Armored Droplets as Soft Nanocarriers for Encapsulation and Release under Flow Conditions

Technical challenges in precision medicine and environmental remediation create an increasing demand for smart materials that can select and deliver a probe load to targets with high precision. In this context, soft nanomaterials have attracted considerable attention due to their ability to simultaneously adapt their morphology and functionality to complex ambients. Two major challenges are to precisely control this adaptability under dynamic conditions and provide predesigned functionalities that can be manipulated by external stimuli. Here, we report on the computational design of a distinctive class of soft nanocarriers, built from armored nanodroplets, able to selectively encapsulate or release a probe load under specific flow conditions. First, we describe in detail the mechanisms at play in the formation of pocket-like structures in armored nanodroplets and their stability under external flow. Then we use that knowledge to test the capacity of these pockets to yield flow-assisted encapsulation or expulsion of a probe load. Finally, the rheological properties of these nanocarriers are put into perspective with those of delivery systems employed in pharmaceutical and cosmetic technology

Nanoparticles Actively Fragment Armored Droplets

Understanding the complexity of fragmentation processes is essential for regulating intercellular communication in mechanistic biology and developing bottom-up approaches in a large range of multiphase flow processes. In this context, self-fragmentation proceeds without any external mechanical energy input, allowing one to create efficiently micro- and nanodroplets. Here we examine self-fragmentation in emulsion nanodroplets stabilized by solid particles with different surface features. Mesoscopic modeling and accelerated dynamics simulations allow us to overcome the limitations of atomistic simulations and offer detailed insight into the interplay between the evolution of the droplet shape and the particle finite-size effects at the interface. We show that finite-size nanoparticles play an active role in the necking breakup, behaving like nanoscale razors, and affect strongly the thermodynamic properties of the system. The role played by the particles during self-fragmentation might be of relevance to multifunctional biomaterial design and tuning of signaling pathways in mechanistic biology

Removal of Paracetamol Using Effective Advanced Oxidation Processes

Fenton, photo-Fenton, and photo-induced oxidation, were investigated and compared for the treatment of 0.26 mmol L-1 of paracetamol (PCT) in a deionised water matrix, during a reaction span of 120.0 min. Low and high Fenton reagent loads were studied. Particularly, the initial concentration of Fe2+ was varied between 0.09 and 0.18 mmol L-1 while the initial concentration of H2O2 was varied between 2.78 and 11.12 mmol L-1. The quantitative performance of these treatments was evaluated by: (i) measuring PCT concentration; (ii) measuring and modelling TOC conversion, as a means characterizing sample mineralization; and (iii) measuring cytotoxicity to assess the safe application of each treatment. In all cases, organic matter mineralization was always partial, but PCT concentration fell below the detection limit within 2.5 and 20.0 min. The adopted semi-empirical model revealed that photo induced oxidation is the only treatment attaining total organic matter mineralization (¿MAX= 100% in 200.0 min) at the expense of the lowest kinetic constant (k = 0.007 min-1). Conversely, photo-Fenton treatment using high Fenton reagent loads gave a compromise solution (¿MAX= 73% and k = 0.032 min-1). Finally, cytotoxicity assays proved the safe application of photo-induced oxidation and of photo-Fenton treatments using high concentrations of Fenton reagents.Peer ReviewedPostprint (published version

Hemophagocytic syndrome in patients from SLE Registry from the Spanish Society of Rheumatology (RELESSER)

Poster presentationInstituto de Salud Carlos III; PI11/0285

New data on the Silurian-Devonian paleontology and biostratigraphy of Bolivia

P. 269-314In order to precisely establish the bio- and chronostratigraphic position of several levels of the Silurian–Devonian succession of Bolivia, with respect to the International Time Scale, additional Silurian and Devonian localities belonging to the Eastern Cordillera and the Interandean Zone areas have been recently revised and sampled, both for macrofossils and palynomorphs. Specifically, the localities are Ñuñumayani, and Muruhuta from the late Silurian–early Devonian time interval. Correlations with other fossiliferous localities are discussed, namely Huacallani and Rumicorral.S

Single hadron response measurement and calorimeter jet energy scale uncertainty with the ATLAS detector at the LHC

The uncertainty on the calorimeter energy response to jets of particles is derived for the ATLAS experiment at the Large Hadron Collider (LHC). First, the calorimeter response to single isolated charged hadrons is measured and compared to the Monte Carlo simulation using proton-proton collisions at centre-of-mass energies of sqrt(s) = 900 GeV and 7 TeV collected during 2009 and 2010. Then, using the decay of K_s and Lambda particles, the calorimeter response to specific types of particles (positively and negatively charged pions, protons, and anti-protons) is measured and compared to the Monte Carlo predictions. Finally, the jet energy scale uncertainty is determined by propagating the response uncertainty for single charged and neutral particles to jets. The response uncertainty is 2-5% for central isolated hadrons and 1-3% for the final calorimeter jet energy scale.Comment: 24 pages plus author list (36 pages total), 23 figures, 1 table, submitted to European Physical Journal

Measurement of χ c1 and χ c2 production with s√ = 7 TeV pp collisions at ATLAS

The prompt and non-prompt production cross-sections for the χ c1 and χ c2 charmonium states are measured in pp collisions at s√ = 7 TeV with the ATLAS detector at the LHC using 4.5 fb−1 of integrated luminosity. The χ c states are reconstructed through the radiative decay χ c → J/ψγ (with J/ψ → μ + μ −) where photons are reconstructed from γ → e + e − conversions. The production rate of the χ c2 state relative to the χ c1 state is measured for prompt and non-prompt χ c as a function of J/ψ transverse momentum. The prompt χ c cross-sections are combined with existing measurements of prompt J/ψ production to derive the fraction of prompt J/ψ produced in feed-down from χ c decays. The fractions of χ c1 and χ c2 produced in b-hadron decays are also measured

Measurement of the production of a W boson in association with a charm quark in pp collisions at √s = 7 TeV with the ATLAS detector

The production of a W boson in association with a single charm quark is studied using 4.6 fb−1 of pp collision data at s√ = 7 TeV collected with the ATLAS detector at the Large Hadron Collider. In events in which a W boson decays to an electron or muon, the charm quark is tagged either by its semileptonic decay to a muon or by the presence of a charmed meson. The integrated and differential cross sections as a function of the pseudorapidity of the lepton from the W-boson decay are measured. Results are compared to the predictions of next-to-leading-order QCD calculations obtained from various parton distribution function parameterisations. The ratio of the strange-to-down sea-quark distributions is determined to be 0.96+0.26−0.30 at Q 2 = 1.9 GeV2, which supports the hypothesis of an SU(3)-symmetric composition of the light-quark sea. Additionally, the cross-section ratio σ(W + +c¯¯)/σ(W − + c) is compared to the predictions obtained using parton distribution function parameterisations with different assumptions about the s−s¯¯¯ quark asymmetry

Measurement of the flavour composition of dijet events in pp collisions at root s=7 TeV with the ATLAS detector

This paper describes a measurement of the flavour composition of dijet events produced in pp collisions at √s=7 TeV using the ATLAS detector. The measurement uses the full 2010 data sample, corresponding to an integrated luminosity of 39 pb−1. Six possible combinations of light, charm and bottom jets are identified in the dijet events, where the jet flavour is defined by the presence of bottom, charm or solely light flavour hadrons in the jet. Kinematic variables, based on the properties of displaced decay vertices and optimised for jet flavour identification, are used in a multidimensional template fit to measure the fractions of these dijet flavour states as functions of the leading jet transverse momentum in the range 40 GeV to 500 GeV and jet rapidity |y|<2.1. The fit results agree with the predictions of leading- and next-to-leading-order calculations, with the exception of the dijet fraction composed of bottom and light flavour jets, which is underestimated by all models at large transverse jet momenta. The ability to identify jets containing two b-hadrons, originating from e.g. gluon splitting, is demonstrated. The difference between bottom jet production rates in leading and subleading jets is consistent with the next-to-leading-order predictions

Search for a CP-odd Higgs boson decaying to Zh in pp collisions at √s=8TeV with the ATLAS detector

A search for a heavy, CP-odd Higgs boson, A, decaying into a Zboson and a 125GeV Higgs boson, h, with the ATLAS detector at the LHC is presented. The search uses proton–proton collision data at a centre-of-mass energy of 8TeV corresponding to an integrated luminosity of 20.3fb−1. Decays of CP-even hbosons to ττor bbpairs with the Zboson decaying to electron or muon pairs are considered, as well as h →bbdecays with the Zboson decaying to neutrinos. No evidence for the production of an Aboson in these channels is found and the 95% confidence level upper limits derived for σ(gg→A) ×BR(A →Zh) ×BR(h →f¯f)are 0.098–0.013pb for f=τand 0.57–0.014pb for f=bin a range of mA=220–1000GeV. The results are combined and interpreted in the context of two-Higgs-doublet models. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons