalez Juan
- Suarez Indara
- Sudano Elizabeth
- Sudhakar Katta
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- Sulimov Valentin
- Sultanov Georgi
- Summers Don
- Sumorok Konstanty
- Sumowidagdo Suharyo
- Sun Werner
- Sunar Cerci Deniz
- Sung Kevin
- Surat Ugur Emrah
- Svintradze Irakli
- Svyatkovskiy Alexey
- Swanson Joshua
- Swartz Morris
- Symonds Philip
- Szillasi Zoltan
- Szleper Michal
- Sznajder Andre
- Sánchez Hernández Alberto
- Tabarelli de Fatis Tommaso
- Tadel Matevz
- Takahashi Maiko
- Tali Bayram
- Tambe Norbert
- Tan Ping
- Tao Junquan
- Tapper Alexander
- Taroni Silvia
- Tatarinov Aysen
- Taurok Anton
- Tauscher Ludwig
- Taylor Lucas
- Tcholakov Vanio
- Teischinger Florian
- Temple Jeffrey
- Tenchini Roberto
- Teng Haiyun
- Teo Wee Don
- Teodorescu Liliana
- Teyssier Daniel
- Thea Alessandro
- Theofilatos Konstantinos
- Thiebaux Christophe
- Thom Julia
- Thomas Laurent
- Thomas Scott
- Thompson Joshua
- Thomsen Jan
- Thyssen Filip
- Tiko Andres
- Timciuc Vladlen
- Tinti Gemma
- Tiras Emrah
- Titov Maksym
- Tkaczyk Slawek
- To Wing
- Toback David
- Tomalin Ian R.
- Tomaszewska Justyna
- Tomei Thiago
- Tonelli Guido
- Tonjes Marguerite
- Tonwar Suresh C.
- Topakli Huseyin
- Torassa Ezio
- Toropin Alexander
- Torre Paola
- Tosi Mia
- Tosi Silvano
- Tourneur Stephane
- Tourtchanovitch Leonid
- Traczyk Piotr
- Tran Nhan Viet
- Trapani Pier Paolo
- Travaglini Riccardo
- Trayanov Rumen
- Treille Daniel
- Triantis Frixos A.
- Tricomi Alessia
- Tripathi Mani
- Trocino Daniele
- Trocsanyi Zoltan Laszlo
- Troendle Daniel
- Troitsky Sergey
- Tropiano Antonio
- Troshin Sergey
- Tsang Ka Vang
- Tschudi Yohann
- Tsirou Andromachi
- Tu Yanjun
- Tucker Jordan
- Tully Christopher
- Tumasyan Armen
- Tuo Shengquan
- Tuominen Eija
- Tuominiemi Jorma
- Tuovinen Esa
- Tupputi Salvatore
- Turkewitz Jared
- Turner Mark
- Tuuva Tuure
- Tuve Cristina
- Twedt Elizabeth
- Tytgat Michael
- Tyurin Nikolay
- Tzeng Yeng-Ming
- Ujvari Balazs
- Ulmer Keith
- Ungaro Donatella
- Uplegger Lorenzo
- Urscheler Christina
- Uvarov Lev
- Uzun Dilber
- Uzunian Andrey
- Vaandering Eric Wayne
- Valdata Marisa
- Valls Nil
- Valuev Vyacheslav
- Van Doninck Walter
- Van Haevermaet Hans
- Van Hove Pierre
- Van Mechelen Pierre
- Van Mulders Petra
- Van Onsem Gerrit Patrick
- Van Remortel Nick
- Van Spilbeeck Alex
- Vander Velde Catherine
- Vanelderen Lukas
- Vanini Sara
- Vanlaer Pascal
- Varela Joao
- Varelas Nikos
- Vartak Adish
- Vasquez Sierra Ricardo
- Vaughan Jennifer
- Vavilov Sergey
- Vazquez Acosta Monica
- Vazquez Valencia Fabiola
- Veelken Christian
- Veeraraghavan Venkatesh
- Velasco Mayda
- Velicanu Dragos
- Velkovska Julia
- Venturi Andrea
- Verdier Patrice
- Verdini Piero Giorgio
- Veres Gabor Istvan
- Vergili Latife Nukhet
- Vergili Mehmet
- Verwilligen Piet
- Verzetti Mauro
- Veszpremi Viktor
- Vesztergombi Gyorgy
- Veverka Jan
- Vichoudis Paschalis
- Vidal Marono Miguel
- Vidal Richard
- Vila Ivan
- Vilar Cortabitarte Rocio
- Vilela Pereira Antonio
- Villasenor-Cendejas Luis Manuel
- Villella Ilaria
- Vinogradov Alexey
- Virdee Tejinder
- Viret Sébastien
- Vischia Pietro
- Vishnevskiy Dmitry
- Vitulo Paolo
- Viviani Claudio
- Vizan Garcia Jesus Manuel
- Vlasov Evgueni
- Vlimant Jean-Roch
- Vodopiyanov Igor
- Vogel Helmut
- Volkov Alexey
- Volobouev Igor
- Volodko Anton
- Volpe Roberta
- Vorobiev Igor
- Vorobyev Alexey
- Vorobyev Andrey
- Voutilainen Mikko
- Vuosalo Carl
- Vutova Mariana
- Wagner Philipp
- Wagner Stephen Robert
- Wagner-Kuhr Jeannine
- Wakefield Stuart
- Wallny Rainer
- Walsh Roberval
- Walsh Sinead
- Waltenberger Wolfgang
- Walzel Gerhard
- Wan Zongru
- Wang Dayong
- Wang Jian
- Wang Jian
- Wang Minzu
- Wang Siguang
- Wang Xianyou
- Wang Zheng
- Wardle Nicholas
- Wardrope David
- Wasserbaech Steven
- Wayne Mitchell
- Weber Hannsjoerg Artur
- Weber Hendrik
- Weber Martin
- Weber Matthias
- Wehrli Lukas
- Weiler Thomas
- Weinberg Marc
- Wendland Lauri
- Weng Joanna
- Weng Yao
- Wenger Edward Allen
- Werner Jeremy Scott
- West Christopher
- Wetzel James
- Whitbeck Andrew
- Whitmore Juliana
- Whyntie Tom
- Wickens John
- Wickramage Nadeesha
- Widl Edmund
- Wigmans Richard
- Wilken Rachel
- Wilkinson Richard
- Williams Grayson
- Williams Thomas
- Willmott Carlos
- Wimpenny Stephen
- Winn Dave
- Winstrom Lucas
- Wissing Christoph
- Wittich Peter
- Wittmer Bruno
- Wolf Matthias
- Wolf Roger
- Womersley William John
- Won Steven
- Wood Darien
- Wood Jeffrey Scott
- Wood John
- Worm Steven
- Wright Douglas
- Wrochna Grzegorz
- Wu Weimin
- Wulz Claudia-Elisabeth
- Wyslouch Bolek
- Wöhri Hermine Katharina
- Würthwein Frank
- Xiao Hong
- Xie Si
- Xu Ming
- Yagil Avraham
- Yalvac Metin
- Yang Fan
- Yang Mingming
- Yang Yong
- Yang Zong-Chang
- Yazgan Efe
- Yelton John
- Yetkin Taylan
- Yi Kai
- Yildirim Eda
- Yilmaz Yetkin
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- Yoon Sungho
- York Andrew
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yun Jae Chul
- Zabel James
- Zabi Alexandre
- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Marco
- Zang Jingjing
- Zang Shi-Lei
- Zarubin Anatoli
- Zatserklyaniy Andriy
- Zeinali Maryam
- Zeise Manuel
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhang Zhen
- Zheng Yu
- Zhokin Alexander
- Zhu Bo
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Ziebarth Eva Barbara
- Ziegler Jill
- Zielinski Marek
- Zito Giuseppe
- Zotto Pierluigi
- Zou Wei
- Zuranski Andrzej
- Zöller Marc Henning
- Publication venue
- Publication date
- 01/01/2012
- Field of study
Discutindo a educação ambiental no cotidiano escolar: desenvolvimento de projetos na escola formação inicial e continuada de professores
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Acosta Darin
- Acosta Jhon Gabriel
- Adam Nadia
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Afanasiev Serguei
- Agostino Lorenzo
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Aguilo Ernest
- Ahmad Muhammad
- Ahmed Ijaz
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akgun Ugur
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alexander James
- Aliev Takhmasib
- Almeida Nuno
- Alver Burak
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anastassov Anton
- Anderson Jacob
- Anderson Michael
- Andrea Jeremy
- Andreev Valeri
- Andreev Vladimir
- Andreev Yuri
- Andrews Warren
- Anghel Ioana Maria
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Aranyi Attila
- Arce Pedro
- Arcidiacono Roberta
- Arenton Michael Wayne
- Arfaei Hessamaddin
- Argiro Stefano
- Arisaka Katsushi
- Arneodo Michele
- Asaadi Jonathan
- Asghar Muhammad Irfan
- Askew Andrew
- Assran Yasser
- Ata Metin
- Atac Muzaffer
- Atramentov Oleksiy
- Attikis Alexandros
- Auffray Etiennette
- Autermann Christian Tobias
- Auzinger Georg
- Avery Paul
- Avetisyan Aram
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M.
- Babb John
- Bacchetta Nicola
- Bachtis Michail
- Baden Drew
- Baesso Paolo
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bai Yuting
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Bakken Jon Alan
- Balazs Michael
- Ball Austin
- Ball Gordon
- Ballin Jamie
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Banzuzi Kukka
- Barbagli Giuseppe
- Barberis Emanuela
- Barbone Lucia
- Bardak Cemile
- Barfuss Anne-fleur
- Bargassa Pedrame
- Barge Derek
- Baringer Philip
- Barker Anthony
- Barnes Virgil E.
- Barnett Bruce Arnold
- Barney David
- Barone Luciano
- Barrett Matthew
- Bartalini Paolo
- Barth Christian
- Basegmez Suzan
- Basso Lorenzo
- Battilana Carlo
- Baty Clement
- Bauer Gerry
- Bauer Julia
- Bauerdick Lothar A. T.
- Baumgartel Darin
- Baur Ulrich
- Bazterra Victor Eduardo
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beaupere Nicolas
- Bedjidian Marc
- Behrenhoff Wolf
- Behrens Ulf
- Belforte Stefano
- Beliy Nikita
- Bell Alan James
- Bell Ken W.
- Bellan Paolo
- Bellan Riccardo
- Bellinger James Nugent
- Belyaev Alexander
- Benaglia Andrea
- Bencze Gyorgy
- Bendavid Joshua
- Bender Walter
- Benedetti Daniele
- Benelli Gabriele
- Benhabib Lamia
- Beni Noemi
- Benucci Leonardo
- Benussi Luigi
- Benvenuti Alberto
- Beretvas Andrew
- Bergauer Thomas
- Bergholz Matthias
- Beri Suman Bala
- Bernardini Jacopo
- Bernet Colin
- Berry Douglas
- Berry Edmund
- Berryhill Jeffrey
- Bertl Willi
- Berzano Umberto
- Besancon Marc
- Betchart Burton
- Bethani Agni
- Betts Russell Richard
- Beuselinck Raymond
- Bhat Pushpalatha C.
- Bhatnagar Vipin
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhatti Anwar
- Bialas Wojciech
- Bian Jian-Guo
- Bianchini Lorenzo
- Bianco Stefano
- Biasini Maurizio
- Biino Cristina
- Bilei Gian Mario
- Bilinskas Mykolas Jurgis
- Bilki Burak
- Bilmis Selcuk
- Biselli Angela
- Bisello Dario
- Bitioukov Sergei
- Blekman Freya
- Blobel Volker
- Bloch Daniel
- Bloch Ingo
- Bloch Philippe
- Bloom Kenneth
- Bluj Michal
- Blumenfeld Barry
- Blyweert Stijn
- Bobrovskyi Sergei
- Boccali Tommaso
- Bocci Andrea
- Bochenek Joseph
- Bodek Arie
- Bodin David
- Boeriu Oana
- Boldizsar Laszlo
- Bolla Gino
- Bolognesi Sara
- Bolton Tim
- Bona Marcella
- Bonacorsi Daniele
- Bonato Alessio
- Bondu Olivier
- Bontenackels Michael
- Boos Edouard
- Borcherding Frederick
- Bornheim Adolf
- Borras Kerstin
- Borrello Laura
- Bortignon Pierluigi
- Bortoletto Daniela
- Bose Suvadeep
- Bose Tulika
- Bostock Francis
- Botta Cristina
- Boudoul Gaelle
- Boulahouache Chaouki
- Boumediene Djamel
- Bourilkov Dimitri
- Boutemeur Madjid
- Boutle Sarah
- Braibant-Giacomelli Sylvie
- Branca Antonio
- Branson James G.
- Breedon Richard
- Breuker Horst
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- Yohay Rachel
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- Yumiceva Francisco
- Yun Jae Chul
- Zabel James
- Zabi Alexandre
- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Marco
- Zang Jingjing
- Zang Shi-Lei
- Zarubin Anatoli
- Zatserklyaniy Andriy
- Zeinali Maryam
- Zeise Manuel
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhang Linlin
- Zhang Zhen
- Zheng Yu
- Zhokin Alexander
- Zhu Bo
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Ziebarth Eva Barbara
- Ziegler Jill
- Zielinski Marek
- Zito Giuseppe
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou Wei
- Zumerle Gianni
- Zuranski Andrzej
- Zöller Marc Henning
- Publication venue
- Publication date
- 01/01/2011
- Field of study
A presente pesquisa buscou discutir como a Educação Ambiental (EA) vem sendo trabalhada, no Ensino Fundamental e como os docentes desta escola compreendem e vem inserindo a EA no cotidiano escolar., em uma escola estadual do município de Tangará da Serra/MT, Brasil. Para tanto, realizou-se entrevistas com os professores que fazem parte de um projeto interdisciplinar de EA na escola pesquisada. Verificou-se que o projeto da escola não vem conseguindo alcançar os objetivos propostos por: desconhecimento do mesmo, pelos professores; formação deficiente dos professores, não entendimento da EA como processo de ensino-aprendizagem, falta de recursos didáticos, planejamento inadequado das atividades. A partir dessa constatação, procurou-se debater a impossibilidade de tratar do tema fora do trabalho interdisciplinar, bem como, e principalmente, a importância de um estudo mais aprofundado de EA, vinculando teoria e prática, tanto na formação docente, como em projetos escolares, a fim de fugir do tradicional vínculo “EA e ecologia, lixo e horta”.Facultad de Humanidades y Ciencias de la Educació
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
- Author
- Abassi Yama
- Abelin Jennifer G
- Abolhalaj Milad
- Abraham Tara S
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F
- Adamus Tomasz
- Addepalli Murali
- Addepalli Murali
- Adjei Alex A
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C
- Albershardt Tina C
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T
- Alley Evan W
- Allison James
- Allison James
- Allison James
- Alston Tesha
- Alt Jürgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anand Snjezana
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H I
- Andtbacka Robert H I
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S
- Antonia Scott J
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F
- Arina Ainhoa
- Armand Philippe
- Armenta Paul
- Armet Caroline M
- Arnoux Thomas
- Ascarateil Stephane
- Askmyr David
- Atkins Michael
- Atkins Michael B
- Atkinson Victoria
- Au Katrina
- Autio Karen A
- Awad Mark
- Bagarazzi Mark
- Bai Dina
- Baia Gilson
- Baird Jason
- Bajaj Anshika
- Balatoni Timea
- Balboni Tracy
- Balch Leslie
- Bang Andrew
- Bao Riyue
- Bao Yangyi
- Bao Yangyi
- Barakat David
- Barberi Theresa
- Barker Christopher A
- Barnea Eytan
- Barras David
- Bartkowiak Todd
- Bartlett David
- Bartlett David
- Bartlett David
- Bartlett David
- Barton Sunjay M
- Barve Minal
- Bauer Todd
- Bauer Todd W
- Bauman Julie
- Baumgaertner Petra
- Bauml Joshua
- Beceren-Braun Figen
- Beck Kristen
- Becker Annette
- Beckers Johannes
- Beckett Michael A
- Bedognetti Davide
- Bedognetti Davide
- Bedognetti Davide
- Bell Bryan
- Bell Charles J M
- Bell Peter
- Beltran Pedro
- Bender Lewis H
- Bender Steven
- Bennett Mark K
- Benz Steven
- Bera Tapan
- Berglund Peter
- Berglund Peter
- Berkey Sara
- Bernatchez Chantale
- Berry John S
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- Zeng Xue
- Zha Yuanyuan
- Zhang Danhui
- Zhang Jing
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- Zhang Winter
- Zhang Yanping
- Zhao Fei
- Zhao Leyna
- Zhao Xingli
- Zheng Lianxing
- Zheng Wenxin
- Zheng Xianxian
- Zheng Yi
- Zhong Hong
- Zhou Li
- Zhou Xiangjun
- Zippelius Alfred
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zou Jun
- Zuba-Surma Ewa
- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
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