49 research outputs found

    Measuring our Peculiar Velocity by "Pre-deboosting" the CMB

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    It was recently shown that our peculiar velocity \beta with respect to the CMB induces mixing among multipoles and off-diagonal correlations at all scales which can be used as a measurement of \beta, which is independent of the standard measurement using the CMB temperature dipole. The proposed techniques rely however on a perturbative expansion which breaks down for \ell \gtrsim 1/(\beta) \approx 800. Here we propose a technique which consists of deboosting the CMB temperature in the time-ordered data and show that it extends the validity of the perturbation analysis multipoles up to \ell \sim 10000. We also obtain accurate fitting functions for the mixing between multipoles valid in a full non-linear treatment. Finally we forecast the achievable precision with which these correlations can be measured in a number of current and future CMB missions. We show that Planck could measure the velocity with a precision of around 60 km/s, ACTPol in 4 years around 40 km/s, while proposed future experiments could further shrink this error bar by over a factor of around 2.Comment: 14 pages, 7 figures. Revised projections for ACTPol, SPTPol and ACBAR; included projections for BICEP2; extended conclusions; typos correcte

    Balance algorithm for cluster randomized trials

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    <p>Abstract</p> <p>Background</p> <p>Within cluster randomized trials no algorithms exist to generate a full enumeration of a block randomization, balancing for covariates across treatment arms. Furthermore, often for practical reasons multiple blocks are required to fully randomize a study, which may not have been well balanced within blocks.</p> <p>Results</p> <p>We present a convenient and easy to use randomization tool to undertake allocation concealed block randomization. Our algorithm highlights allocations that minimize imbalance between treatment groups across multiple baseline covariates.</p> <p>We demonstrate the algorithm using a cluster randomized trial in primary care (the PRE-EMPT Study) and show that the software incorporates a trade off between independent random allocations that were likely to be imbalanced, and predictable deterministic approaches that would minimise imbalance. We extend the methodology of single block randomization to allocate to multiple blocks conditioning on previous allocations.</p> <p>Conclusion</p> <p>The algorithm is included as Additional file <supplr sid="S1">1</supplr> and we advocate its use for robust randomization within cluster randomized trials.</p> <suppl id="S1"> <title> <p>Additional File 1</p> </title> <text> <p><b>Cluster randomization allocation algorithm version 1.</b> Algorithms scripted in R to provide robust cluster randomization.</p> </text> <file name="1471-2288-8-65-S1.zip"> <p>Click here for file</p> </file> </suppl

    COrE (Cosmic Origins Explorer) A White Paper

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    COrE (Cosmic Origins Explorer) is a fourth-generation full-sky, microwave-band satellite recently proposed to ESA within Cosmic Vision 2015-2025. COrE will provide maps of the microwave sky in polarization and temperature in 15 frequency bands, ranging from 45 GHz to 795 GHz, with an angular resolution ranging from 23 arcmin (45 GHz) and 1.3 arcmin (795 GHz) and sensitivities roughly 10 to 30 times better than PLANCK (depending on the frequency channel). The COrE mission will lead to breakthrough science in a wide range of areas, ranging from primordial cosmology to galactic and extragalactic science. COrE is designed to detect the primordial gravitational waves generated during the epoch of cosmic inflation at more than 3σ3\sigma for r=(T/S)>=103r=(T/S)>=10^{-3}. It will also measure the CMB gravitational lensing deflection power spectrum to the cosmic variance limit on all linear scales, allowing us to probe absolute neutrino masses better than laboratory experiments and down to plausible values suggested by the neutrino oscillation data. COrE will also search for primordial non-Gaussianity with significant improvements over Planck in its ability to constrain the shape (and amplitude) of non-Gaussianity. In the areas of galactic and extragalactic science, in its highest frequency channels COrE will provide maps of the galactic polarized dust emission allowing us to map the galactic magnetic field in areas of diffuse emission not otherwise accessible to probe the initial conditions for star formation. COrE will also map the galactic synchrotron emission thirty times better than PLANCK. This White Paper reviews the COrE science program, our simulations on foreground subtraction, and the proposed instrumental configuration.Comment: 90 pages Latex 15 figures (revised 28 April 2011, references added, minor errors corrected

    Searches for clustering in the time integrated skymap of the ANTARES neutrino telescope

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    This paper reports a search for spatial clustering of the arrival directions of high energy muon neutrinos detected by the ANTARES neutrino telescope. An improved two-point correlation method is used to study the autocorrelation of 3058 neutrino candidate events as well as cross-correlations with other classes of astrophysical objects: sources of high energy gamma rays, massive black holes and nearby galaxies. No significant deviations from the isotropic distribution of arrival directions expected from atmospheric backgrounds are observed

    A search for neutrino emission from the Fermi bubbles with the ANTARES telescope

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    Analysis of the Fermi-LAT data has revealed two extended structures above and below the Galactic Centre emitting gamma rays with a hard spectrum, the so-called Fermi bubbles. Hadronic models attempting to explain the origin of the Fermi bubbles predict the emission of high-energy neutrinos and gamma rays with similar fluxes. The ANTARES detector, a neutrino telescope located in the Mediterranean Sea, has a good visibility to the Fermi bubble regions. Using data collected from 2008 to 2011 no statistically significant excess of events is observed and therefore upper limits on the neutrino flux in TeV range from the Fermi bubbles are derived for various assumed energy cutoffs of the source

    Optimal strategies for monitoring lipid levels in patients at risk or with cardiovascular disease: a systematic review with statistical and cost-effectiveness modelling

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