205 research outputs found
Phosphoisoprenoids Modulate Association of Rab Geranylgeranyltransferase with REP-1
Rab geranylgeranyltransferase (RabGGTase or GGTase-II) catalyzes the post-translational prenylation of Rab proteins. Rab proteins are recognized as substrates only when they are complexed to Rab Escort Protein (REP). The classical model of prenylation complex assembly assumes initial formation of the Rab.REP binary complex, which subsequently binds to RabGGTase loaded with the isoprenoid donor geranylgeranyl pyrophosphate (GGpp). We demonstrate here that REP-1 can also associate with RabGGTase in the absence of Rab protein and that this interaction is dramatically strengthened by the presence of phosphoisoprenoids such as GGpp. The GGpp-dependent interaction between RabGGTase and REP-1 was observed using affinity precipitations and gel filtration and was quantitated on the basis of fluorescence assays. In the presence of GGpp, REP-1 binds to RabGGTase with a K(d) value of similar to10 nM, while in its absence the affinity between the two proteins is in the micromolar range. We further demonstrate that binding of Rab7 to the RabGGTase.GGpp.REP-1 complex occurs without prior dissociation of REP-1. Analysis of binding and prenylation rate constants indicate that the RabGGTase.GGpp.REP-1 complex can function as a kinetically competent intermediate of the prenylation reaction. We conclude that, depending on the prevailing concentrations, binding of REP-1 to RabGGTase in the presence of GGpp may serve as an alternative pathway for the assembly of the prenylation machinery in vivo. Implications of these findings for the role of REP-1 in the prenylation reaction are discussed
Sparsity order estimation for single snapshot compressed sensing
In this paper we discuss the estimation of the spar-sity order for a Compressed Sensing scenario where only a single snapshot is available. We demonstrate that a specific design of the sensing matrix based on Khatri-Rao products enables us to transform this problem into the estimation of a matrix rank in the presence of additive noise. Thereby, we can apply existing model order selection algorithms to determine the sparsity order. The matrix is a rearranged version of the observation vector which can be constructed by concatenating a series of non-overlapping or overlapping blocks of the original observation vector. In both cases, a Khatri-Rao structured measurement matrix is required with the main difference that in the latter case, one of the factors must be a Vandermonde matrix. We discuss the choice of the parameters and show that an increasing amount of block overlap improves the sparsity order estimation but it increases the coherence of the sensing matrix. We also explain briefly that the proposed measurement matrix design introduces certain multilinear structures into the observations which enables us to apply tensor-based signal processing, e.g., for enhanced denoising or improved sparsity order estimation. © 2014 IEEE
Photoproduction of mesons off nuclei
Recent results for the photoproduction of mesons off nuclei are reviewed.
These experiments have been performed for two major lines of research related
to the properties of the strong interaction. The investigation of nucleon
resonances requires light nuclei as targets for the extraction of the isospin
composition of the electromagnetic excitations. This is done with quasi-free
meson photoproduction off the bound neutron and supplemented with the
measurement of coherent photoproduction reactions, serving as spin and/or
isospin filters. Furthermore, photoproduction from light and heavy nuclei is a
very efficient tool for the study of the interactions of mesons with nuclear
matter and the in-medium properties of hadrons. Experiments are currently
rapidly developing due to the combination of high quality tagged (and
polarized) photon beams with state-of-the-art 4pi detectors and polarized
targets
Electron Scattering From High-Momentum Neutrons in Deuterium
We report results from an experiment measuring the semi-inclusive reaction
where the proton is moving at a large angle relative to the
momentum transfer. If we assume that the proton was a spectator to the reaction
taking place on the neutron in deuterium, the initial state of that neutron can
be inferred. This method, known as spectator tagging, can be used to study
electron scattering from high-momentum (off-shell) neutrons in deuterium. The
data were taken with a 5.765 GeV electron beam on a deuterium target in
Jefferson Laboratory's Hall B, using the CLAS detector. A reduced cross section
was extracted for different values of final-state missing mass ,
backward proton momentum and momentum transfer . The data
are compared to a simple PWIA spectator model. A strong enhancement in the data
observed at transverse kinematics is not reproduced by the PWIA model. This
enhancement can likely be associated with the contribution of final state
interactions (FSI) that were not incorporated into the model. A ``bound neutron
structure function'' was extracted as a function of and
the scaling variable at extreme backward kinematics, where effects of
FSI appear to be smaller. For MeV/c, where the neutron is far
off-shell, the model overestimates the value of in the region of
between 0.25 and 0.6. A modification of the bound neutron structure
function is one of possible effects that can cause the observed deviation.Comment: 33 pages RevTeX, 9 figures, to be submitted to Phys. Rev. C. Fixed 1
Referenc
Complete measurement of three-body photodisintegration of 3He for photon energies between 0.35 and 1.55 GeV
The three-body photodisintegration of 3He has been measured with the CLAS
detector at Jefferson Lab, using tagged photons of energies between 0.35 GeV
and 1.55 GeV. The large acceptance of the spectrometer allowed us for the first
time to cover a wide momentum and angular range for the two outgoing protons.
Three kinematic regions dominated by either two- or three-body contributions
have been distinguished and analyzed. The measured cross sections have been
compared with results of a theoretical model, which, in certain kinematic
ranges, have been found to be in reasonable agreement with the data.Comment: 22 pages, 25 eps figures, 2 tables, submitted to PRC. Modifications:
removed 2 figures, improvements on others, a few minor modifications to the
tex
A Kinematically Complete Measurement of the Proton Structure Function F2 in the Resonance Region and Evaluation of Its Moments
We measured the inclusive electron-proton cross section in the nucleon
resonance region (W < 2.5 GeV) at momentum transfers Q**2 below 4.5 (GeV/c)**2
with the CLAS detector. The large acceptance of CLAS allowed for the first time
the measurement of the cross section in a large, contiguous two-dimensional
range of Q**2 and x, making it possible to perform an integration of the data
at fixed Q**2 over the whole significant x-interval. From these data we
extracted the structure function F2 and, by including other world data, we
studied the Q**2 evolution of its moments, Mn(Q**2), in order to estimate
higher twist contributions. The small statistical and systematic uncertainties
of the CLAS data allow a precise extraction of the higher twists and demand
significant improvements in theoretical predictions for a meaningful comparison
with new experimental results.Comment: revtex4 18 pp., 12 figure
eta-prime photoproduction on the proton for photon energies from 1.527 to 2.227 GeV
Differential cross sections for the reaction gamma p -> eta-prime p have been
measured with the CLAS spectrometer and a tagged photon beam with energies from
1.527 to 2.227 GeV. The results reported here possess much greater accuracy
than previous measurements. Analyses of these data indicate for the first time
the coupling of the etaprime N channel to both the S_11(1535) and P_11(1710)
resonances, known to couple strongly to the eta N channel in photoproduction on
the proton, and the importance of j=3/2 resonances in the process.Comment: 6 pages, 3 figure
Measurement of the Deuteron Structure Function F2 in the Resonance Region and Evaluation of Its Moments
Inclusive electron scattering off the deuteron has been measured to extract
the deuteron structure function F2 with the CEBAF Large Acceptance Spectrometer
(CLAS) at the Thomas Jefferson National Accelerator Facility. The measurement
covers the entire resonance region from the quasi-elastic peak up to the
invariant mass of the final-state hadronic system W~2.7 GeV with four-momentum
transfers Q2 from 0.4 to 6 (GeV/c)^2. These data are complementary to previous
measurements of the proton structure function F2 and cover a similar
two-dimensional region of Q2 and Bjorken variable x. Determination of the
deuteron F2 over a large x interval including the quasi-elastic peak as a
function of Q2, together with the other world data, permit a direct evaluation
of the structure function moments for the first time. By fitting the Q2
evolution of these moments with an OPE-based twist expansion we have obtained a
separation of the leading twist and higher twist terms. The observed Q2
behaviour of the higher twist contribution suggests a partial cancellation of
different higher twists entering into the expansion with opposite signs. This
cancellation, found also in the proton moments, is a manifestation of the
"duality" phenomenon in the F2 structure function
Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector
A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results
Jet size dependence of single jet suppression in lead-lead collisions at sqrt(s(NN)) = 2.76 TeV with the ATLAS detector at the LHC
Measurements of inclusive jet suppression in heavy ion collisions at the LHC
provide direct sensitivity to the physics of jet quenching. In a sample of
lead-lead collisions at sqrt(s) = 2.76 TeV corresponding to an integrated
luminosity of approximately 7 inverse microbarns, ATLAS has measured jets with
a calorimeter over the pseudorapidity interval |eta| < 2.1 and over the
transverse momentum range 38 < pT < 210 GeV. Jets were reconstructed using the
anti-kt algorithm with values for the distance parameter that determines the
nominal jet radius of R = 0.2, 0.3, 0.4 and 0.5. The centrality dependence of
the jet yield is characterized by the jet "central-to-peripheral ratio," Rcp.
Jet production is found to be suppressed by approximately a factor of two in
the 10% most central collisions relative to peripheral collisions. Rcp varies
smoothly with centrality as characterized by the number of participating
nucleons. The observed suppression is only weakly dependent on jet radius and
transverse momentum. These results provide the first direct measurement of
inclusive jet suppression in heavy ion collisions and complement previous
measurements of dijet transverse energy imbalance at the LHC.Comment: 15 pages plus author list (30 pages total), 8 figures, 2 tables,
submitted to Physics Letters B. All figures including auxiliary figures are
available at
http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HION-2011-02
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