Subsystems for all-optical coherent quantum-noise cancellation

Quantum mechanics dictates that a measurement always disturb the measured system. In weak continuous measurements, the trade-off between measurement precision and back-action onto the system yields an optimal measurement sensitivity, which is known as the Standard Quantum Limit (SQL) in opto-mechanical measurements, such as gravitational-wave detection. It corresponds to finding the optimal optical power in a compromise between quantum shot noise and quantum radiation-pressure noise. Coherent quantum-noise cancellation (CQNC) aims at overcoming the SQL and reducing back-action noise via the introduction of an effective negative-mass oscillator. In an alloptical set-up, this oscillator is realised by a detuned optical resonator coupled to incoming light with a beam-splitter and a down-conversion interaction and needs to be matched to the measured system in resonance frequency, damping and coupling strengths. This thesis explores the nature of CQNC and a potential all-optical realisation in theory and experiment, with a particular emphasis on the beam-splitter and the down-conversion interaction. Two possible set-ups are compared theoretically and critical parameters determined. Available opto-mechanical devices were characterised and confirmed to be suitable for CQNC. The down-conversion coupling strength gDC is linked to experimentally obtainable parameters. More than 2.3 dB reduction in uncertainty of two-mode squeezed light were observed. The squeezing measurements yielded gDC = 2\pi\times200 kHz at 100mW pump power, which is well within the initially required range and is in agreement with results from two other measurement methods. Optical resonators coupled via a beam-splitter interaction are studied theoretically and experimentally. In this work, the beam-splitter interaction of strength gBS was realised by a wave plate. A simplified experiment design enabled stabilisation of the coupled resonators. Our experimental observations accurately confirmed our theoretical predictions. The observed mode splitting yielded gBS = 2\pi\times235 kHz, within the updated requirements. Losses and a limited measurement strength will be the limiting factors for CQNC. The updated set of parameters, backed by the conducted experiments, paves the way towards a reduction of radiation-pressure noise of up to 4.8 dB

Coherent Cancellation of Backaction Noise in optomechanical Force Measurements

Optomechanical detectors have reached the standard quantum limit in position and force sensing where measurement backaction noise starts to be the limiting factor for the sensitivity. A strategy to circumvent measurement backaction, and surpass the standard quantum limit, has been suggested by M. Tsang and C. Caves in Phys. Rev. Lett. 105 123601 (2010). We provide a detailed analysis of this method and assess its benefits, requirements, and limitations. We conclude that a proof-of-principle demonstration based on a micro-optomechanical system is demanding, but possible. However, for parameters relevant to gravitational wave detectors the requirements for backaction evasion appear to be prohibitive.Comment: 9 pages, 6 figure

Phase retrieval via regularization in self-diffraction based spectral interferometry

A novel variant of spectral phase interferometry for direct electric-field reconstruction (SPIDER) is introduced and experimentally demonstrated. Other than most previously demonstrated variants of SPIDER, our method is based on a third-order nonlinear optical effect, namely self-diffraction, rather than the second-order effect of sum-frequency generation. On one hand, self-diffraction (SD) substantially simplifies phase-matching capabilities for multi-octave spectra that cannot be hosted by second-order processes, given manufacturing limitations of crystal lengths in the few-micrometer range. On the other hand, however, SD SPIDER imposes an additional constraint as it effectively measures the spectral phase of a self-convolved spectrum rather than immediately measuring the fundamental phase. Reconstruction of the latter from the measured phase and the spectral amplitude of the fundamental turns out to be an ill-posed problem, which we address by a regularization approach. We discuss the numerical implementation in detail and apply it to measured data from a Ti:sapphire amplifier system. Our experimental demonstration used 40-fs pulses and a 500 $\mu$m thick BaF${}_2$ crystal to show that the SD SPIDER signal is sufficiently strong to be separable from stray light. Extrapolating these measurements to the thinnest conceivable nonlinear media, we predict that bandwidths well above two optical octaves can be measured by a suitably adapted SD SPIDER apparatus, enabling the direct characterization of pulses down to single-femtosecond pulse durations. Such characteristics appear out of range for any currently established pulse measurement technique

All-optical coherent quantum-noise cancellation in cascaded optomechanical systems

Coherent quantum noise cancellation (CQNC) can be used in optomechanical sensors to surpass the standard quantum limit (SQL). In this paper, we investigate an optomechanical force sensor that uses the CQNC strategy by cascading the optomechanical system with an all-optical effective negative mass oscillator. Specifically, we analyze matching conditions, losses and compare the two possible arrangements in which either the optomechanical or the negative mass system couples first to light. While both of these orderings yield a sub-SQL performance, we find that placing the effective negative mass oscillator before the optomechanical sensor will always be advantageous for realistic parameters. The modular design of the cascaded scheme allows for better control of the sub-systems by avoiding undesirable coupling between system components, while maintaining similar performance to the integrated configuration proposed earlier. We conclude our work with a case study of a micro-optomechanical implementation.Comment: 9 pages, 6 figures, Appendix A and

Organ-targeted high-throughput in vivo biologics screen identifies materials for RNA delivery

Therapies based on biologics involving delivery of proteins, DNA, and RNA are currently among the most promising approaches. However, although large combinatorial libraries of biologics and delivery vehicles can be readily synthesized, there are currently no means to rapidly characterize them in vivo using animal models. Here, we demonstrate high-throughput in vivo screening of biologics and delivery vehicles by automated delivery into target tissues of small vertebrates with developed organs. Individual zebrafish larvae are automatically oriented and immobilized within hydrogel droplets in an array format using a microfluidic system, and delivery vehicles are automatically microinjected to target organs with high repeatability and precision. We screened a library of lipid-like delivery vehicles for their ability to facilitate the expression of protein-encoding RNAs in the central nervous system. We discovered delivery vehicles that are effective in both larval zebrafish and rats. Our results showed that the in vivo zebrafish model can be significantly more predictive of both false positives and false negatives in mammals than in vitro mammalian cell culture assays. Our screening results also suggest certain structure–activity relationships, which can potentially be applied to design novel delivery vehicles.National Institutes of Health (U.S.) (Transformative Research Award R01 NS073127)National Institutes of Health (U.S.) (Director's Innovator Award DP2 OD002989)David & Lucile Packard Foundation (Award in Science and Engineering)Sanofi Aventis (Firm)Foxconn International Holdings Ltd.Hertz Foundation (Fellowship)University Grants Committee (Hong Kong, China) (Early Career Award 125012)National Natural Science Foundation (China) (81201164)ITC (ITS/376/13)Chinese University of Hong Kong (Grant 9610215)Chinese University of Hong Kong (Grant 7200269

Organ-targeted high-throughput in vivo biologics screen identifies materials for RNA delivery

Therapies based on biologics involving delivery of proteins, DNA, and RNA are currently among the most promising approaches. However, although large combinatorial libraries of biologics and delivery vehicles can be readily synthesized, there are currently no means to rapidly characterize them in vivo using animal models. Here, we demonstrate high-throughput in vivo screening of biologics and delivery vehicles by automated delivery into target tissues of small vertebrates with developed organs. Individual zebrafish larvae are automatically oriented and immobilized within hydrogel droplets in an array format using a microfluidic system, and delivery vehicles are automatically microinjected to target organs with high repeatability and precision. We screened a library of lipid-like delivery vehicles for their ability to facilitate the expression of protein-encoding RNAs in the central nervous system. We discovered delivery vehicles that are effective in both larval zebrafish and rats. Our results showed that the in vivo zebrafish model can be significantly more predictive of both false positives and false negatives in mammals than in vitro mammalian cell culture assays. Our screening results also suggest certain structure–activity relationships, which can potentially be applied to design novel delivery vehicles.National Institutes of Health (U.S.) (Transformative Research Award R01 NS073127)National Institutes of Health (U.S.) (Director's Innovator Award DP2 OD002989)David & Lucile Packard Foundation (Award in Science and Engineering)Sanofi Aventis (Firm)Foxconn International Holdings Ltd.Hertz Foundation (Fellowship)University Grants Committee (Hong Kong, China) (Early Career Award 125012)National Natural Science Foundation (China) (81201164)ITC (ITS/376/13)Chinese University of Hong Kong (Grant 9610215)Chinese University of Hong Kong (Grant 7200269

The European Network for Translational Research in Atrial Fibrillation (EUTRAF): objectives and initial results

Atrial fibrillation (AF) is the most common sustained arrhythmia in the general population. As an age-related arrhythmia AF is becoming a huge socio-economic burden for European healthcare systems. Despite significant progress in our understanding of the pathophysiology of AF, therapeutic strategies for AF have not changed substantially and the major challenges in the management of AF are still unmet. This lack of progress may be related to the multifactorial pathogenesis of atrial remodelling and AF that hampers the identification of causative pathophysiological alterations in individual patients. Also, again new mechanisms have been identified and the relative contribution of these mechanisms still has to be established. In November 2010, the European Union launched the large collaborative project EUTRAF (European Network of Translational Research in Atrial Fibrillation) to address these challenges. The main aims of EUTRAF are to study the main mechanisms of initiation and perpetuation of AF, to identify the molecular alterations underlying atrial remodelling, to develop markers allowing to monitor this processes, and suggest strategies to treat AF based on insights in newly defined disease mechanisms. This article reports on the objectives, the structure, and initial results of this networ

Epitaxial Growth and Processing of Compound Semiconductors

Contains an introduction and reports on three research projects.MIT Lincoln LaboratoryU.S. Air Force - Office of Scientific Research Grant F49620-96-1-0126National Science Foundation Grant DMR 94-00334Joint Services Electronics Progra

Multi-messenger observations of a binary neutron star merger

On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta