345 research outputs found
Early mortality among Aboriginal and non-Aboriginal women who had a preterm birth in Western Australia: A population-based cohort study
Background: Having a preterm (<37 weeks' gestation) birth may increase a woman's risk of early mortality. Aboriginal and Torres Strait Islander (hereafter Aboriginal) women have higher preterm birth and mortality rates compared with other Australian women. Objectives: We investigated whether a history of having a preterm birth was associated with early mortality in women and whether these associations differed by Aboriginal status. Methods: This retrospective cohort study used population-based perinatal records of women who had a singleton birth between 1980 and 2015 in Western Australia linked to Death Registry data until June 2018. The primary and secondary outcomes were all-cause and cause-specific mortality respectively. After stratification by Aboriginal status, rate differences were calculated, and Cox proportional hazard regression was used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for allcause and cause-specific mortality. Results: There were 20,244 Aboriginal mothers (1349 deaths) and 457,357 nonAboriginal mothers (7646 deaths) with 8.6 million person-years of follow-up. The all-cause mortality rates for Aboriginal mothers who had preterm births and term births were 529.5 and 344.0 (rate difference 185.5, 95% CI 135.5, 238.5) per 100,000 person-years respectively. Among non-Aboriginal mothers, the corresponding figures were 125.5 and 88.6 (rate difference 37.0, 95% CI 29.4, 44.9) per 100,000 personyears. The HR for all-cause mortality for Aboriginal and non-Aboriginal mothers associated with preterm birth were 1.48 (95% CI 1.32, 1.66) and 1.35 (95% CI 1.26, 1.44), respectively, compared with term birth. Compared with mothers who had term births, mothers of preterm births had higher relative risks of mortality from diabetes, cardiovascular, digestive and external causes. Conclusions: Both Aboriginal and non-Aboriginal women who had a preterm birth had a moderately increased risk of mortality up to 38 years after the birth, reinforcing the importance of primary prevention and ongoing screening.Helen D. Bailey, Caitlin Gray, Akilew A. Adane, Natalie A. Strobel, Scott W. White, Rhonda Marriott, Gizachew A. Tessema, Carrington C. J. Shepherd, Mary Shar
Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes
AbstractBackground and aimsWe investigated whether objectively measured sedentary time was associated with markers of inflammation in adults with newly diagnosed type 2 diabetes.Methods and resultsWe studied 285 adults (184 men, 101 women, mean age 59.0 ± 9.7) who had been recruited to the Early ACTivity in Diabetes (Early ACTID) randomised controlled trial. C-reactive protein (CRP), adiponectin, soluble intracellular adhesion molecule-1 (sICAM-1), interleukin-6 (IL-6), and accelerometer-determined sedentary time and moderate-vigorous physical activity (MVPA) were measured at baseline and after six-months. Linear regression analysis was used to investigate the independent cross-sectional and longitudinal associations of sedentary time with markers of inflammation.At baseline, associations between sedentary time and IL-6 were observed in men and women, an association that was attenuated following adjustment for waist circumference. After 6 months of follow-up, sedentary time was reduced by 0.4 ± 1.2 h per day in women, with the change in sedentary time predicting CRP at follow-up. Every hour decrease in sedentary time between baseline and six-months was associated with 24% (1, 48) lower CRP. No changes in sedentary time between baseline and 6 months were seen in men.ConclusionsHigher sedentary time is associated with IL-6 in men and women with type 2 diabetes, and reducing sedentary time is associated with improved levels of CRP in women. Interventions to reduce sedentary time may help to reduce inflammation in women with type 2 diabetes
Search for a W' boson decaying to a bottom quark and a top quark in pp collisions at sqrt(s) = 7 TeV
Results are presented from a search for a W' boson using a dataset
corresponding to 5.0 inverse femtobarns of integrated luminosity collected
during 2011 by the CMS experiment at the LHC in pp collisions at sqrt(s)=7 TeV.
The W' boson is modeled as a heavy W boson, but different scenarios for the
couplings to fermions are considered, involving both left-handed and
right-handed chiral projections of the fermions, as well as an arbitrary
mixture of the two. The search is performed in the decay channel W' to t b,
leading to a final state signature with a single lepton (e, mu), missing
transverse energy, and jets, at least one of which is tagged as a b-jet. A W'
boson that couples to fermions with the same coupling constant as the W, but to
the right-handed rather than left-handed chiral projections, is excluded for
masses below 1.85 TeV at the 95% confidence level. For the first time using LHC
data, constraints on the W' gauge coupling for a set of left- and right-handed
coupling combinations have been placed. These results represent a significant
improvement over previously published limits.Comment: Submitted to Physics Letters B. Replaced with version publishe
Measurement of the Lambda(b) cross section and the anti-Lambda(b) to Lambda(b) ratio with Lambda(b) to J/Psi Lambda decays in pp collisions at sqrt(s) = 7 TeV
The Lambda(b) differential production cross section and the cross section
ratio anti-Lambda(b)/Lambda(b) are measured as functions of transverse momentum
pt(Lambda(b)) and rapidity abs(y(Lambda(b))) in pp collisions at sqrt(s) = 7
TeV using data collected by the CMS experiment at the LHC. The measurements are
based on Lambda(b) decays reconstructed in the exclusive final state J/Psi
Lambda, with the subsequent decays J/Psi to an opposite-sign muon pair and
Lambda to proton pion, using a data sample corresponding to an integrated
luminosity of 1.9 inverse femtobarns. The product of the cross section times
the branching ratio for Lambda(b) to J/Psi Lambda versus pt(Lambda(b)) falls
faster than that of b mesons. The measured value of the cross section times the
branching ratio for pt(Lambda(b)) > 10 GeV and abs(y(Lambda(b))) < 2.0 is 1.06
+/- 0.06 +/- 0.12 nb, and the integrated cross section ratio for
anti-Lambda(b)/Lambda(b) is 1.02 +/- 0.07 +/- 0.09, where the uncertainties are
statistical and systematic, respectively.Comment: Submitted to Physics Letters
Search for new physics in events with opposite-sign leptons, jets, and missing transverse energy in pp collisions at sqrt(s) = 7 TeV
A search is presented for physics beyond the standard model (BSM) in final
states with a pair of opposite-sign isolated leptons accompanied by jets and
missing transverse energy. The search uses LHC data recorded at a
center-of-mass energy sqrt(s) = 7 TeV with the CMS detector, corresponding to
an integrated luminosity of approximately 5 inverse femtobarns. Two
complementary search strategies are employed. The first probes models with a
specific dilepton production mechanism that leads to a characteristic kinematic
edge in the dilepton mass distribution. The second strategy probes models of
dilepton production with heavy, colored objects that decay to final states
including invisible particles, leading to very large hadronic activity and
missing transverse energy. No evidence for an event yield in excess of the
standard model expectations is found. Upper limits on the BSM contributions to
the signal regions are deduced from the results, which are used to exclude a
region of the parameter space of the constrained minimal supersymmetric
extension of the standard model. Additional information related to detector
efficiencies and response is provided to allow testing specific models of BSM
physics not considered in this paper.Comment: Replaced with published version. Added journal reference and DO
Measurement of isolated photon production in pp and PbPb collisions at sqrt(sNN) = 2.76 TeV
Isolated photon production is measured in proton-proton and lead-lead
collisions at nucleon-nucleon centre-of-mass energies of 2.76 TeV in the
pseudorapidity range |eta|<1.44 and transverse energies ET between 20 and 80
GeV with the CMS detector at the LHC. The measured ET spectra are found to be
in good agreement with next-to-leading-order perturbative QCD predictions. The
ratio of PbPb to pp isolated photon ET-differential yields, scaled by the
number of incoherent nucleon-nucleon collisions, is consistent with unity for
all PbPb reaction centralities.Comment: Submitted to Physics Letters
The first Hubble diagram and cosmological constraints using superluminous supernovae
This paper has gone through internal review by the DES collaboration.
It has Fermilab preprint number 19-115-AE and DES
publication number 13387. We acknowledge support from EU/FP7-
ERC grant 615929. RCN would like to acknowledge support from
STFC grant ST/N000688/1 and the Faculty of Technology at the
University of Portsmouth. LG was funded by the European Union’s
Horizon 2020 Framework Programme under the Marie Skłodowska-
Curie grant agreement no. 839090. This work has been partially
supported by the Spanish grant PGC2018-095317-B-C21 within
the European Funds for Regional Development (FEDER). Funding
for the DES Projects has been provided by the U.S. Department
of Energy, the U.S. National Science Foundation, the Ministry
of Science and Education of Spain, the Science and Technology
Facilities Council of the United Kingdom, the Higher Education
Funding Council for England, the National Center for Supercomputing
Applications at the University of Illinois at Urbana-Champaign,
the Kavli Institute of Cosmological Physics at the University of
Chicago, the Center for Cosmology and Astro-Particle Physics at
the Ohio State University, the Mitchell Institute for Fundamental
Physics and Astronomy at Texas A&M University, Financiadora
de Estudos e Projetos, Fundac¸ ˜ao Carlos Chagas Filho de Amparo
`a Pesquisa do Estado do Rio de Janeiro, Conselho Nacional de
Desenvolvimento Cient´ıfico e Tecnol´ogico and the Minist´erio da
Ciˆencia, Tecnologia e Inovac¸ ˜ao, the Deutsche Forschungsgemeinschaft,
and the Collaborating Institutions in the Dark Energy Survey.
The Collaborating Institutions are Argonne National Laboratory, the
University of California at Santa Cruz, the University of Cambridge,
Centro de Investigaciones Energ´eticas, Medioambientales y Tecnol
´ogicas-Madrid, the University of Chicago, University College
London, the DES-Brazil Consortium, the University of Edinburgh,
the Eidgen¨ossische Technische Hochschule (ETH) Z¨urich, Fermi
NationalAccelerator Laboratory, theUniversity of Illinois atUrbana-
Champaign, the Institut de Ci`encies de l’Espai (IEEC/CSIC), the
Institut de F´ısica d’Altes Energies, Lawrence Berkeley National
Laboratory, the Ludwig-Maximilians Universit¨at M¨unchen and the
associated Excellence Cluster Universe, the University of Michigan,
the National Optical Astronomy Observatory, the University of
Nottingham, The Ohio State University, the University of Pennsylvania,
the University of Portsmouth, SLAC National Accelerator
Laboratory, Stanford University, the University of Sussex, Texas
A&M University, and the OzDES Membership Consortium. Based
in part on observations at Cerro Tololo Inter-American Observatory,
National Optical Astronomy Observatory, which is operated by the
Association of Universities for Research in Astronomy (AURA) under a cooperative agreement with the National Science Foundation.
The DES data management system is supported by the
National Science Foundation under grant numbers AST-1138766
and AST-1536171. The DES participants from Spanish institutions
are partially supported by MINECO under grants AYA2015-
71825, ESP2015-66861, FPA2015-68048, SEV-2016-0588, SEV-
2016-0597, and MDM-2015-0509, some of which include ERDF
funds from the European Union. IFAE is partially funded by the
CERCA program of the Generalitat de Catalunya. Research leading
to these results has received funding from the European Research
Council under the European Union Seventh Framework Programme
(FP7/2007-2013) including ERC grant agreements 240672, 291329,
and 306478.We acknowledge support from the Australian Research
Council Centre of Excellence for All-skyAstrophysics (CAASTRO),
through project number CE110001020, and the Brazilian Instituto
Nacional de Ciˆencia e Tecnologia (INCT) e-Universe (CNPq grant
465376/2014-2).
This paper has been authored by Fermi Research Alliance, LLC
under Contract No.DE-AC02-07CH11359 with theU.S.Department
of Energy, Office of Science, Office of High Energy Physics. The
United States Government retains and the publisher, by accepting
the paper for publication, acknowledges that the United States
Government retains a non-exclusive, paid-up, irrevocable, worldwide
license to publish or reproduce the published form of this paper,
or allow others to do so, for United States Government purposes.We present the first Hubble diagram of superluminous supernovae (SLSNe) out to a redshift of two, together with constraints
on the matter density, M, and the dark energy equation-of-state parameter, w(≡p/ρ). We build a sample of 20 cosmologically
useful SLSNe I based on light curve and spectroscopy quality cuts. We confirm the robustness of the peak–decline SLSN I
standardization relation with a larger data set and improved fitting techniques than previous works. We then solve the SLSN
model based on the above standardization via minimization of the χ2 computed from a covariance matrix that includes statistical
and systematic uncertainties. For a spatially flat cold dark matter ( CDM) cosmological model, we find M = 0.38+0.24
−0.19,
with an rms of 0.27 mag for the residuals of the distance moduli. For a w0waCDM cosmological model, the addition of SLSNe I
to a ‘baseline’ measurement consisting of Planck temperature together with Type Ia supernovae, results in a small improvement
in the constraints of w0 and wa of 4 per cent.We present simulations of future surveys with 868 and 492 SLSNe I (depending on
the configuration used) and show that such a sample can deliver cosmological constraints in a flat CDM model with the same
precision (considering only statistical uncertainties) as current surveys that use Type Ia supernovae, while providing a factor of
2–3 improvement in the precision of the constraints on the time variation of dark energy, w0 and wa. This paper represents the
proof of concept for superluminous supernova cosmology, and demonstrates they can provide an independent test of cosmology
in the high-redshift (z > 1) universe.EU/FP7-ERC grant 615929STFC grant ST/N000688/1Faculty of Technology at the
University of PortsmouthEuropean Union’s
Horizon 2020 Framework Programme under the Marie Skłodowska-
Curie grant agreement no. 839090Spanish grant PGC2018-095317-B-C21 within
the European Funds for Regional Development (FEDER)U.S. Department
of EnergyU.S. National Science FoundationMinistry
of Science and Education of SpainScience and Technology
Facilities Council of the United KingdomHigher Education
Funding Council for EnglandNational Center for Supercomputing
Applications at the University of Illinois at Urbana-Champaign,Kavli Institute of Cosmological Physics at the University of
ChicagoCenter for Cosmology and Astro-Particle Physics at
the Ohio State UniversityMitchell Institute for Fundamental
Physics and Astronomy at Texas A&M University, Financiadora
de Estudos e Projetos, Fundacão Carlos Chagas Filho de Amparo
`a Pesquisa do Estado do Rio de Janeiro, Conselho Nacional de
Desenvolvimento Científico e Tecnológico and the Ministério da
Ciencia, Tecnologia e InovacãoDeutsche ForschungsgemeinschaftCollaborating Institutions in the Dark Energy Survey.National Science Foundation under grant numbers AST-1138766
and AST-1536171.T MINECO under grants AYA2015-
71825, ESP2015-66861, FPA2015-68048, SEV-2016-0588, SEV-
2016-0597, and MDM-2015-0509, some of which include ERDF
funds from the European Union.CERCA program of the Generalitat de Catalunya.European Research
Council under the European Union Seventh Framework Programme
(FP7/2007-2013) including ERC grant agreements 240672, 291329,
and 306478.Australian Research
Council Centre of Excellence for All-skyAstrophysics (CAASTRO),
through project number CE110001020Brazilian Instituto
Nacional de Ciˆencia e Tecnologia (INCT) e-Universe (CNPq grant
465376/2014-2)Fermi Research Alliance, LLC
under Contract No.DE-AC02-07CH11359 with theU.S.Department
of Energy, Office of Science, Office of High Energy Physic
First cosmology results using SNe Ia from the dark energy survey: analysis, systematic uncertainties, and validation
International audienceWe present the analysis underpinning the measurement of cosmological parameters from 207 spectroscopically classified type Ia supernovae (SNe Ia) from the first three years of the Dark Energy Survey Supernova Program (DES-SN), spanning a redshift range of 0.01
First cosmology results using type Ia supernovae from the Dark Energy Survey: constraints on cosmological parameters
We present the first cosmological parameter constraints using measurements of type Ia supernovae (SNe Ia) from the Dark Energy Survey Supernova Program (DES-SN). The analysis uses a subsample of 207 spectroscopically confirmed SNe Ia from the first three years of DES-SN, combined with a low-redshift sample of 122 SNe from the literature. Our "DES-SN3YR" result from these 329 SNe Ia is based on a series of companion analyses and improvements covering SN Ia discovery, spectroscopic selection, photometry, calibration, distance bias corrections, and evaluation of systematic uncertainties. For a flat LCDM model we find a matter density Omega_m = 0.331 +_ 0.038. For a flat wCDM model, and combining our SN Ia constraints with those from the cosmic microwave background (CMB), we find a dark energy equation of state w = -0.978 +_ 0.059, and Omega_m = 0.321 +_ 0.018. For a flat w0waCDM model, and combining probes from SN Ia, CMB and baryon acoustic oscillations, we find w0 = -0.885 +_ 0.114 and wa = -0.387 +_ 0.430. These results are in agreement with a cosmological constant and with previous constraints using SNe Ia (Pantheon, JLA)
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