514 research outputs found
Busy toy designs reduce the specificity of mothers' references to toy parts during toy play with their toddlers
When a parent is playing with a toy with his or her child, might a toy's "busy" visual design negatively impact the specificity and quality of the parent's talk? In this study, 24 mother-toddler (M = 23.5 months) dyads played with both (a) unmodified visually busy commercial toys and (b) modified visually "simple" versions of these commercial toys. Our focus was on the specificity of mothers' 552 references to the main parts of the toys (i.e., the rings of a stacking ring toy and the blocks of a nesting block toy), which was found to be impacted by the toys' visual design. That is, with simple toys, mothers produced a significantly greater proportion of specific references (e.g., the blue ring) than non-specific references (e.g., this/that one). Indeed, the proportion of specific references was three times greater in play with the simple toys than with the busy toys. Busy toys also reduced the number of references to parts of the toy overall and children's exposure to vocabulary such as colour terms used within specific references. These results underscore that the visual design of toys is an important aspect to consider, particularly in contexts where the goal may be to foster adult-child language and a child's exposure to more information-rich vocabulary terms during toy play with an adult. © 2019, Canadian Association of Speech-Language Pathologists and Audiologists. All rights reserved
Anomalies of ac driven solitary waves with internal modes: Nonparametric resonances induced by parametric forces
We study the dynamics of kinks in the model subjected to a
parametric ac force, both with and without damping, as a paradigm of solitary
waves with internal modes. By using a collective coordinate approach, we find
that the parametric force has a non-parametric effect on the kink motion.
Specifically, we find that the internal mode leads to a resonance for
frequencies of the parametric driving close to its own frequency, in which case
the energy of the system grows as well as the width of the kink. These
predictions of the collective coordinate theory are verified by numerical
simulations of the full partial differential equation. We finally compare this
kind of resonance with that obtained for non-parametric ac forces and conclude
that the effect of ac drivings on solitary waves with internal modes is exactly
the opposite of their character in the partial differential equation.Comment: To appear in Phys Rev
Prevalence of adverse drug reactions in adult patients on antiretrovirals at Kenyatta National Hospital, comprehensive Care Centre
Background: There has been an increased access to anti-retrovirals in resourceconstrainedsettings. However, few studies have addressed the area of adverse drugreactions in these settings.Objective: To determine the prevalence of adverse drugs reactions in HIV-infectedpersons receiving anti-retrovirals.Design: A retrospective cohort study.Setting: Kenyatta National Hospital, Comprehensive Care Centre.Subjects: Adult patients receiving anti-retroviral drug during the four year periodbetween January 2003 and December 2006.Main outcome measures: The primary outcome was a documented adverse drug reactionafter exposure to antiretrovirals.Results: Systematic random sampling was used to pick 350 patients’ files. There were219 recorded adverse drug reactions in 170 (48.6%) patients (some patients had morethan one adverse drug reaction). Peripheral neuropathy was the most common adversedrug reaction with a prevalence of 28.9% followed by lipid abnormalities at 14.3%.Conclusion: This study indicates a high prevalence of adverse drug reactionsamong HIV/AIDS patients on anti-retroviral therapy at Kenyatta National Hospital,Comprehensive Care Centre
Preparation and Solid-state Structural, Electronic, and Magnetic Properties of the 5-Cyano-1,3-benzene-Bridged Bis(1,2,3,5-dithiadiazolyl) and Bis(1,2,3,5-diselenadiazolyl) [5-CN-1,3-C6H3(CN2E2)2] (E = S, Se)
The preparation and solid-state characterization of the bifunctional radicals [4,4’-(5-cyanobenzene)-1,3-bis(1,2,3,5-dithiadiazolyl)] and [4,4’-(5-cyanobenzene)-1,3-bis( 1,2,3,5-diselenadiazolyl)] [5-CN-1,3-C6H3(CN2E2)2] (E = S, Se) are described. The crystals of the two title compounds are isomorphous and belong to the monoclinic space group P21/c, with (for E = S) a = 7.00(2), b = 30.050(6), c = 10.713(8) Å, β = 104.80(10)°, V = 2179(6) Å3, Z = 8 and (for E = Se) a = 7.124(4), b = 30.50(2), c = 10.874(2) Å, β = 105.46(3)°, V = 2277(2) Å3, Z = 8. The crystal structures consist of stacks of diradicals running parallel to x; radical dimerization up and down the stack generates a zigzag arrangement, as seen in the related 1,3-phenylene structures. Along the stacking axis the mean intradimer E-E contacts are 3.12 (E = S) and 3.23 Å (E = Se), while the mean interdimer E- - -E distances are 3.89 (E = S) and 3.91 Å (E = Se). Magnetic and conductivity data are presented and discussed in light of extended Hückel band structure calculations
Mapping the energy landscape of biomolecules using single molecule force correlation spectroscopy (FCS): Theory and applications
In the current AFM experiments the distribution of unfolding times, P(t), is
measured by applying a constant stretching force f_s from which the apparent
unfolding rate is obtained. To describe the complexity of the underlying energy
landscape requires additional probes that can incorporate the dynamics of
tension propagation and relaxation of the polypeptide chain upon force quench.
We introduce a theory of force correlation spectroscopy (FCS) to map the
parameters of the energy landscape of proteins. In the FCS the joint
distribution, P(T,t) of folding and unfolding times is constructed by repeated
application of cycles of stretching at constant fs, separated by release
periods T during which the force is quenched to f_q<f_s. During the release
period, the protein can collapse to a manifold of compact states or refold. We
show that P(T,t) can be used to resolve the kinetics of unfolding as well as
formation of native contacts and to extract the parameters of the energy
landscape using chain extension as the reaction coordinate and P(T,t). We
illustrate the utility of the proposed formalism by analyzing simulations of
unfolding-refolding trajectories of a coarse-grained protein S1 with beta-sheet
architecture for several values of f_s, T and f_q=0. The simulations of
stretch-relax trajectories are used to map many of the parameters that
characterize the energy landscape of S1.Comment: 23 pages, 9 figures; accepted to Biophysical Journa
The role of proteomics in defining the human embryonic secretome
Non-invasive gamete and embryo assessment is considered an important focus in assisted reproductive technologies (ART). Currently, the selection of embryos for transfer is based on morphological indices. Though successful, the field of ART would benefit from a non-invasive quantitative method of viability determination. Omics technologies, including transcriptomics, proteomics and metabolomics, have already begun providing evidence that viable gametes and embryos possess unique molecular profiles with potential biomarkers that can be utilized for developmental and/or viability selection. Unlike the human genome that is relatively fixed and steady throughout the human body, the human proteome, estimated at over a million proteins, is more complex, diverse and dynamic. It is the proteins themselves that contribute to the physiological homeostasis in any cell or tissue. Of particular interest in ART is the secretome, those proteins that are produced within the embryo and secreted into the surrounding environment. Defining the human embryonic secretome has the potential to expand our knowledge of embryonic cellular processes, including the complex dialogue between the developing embryo and its maternal environment, and may also assist in identifying those embryos with the highest implantation potential. Advances in proteomic technologies have allowed the non-invasive profiling of the human embryonic secretome with ongoing research focused on correlation with outcome. From a clinical perspective, embryo selection based on morphological assessment and non-invasive analysis of the human embryonic secretome may improve IVF success and lead to routine single embryo transfers
Deficiencies in the soil quality concept and its application
Soil quality is a concept that has deeply divided the soil science community. It has
been institutionalized and advocated without full consideration of concept weaknesses and
contradictions. Our paper highlights its disfunctional definition, flawed approach to
quantification, and failure to integrate simultaneous functions, which often require contradictory
soil properties and/or management. While the concept arose from a call to protect the
environment and sustain the soil resource, soil quality indexing as implemented may actually
impair some soil functions, environmental quality, or other societal priorities. We offer the
alternative view that emphasis on known principles of soil management is a better expenditure of
limited resources for soil stewardship than developing and deploying subjective indices which fail
to integrate across the necessary spectrum of management outcomes. If the soil quality concept
is retained, we suggest precisely specifying soil use, not function or capacity, as the criteria for
attribute evaluation. Emphasis should be directed toward using available technical information to
motivate and educate farmers on management practices that optimize the combined goals of high
crop production, low environmental degradation, and a sustained resource
Molecular Conductors from Neutral-Radical Charge-Transfer Salts:Preparation and Characterization of an Iodine-Doped Hexagonal Phase of 1,2,3,5-Dithiadiazolyl ([HCN2S2]∙)
Sublimation of 1,2,3,5-dithiadiazolyl in vacuo affords a triclinic phase of the dimer [HCN2S2]2. The crystals belong to the space group P¯1, a = 6.816(3), b = 13.940(2), c = 14.403(3) Å, α = 116.830(14), β = 98.64(3), γ = 99.18(3)°, FW = 212.4 (for [HCN2S2]2·[N2]0.08) Z = 6. The crystal structure consists of stacked dimers, with three dimers per asymmetric unit. Pairs of asymmetric units, related by an inversion center, generate a pinwheel motif consisting of six dimers. The columnar structure associated with these pinwheels forms close-packed sets of “molecular tubes”. Cosublimation of the radical in the presence of iodine in the mole ratio (HCN2S2:I = 5:1) yields an iodine-doped hexagonal phase of composition [HCN2S2]6[I]1.1. Crystals of this material belong to the space group P61, a = b = 14.132(16), c = 3.352(5) Å, FW = 128.20, Z = 6. The crystal structure consists of sixfold pinwheels in which the now evenly spaced HCN2S2 rings form a spiral about the 61 axis. The iodine atoms lie within the columnar cavity of the pinwheels in a disordered array wrapped tightly about the sixfold screw axis. The single-crystal conductivity of the doped material is 15 S cm-1 at room temperature. Raman spectroscopic and magnetic susceptibility measurements on the doped material are reported
Resonances in the dynamics of kinks perturbed by ac forces
We study the dynamics of kinks perturbed by an ac force, both with
and without damping. We address this issue by using a collective coordinate
theory, which allows us to reduce the problem to the dynamics of the kink
center and width. We carry out a careful analysis of the corresponding ordinary
differential equations, of Mathieu type in the undamped case, finding and
characterizing the resonant frequencies and the regions of existence of
resonant solutions. We verify the accuracy of our predictions by numerical
simulation of the full partial differential equation, showing that the
collective coordinate prediction is very accurate. Numerical simulations for
the damped case establish that the strongest resonance is the one at half the
frequency of the internal mode of the kink. In the conclusion we discuss on the
possible relevance of our results for other systems, especially the sine-Gordon
equation. We also obtain additional results regarding the equivalence between
different collective coordinate methods applied to this problem.Comment: 23 pages, 7 figures, REVTeX, accepted for publication in Phys. Rev.
Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector
A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results
- …