127 research outputs found
Interaction of human tRNA-dihydrouridine synthase-2 with interferon-induced protein kinase PKR
- Author
- Publication venue
- Oxford University Press
- Publication date
- Field of study
PKR is an interferon (IFN)-induced protein kinase, which is involved in regulation of antiviral innate immunity, stress signaling, cell proliferation and programmed cell death. Although a low amount of PKR is expressed ubiquitously in all cell types in the absence of IFNs, PKR expression is induced at transcriptional level by IFN. PKR's enzymatic activity is activated by its binding to one of its activators. Double-stranded (ds) RNA, protein activator PACT and heparin are the three known activators of PKR. Activation of PKR in cells leads to a general block in protein synthesis due to phosphorylation of eIF2α on serine 51 by PKR. PKR activation is regulated very tightly in mammalian cells and a prolonged activation of PKR leads to apoptosis. Thus, positive and negative regulation of PKR activation is important for cell viability and function. The studies presented here describe human dihydrouridine synthase-2 (hDUS2) as a novel regulator of PKR. We originally identified hDUS2 as a protein interacting with PACT in a yeast two-hybrid screen. Further characterization revealed that hDUS2 also interacts with PKR through its dsRNA binding/dimerization domain and inhibits its kinase activity. Our results suggest that hDUS2 may act as a novel inhibitor of PKR in cells
Activation of interferon-inducible 2′5′ oligoadenylate synthetase by adenoviral VAI RNA
- Publication venue
- 'American Society for Biochemistry & Molecular Biology (ASBMB)'
- Publication date
- 17/02/1995
- Field of study
2′-5′ oligoadenylate (2-5(A)) synthetase and protein kinase, RNA activated (PKR) are the only two known enzymes that bind double-stranded RNA (dsRNA) and get activated by it. We have previously identified their dsRNA binding domains, which do not have any sequence homology. Here, we report a profound difference between the two enzymes with respect to the structural features of the dsRNA that are required for their activation. The adenoviral virus-associated type I (VAI) RNA cannot activate PKR, although it binds to the protein and thereby prevents its activation by authentic dsRNA. In contrast, we observed that VAI RNA can both bind and activate 2-5(A) synthetase. Mutations in VAI RNA, which removed occasional mismatches present in its double-stranded stems, markedly enhanced its 2-5(A) synthetase-activating capacity. These mutants, however, are incapable of activating PKR. Other mutations, which disrupted the structure of the central stem-loop region of the VAI RNA, reduced its ability to activate 2-5(A) synthetase. These debilitated mutants could bind to the synthetase protein, although they fail to bind to PKR
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
- Author
- Abano Nenette
- Abbdul-saheb Mudhar
- Adedoyin Temi
- Adell Victoria
- Adesina Tolu
- Adie Katja
- Adil-Smith Jennifer
- Ahmad Nasar
- Ahmed Ashraf
- Ahmed Iman
- Al-Mayhani Talal
- Al-Shahi Salman Rustam
- Al-Shahi Salman Rustam
- Alam Mohammad Irfan
- Albazzaz Mo
- Ali Ali
- Alipio Francis
- Allen Christopher
- Allison Joanna
- Amey Isobel
- Amis Elaine
- Amlani Sageet
- Amoils Shannon
- Amor Kelly
- Anderson Rosemary
- Andole Sreeman
- Anjum Talat
- Ankolekar Sandeep
- Annamalai Arunkumar
- Anthony Alpha
- Anversha Ajmal
- Anwar Ijaz
- Anwar Sajjad
- Appleton Jason
- Argandona Lucia
- Armitage Jane
- Ashton Amy
- Atkinson Natalie
- Auld Grace
- Avis Joanne
- Aweid Basaam
- Ayres Georgina
- Azhar Khalid
- Bagnall Caroline
- Baig Farrukh
- Baigent Colin
- Bailey Duncan
- Baird Yolanda
- Bakawala Rehana
- Baker John
- Baker Pauline
- Balazikova Olga
- Balian Linda
- Baliga Vidya
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- Ball Julie
- Ball Margaret
- Ballantine Robert
- Bamford John
- Banaras Azra
- Barber Mark
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- Barker James
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- Bhalla Ajay
- Bharaj Kiranjit
- Bhargava Maneesh
- Bhaskaran Biju
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- Bhatnagar Priya
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- Birns Jonathan
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- du Plessis Johann C
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- Salek-Haddadi Afraim
- Salih Isam
- Sally Moore
- Sandercock Peter A G
- Sangombe Mirriam
- Sangster Graeme
- Sanyal Ranjan
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- Sarah Procter
- Sattar Naweed
- Sattar Saira
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- Saulat Afaq
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- Subramonian Santhosh
- Sudlow Cathie
- Sudlow Cathie L M
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- Sutton Patrick
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- Thorpe Kevin
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- Vasileiadis Evangelos
- Vassallo Joseph
- Venter Marius
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- Verrion Anna
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- Vickers Carinna
- Walford Jamie
- Walker Allan
- Walker Marion
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- Walker Susannah
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- Wallace Rebecca
- Wallace Rebecca
- Walstow Deborah
- Walter Deborah
- Walters Ashleigh
- Wani Mushtaq
- Ward Deborah
- Wardlaw Joanna M
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- Waterfield Kelly
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- Waugh Dean
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- Webber Adam
- Webster Timothy
- Weinling Marie
- Weir Nic
- Weir Pauline
- Welch Angela
- Werring David
- Werring David J
- Whitcher Alison
- White James
- White Julie
- White Philip M
- White Susan
- Whiteley William
- Whiteley William N
- Whiteman Jessica
- Whiteman Jessica
- Whiting Robert
- Whittamore Katherine
- Wiggam Ivan
- Wilding Peter
- Wilkes Gwendoline
- Wilkinson Mark
- Willberry Angela
- Williams Carol
- Williams Rebecca
- Williams-Yesson Barbara
- Willmot Mark
- Wilson David
- Wilson Duncan
- Wilson Jenny
- Wilson Lisa
- Wilson Sarah
- Wiltshire Alison
- Wood Diane
- Wood Edith
- Wood Lisa
- Woodward Stephen
- Wright Fiona
- Wroath Belinda
- Wynter Inez
- Yadava Rajendra
- Yip Brigitte
- Young Andrew
- Zachariah George
- Zahoor Tajammal
- Zoe Mellor
- Publication venue
- 'Elsevier BV'
- Publication date
- 22/05/2019
- Field of study
Background
Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy
Surface-enhanced Raman spectroscopy of blood serum based on gold nanoparticles for the diagnosis of the oral squamous cell carcinoma
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar M. S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G. R.
- Abedalthagafi M.
- Abel L.
- Abernathy C.
- Abraheem A.
- Abul-Husn N. S.
- Acquilini D.
- Adams C.
- Adams E. L.
- Adams K.
- Adamsara A.
- Adanini O.
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal S.
- Aguero D.
- Ahmad N.
- Ahmadi S.
- Ahmed A.
- Ahmed C.
- Akeroyd L.
- Akhtar M. N.
- Akinkugbe O.
- Aksentijevich A.
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z. Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G. M.
- Albakri J. K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha A. E.
- Alexander P.
- Alfonso J.
- Alghamdi B.
- Alghamdi J.
- Ali A.
- Ali A.
- Ali I. A. M.
- Ali S.
- Aliannejad R.
- Aljawini N.
- AlJohani S.
- Alkwai S.
- Allan A.
- Allan E.
- Allan J.
- Alldis Z.
- Allen L.
- Allen M.
- Allen S.
- Allibone S.
- Allison K. S.
- Allos R.
- Ally S. M.
- AlMalik A.
- Almalki F.
- Almohammed I.
- Almutairi M.
- Alotaibi S.
- Alowayn A. M.
- Alqahtani S.
- Alqubaishi F.
- Alrashed M.
- Alshareef A.
- Alsolm E.
- Alswailm M.
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- Wright D.
- Wright J.
- Wright M.
- Wrobel N.
- Wu Y.
- Wulandari R.
- Wyllie D. H.
- Wynter I.
- Xavier K.
- Xue X.
- Yadav A.
- Yang J.
- Yassen A. M.
- Yates B.
- Ye C.
- Yun N.
- Zainy T.
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- Zlatopolsky M.
- Zollner S.
- Zongo O.
- Zucchi P.
- Zyndorf M.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
- A. -G. Wu
- A. C. Ma
- A. K. Au
- Abdel-Aziz A. K.
- Abdelfatah S.
- Abdellatif M.
- Abdoli A.
- Abel S.
- Abeliovich H.
- Abildgaard M. H.
- Abudu Y. P.
- Acevedo-Arozena A.
- Adamopoulos I. E.
- Adeli K.
- Adolph T. E.
- Adornetto A.
- Aflaki E.
- Agam G.
- Agarwal A.
- Aggarwal B. B.
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- Agostinis P.
- Agrewala J. N.
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- Aguilar P. V.
- Ahmad S. T.
- Ahmed Z. M.
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- Aits S.
- Aizawa S.
- Akkoc Y.
- Akoumianaki T.
- Akpinar H. A.
- Al-Abd A. M.
- Al-Akra L.
- Al-Gharaibeh A.
- Alaoui-Jamali M. A.
- Alberti S.
- Alcocer-Gomez E.
- Alessandri C.
- Ali M.
- Alim Al-Bari M. A.
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- Alizadeh J.
- Almacellas E.
- Almasan A.
- Alonso A.
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- Zheng K.
- Zheng L.
- Zheng S.
- Zheng X. -L.
- Zheng Y.
- Zheng Z. -G.
- Zhivotovsky B.
- Zhong Q.
- Zhou A.
- Zhou B.
- Zhou C.
- Zhou G.
- Zhou H.
- Zhou H.
- Zhou H.
- Zhou J.
- Zhou J.
- Zhou J.
- Zhou J.
- Zhou K.
- Zhou R.
- Zhou X. -J.
- Zhou Y.
- Zhou Y.
- Zhou Y.
- Zhou Z.
- Zhou Z. -Y.
- Zhu B.
- Zhu C.
- Zhu G. -Q.
- Zhu H.
- Zhu H.
- Zhu H.
- Zhu W. -G.
- Zhu Y.
- Zhu Y.
- Zhuang H.
- Zhuang X.
- Zientara-Rytter K.
- Zimmermann C. M.
- Ziviani E.
- Zoladek T.
- Zong W. -X.
- Zorov D. B.
- Zorzano A.
- Zou W.
- Zou Z.
- Zou Z.
- Zuryn S.
- Zwerschke W.
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
Plasma lipid profiles discriminate bacterial from viral infection in febrile children
- Author
- Abdulla Amina F.
- Abelake Eugenia
- Adeel Abdul O.A.
- Aebi C.
- Agapow Paul Michael
- Agbeko R.
- Agyeman P.
- Anderson Suzanne T. B.
- Antonio Martin
- Baer W.
- Barham Heather
- Barral-Arca Ruth
- Barrios Xavier Gabaldó
- Bartlett Maeve
- Baumgart Hinrich
- Baumgartner Markus
- Behrends Uta
- Bellos Evangelos
- Berger C.
- Bernhard-Stirnemann S.
- Biebl Ariane
- Binder Alexander
- Birnbacher Robert
- Blanke Jan-Gerd
- Boeddha Navin P.
- Boelke Carsten
- Bojang Kalifa
- Bokhandi Sumit S.
- Breukels Meike A.
- Breuling Kai
- Brinkman Daniëlle M.C.
- Brió Sanagustín Sonia
- Brunner Jürgen
- Buller Maria
- Camuzeaux Stephane
- Carreras Eduardo
- Carrol Enitan
- Carter Stephanie
- Cebey-López Miriam
- Coin Lachlan
- Cole Fatoumata
- Concha-Torre Andres
- Contreras J. Ruiz
- Cooke Elizabeth Fernández
- Crate Lindsay
- Curras-Tuala MJ.
- Dahlem Peter
- Davies Patrick
- de Groot Ronald C.A.
- de Korte Carla C.M.M.
- de Vries Esther
- de Waal Wouter J.
- Deep Akash
- Dekkers Roel
- Dietrich Beate
- Dings-Lammertink Anouk
- Doedens Rienus A.
- Donker AlbertineE.
- Dousma Mieke
- Driessen Gertjan Jan A.
- Eber Ernst
- Eleftherohorinou Hariklia
- Elias Johannes
- Ellacuriagal Antonio Salas
- Emhofer Josef
- Emonts Marieke
- Etschmaier Rosa
- Faber Tina E.
- Farr Sebastian
- Faust Saul
- Fernandez Silveira Laura
- Fernández Reyes
- Fink Colin
- Forte Miguel Sanchez
- Fortune Peter-Marc
- Frederick H.
- Galassini Rachel
- García Natalia
- Gerrits Gerardus Peter Jm M.
- Gerver Jan A.M.
- Giannoni E.
- Giménez-Sánchez Francisco
- Girtler Ylenia
- Gomez-Rial Jose
- Gormley Stuart
- Grela Beiroa Andrea
- Gribbin Andrew
- Grigorow Irina
- Guillén Sara
- Gómez-Carballa Alberto
- Hamilton Shea
- Hardy Katie
- Hasters P.
- Hazelzet Jan
- Heidema Jojanneke
- Heimann Konrad
- Heininger U.
- Herberg Jethro A.
- Hoggart Clive
- Hourmat Bernardo
- Hudnott Phil
- Ibarrondo Cristina Epalza
- Iglesias Pilar Leboráns
- Ihm Ulrike
- Inwald David
- Jackson Heather R.
- Jacobs Monique A.M.
- Jansen Nicolaas Johannes Georgius
- Jaros Zdenek
- Jennings R.
- Johnston J.
- Justicia-Grande Antonio
- Kaforou Myrsini
- Kahlert C.
- Kalhoff Hermann
- Kaulfersch Wilhelm
- Kawczynski Pawel
- Kebbeh Ngange
- Kemen Christoph
- Kenwright R.
- khan Saidy
- Klobassa Daniela S.
- Klocker Nina
- Klucovska Kristine
- Kneyber Martin Christiaan Jacques
- Kohlmaier B.
- Komini Eleni
- Koopman-Keemink Yvonne
- Kramer Lydia
- Kuijpers T. W.
- Köster Bernhard
- Langenhorst Veerle J.
- Leusink José
- Levin Michael
- Lewis Matthew R.
- León-León María Cruz
- Loza Bettina F.
- Lozano María José
- Maconochie Ian
- Martinez-Santos Alba-Elena
- Martinon-Torres Federico
- MartinónTorres Nazareth
- Mashbat Meg
- McClure Myra
- McCorkell Jenni
- McCready Sharon
- Menikou Stephanie
- Merth Istvan T.
- Miedema Carien J.
- Mingorance Álvaro Navarro
- Momodou None
- Moreno David
- Morillo Gutiérrez Beatriz
- Mustafa Sobia
- Nadel Simon
- Navarra Helen
- Navarro Marisa
- Neeleman Chris
- Neth Olaf
- Neubert Antje
- Niederer-Loher A.
- Nijman Ruud Gerard
- Noordzij Jeroen G.
- Nsirim Eniola
- O'Neill Lauren
- Obihara Charlie C.C.
- Ortner Daniel
- Oñate Vergara Eider
- Pacheco Pablo Obando
- Padilla Ma del Carmen Martínez
- Pajkrt Dasja
- Palacios Alba
- Pardo-Seco Jacobo
- Patel Rekha
- Patel Sanjay Valabh
- Pathan Nazima
- Paulus Stéphane
- Pescollderungg Lydia
- Peters Mark
- Pfurtscheller Klaus
- Philipsen H.L.A.
- Pinnock Elli
- Pischedda Sara
- Pollard AJ.
- Poortman Geriska H.
- Posfay-Barbe K.M.
- Potgieter Steph T.
- Potjewijd Joke
- Power Sue
- Pérez Belén Mosquera
- Rahman Rahmeen
- Ramaiah Raghu
- Redondo Collazo Lorenzo
- Reiter Karl
- Relly C.
- Reyes Susana Beatriz
- Ridout Jenna
- Ristic Goran
- Rivero Calle Irene
- Rodríguez-Tenreiro Carmen
- Rojo Pablo
- Rosias Philippe P.R.
- Royad C.
- Rödl Siegfried
- Sagmeister Manfred
- Salas Antonio
- Sancho Shimizu Vanessa
- Sanders Elisabeth A. M.
- Sands Caroline
- Sarr Isatou
- Schlapbach Luregn
- Schweintzger Nina
- Secka Fatou
- Sellner Andrea
- Serén Fernández Sonia
- Sey Gibbi
- Silva María Del Sol Porto
- Sonnleitner Astrid
- Sperl Matthias
- Sprong Tom
- Standing Fran
- Stelzl Wolfgang
- Stocker M.
- Sánchez José María
- Tato Luis Manuel Prieto
- ten Tussher Gavin W.
- Thakker Clare
- Thio Bernard J.
- Thomas Gilleh
- Thurston Sarah
- Till Holger Karl H.
- Tramper-Stranders Gerdien A.
- Trobisch Andreas
- Tuffrey Catherine
- Universitat Autònoma de Barcelona
- van de Beek Diederik
- van der Ende Arie
- Van der Flier Michiel
- van der Meer H.
- van Deuren M.
- van Furth Marceline
- van Kuppevelt A.J.M.
- van Overbeek - van Gils A. Lidy T.
- van Wermeskerken A.M.
- Veen J. Homan-van der
- Vega Ana Karina
- Verwijs W.A.
- Vicente Luisa García
- Vierzig Anne
- Vilanova-Trillo Lucía
- Vivanco Ana
- Vogel Ulrich
- Wang Xinzhu
- Weingarten Christina
- Welke Stefanie
- White Deborah K.
- White Sonia
- Willis Louise
- Wimmer Andreas
- Wintergerst Uwe
- Wolfs T.F.W.
- Wright Victoria
- Wüller Daniel
- Young Zoe
- Zaunschirm Andrew
- Zenz Werner
- Ziuraite Ieva
- Álvarez Cristina Álvarez
- Álvez González Fernando
- Žukovskaja Veslava
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The 'omics' approaches to identifying biomarkers from the host-response to bacterial infection are promising. In this study, lipidomic analysis was carried out with plasma samples obtained from febrile children with confirmed bacterial infection (n = 20) and confirmed viral infection (n = 20). We show for the first time that bacterial and viral infection produces distinct profile in the host lipidome. Some species of glycerophosphoinositol, sphingomyelin, lysophosphatidylcholine and cholesterol sulfate were higher in the confirmed virus infected group, while some species of fatty acids, glycerophosphocholine, glycerophosphoserine, lactosylceramide and bilirubin were lower in the confirmed virus infected group when compared with confirmed bacterial infected group. A combination of three lipids achieved an area under the receiver operating characteristic (ROC) curve of 0.911 (95% CI 0.81 to 0.98). This pilot study demonstrates the potential of metabolic biomarkers to assist clinicians in distinguishing bacterial from viral infection in febrile children, to facilitate effective clinical management and to the limit inappropriate use of antibiotics
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- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
- Adeli K
- Adolph TE
- Adornetto A
- Aflaki E
- Agam G
- Agarwal A
- Aggarwal BB
- Agnello M
- Agostinis P
- Agrewala JN
- Agrotis A
- Aguilar PV
- Ahmad ST
- Ahmed ZM
- Ahumada-Castro U
- Aits S
- Aizawa S
- Akkoc Y
- Akoumianaki T
- Akpinar HA
- Al-Abd AM
- Al-Akra L
- Al-Gharaibeh A
- Alaoui-Jamali MA
- Alberti S
- Alcocer-Gómez E
- Alessandri C
- Ali M
- Alim Al-Bari MA
- Aliwaini S
- Alizadeh J
- Almacellas E
- Almasan A
- Alonso A
- Alonso GD
- Altan-Bonnet N
- Altieri DC
- Alves da Costa C
- Alves S
- Alzaharna MM
- Amadio M
- Amantini C
- Amaral C
- Ambrosio S
- Amer AO
- Ammanathan V
- An Z
- Andersen SU
- Andrabi SA
- Andrade-Silva M
- Andres AM
- Angelini S
- Ann D
- Anozie UC
- Ansari MY
- Antas P
- Antebi A
- Antón Z
- Anwar T
- Apetoh L
- Apostolova N
- Araki T
- Araki Y
- Arasaki K
- Araya J
- Araújo WL
- Arden C
- Arguelles S
- Arias E
- Arikkath J
- Arimoto H
- Ariosa AR
- Armstrong-James D
- Arnauné-Pelloquin L
- Aroca A
- Arroyo DS
- Arsov I
- Artero R
- Arévalo M-A
- Asaro DML
- Aschner M
- Ashrafizadeh M
- Ashur-Fabian O
- Atanasov AG
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- Auberger P
- Auner HW
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- Zheng G
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- Zheng Y
- Zheng Z-G
- Zhivotovsky B
- Zhong Q
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- Zhou Z
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- Zhu B
- Zhu C
- Zhu G-Q
- Zhu H
- Zhu H
- Zhu H
- Zhu W-G
- Zhu Y
- Zhu Y
- Zhuang H
- Zhuang X
- Zientara-Rytter K
- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
- Zou Z
- Zou Z
- Zuryn S
- Zwerschke W
- Álvarez ÉMC
- Ávalos Y
- Önal G
- Üstün S
- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Identification of regulatory variants associated with genetic susceptibility to meningococcal disease.
- Author
- Abdulla Amina
- Abelake Eugenia
- Adeel AOA
- Aebi Christoph
- Agapow Paul
- Agbeko Rachel
- Agyeman Philipp
- Alvarez Alvarez Cristina
- Alvez Gonzalez Fernando
- Anderson Suzanne
- Antonio Martin
- Arpe Volker
- Ausserer Bernd
- Baer Walter
- Barham Heather
- Barral-Arca Ruth
- Bartlett Maeve
- Beatriz Reyes Susana
- Beckmann Regina
- Bellos Evangelos
- Bensch Juergen
- Berger Christoph
- Berger Thomas
- Bernhard-Stirnemann Sara
- Binder Alexander
- Bindl Lutz
- Bittrich Hans J
- Boeddha NP
- Bojang Kalifa
- Bokhandi S
- Borghini Lisa
- Brangenberg Ralf
- Breuer HA
- Breukels MA
- Brinkman DMC
- Brio Sanagustin Sonia
- Broede Hans
- Bruckner Robert
- Carreras Eduardo
- Carrol Enitan D
- Carter Stephanie
- Cebey-Lopez Miriam
- Coin Lachlan J
- Cole Fatoumatta
- Concha Torre Andres
- Consortium EUCLIDS
- Cratev Lindsey
- Cremer Manfred
- Davies P
- Davila Sonia
- de Groot Ronald
- de Korte CCMM
- de Vries E
- de Waal WJ
- Deeg KH
- Deep Akash
- Dekkers R
- Diab Gedeon
- Dilch Alfred
- Dings-Lammertink A
- Doedens RA
- Donker AE
- Dousma M
- Driessen GJA
- Eitelberger Franz
- Eleftherohorinou Hariklia
- Emonts Marieke
- Evert W
- Faber TE
- Faust S
- Fedlmaier Michael
- Fernandez Silveira Laura
- Fernandez Reyes
- Fink Colin
- Foerster Kai Martin
- Fortune PM
- Frederick Hannah
- Fucik Peter
- Fusch Christoph
- Gabaldo Barrios Xavier
- Gabriel Markwart
- Galassini Rachel
- Garcia Vicente Luisa
- Garcia Natalia
- Geishofer Gotho
- Gerrits GPJM
- Gerver JAM
- Giannoni Eric
- Gimenez Sanchez Francisco
- Goepel Wolfgang
- Goerke W
- Gomez Rial Jose
- Gomez-Carballa Alberto
- Gormley Stuart
- Grela Beiroa Andrea
- Gribbin Andrew
- Groeblacher-Roth Helene
- Groneck Peter
- Grube Regina
- Gruber Alois
- Guillen Sara
- Hamilton Shea
- Hammer Jurg
- Hardy Katie
- Hasters Paul
- Hauser Erwin
- Hautz Juergen
- Hazelzet Jan
- Heidema J
- Heininger Ulrich
- Hennenberger Axel
- Herberg Jethro
- Herrmann Johanna
- Herting Egbert
- Hibberd Martin L
- Hofmann Thomas
- Hoggart Clive
- Homan-van der Veen J
- Hourmat Bernardo
- Hudnott Phil
- Huemer Christian
- Hueseman D
- Inwald David
- Jacobs MAM
- Jansen NJG
- Jennings Rebecca
- Johnston Joanne
- Jose Curras-Tuala Maria
- Jose Lozano Maria
- Justicia Grande Antonio
- Kaforou Myrsini
- Kahlert Christian
- Kalhoff Hermann
- Kasper Johannes-Martin
- Kawczynski P
- Kebbeh Ngane
- Kenwright Rhian
- Klinge Jens
- Klobassa Daniela
- Klucovska K
- Knaufer-Schiefer Suzanne
- Kneyber MCJ
- Koch Hartmut
- Koch Reinhard
- Koenig Michael
- Koopman-Keemink Y
- Kronberger Martina
- Kuijpers Taco W
- Kumlien Bjoern
- Kunze Wolfgang
- Kurnik Peter
- Laessig Wolfgang
- Langenhorst VJ
- Leborans Iglesias Pilar
- Lenz Kurt
- Leon Leon Maria Cruz
- Leusink J
- Levin Michael
- Lischka Andreas
- Loranth Kathrin
- Loza BF
- Luigs Petra
- Maak Bernhard
- Mahler Klaus
- Markart Markus
- Martin Mueller
- Martinez Padilla Ma del Carmen
- Martinez Santos Alba Elena
- Martinon Sanchez Jose Maria
- Martinon-Torres Federico
- Martinon-Torres Nazareth
- Mashbat Meg
- McCorkell Jenni
- McCready Sharon
- Meier Primrose
- Meissl Manfred
- Menikou Stefanie
- Merth IT
- Miedema CJ
- Miething Robert
- Mitter Horst
- Moreno David
- Moser Reinhard
- Mosquera Perez Belen
- Mueller Herbert
- Mustafa Sobia
- Nadel Simon
- Navarra Helen
- Navarro Mingorance Alvaro
- Navarro Marisa
- Neeleman C
- Neth Olaf
- Nicolai T Homas
- Niederer-Loher Anita
- Noordzij JG
- Nossal Robert
- Nsirim Eniola
- O'Neill Lauren
- Obando Pacheco Pablo
- Obihara CC
- Onate Vergara Eider
- Pajkrt D
- Paky Franz
- Palacios Alba
- Pardo-Seco Jacobo
- Patel Rekha
- Patel S
- Pathan N
- Paulus Stephane
- Penzien Johann M
- Pernice Walter
- Peters Jochen
- Peters Mark
- Pfau Eberhard
- Pfurtscheller Klaus
- Philipsen HLA
- Pinnock Ellie
- Pischedda Sara
- Png Eileen
- Pollard Andrew J
- Poortman GH
- Porto Silva Maria del Sol
- Posfay-Barbe Klara M
- Potgieter ST
- Potjewijd J
- Power Sue
- Prieto Tato Luis Manuel
- Quietzach J
- Rahman Rahmeen
- Ramaiah R
- Redondo-Collazo Lorenzo
- Reiter Hans-Ludwig
- Reiter Karl
- Relly Christa
- Ridout Jenna
- Rivero Calle Irene
- Rodriguez-Tenreiro Carmen
- Roedl Siegfried
- Rojo Pablo
- Rosias PPR
- Royad C
- Ruiz Contreras J
- Runge Klaus
- Saidykhan Momodou
- Salas Antonio
- Salzer Hans R
- Sanchez Forte Miguel
- Sancho-Shimizu Vanessa
- Sanders EAM
- Sarr Isatou
- Schaller Gerhard
- Scheibenpflug Christian
- Schermann Peter
- Schimmel Ulf
- Schlapbach Luregn J
- Schmidt Andreas
- Schuermann Roland
- Schulz Dietrich
- Schwarick Juergen
- Schwarz Rudolf
- Schweitzer-Krantz Susanne
- Secka Fatou
- Seidenberg Juergen
- Seidler Ekkehard
- Seitz Christiane
- Seren Fernandez Sonia
- Sey Gibbi
- Sillaber Ursula
- Simic-Schleicher G
- Simma Burkhard
- Sitzmann Friedrich C
- Sontheimer D
- Sperl Wolfgang
- Sprong T
- Standing Fran
- Stocker Martin
- Strasser Friedrich
- Streif Werner
- Ta Van Hop
- ten Tussher GW
- Thakker Clare
- Thio BJ
- Thomas Gilleh
- Thurston Sarah
- Tillmann Roland
- Toepke Baerbel
- Tramper-Stranders GA
- Tuffrey Catherine
- van de Beek D
- van der Ende A
- van der Flier M
- Van der Flier Michiel
- van der Meer H
- van Deuren M
- van Furth AM Tutu
- van Kuppevelt AJM
- van Overbeek-van Gils ALT
- van Wermeskerken AM
- Varnholt Verena
- Vega Ana
- Verwijs WA
- Vivanco Ana
- von der Wense Axel
- Walcher Wolfgang
- Weigand Nicola
- Weikmann Eckart
- Weiss Ute
- White Deborah
- White Sonia
- Willis Louise
- Wocko Lucia
- Wolfs TFW
- Wright Victoria J
- Young Zoe
- Zenz Werner
- Zobel Gerfried
- Zoehrer Bettina
- Zwiauer Karl
- Publication venue
- Sci Rep
- Publication date
- 01/01/2019
- Field of study
Non-coding genetic variants play an important role in driving susceptibility to complex diseases but their characterization remains challenging. Here, we employed a novel approach to interrogate the genetic risk of such polymorphisms in a more systematic way by targeting specific regulatory regions relevant for the phenotype studied. We applied this method to meningococcal disease susceptibility, using the DNA binding pattern of RELA - a NF-kB subunit, master regulator of the response to infection - under bacterial stimuli in nasopharyngeal epithelial cells. We designed a custom panel to cover these RELA binding sites and used it for targeted sequencing in cases and controls. Variant calling and association analysis were performed followed by validation of candidate polymorphisms by genotyping in three independent cohorts. We identified two new polymorphisms, rs4823231 and rs11913168, showing signs of association with meningococcal disease susceptibility. In addition, using our genomic data as well as publicly available resources, we found evidences for these SNPs to have potential regulatory effects on ATXN10 and LIF genes respectively. The variants and related candidate genes are relevant for infectious diseases and may have important contribution for meningococcal disease pathology. Finally, we described a novel genetic association approach that could be applied to other phenotypes
Estimating global injuries morbidity and mortality : methods and data used in the Global Burden of Disease 2017 study
- Author
- Abd El Razek Muhammed Magdy
- Abdelalim Ahmed
- Abdeldayem Amer Yasser Sami
- Abdollahpour Ibrahim
- Abdulkader Rizwan Suliankatchi
- Abedi Aidin
- Abegaz Kedir Hussein
- Abosetugn Akine Eshete
- Abushouk Abdelrahman I
- Abushouk Abdelrahman I.
- Adebayo Oladimeji M
- Adebayo Oladimeji M.
- Adema Bereket Duko
- Adsuar Jose C
- Adsuar Jose C.
- Advani Shailesh M
- Advani Shailesh M.
- Agudelo-Botero Marcela
- Ahmad Tauseef
- Ahmed Muktar Beshir
- Ahmed Rushdia
- Alahdab Fares
- Alanezi Fahad Mashhour
- Alema Niguse Meles
- Alemu Biresaw Wassihun
- Alghnam Suliman A
- Alghnam Suliman A.
- Ali Beriwan Abdulqadir
- Ali Saqib
- Alinia Cyrus
- Alipour Vahid
- Aljunid Syed Mohamed
- Almasi-Hashiani Amir
- Almasri Nihad A
- Almasri Nihad A.
- Altirkawi Khalid
- Andrei Catalina Liliana
- Angga Pribadi Dimas Ria
- Anggraini Ningrum Dina Nur
- Ansari-Moghaddam Alireza
- Anvari Davood
- Arab-Zozani Morteza
- Arabloo Jalal
- Arefi Zohreh
- Aremu Olatunde
- Ariani Filippo
- Arora Amit
- Asaad Malke
- Ayala Quintanilla Beatriz Paulina
- Ayano Getinet
- Ayanore Martin Amogre
- Azarian Ghasem
- Badawi Alaa
- Badiye Ashish D
- Badiye Ashish D.
- Baig Atif Amin
- Bairwa Mohan
- Bakhtiari Ahad
- Balachandran Arun
- Bali Ahmed Omar
- Banach Maciej
- Banerjee Srikanta K
- Banerjee Srikanta K.
- Banik Palash Chandra
- Banstola Amrit
- Barker-Collo Suzanne Lyn
- Barzegar Akbar
- Bayati Mohsen
- Bazargan-Hejazi Shahrzad
- Bedi Neeraj
- Behzadifar Masoud
- Belete Habte
- Bennett Derrick A
- Bennett Derrick A.
- Bensenor Isabela M
- Bensenor Isabela M.
- Berhe Kidanemaryam
- Bertolacci Gregory J
- Bertolacci Gregory J.
- Bhagavathula Akshaya Srikanth
- Bhardwaj Pankaj
- Bhat Anusha Ganapati
- Bhattacharyya Krittika
- Bhutta Zulfiqar A
- Bhutta Zulfiqar A.
- Bibi Sadia
- Bicer Burcu Kucuk
- Bijani Ali
- Boloor Archith
- Borges Guilherme
- Borschmann Rohan
- Borzì Antonio Maria
- Boufous Soufiane
- Braithwaite Dejana
- Briko Nikolay Ivanovich
- Brugha Traolach
- Budhathoki Shyam S
- Budhathoki Shyam S.
- Bärnighausen Till Winfried
- Car Josip
- Car Lorainne Tudor
- Carvalho Félix
- Castaldelli-Maia João Mauricio
- Castañeda-Orjuela Carlos A
- Castañeda-Orjuela Carlos A.
- Castelpietra Giulio
- Castle Chris D
- Castle Chris D.
- Catalá-López Ferrán
- Cerin Ester
- Chandan Joht S
- Chapman Jens Robert
- Chattu Soosanna Kumary
- Chattu Vijay Kumar
- Chatziralli Irini
- Chaudhary Neha
- Cho Daniel Youngwhan
- Choi Jee-Young J
- Christopher Devasahayam J
- Chu Dinh-Toi
- Cicuttini Flavia M
- Coelho João M
- Costa Vera M
- Cunningham Matthew
- Cárdenas Rosario
- Dahlawi Saad M A
- Dandona Rakhi
- Darwesh Aso Mohammad
- Daryani Ahmad
- Defo Barthelemy Kuate
- Demeke Feleke Mekonnen
- Demoz Gebre Teklemariam
- Demsie Desalegn Getnet
- Deribe Kebede
- Desai Rupak
- Dharmaratne Samath Dhamminda
- Dibaji Forooshani Zahra Sadat
- Dingels Zachary V
- Dingels Zachary V.
- Do Hoa Thi
- Doyle Kerrie E
- Driscoll Tim Robert
- Dubljanin Eleonora
- Dávila-Cervantes Claudio Alberto
- Eagan Arielle Wilder
- Eddine Aichour Miloud Taki
- El-Jaafary Shaimaa I
- El-Khatib Ziad
- Elemineh Demelash Abewa
- Ellingsen Christian Lycke
- Eskandarieh Sharareh
- Eyawo Oghenowede
- Faris Pawan Sirwan
- Faro Andre
- Farzadfar Farshad
- Fereshtehnejad Seyed-Mohammad
- Fernandes Eduarda
- Ferrara Pietro
- Filipino Pepito Veincent Christian
- Fischer Florian
- Folayan Morenike Oluwatoyin
- Fomenkov Artem Alekseevich
- Foroutan Masoud
- Fox Jack T
- Fox Jack T.
- Francis Joel Msafiri
- Franklin Richard Charles
- Fukumoto Takeshi
- Geberemariyam Biniyam Sahiledengle
- Gebremariam Hadush
- Gebremedhin Ketema Bizuwork
- Gebremeskel Gebreamlak Gebremedhn
- Gebremeskel Leake G
- Gebremichael Berhe
- Gedefaw Getnet Azeze
- Geta Birhanu
- Getenet Agegnehu Bante
- Ghafourifard Mansour
- Ghamari Farhad
- Gheshlagh Reza Ghanei
- Gholamian Asadollah
- Gilani Syed Amir
- Gill Tiffany K
- Goudarzian Amir Hossein
- Goulart Alessandra C
- Grada Ayman
- Grivna Michal
- Guimarães Rafael Alves
- Guo Yuming
- Gupta Gaurav
- Haagsma Juanita A
- Hall Brian James
- Hamadeh Randah R
- Hamidi Samer
- Hamilton Erin B
- Hamilton Erin B.
- Handiso Demelash Woldeyohannes
- Haro Josep Maria
- Hasanzadeh Amir
- Hassan Shoaib
- Hassanipour Soheil
- Hassankhani Hadi
- Hassen Hamid Yimam
- Havmoeller Rasmus
- Hay Simon I
- Hendrie Delia
- Henry Nathaniel J
- Henry Nathaniel J.
- Heydarpour Fatemeh
- Ho Hung Chak
- Hoang Chi Linh
- Hole Michael K
- Holla Ramesh
- Hossain Naznin
- Hosseinzadeh Mehdi
- Hostiuc Sorin
- Hu Guoqing
- Huey Lee Shaun Wen
- Híjar Martha
- Ibitoye Segun Emmanuel
- Ilesanmi Olayinka Stephen
- Inbaraj Leeberk Raja
- Ivers Rebecca Q
- Jahani Mohammad Ali
- Jakovljevic Mihajlo
- Jalilian Farzad
- James Spencer L
- James Spencer L.
- Jayaraman Sudha
- Jayatilleke Achala Upendra
- Jha Ravi Prakash
- John-Akinola Yetunde O
- Jonas Jost B
- Jones Kelly M
- Joseph Nitin
- Joukar Farahnaz
- Jozwiak Jacek Jerzy
- Jungari Suresh Banayya
- Jürisson Mikk
- Kabir Chowdhury Mohiuddin Ahsanul
- Kabir Ali
- Kahsay Amaha
- Kalankesh Leila R
- Kalhor Rohollah
- Kamil Teshome Abegaz
- Kanchan Tanuj
- Kapoor Neeti
- Karami Manoochehr
- Kasaeian Amir
- Kassaye Hagazi Gebremedhin
- Kavetskyy Taras
- Kayode Gbenga A
- Keiyoro Peter Njenga
- Kelbore Abraham Getachew
- Khader Yousef Saleh
- Khafaie Morteza Abdullatif
- Khalid Nauman
- Khalil Ibrahim A
- Khalilov Rovshan
- Khan Ejaz Ahmad
- Khan Junaid
- Khan Maseer
- Khanna Tripti
- Khazaei Salman
- Khazaie Habibolah
- Khundkar Roba
- Kiirithio Daniel N
- Kim Daniel
- Kim Young-Eun
- Kim Yun Jin
- Kisa Adnan
- Kisa Sezer
- Komaki Hamidreza
- Kondlahalli Shivakumar K M
- Koolivand Ali
- Korshunov Vladimir Andreevich
- Koyanagi Ai
- Kraemer Moritz U G
- Krishan Kewal
- Kugbey Nuworza
- Kumar Manasi
- Kumar Narinder
- Kumar Nithin
- Kumar Vivek
- Kumaresh Girikumar
- Lami Faris Hasan
- Lansingh Van C
- Lasrado Savita
- Latifi Arman
- Lauriola Paolo
- Leasher Janet L
- LeGrand Kate E
- LeGrand Kate E.
- Leo Diego De
- Li Shanshan
- Liu Xuefeng
- Liu Zichen
- Lopez Alan D
- Lotufo Paulo A
- Lyons Ronan A
- Machado Daiane Borges
- Madadin Mohammed
- Mahotra Narayan Bahadur
- Majdan Marek
- Majeed Azeem
- Maled Venkatesh
- Malta Deborah Carvalho
- Manafi Amir
- Manafi Navid
- Manda Ana-Laura
- Manjunatha Narayana
- Mansour-Ghanaei Fariborz
- Mansournia Mohammad Ali
- Maravilla Joemer C
- Mason-Jones Amanda J
- Masoumi Seyedeh Zahra
- Massenburg Benjamin Ballard
- Maulik Pallab K
- Mehndiratta Man Mohan
- Melketsedik Zeleke Aschalew
- Memiah Peter T N
- Mendoza Walter
- Menezes Ritesh G
- Mengesha Melkamu Merid
- Meretoja Atte
- Meretoja Tuomo J
- Merie Hayimro Edemealem
- Mestrovic Tomislav
- Miazgowski Bartosz
- Miazgowski Tomasz
- Miller Ted R
- Mini G K
- Mirica Andreea
- Mirrakhimov Erkin M
- Mirzaei-Alavijeh Mehdi
- Mithra Prasanna
- Moazen Babak
- Mofizul Islam M
- Moghadam Telma Zahirian
- Moghadaszadeh Masoud
- Mohamadi Efat
- Mohammad Sajadi S
- Mohammad Yousef
- Mohammadian-Hafshejani Abdollah
- Mohammadpourhodki Reza
- Mohammed Jemal Abdu
- Mohammed Shafiu
- Mohebi Farnam
- Mohseni Bandpei Mohammad A
- Mokdad Ali H
- Molokhia Mariam
- Monasta Lorenzo
- Moodley Yoshan
- Moradi Ghobad
- Moradi Masoud
- Moradi-Lakeh Maziar
- Moradzadeh Rahmatollah
- Morawska Lidia
- Morrison Shane Douglas
- Mossie Tilahun Belete
- Muluneh Atalay Goshu
- Musa Kamarul Imran
- Mustafa Ghulam
- Naderi Mehdi
- Nagarajan Ahamarshan Jayaraman
- Naghibi Irvani Seyed Sina
- Naik Gurudatta
- Naimzada Mukhammad David
- Najafi Farid
- Nangia Vinay
- Nasab Mostafa Dianati
- Nascimento Bruno Ramos
- Naserbakht Morteza
- Nayak Vinod
- Nazari Javad
- Ndwandwe Duduzile Edith
- Negoi Ionut
- Ngunjiri Josephine W
- Nguyen Cuong Tat
- Nguyen Diep Ngoc
- Nguyen Trang Huyen
- Nikbakhsh Rajan
- Nnaji Chukwudi A
- Ofori-Asenso Richard
- Ogbo Felix Akpojene
- Oghenetega Onome Bright
- Oh In-Hwan
- Olagunju Andrew T
- Olagunju Tinuke O
- Onwujekwe Obinna E
- Orpana Heather M
- Ota Erika
- Otstavnov Nikita
- Otstavnov Stanislav S
- P A Mahesh
- Padubidri Jagadish Rao
- Pakhale Smita
- Pakshir Keyvan
- Panda-Jonas Songhomitra
- Park Eun-Kee
- Patel Sangram Kishor
- Pathak Ashish
- Pati Sanghamitra
- Paulos Kebreab
- Peden Amy E
- Pereira Jeevan
- Phillips Michael R
- Pigott David M
- Polibin Roman V
- Polinder Suzanne
- Pourmalek Farshad
- Pourshams Akram
- Poustchi Hossein
- Prakash Swayam
- Puri Parul
- Rabiee Mohammad
- Rabiee Navid
- Radfar Amir
- Rafay Anwar
- Rafiee Ata
- Rafiei Alireza
- Rahim Fakher
- Rahimi Siavash
- Rahman Muhammad Aziz
- Rajabpour-Sanati Ali
- Rajati Fatemeh
- Rakovac Ivo
- Rao Sowmya J
- Rashad Salem Marwa R
- Rashedi Vahid
- Rastogi Prateek
- Rathi Priya
- Rawaf Salman
- Rawal Lal
- Rawassizadeh Reza
- Reiner Robert C
- Renjith Vishnu
- Resnikoff Serge
- Rezapour Aziz
- Ribeiro Ana Isabel
- Rickard Jennifer
- Riera Lidia Sanchez
- Rios González Carlos Miguel
- Roberts Nicholas L S
- Roberts Nicholas L.S.
- Roever Leonardo
- Ronfani Luca
- Roshandel Gholamreza
- Saddik Basema
- Safarpour Hamid
- Safdarian Mahdi
- Salamati Payman
- Salem Hosni
- Salz Inbal
- Samy Abdallah M
- Sanabria Juan
- Santric Milicevic Milena M
- Sarker Abdur Razzaque
- Sarveazad Arash
- Sathian Brijesh
- Sawhney Monika
- Sayyah Mehdi
- Schwebel David C
- Seedat Soraya
- Senthilkumaran Subramanian
- Seyedmousavi Seyedmojtaba
- Sha Feng
- Shaahmadi Faramarz
- Shahabi Saeed
- Shaikh Masood Ali
- Shams-Beyranvand Mehran
- Shariful Islam Sheikh Mohammed
- Sheikh Aziz
- Shigematsu Mika
- Shin Jae Il
- Shiri Rahman
- Siabani Soraya
- Sigfusdottir Inga Dora
- Silva Diana Dias da
- Singh Jasvinder A
- Singh Pankaj Kumar
- Sinha Dhirendra Narain
- Soheili Amin
- Soriano Joan B
- Sorrie Muluken Bekele
- Soyiri Ireneous N
- Stokes Mark A
- Sufiyan Mu'awiyyah Babale
- Syed Zahiruddin Quazi
- Sykes Bryan L
- Sylte Dillon O
- Sylte Dillon O.
- T Antonio Carl Abelardo
- Tabarés-Seisdedos Rafael
- Tabb Karen M
- Taddele Biruk Wogayehu
- Tefera Yonatal Mesfin
- Tehrani-Banihashemi Arash
- Tekulu Gebretsadkan Hintsa
- Tesema Tesema Ayenew Kassie
- Tesfay Berhe Etsay
- Thapar Rekha
- Thi Nguyen Huong Lan
- Titova Mariya Vladimirovna
- Tlaye Kenean Getaneh
- Tohidinik Hamid Reza
- Topor-Madry Roman
- Tran Bach Xuan
- Tran Khanh Bao
- Tripathy Jaya Prasad
- Tsai Alexander C
- Tsatsakis Aristidis
- Ullah Irfan
- Ullah Saif
- Unnikrishnan Bhaskaran
- Upadhyay Era
- Uthman Olalekan A
- Valdez Pascual R
- Vasankari Tommi Juhani
- Vecchia Carlo La
- Veisani Yousef
- Velásquez Ilais Moreno
- Venketasubramanian Narayanaswamy
- Violante Francesco S
- Vlassov Vasily
- Vos Theo
- Waheed Yasir
- Wang Yuan-Pang
- Wiangkham Taweewat
- Wolde Haileab Fekadu
- Woldeyes Dawit Habte
- Wondmeneh Temesgen Gebeyehu
- Wondmieneh Adam Belay
- Wu Ai-Min
- Wyper Grant M A
- Yadav Rajaram
- Yadollahpour Ali
- Yano Yuichiro
- Yaw Appiah Seth Christopher
- Yaya Sanni
- Yazdi-Feyzabadi Vahid
- Ye Pengpeng
- Yip Paul
- Yisma Engida
- Yonemoto Naohiro
- Yoon Seok-Jun
- Youm Yoosik
- Younis Mustafa Z
- Yousefi Zabihollah
- Yu Chuanhua
- Yu Yong
- Zaidi Zoubida
- Zaki Maysaa El Sayed
- Zaman Sojib Bin
- Zamani Mohammad
- Zandian Hamed
- Zarei Fatemeh
- Zhang Yunquan
- Zhang Zhi-Jiang
- Ziapour Arash
- Zodpey Sanjay
- Publication venue
- Publication date
- 06/12/2019
- Field of study
Background While there is a long history of measuring death and disability from injuries, modern research methods must account for the wide spectrum of disability that can occur in an injury, and must provide estimates with sufficient demographic, geographical and temporal detail to be useful for policy makers. The Global Burden of Disease (GBD) 2017 study used methods to provide highly detailed estimates of global injury burden that meet these criteria. Methods In this study, we report and discuss the methods used in GBD 2017 for injury morbidity and mortality burden estimation. In summary, these methods included estimating cause-specific mortality for every cause of injury, and then estimating incidence for every cause of injury. Non-fatal disability for each cause is then calculated based on the probabilities of suffering from different types of bodily injury experienced. Results GBD 2017 produced morbidity and mortality estimates for 38 causes of injury. Estimates were produced in terms of incidence, prevalence, years lived with disability, cause-specific mortality, years of life lost and disability-adjusted life-years for a 28-year period for 22 age groups, 195 countries and both sexes. Conclusions GBD 2017 demonstrated a complex and sophisticated series of analytical steps using the largest known database of morbidity and mortality data on injuries. GBD 2017 results should be used to help inform injury prevention policy making and resource allocation. We also identify important avenues for improving injury burden estimation in the future.Peer reviewe
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