London School of Hygiene & Tropical Medicine

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    3379 research outputs found

    Search strategies for "Scoping study of Economic and Data System Considerations for Climate Change and Pandemic Preparedness in Africa"

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    The search strategies looked for information on four concepts: climate change; communicable diseases with pandemic potential; data systems for pandemic preparedness; Africa. The search strategy was compiled in the OvidSP Medline ALL database and refined until the results retrieved reflected the scope of the project. 6 databases were searched on 27 November 2023. They were: OvidSP Medline ALL, OvidSP Embase Classic+Embase, OvidSP Global Health, OvidSP Econlit, EBSCOhost Africa-Wide Information, Web of Science Core Collection (containing Science Citation Index Expanded, Social Sciences Citation Index, Arts & Humanities Citation Index, Conference Proceedings Citation Index Science, Conference Proceedings Citation Index Social Science & Humanities, Emerging Sources Citation Index). All searches were limited by date to items published 2010-present

    The Learning Together intervention: study data from three surveys in the INCLUSIVE cluster randomised controlled trial

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    Survey data from the INCLUSIVE study, a cluster-randomised controlled trial to test the Learning Together intervention to reduce bullying and aggression in English secondary schools. Components of the Learning Together intervention included staff training in restorative practice, facilitated school action groups, and a student social and emotional skills curriculum. Primary outcomes, measured at 36 months, were: self-reported experience of bullying victimisation measured using the Gatehouse Bullying Scale (GBS) and perpetration of aggression measured using the Edinburgh Study of Youth Transitions and Crime (ESYTC) school misbehaviour subscale. Secondary outcomes were: GBS and ESYTC scores at 24 months; quality of life measured with the Paediatric Quality of Life Inventory, wellbeing measured with the validated Short Warwick-Edinburgh Mental Well-Being Scale, psychological problems measured with the Strengths and Difficulties Questionnaire, bullying perpetration measured with the Modified Aggression Scale bullying subscale, substance use assessed using validated age-appropriate questions about cigarette smoking, alcohol use, and illicit drug use taken from national surveys, sexual risk behaviour (age of sexual debut and use of contraception at first sex), use of NHS health services (self-reported use of primary care, accident and emergency, or other service in the past 12 months), and contact with police (self-report of being stopped, reprimanded, or picked up by the police in the past 12 months), all measured at 36 months. The trial is registered with ISRCTN (ISRCTN10751359)

    PRIME -- Papillomavirus Rapid Interface for Modelling and Economics

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    PRIME is a static model of HPV vaccination that uses proportional impact to estimate the health impact and cost-effectiveness of HPV vaccination in low- and middle income countries

    Data collection tools for: "Changing rainfall patterns, household water use and health: risks and household responses in rural Gambia"

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    The overall aim of the study was to identify the household behavioural responses to changes in rainfall patterns by rural communities in The Gambia, and the risks or benefits to health these responses may pose. This collection contains topic guides used for semi-structured interviews performed with men and women (first-round and follow-up), topic guides for follow-up interviews with village elders/chiefs, picture cards used in ranking exercises during follow -up interview with women and men, and coding used for analysis of qualitative interviews


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    Code to produce the figures in "Protecting infants against RSV disease: an impact and cost-effectiveness comparison of long-acting monoclonal antibodies and maternal vaccination". The code heavily depends on a package which runs the simulations and cost-effectiveness for user-defined parameters, rsvie. The information in data/, data-raw/, and datasource/ relate to the England and Wales-specific information parameterising the burden, risk of outcomes, costs and QALY loss. For more details on how this works, please see the rsvie package. The figs/ folder contains all the figures in the manuscript and supplementary. The outputs/ folder contains large RDS files that contain all the information about the impact and cost-effectiveness of each model after running the simulations via the 'rsvie`; package. The R/ folder contains all the code used to run the models, process the outputs and plot the figures

    Promoting inclusion in decent work for Ugandan young people: will reducing violence help? Qualitative interview and focus group data

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    Qualitative data collected for the project "Promoting inclusion in decent work for Ugandan young people: will reducing violence help?". It is comprised of transcripts for 4 focus group discussions (FGDs), 24 in-depth interviews (IDIs) and 18 key informant interviews (KIIs)

    Promoting Inclusion in Decent Work for Ugandan Young People, 2020

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    There is little empirical evidence either globally or in Uganda on how experiences of violence in childhood and adolescence affect a) participation in skills programmes, entry into work, and decent employment; and b) about the extent and nature of physical, sexual and emotional violence experienced by young people in their workplaces. The qualitative component of this study examines people's experiences of being recruited into skills and employment programmes in Uganda, how programme recruitment mechanisms might in the exclusion of vulnerable young people, particularly those experiencing violence and/or child labour, and young people's views on the provision of violence prevention strategies within skills training programmes. The qualitative data collected as part of this study comprises of transcripts from four focus group discussions (FGDs) and 24 in-depth interviews (IDIs) with adolescents who either have or have not participated in skills training, and 18 key informant interviews (KIIs)

    SARS-CoV-2 Seroprevalence in The Gambia dataset

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    A quantitative dataset containing information on COVID seroprevalence in pregnant women, based upon an analysis of samples collected from 803 women between October 2019 – March 2022 in Farafenni, North Bank Region of The Gambia. This is a sub-set of women in the PRECISE Study where pregnant women were recruited to the cohort and followed up during their pregnancy

    Data from: Quantification of sporozoite expelling by Anopheles mosquitoes infected with laboratory and naturally circulating P. falciparum gametocytes

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    It is currently unknown whether all Plasmodium falciparum infected mosquitoes are equally infectious. We assessed sporogonic development using cultured gametocytes in the Netherlands and naturally circulating strains in Burkina Faso. We quantified the number of sporozoites expelled into artificial skin in relation to intact oocysts, ruptured oocysts, and residual salivary gland sporozoites. Sporozoites were quantified by highly sensitive qPCR; intact and ruptured oocysts by fluorescence microscopy following antibody staining of circumsporozoite protein. In laboratory conditions, higher total sporozoite burden in mosquitoes was associated with a shorter duration of sporogony (p<0.001). Overall, 53% (116/216) of P. falciparum infected An. stephensi mosquitoes expelled sporozoites into artificial skin. The medians of expelled and residual salivary gland sporozoites were 136 (IQR: 34-501) and 23,947 (IQR: 9127-78,380), respectively. There was a strong positive correlation between ruptured oocyst number and salivary gland sporozoite load (ρ=0.8; p<0.0001) and a weaker positive correlation between salivary gland sporozoite load and the number of sporozoites expelled (ρ=0.35; p=0.0002). In Burkina Faso, An. coluzzii mosquitoes were infected by natural gametocyte carriers. Among mosquitoes that were salivary gland sporozoite positive, 89% (33/37) expelled sporozoites with a median of 1035 expelled sporozoites (IQR: 171-2969) and harbored a median of 45,100 residual salivary gland sporozoites (IQR: 20,310-164,900). Again, we observed a strong correlation between ruptured oocyst number and salivary gland sporozoite load (ρ=0.9; p<0.0001) and a positive correlation between salivary gland sporozoite load and the number of sporozoites expelled (ρ=0.7; p<0.0001). Mosquito salivary glands in Burkina Faso harbored 1-3 distinct parasite clones; several mosquitoes expelled multiple parasite clones during probing.Whilst sporozoite expelling was regularly observed from mosquitoes with low infection burdens, our findings indicate that mosquito infection burden is associated with the number of expelled sporozoites. Future work is required to determine the direct implications of these findings for transmission potential

    Data for: "Evaluation of a district-wide sanitation programme in rural Malawi: does it include people living with disabilities?"

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    This study aimed to explore the extent to which people living with disabilities participated in a Community-Led Total Sanitation (CLTS) intervention delivered in rural Malawi. Specifically, the study aimed to compare CLTS participation between households with and without a member with a disability, and between household members with and without a disability. Data was collected in the Chiradzulu district of Malawi. A household questionnaire was administered to collect information about CLTS participation and disability. Household-level and individual-level data are presented on separate tabs. Each row represents an individual or household interviewed, and indicates demographic information, household and individual disability status and participation in key CLTS activities


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