Reglas forma-función en la etapa de las primeras palabras: un estudio longitudinal de dos niñas

This work analyzes pragmatic development in the first words stage, specifically the form-function rules that infants construct for communicating. It presents data from two children who took part in a longitudinal/ observational case study research. Our results point to the general tendencies identified with respect to form-function rules (Ninio, 1994b; Ninio & Snow, 1996) and to the existence of inter-individual differences. These differences refer to: a) the mapping of form-function rules and b) pragmatic flexibility. Differences in early lexical acquisition are related to the children’s general communicative profilesEste trabajo analiza el desarrollo pragmático en la etapa de las primeras palabras, específicamente las reglas forma-función que los niños construyen para comunicarse. Presenta datos de dos niñas que formaron parte de una investigación longitudinal de estudio de casos. Nuestros resultados señalan las tendencias generales identificadas con respecto a las reglas forma-función (Ninio, 1994b; Ninio y Snow, 1996), así como la existencia de diferencias interindividuales. Esas diferencias se refieren a: a) las reglas de correspondencia forma-función y b) la flexibilidad pragmátic

Aprendre a expressar intencions comunicatives a través del llenguatge.

Amb el present treball volem compartir amb la comunitat educativa alguns dels resultats de la investigació que hem dut a terme en els darrers anys sobre el desenvolupament inicial de la comunicació i del llenguatge. La nostra recerca s’ha realitzat amb infants petits, durant els primers divuit mesos de vida. Però molts dels plantejaments generals que l’han orientat i dels resultats i conclusions que se’n deriven van més enllà d’aquest període d’edat en sentit estricte, i creiem que poden ajudar a donar pistes –o si més no, a motivar a la reflexió– sobre com enfocar l’acció educativa escolar i familiar amb l’objectiu de potenciar el millor desenvolupament comunicatiu i lingüístic dels infants

The importance of early parenting for later child outcomes: A study with Spanish families with children with disabilities

Children with different disability conditions have varied developmental trajectories, which perhaps influences parent-child interaction. For these and all infants, an optimal home environment that includes good parenting and positive parent-child interactions predicts better developmental outcomes (Spiker et al., 2005). Interventions using a family-centered, parenting-focused approach result in better parenting behavior that contributes to improved early child development (Avellar & Suplee, 2013; Roggman & Cardia, 2016). Information on parent-child interaction patterns is needed to guide intervention in natural contexts of families (Fuligni & Brooks-Gunn, 2013). Parent-child interaction data were collected from 44 mothers and 35 fathers interacting with their children (23 to 47 months) who had a disability and were in one of eight Spanish Early Interventions Centers. Mothers and fathers, separately, auto-recorded 10-minute play sessions at home. Parental interactions were assessed using PICCOLO (Roggman et al., 2013), a standardized measure of parenting. Two independent observers coded the interactions; strong intra-class correlation coefficients were found (.82 to .97 for mothers, .77 to .89 for fathers). The BSID-III scales (Bayley, 2015) assessed children’s development. Mothers scored slightly higher than did fathers. Scores varied by PICCOLO domains but were consistent with other PICCOLO studies of typical developing children (Roggman et al., 2013). Mother and father’s scores correlated indicating that the higher the scores of mothers in any dimension correlated with those of the parents combined. Positive significant Pearson correlations were found between parenting and child’s development with different patterns of father and mother domains predicting better language and cognitive outcomes. Although barriers to optimal parenting need further investigation, PICCOLO can be a useful tool to support optimal parenting.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Metodología Alternativa para la Eficacia del Funcionamiento de los Equipos Directivos

El presente artículo se deriva de los resultados de investigación, que centran su atención en el funcionamiento de los equipos de dirección; órgano que constituye el mecanismo primario para garantizar la participación y el compromiso con las metas y objetivos institucionales. Entre los resultados fundamentales se destacan los pocos antecedentes de investigaciones referenciales sobre el tema y las insuficientes propuestas de procedimiento e indicadores, que permitan un análisis valorativo orientado hacia el perfeccionamiento del funcionamiento de los consejos de dirección. Además se logró sistematizar las regularidades del funcionamiento de los consejos estudiados. Basado en lo anterior, se considera que la metodología planteada permite apoyar el proceso de cambio organizativo, que se ejecute en el ámbito institucional. El objetivo de este trabajo es diseñar una metodología para el análisis del funcionamiento de los consejos de dirección del sistema gerencial del Ministerio de la Agricultura (MINAG). El mismo muestra la base conceptual para el análisis, las generalidades del funcionamiento en las organizaciones estudiadas y proporciona la metodología para su análisis; es posible además su integración al sistema de seguimiento y control de las instituciones, específicamente en el área relacionada con los Métodos y Estilo de Dirección del Sistema de Gestión y Dirección Empresarial

Monocyte-to-HDL ratio and non-HDL cholesterol were predictors of septic shock in newborns

Background: The association between lipoprotein levels and late-onset neonatal sepsis has shown controversial results. The aims are to assess lipid profile, cytokines, and Monocyte-to-HDL (M/H) ratio as diagnostic and prognostic markers for late-onset neonatal sepsis. Methods: This prospective study included 49 septic neonates and 17 controls. Cholesterol (CT), Triglyceride (TG), Very-Low-Density (VLDLc), Low-Density (LDLc), and High-Density Lipoproteins (HDLc) were measured at admission (D0) and on days 3, 7 and 10 to evaluate septic shock outcomes. Cytokines and monocytes were evaluated by flow cytometry. Results: Septic newborns showed higher IL-6 and IL-8 at D0 and CT levels on D7 and on D10, which also presented higher TG, VLDLc and non-HDL cholesterol concentrations than controls. The septic shock group (n = 22) revealed a higher number of male subjects, CRP, IL-6, IL-8 and IL-10 levels, while lower TG, HDLc, monocyte numbers and M/H ratio at admission compared to the non-shock group (n = 27). M/H ratio and non-HDL cholesterol on D0 were risk factors for septic shock (OR = 0.70, 0.49‒0.99; OR = 0.96, 0.92‒0.99, respectively). Decreasing levels from D0 to D3 of CT (OR = 0.96, 0.93‒0.99), VLDLc (OR = 0.91, 0.85‒0.98), and non-HDL cholesterol (OR = 0.92, 0.87‒0.98) were also predictors of septic shock. Conclusions: Lower M/H ratios and non-HDL cholesterol at admission and decreasing levels of cholesterol, VLDLc and non-HDL cholesterol during a hospital stay are associated with the development of septic shock in newborns with late-onset neonatal sepsis

Week 48 resistance analyses of the once-daily, single-tablet regimen darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) in adults living with HIV-1 from the Phase III Randomized AMBER and EMERALD Trials

Darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) 800/150/200/10 mg is being investigated in two Phase III trials, AMBER (NCT02431247; treatment-naive adults) and EMERALD (NCT02269917; treatment-experienced, virologically suppressed adults). Week 48 AMBER and EMERALD resistance analyses are presented. Postbaseline samples for genotyping/phenotyping were analyzed from protocol-defined virologic failures (PDVFs) with viral load (VL) >= 400 copies/mL at failure/later time points. Post hoc analyses were deep sequencing in AMBER, and HIV-1 proviral DNA from baseline samples (VL = 3 thymidine analog-associated mutations (24% not fully susceptible to tenofovir) detected at screening. All achieved VL <50 copies/mL at week 48 or prior discontinuation. D/C/F/TAF has a high genetic barrier to resistance; no darunavir, primary PI, or tenofovir RAMs were observed through 48 weeks in AMBER and EMERALD. Only one postbaseline M184I/V RAM was observed in HIV-1 of an AMBER participant. In EMERALD, baseline archived RAMs to darunavir, emtricitabine, and tenofovir in participants with prior VF did not preclude virologic response

Miradas y voces de la Investigación Educativa III : Formación y desarrollo profesional docente. Innovación Educativa con miras a la justicia social. Aportes desde la Investigación Educativa

Fil: Ferreyra, Horacio Ademar. Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Sañudo Guerra, Lya. Universidad Católica de Córdoba. Facultad de Educación; Argentin

Analysis of shared heritability in common disorders of the brain

ience, this issue p. eaap8757 Structured Abstract INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed study of phenotypes with different ages of onset, severity, and presentation poses a considerable challenge. Recently developed heritability methods allow us to accurately measure correlation of genome-wide common variant risk between two phenotypes from pools of different individuals and assess how connected they, or at least their genetic risks, are on the genomic level. We used genome-wide association data for 265,218 patients and 784,643 control participants, as well as 17 phenotypes from a total of 1,191,588 individuals, to quantify the degree of overlap for genetic risk factors of 25 common brain disorders. RATIONALE Over the past century, the classification of brain disorders has evolved to reflect the medical and scientific communities' assessments of the presumed root causes of clinical phenomena such as behavioral change, loss of motor function, or alterations of consciousness. Directly observable phenomena (such as the presence of emboli, protein tangles, or unusual electrical activity patterns) generally define and separate neurological disorders from psychiatric disorders. Understanding the genetic underpinnings and categorical distinctions for brain disorders and related phenotypes may inform the search for their biological mechanisms. RESULTS Common variant risk for psychiatric disorders was shown to correlate significantly, especially among attention deficit hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder (MDD), and schizophrenia. By contrast, neurological disorders appear more distinct from one another and from the psychiatric disorders, except for migraine, which was significantly correlated to ADHD, MDD, and Tourette syndrome. We demonstrate that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine. We also identify significant genetic sharing between disorders and early life cognitive measures (e.g., years of education and college attainment) in the general population, demonstrating positive correlation with several psychiatric disorders (e.g., anorexia nervosa and bipolar disorder) and negative correlation with several neurological phenotypes (e.g., Alzheimer's disease and ischemic stroke), even though the latter are considered to result from specific processes that occur later in life. Extensive simulations were also performed to inform how statistical power, diagnostic misclassification, and phenotypic heterogeneity influence genetic correlations. CONCLUSION The high degree of genetic correlation among many of the psychiatric disorders adds further evidence that their current clinical boundaries do not reflect distinct underlying pathogenic processes, at least on the genetic level. This suggests a deeply interconnected nature for psychiatric disorders, in contrast to neurological disorders, and underscores the need to refine psychiatric diagnostics. Genetically informed analyses may provide important "scaffolding" to support such restructuring of psychiatric nosology, which likely requires incorporating many levels of information. By contrast, we find limited evidence for widespread common genetic risk sharing among neurological disorders or across neurological and psychiatric disorders. We show that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures. Further study is needed to evaluate whether overlapping genetic contributions to psychiatric pathology may influence treatment choices. Ultimately, such developments may pave the way toward reduced heterogeneity and improved diagnosis and treatment of psychiatric disorders

Cabbage and fermented vegetables : From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19

Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT(1)R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT(1)R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity.Peer reviewe

Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies

There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR gamma:Peroxisome proliferator-activated receptor, NF kappa B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2 alpha:Elongation initiation factor 2 alpha). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT(1)R axis (AT(1)R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity