1,889 research outputs found
One-Bone Forearm Procedure for Acquired Pseudoarthrosis of the Ulna Combined with Radial Head Dislocation in a Child: A Case with 20 Years Follow-Up
This report describes a 6 year-old boy who was treated with one-bone forearm procedure for acquired pseudoarthrosis of the ulna combined with radial head dislocation after radical ulna debridement for osteomyelitis. At more than 20 years of follow-up, the patient had a nearly full range of elbow movements with a few additional surgical procedures. Pronation and supination was restricted by 45°, but the patient had near-normal elbow and hand functions without the restriction of any daily living activity. This case shows that one-bone forearm formation is a reasonable option for forearm stability in longstanding pseudoarthrosis of the ulna with radial head dislocation in a child
DataSHIELD – new directions and dimensions
In disciplines such as biomedicine and social sciences, sharing and combining sensitive individual-level data is often prohibited by ethical-legal or governance constraints and other barriers such as the control of intellectual property or the huge sample sizes. DataSHIELD (Data Aggregation Through Anonymous Summary-statistics from Harmonised Individual-levEL Databases) is a distributed approach that allows the analysis of sensitive individual-level data from one study, and the co-analysis of such data from several studies simultaneously without physically pooling them or disclosing any data.
Following initial proof of principle, a stable DataSHIELD platform has now been implemented in a number of epidemiological consortia. This paper reports three new applications of DataSHIELD including application to post-publication sensitive data analysis, text data analysis and privacy protected data visualisation. Expansion of DataSHIELD analytic functionality and application to additional data types demonstrate the broad applications of the software beyond biomedical sciences
Glucocorticoids—All-Rounders Tackling the Versatile Players of the Immune System
Glucocorticoids regulate fundamental processes of the human body and control cellular functions such as cell metabolism, growth, differentiation, and apoptosis. Moreover, endogenous glucocorticoids link the endocrine and immune system and ensure the correct function of inflammatory events during tissue repair, regeneration, and pathogen elimination via genomic and rapid non-genomic pathways. Due to their strong immunosuppressive, anti-inflammatory and anti-allergic effects on immune cells, tissues and organs, glucocorticoids significantly improve the quality of life of many patients suffering from diseases caused by a dysregulated immune system. Despite the multitude and seriousness of glucocorticoid-related adverse events including diabetes mellitus, osteoporosis and infections, these agents remain indispensable, representing the most powerful, and cost-effective drugs in the treatment of a wide range of rheumatic diseases. These include rheumatoid arthritis, vasculitis, and connective tissue diseases, as well as many other pathological conditions of the immune system. Depending on the therapeutically affected cell type, glucocorticoid actions strongly vary among different diseases. While immune responses always represent complex reactions involving different cells and cellular processes, specific immune cell populations with key responsibilities driving the pathological mechanisms can be identified for certain autoimmune diseases. In this review, we will focus on the mechanisms of action of glucocorticoids on various leukocyte populations, exemplarily portraying different autoimmune diseases as heterogeneous targets of glucocorticoid actions: (i) Abnormalities in the innate immune response play a crucial role in the initiation and perpetuation of giant cell arteritis (GCA). (ii) Specific types of CD4+ T helper (Th) lymphocytes, namely Th1 and Th17 cells, represent important players in the establishment and course of rheumatoid arthritis (RA), whereas (iii) B cells have emerged as central players in systemic lupus erythematosus (SLE). (iv) Allergic reactions are mainly triggered by several different cytokines released by activated Th2 lymphocytes. Using these examples, we aim to illustrate the versatile modulating effects of glucocorticoids on the immune system. In contrast, in the treatment of lymphoproliferative disorders the pro-apoptotic action of glucocorticoids prevails, but their mechanisms differ depending on the type of cancer. Therefore, we will also give a brief insight into the current knowledge of the mode of glucocorticoid action in oncological treatment focusing on leukemia
The endogenous anti-angiogenic VEGF isoform, VEGF165b inhibits human tumour growth in mice
Vascular endothelial growth factor-A is widely regarded as the principal stimulator of angiogenesis required for tumour growth. VEGF is generated as multiple isoforms of two families, the pro-angiogenic family generated by proximal splice site selection in the terminal exon, termed VEGFxxx, and the anti-angiogenic family formed by distal splice site selection in the terminal exon, termed VEGFxxxb, where xxx is the amino acid number. The most studied isoforms, VEGF165 and VEGF165b have been shown to be present in tumour and normal tissues respectively. VEGF165b has been shown to inhibit VEGF- and hypoxia-induced angiogenesis, and VEGF-induced cell migration and proliferation in vitro. Here we show that overexpression of VEGF165b by tumour cells inhibits the growth of prostate carcinoma, Ewing's sarcoma and renal cell carcinoma in xenografted mouse tumour models. Moreover, VEGF165b overexpression inhibited tumour cell-mediated migration and proliferation of endothelial cells. These data show that overexpression of VEGF165b can inhibit growth of multiple tumour types in vivo indicating that VEGF165b has potential as an anti-angiogenic, anti-tumour strategy in a number of different tumour types, either by control of VEGF165b expression by regulation of splicing, overexpression of VEGF165b, or therapeutic delivery of VEGF165b to tumours
Quadrupole Anisotropy in Dihadron Azimuthal Correlations in Central Au Collisions at =200 GeV
The PHENIX collaboration at the Relativistic Heavy Ion Collider (RHIC)
reports measurements of azimuthal dihadron correlations near midrapidity in
Au collisions at =200 GeV. These measurements
complement recent analyses by experiments at the Large Hadron Collider (LHC)
involving central Pb collisions at =5.02 TeV, which
have indicated strong anisotropic long-range correlations in angular
distributions of hadron pairs. The origin of these anisotropies is currently
unknown. Various competing explanations include parton saturation and
hydrodynamic flow. We observe qualitatively similar, but larger, anisotropies
in Au collisions compared to those seen in Pb collisions at the
LHC. The larger extracted values in Au collisions at RHIC are
consistent with expectations from hydrodynamic calculations owing to the larger
expected initial-state eccentricity compared with that from Pb
collisions. When both are divided by an estimate of the initial-state
eccentricity the scaled anisotropies follow a common trend with multiplicity
that may extend to heavy ion data at RHIC and the LHC, where the anisotropies
are widely thought to arise from hydrodynamic flow.Comment: 375 authors, 7 pages, 5 figures. Published in Phys. Rev. Lett. v2 has
minor changes to text and figures in response to PRL referee suggestions.
Plain text data tables for the points plotted in figures for this and
previous PHENIX publications are (or will be) publicly available at
http://www.phenix.bnl.gov/papers.htm
Double Spin Asymmetry of Electrons from Heavy Flavor Decays in p+p Collisions at sqrt(s)=200 GeV
We report on the first measurement of double-spin asymmetry, A_LL, of
electrons from the decays of hadrons containing heavy flavor in longitudinally
polarized p+p collisions at sqrt(s)=200 GeV for p_T= 0.5 to 3.0 GeV/c. The
asymmetry was measured at mid-rapidity (|eta|<0.35) with the PHENIX detector at
the Relativistic Heavy Ion Collider. The measured asymmetries are consistent
with zero within the statistical errors. We obtained a constraint for the
polarized gluon distribution in the proton of |Delta g/g(log{_10}x=
-1.6^+0.5_-0.4, {mu}=m_T^c)|^2 < 0.033 (1 sigma), based on a leading-order
perturbative-quantum-chromodynamics model, using the measured asymmetry.Comment: 385 authors, 17 pages, 15 figures, 5 tables. Submitted to Phys. Rev.
D. Plain text data tables for the points plotted in figures for this and
previous PHENIX publications are (or will be) publicly available at
http://www.phenix.bnl.gov/papers.htm
Centrality categorization for R_{p(d)+A} in high-energy collisions
High-energy proton- and deuteron-nucleus collisions provide an excellent tool
for studying a wide array of physics effects, including modifications of parton
distribution functions in nuclei, gluon saturation, and color neutralization
and hadronization in a nuclear environment, among others. All of these effects
are expected to have a significant dependence on the size of the nuclear target
and the impact parameter of the collision, also known as the collision
centrality. In this article, we detail a method for determining centrality
classes in p(d)+A collisions via cuts on the multiplicity at backward rapidity
(i.e., the nucleus-going direction) and for determining systematic
uncertainties in this procedure. For d+Au collisions at sqrt(s_NN) = 200 GeV we
find that the connection to geometry is confirmed by measuring the fraction of
events in which a neutron from the deuteron does not interact with the nucleus.
As an application, we consider the nuclear modification factors R_{p(d)+A}, for
which there is a potential bias in the measured centrality dependent yields due
to auto-correlations between the process of interest and the backward rapidity
multiplicity. We determine the bias correction factor within this framework.
This method is further tested using the HIJING Monte Carlo generator. We find
that for d+Au collisions at sqrt(s_NN)=200 GeV, these bias corrections are
small and vary by less than 5% (10%) up to p_T = 10 (20) GeV. In contrast, for
p+Pb collisions at sqrt(s_NN) = 5.02 TeV we find these bias factors are an
order of magnitude larger and strongly p_T dependent, likely due to the larger
effect of multi-parton interactions.Comment: 375 authors, 18 pages, 16 figures, 4 tables. Submitted to Phys. Rev.
C. Plain text data tables for the points plotted in figures for this and
previous PHENIX publications are (or will be) publicly available at
http://www.phenix.bnl.gov/papers.htm
Transverse-Momentum Dependence of the J/psi Nuclear Modification in d+Au Collisions at sqrt(s_NN)=200 GeV
We present measured J/psi production rates in d+Au collisions at sqrt(s_NN) =
200 GeV over a broad range of transverse momentum (p_T=0-14 GeV/c) and rapidity
(-2.2<y<2.2). We construct the nuclear-modification factor R_dAu for these
kinematics and as a function of collision centrality (related to impact
parameter for the R_dAu collision). We find that the modification is largest
for collisions with small impact parameters, and observe a suppression
(R_dAu<1) for p_T<4 GeV/c at positive rapidities. At negative rapidity we
observe a suppression for p_T1) for p_T>2
GeV/c. The observed enhancement at negative rapidity has implications for the
observed modification in heavy-ion collisions at high p_T.Comment: 384 authors, 24 pages, 19 figures, 13 tables. Submitted to Phys. Rev.
C. Plain text data tables for the points plotted in figures for this and
previous PHENIX publications are publicly available at
http://www.phenix.bnl.gov/phenix/WWW/info/data/ppg123_data.htm
Suppression of back-to-back hadron pairs at forward rapidity in d+Au Collisions at sqrt(s_NN)=200 GeV
Back-to-back hadron pair yields in d+Au and p+p collisions at sqrt(s_NN)=200
GeV were measured with the PHENIX detector at the Relativistic Heavy Ion
Collider. Rapidity separated hadron pairs were detected with the trigger hadron
at pseudorapidity |eta|<0.35 and the associated hadron at forward rapidity
(deuteron direction, 3.0<eta<3.8). Pairs were also detected with both hadrons
measured at forward rapidity; in this case the yield of back-to-back hadron
pairs in d+Au collisions with small impact parameters is observed to be
suppressed by a factor of 10 relative to p+p collisions. The kinematics of
these pairs is expected to probe partons in the Au nucleus with low fraction x
of the nucleon momenta, where the gluon densities rise sharply. The observed
suppression as a function of nuclear thickness, p_T, and eta points to cold
nuclear matter effects arising at high parton densities.Comment: 381 authors, 6 pages, 4 figures. Published in Phys. Rev. Lett.
(http://link.aps.org/doi/10.1103/PhysRevLett.107.172301). v3 has minor
changes to match published version
(http://www.phenix.bnl.gov/phenix/WWW/info/pp1/128/PhysRevLett.107.172301)
Plain text data tables for points plotted in figures are publicly available
at http://www.phenix.bnl.gov/phenix/WWW/info/data/ppg128_data.htm
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