What will lead Asian consumers into circular consumption? An empirical study of purchasing refurbished smartphones in Japan and Indonesia

Although smartphones are small mini-computers, their impact on the environment is no longer small. In terms of e-waste, the challenges faced by many nations in Asia, where limited recovery and recycling practices exist, include sustainable choice and consumption habits. This study investigated the factors that affect Asian consumers behavioral intention in purchasing unbranded third-party and original equipment manufacturer (OEM)-branded refurbished smartphones, respectively. Through online surveys and analysis of a representative sample of 1200 mobile phone users in Japan and Indonesia, the findings showed that in both countries, perceived risk, consumer innovativeness, and (to some extent) price are all vital factors affecting the participation of consumers in circular consumption. The study also examined mobile phone/smartphone markets and the related legislation in Japan and Indonesia to develop field-driven hypotheses and identify the salient characteristics of the circular economy (CE) for refurbishment in both countries. In Japan, the difference in purchase intention (PI) between unbranded third-party refurbished and OEM-branded smartphones is much smaller than in Indonesia. The demand for refurbished smartphones supplied by an OEM in Indonesia is relatively higher than in Japan. The findings from this cross-cultural study can yield rich insights for CE business practitioners who seek to grasp overall patterns across the two countries and identify the salient features of each country, improving their regional marketing initiatives

Consistent characterisation factors at midpoint and endpoint relevant to agricultural water scarcity arising from freshwater consumption

ABSTRACT: Purpose The shortage of agricultural water from freshwater sources is a growing concern because of the relatively large amounts needed to sustain food production for an increasing population. In this context, an impact assessment methodology is indispensable for the identification and assessment of the potential consequences of freshwater consumption in relation to agricultural water scarcity. This paper reports on the consistent development of midpoint and endpoint characterisation factors (CFs) for assessing these impacts. Methods Midpoint characterisation factors focus specifically on shortages in food production resulting from agricultural water scarcity. These were calculated by incorporating country-specific compensation factors for physical availability of water resources and socio-economic capacity in relation to the irrigation water demand for agriculture. At the endpoint, to reflect the more complex impact pathways from food production losses to malnutrition damage from agricultural water scarcity, international food trade relationships and economic adaptation capacity were integrated in the modelling with measures of nutritional vulnerability for each country. Results and discussion The inter-country variances of CFs at the midpoint revealed by this study were larger than those derived using previously developed methods, which did not integrate compensation processes by food stocks. At the endpoint level, both national and trade-induced damage through international trade were quantified and visualised. Distribution of malnutrition damage was also determined by production and trade balances for commodity groups in water-consuming countries, as well as dependency on import ratios for importer countries and economic adaptation capacity in each country. By incorporating the complex relationships between these factors, estimated malnutrition damage due to freshwater consumption at the country scale showed good correlation with total reported nutritional deficiency damage. Conclusions The model allows the establishment of consistent CFs at the midpoint and endpoint for agricultural water scarcity resulting from freshwater consumption. The complex relationships between food production supply and nutrition damage can be described by considering the physical and socio-economic parameters used in this study. Developed CFs contribute to a better assessment of the potential impacts associated with freshwater consumption in global supply chains and to life cycle assessment and water footprint assessments

The immunoreceptor adapter protein DAP12 suppresses B lymphocyte–driven adaptive immune responses

Human and mouse B cells lacking functional DAP12 are hyperresponsive, and DAP12 works with MAIR-II (CD300d) to negatively regulate B cell activity

Minimal information for studies of extracellular vesicles 2018 (MISEV2018):a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points