Pathogenesis of distal renal tubular acidosis

Distal renal tubular acidosis (RTA) is a syndrome characterized by hyperchloremic metabolic acidosis and an inappropriately high urine pH relative to the degree of acidosis. The clinical presentation is frequently complicated by nephrocalcinosis, hypercalciuria, and nephrolithiasis. Less frequent presenting manifestations include hypokalemia and osteomalacia (for review of clinical features, see Refs. 1–4). Initially, all cases of renal tubular acidosis were considered to have similar pathophysiologic mechanisms, but subsequent studies have subdivided the group into abnormalities of bicarbonate reabsorption (proximal RTA), disorders of net acid excretion (distal or classical), and defects of ammonium production. In the present review, we will limit our discussion to the pathogenesis of distal RTA

Minimal renormalization without epsilon-expansion: Amplitude functions in three dimensions below T_c

Massive field theory at fixed dimension d<4 is combined with the minimal subtraction scheme to calculate the amplitude functions of thermodynamic quantities for the O(n) symmetric phi^4 model below T_c in two-loop order. Goldstone singularities arising at an intermediate stage in the calculation of O(n) symmetric quantities are shown to cancel among themselves leaving a finite result in the limit of zero external field. From the free energy we calculate the amplitude functions in zero field for the order parameter, specific heat and helicity modulus (superfluid density) in three dimensions. We also calculate the q^2 part of the inverse of the wavenumber-dependent transverse susceptibility chi_T(q) which provides an independent check of our result for the helicity modulus. The two-loop contributions to the superfluid density and specific heat below T_c turn out to be comparable in magnitude to the one-loop contributions, indicating the necessity of higher-order calculations and Pade-Borel type resummations.Comment: 41 pages, LaTeX, 8 PostScript figures, submitted to NPB [FS

Human Metapneumovirus Detection in Patients with Severe Acute Respiratory Syndrome

We used a combination approach of conventional virus isolation and molecular techniques to detect human metapneumovirus (HMPV) in patients with severe acute respiratory syndrome (SARS). Of the 48 study patients, 25 (52.1%) were infected with HMPV; 6 of these 25 patients were also infected with coronavirus, and another 5 patients (10.4%) were infected with coronavirus alone. Using this combination approach, we found that human laryngeal carcinoma (HEp-2) cells were superior to rhesus monkey kidney (LLC-MK2) cells commonly used in previous studies for isolation of HMPV. These widely available HEp-2 cells should be included in conjunction with a molecular method for cell culture followup to detect HMPV, particularly in patients with SARS

Measurement of Cosmic-ray Muon-induced Spallation Neutrons in the Aberdeen Tunnel Underground Laboratory

AbstractMuon-induced neutrons are one of the major backgrounds to various underground experiments, such as dark matter searches, low-energy neutrino oscillation experiments and neutrino-less double beta-decay experiments. Previous experiments on the underground production rate of muon-induced neutrons were mostly carried out either at shallow sites or at very deep sites. The Aberdeen Tunnel experiment aims to measure the neutron production rate at a moderate depth of 611 meters water equivalent. Our apparatus comprises of six layers of plastic-scintillator hodoscopes for tracking the incident cosmic-ray muons, and 760 L of gadolinium-doped liquid-scintillator for both neutron production and detection targets. In this paper, we describe the design and the performance of the apparatus. The preliminary result on the measurement of neutron production rate is also presented

Comparative community burden and severity of seasonal and pandemic influenza: results of the Flu Watch cohort study

BACKGROUND: Assessment of the effect of influenza on populations, including risk of infection, illness if infected, illness severity, and consultation rates, is essential to inform future control and prevention. We aimed to compare the community burden and severity of seasonal and pandemic influenza across different age groups and study years and gain insight into the extent to which traditional surveillance underestimates this burden. METHODS: Using preseason and postseason serology, weekly illness reporting, and RT-PCR identification of influenza from nasal swabs, we tracked the course of seasonal and pandemic influenza over five successive cohorts (England 2006-11; 5448 person-seasons' follow-up). We compared burden and severity of seasonal and pandemic strains. We weighted analyses to the age and regional structure of England to give nationally representative estimates. We compared symptom profiles over the first week of illness for different strains of PCR-confirmed influenza and non-influenza viruses using ordinal logistic regression with symptom severity grade as the outcome variable. FINDINGS: Based on four-fold titre rises in strain-specific serology, on average influenza infected 18% (95% CI 16-22) of unvaccinated people each winter. Of those infected there were 69 respiratory illnesses per 100 person-influenza-seasons compared with 44 per 100 in those not infected with influenza. The age-adjusted attributable rate of illness if infected was 23 illnesses per 100 person-seasons (13-34), suggesting most influenza infections are asymptomatic. 25% (18-35) of all people with serologically confirmed infections had PCR-confirmed disease. 17% (10-26) of people with PCR-confirmed influenza had medically attended illness. These figures did not differ significantly when comparing pandemic with seasonal influenza. Of PCR-confirmed cases, people infected with the 2009 pandemic strain had markedly less severe symptoms than those infected with seasonal H3N2. INTERPRETATION: Seasonal influenza and the 2009 pandemic strain were characterised by similar high rates of mainly asymptomatic infection with most symptomatic cases self-managing without medical consultation. In the community the 2009 pandemic strain caused milder symptoms than seasonal H3N2

Measurements of differential production cross sections for a Z boson in association with jets in pp collisions at root s=8 TeV

Peer reviewe

Search for leptophobic Z ' bosons decaying into four-lepton final states in proton-proton collisions at root s=8 TeV

Peer reviewe