Uruk Colonies and Anatolian Communities: An Interim Report on the 1992-1993 Excavations at Hacinebi, Turkey

The first Mesopotamian city-states in the Uruk period (ca. 3800-3100 B. C.) pursued a strategy of commercial expansion into neighboring areas of the Zagros Mountains, Syria, and southeastern Anatolia. Recent research in these areas has located several Uruk outposts, in what is apparently the world\u27s earliest-known colonial system. Although some Uruk colonies have been excavated, virtually nothing is known about either the operation of this system or its role in the development of local polities in Anatolia. Excavations at the site of Hacinebi, on the Euphrates River trade route, investigate the effects of the Uruk Expansion on the social, economic, and political organization of southeastern Anatolia during the fourth millennium B. C. Hacinebi has two main Late Chalcolithic occupations - a pre-contact phase A and a later contact phase B with high concentrations of Uruk ceramics, administrative artifacts, and other Mesopotamian forms of material culture. The Hacinebi excavations thus provide a rare opportunity to investigate the relationship between the Uruk colonies and the local populations with whom they traded, while clarifying the role of long-distance exchange in the development of complex societies in Anatolia. Several lines of evidence suggest that the period of contact with Mesopotamia began in the Middle Uruk period, earlier than the larger colonies at sites such as Habuba Kabira-South and Jebel Aruda in Syria. The concentrations of Uruk material culture and the patterns of food consumption in the northeastern corner of the Local Late Chalcolithic settlement are consistent with the interpretation that a small group of Mesopotamian colonists lived as a socially distinct enclave among the local inhabitants of Hacinebi. There is no evidence for either Uruk colonial domination or warfare between the colonists and the native inhabitants of Hacinebi. Instead, the presence of both Anatolian and Mesopotamian seal impressions at the site best fits a pattern of peaceful exchange between the two groups. The evidence for an essential parity in long-term social and economic relations between the Mesopotamian merchants and local inhabitants of Hacinebi suggests that the organization of prehistoric Mesopotamian colonies differed markedly from that of the better-known 16th-20th century European colonial systems in Africa, Asia, and the Americas

27874 Correlation of itch response to roflumilast cream with disease severity and patient-reported outcomes in patients with chronic plaque psoriasis

Roflumilast cream is a nonsteroidal, selective phosphodiesterase-4 inhibitor in development for plaque psoriasis (PsO). A Phase 2b, double-blinded trial randomized adults with PsO (2-20% body surface area) to once daily roflumilast 0.3%, roflumilast 0.15%, or vehicle for 12 weeks (NCT03638258). Throughout the trial, itch and its impact were evaluated via patient reported outcomes (PROs): Worst Itch Numeric Rating Scale (WI–NRS), Itch related Sleep Loss (IRSL), and Dermatology Life Quality Index (DLQI). This posthoc analysis reports correlation of WI–NRS with other PROs and with disease severity. Overall, 331 patients were randomized (109 to roflumilast 0.3%, 113 to 0.15%, and 109 to vehicle). At baseline, the mean WI–NRS score was 5.87. Throughout the trial, both roflumilast doses showed similar improvements in WI–NRS starting at Week 2 and were significantly superior to vehicle (P ≤.002). At baseline, Pearson correlation coefficients (PCCs) for WI–NRS and Psoriasis Area and Severity Index (PASI) were 0.189, 0.282, 0.205 for roflumilast 0.3%, roflumilast 0.15%, and vehicle, respectively (P ≤.033 for all correlations); for WI–NRS and IRSL: 0.548, 0.646, 0.652 (P ˂.001); for WI–NRS and DLQI: 0.445, 0.617, 0.422 (P ˂.001). At Week 8, PCCs for WI–NRS and PASI were 0.420, 0.409, 0.365 (P ˂.001); for WI–NRS and IRSL: 0.673, 0.725, 0.696 (P ˂.001); for WI–NRS and DLQI: 0.607, 0.823, 0.529. Treatment with roflumilast resulted in rapid and robust improvement in the severity of itch associated with PsO. Itch response to roflumilast was independent of disease severity and positively correlated with patient-reported sleep loss and quality of life improvement

Bounded H∞\mathbf{H_\infty}-Calculus for Differential Operators on Conic Manifolds with Boundary

We derive conditions that ensure the existence of a bounded $H_\infty$-calculus in weighted $L_p$-Sobolev spaces for closed extensions $\underline{A}_T$ of a differential operator $A$ on a conic manifold with boundary, subject to differential boundary conditions $T$. In general, these conditions ask for a particular pseudodifferential structure of the resolvent $(\lambda-\underline{A}_T)^{-1}$ in a sector $\Lambda\subset\mathbf{C}$. In case of the minimal extension they reduce to parameter-ellipticity of the boundary value problem $(A,T)$. Examples concern the Dirichlet and Neumann Laplacians.Comment: 23 page

A Study of Catalogued Nearby Galaxy Clusters in the SDSS-DR4: I. Cluster Global Properties

We have selected a sample of 88 nearby (z<0.1) galaxy clusters from the SDSS-DR4 with redshift information for the cluster members. We have derived global properties for each cluster, such as their mean recessional velocity, velocity dispersion, and virial radii. Cluster galaxies have been grouped in two families according to their $u-r$ colours. The total sample consists of 10865 galaxies. As expected, the highest fraction of galaxies (62%) turned to be early-type (red) ones, being located at smaller distances from the cluster centre and showing lower velocity dispersions than late-type (blue) ones. The brightest cluster galaxies are located in the innermost regions and show the smallest velocity dispersions. Early-type galaxies also show constant velocity dispersion profiles inside the virial radius and a mild decline in the outermost regions. In contrast, late-type galaxies show always decreasing velocity dispersions profiles. No correlation has been found between the fraction of blue galaxies and cluster global properties, such as cluster velocity dispersion and galaxy concentration. In contrast, we found correlation between the X-ray luminosity and the fraction of blue galaxies. These results indicate that early- and late-type galaxies may have had different evolution. Thus, blue galaxies are located in more anisotropic and radial orbits than early-type ones. Their star formation seems to be independent of the cluster global properties in low mass clusters, but not for the most massive ones. These observational results suggest that the global environment could be important for driving the evolution of galaxies in the most massive cluster ($\sigma > 800$ km s$^{-1}$). However, the local environment could play a key role in galaxy evolution for low mass clusters.Comment: 19 pages, 11 figures, accepted for publication in A&

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of "big data" (i.e., genetic and epigenetic data, multimodal MRI, and electroencephalography data). These international efforts have yielded the largest neuroimaging studies to date in schizophrenia, bipolar disorder, major depressive disorder, post-traumatic stress disorder, substance use disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorders, epilepsy, and 22q11.2 deletion syndrome. More recent ENIGMA WGs have formed to study anxiety disorders, suicidal thoughts and behavior, sleep and insomnia, eating disorders, irritability, brain injury, antisocial personality and conduct disorder, and dissociative identity disorder. Here, we summarize the first decade of ENIGMA's activities and ongoing projects, and describe the successes and challenges encountered along the way. We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in clinical syndromes across diverse samples and associated genetic, environmental, demographic, cognitive, and psychosocial factors

International Veterinary Epilepsy Task Force recommendations for systematic sampling and processing of brains from epileptic dogs and cats

Traditionally, histological investigations of the epileptic brain are required to identify epileptogenic brain lesions, to evaluate the impact of seizure activity, to search for mechanisms of drug-resistance and to look for comorbidities. For many instances, however, neuropathological studies fail to add substantial data on patients with complete clinical work-up. This may be due to sparse training in epilepsy pathology and or due to lack of neuropathological guidelines for companion animals. The protocols introduced herein shall facilitate systematic sampling and processing of epileptic brains and therefore increase the efficacy, reliability and reproducibility of morphological studies in animals suffering from seizures. Brain dissection protocols of two neuropathological centres with research focus in epilepsy have been optimised with regards to their diagnostic yield and accuracy, their practicability and their feasibility concerning clinical research requirements. The recommended guidelines allow for easy, standardised and ubiquitous collection of brain regions, relevant for seizure generation. Tissues harvested the prescribed way will increase the diagnostic efficacy and provide reliable material for scientific investigations

Preparation and optical properties of novel bioactive photonic crystals obtained from core-shell poly(styrene/α-tert-butoxy-ω-vinylbenzyl-polyglycidol) microspheres

Optical properties of polymer microspheres with polystyrene cores and polyglycidol-enriched shells poly(styrene/α-tert-butoxy-ω-vinylbenzyl-polyglycidol) (P(S/PGL) particles with number average diameters Dn determined by scanning electron microscopy equal 237 and 271 nm), were studied before and after immobilization of ovalbumin. The particles were synthesized by emulsifier-free emulsion copolymerization of styrene and polyglycidol macromonomer (poly(styrene/α-tert-butoxy-ω-vinylbenzyl-polyglycidol)) initiated with potassium persulfate. Molar fraction of polyglycidol units in the interfacial layer of the microspheres determined by XPS was equal 42.6 and 34.0%, for the particles with Dn equal 137 and 271 nm, respectively. Colloidal crystals from the aforementioned particles were prepared by deposition of particle suspensions on the glass slides and subsequent evaporation of water. It was found that optical properties of colloidal crystals from the P(S/PGL) microspheres strongly depend on modification of their interfacial layer by covalent immobilization of ovalbumin. The coating of particles with ovalbumin resulted in decreasing their refractive index from 1.58 to 1.52

First Low-Latency LIGO+Virgo Search for Binary Inspirals and their Electromagnetic Counterparts

Aims. The detection and measurement of gravitational-waves from coalescing neutron-star binary systems is an important science goal for ground-based gravitational-wave detectors. In addition to emitting gravitational-waves at frequencies that span the most sensitive bands of the LIGO and Virgo detectors, these sources are also amongst the most likely to produce an electromagnetic counterpart to the gravitational-wave emission. A joint detection of the gravitational-wave and electromagnetic signals would provide a powerful new probe for astronomy. Methods. During the period between September 19 and October 20, 2010, the first low-latency search for gravitational-waves from binary inspirals in LIGO and Virgo data was conducted. The resulting triggers were sent to electromagnetic observatories for followup. We describe the generation and processing of the low-latency gravitational-wave triggers. The results of the electromagnetic image analysis will be described elsewhere. Results. Over the course of the science run, three gravitational-wave triggers passed all of the low-latency selection cuts. Of these, one was followed up by several of our observational partners. Analysis of the gravitational-wave data leads to an estimated false alarm rate of once every 6.4 days, falling far short of the requirement for a detection based solely on gravitational-wave data.Comment: 13 pages, 13 figures. For a repository of data used in the publication, go to: http://dcc.ligo.org/cgi-bin/DocDB/ShowDocument?docid=P1100065 Also see the announcement for this paper on ligo.org at: http://www.ligo.org/science/Publication-S6CBCLowLatency