Transdermal β-Blocker Therapy in Essential Hypertension

Transdermal drug delivery has been applied to various agents in an effort to decrease the frequency of drug administration and increase the patients compliance. In our study, we demonstrated that transdermal application of a ß-blocker (20 mg mepindolol) in patients with essential hypertension led to effective blood pressure lowering effect within 1 week (160.1 ±6.1 mm Hg/95.8 ± 8.3 mm Hg vs 136.8 ± 7.2 mm Hg/84.3 ± 5.0 mm Hg; Ρ < 0.05). A controlled study of transdermal versus oral ß-blocker administration in hypertensives is necessary before this new therapeutic system is introduced in antihypertensive treatment. Am J Hypertens 1988; 1:199S-200

Determination of nutrient salts by automatic methods both in seawater and brackish water: the phosphate blank

9 páginas, 2 tablas, 2 figurasThe main inconvenience in determining nutrients in seawater by automatic methods is simply solved: the preparation of a suitable blank which corrects the effect of the refractive index change on the recorded signal. Two procedures are proposed, one physical (a simple equation to estimate the effect) and the other chemical (removal of the dissolved phosphorus with ferric hydroxide).Support for this work came from CICYT (MAR88-0245 project) and Conselleria de Pesca de la Xunta de GaliciaPeer reviewe

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Evaluation of Patients with Hypertension: Diagnosis, Screening and Risk Stratification

Hypertension has been defined as blood pressure levels of 140/90mm Hg or greater. This has been arbitrarily based on epidemiological evidence that demonstrates the risk associated with blood pressure levels and the benefits to be expected from therapy. Conventional blood pressure measurements with a sphygmomanometer are adequate in most patients for evaluation of arterial hypertension. Out-of-office self-measurements of blood pressure or 24-hour blood pressure recordings provide useful additional information and can help to exclude `white coat hypertension' or office hypertension. The objective of screening patients with hypertension is to detect any treatable causes and to assess the cardiovascular risk by ascertaining the extent of target organ damage and other cardiovascular risk factors. A basic screening programme is appropriate in the majority of older patients with hypertension to exclude treatable causes. Additional investigations are necessary in young patients and those with suspicion of an identifiable cause. Target organ damage and cardiovascular risk factors have to be evaluated in each patient with hypertension since the incidence of cardiovascular disease is related to the profile of these risk factors. Accordingly, the clinical management of patients with hypertension depends not on blood pressure levels alone but also on the burden of associated risk factors. The Sixth Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure has recently recommended a classification that stratifies patients with hypertension into risk groups for therapeutic decisions. It has to be pointed out that there is uncertainty about the prognostic relevance of risk stratification in patients over the age of 80 years.Hypertension, Blood-pressure-monitoring, Reviews-on-disease, Hypertension, White-coat-hypertension, Risk-factors, Cardiovascular-disorders