908 research outputs found
Anxiolysis and recognition memory enhancement with long-term supplemental ascorbic acid (vitamin C) in normal rats: possible dose dependency and sex differences
To investigate a possible dose-response relationship and sex differences for anxiolytic
and memory-enhancing effects of ascorbic acid (vitamin C), an adult PVG /c hooded
rats were individually treated for 8 weeks with approximately 61, 114 or 160 mg/kg/
day of ascorbic acid in their drinking water. After their treatment, over 3 consecutive
days they experienced a 5-min trial in an open field (OF) followed by a 5-min trial
in an elevated plus maze (EPM), and then finally a 5-min novel object recognition
(NOR) test in the OF. Dose-related anxiolytic effects were observed that to some
extent depended on the measure of anxiety. In other words, anxiolytic effects were
evident in higher frequencies of walking with 114 mg/kg and 61 mg/kg, higher
frequencies of rearing and lower frequencies of grooming in the OF as well as more
frequent occupation of the EPM open arms. Rats treated with 160 mg/kg explored
a novel versus familiar object in the NOR test to a significantly greater extent than
control rats thereby suggesting enhancement of their recognition memory. Overall,
it appeared that the anxiolytic effects of ascorbic acid were more typical of the lowest
dose, whereas memory enhancement appeared to be confined to the highest dose.
While there were a number of significant sex differences, there was no evidence of
differences between females and males in the effects of ascorbic acid
The morphogenesis of fast growth in plants
- Growth rate represents a fundamental axis of life history variation. Faster growth associated with C4 photosynthesis and annual life history has evolved multiple times, and the resulting diversity in growth is typically explained via resource acquisition and allocation. However, the underlying changes in morphogenesis remain unknown.
- We conducted a phylogenetic comparative experiment with 74 grass species, conceptualising morphogenesis as the branching and growth of repeating modules. We aimed to establish whether faster growth in C4 and annual grasses, compared with C3 and perennial grasses, came from the faster growth of individual modules or higher rates of module initiation.
- Morphogenesis produces fast growth in different ways in grasses using C4 and C3 photosynthesis, and in annual compared with perennial species. C4 grasses grow faster than C3 species through a greater enlargement of shoot modules and quicker secondary branching of roots. However, leaf initiation is slower and there is no change in shoot branching. Conversely, faster growth in annuals than perennials is achieved through greater branching and enlargement of shoots, and possibly faster root branching.
- The morphogenesis of fast growth depends on ecological context, with C4 grasses tending to promote resource capture under competition, and annuals enhancing branching to increase reproductive potential
TeV-scale bileptons, see-saw type II and lepton flavor violation in core-collapse supernova
Electrons and electron neutrinos in the inner core of the core-collapse
supernova are highly degenerate and therefore numerous during a few seconds of
explosion. In contrast, leptons of other flavors are non-degenerate and
therefore relatively scarce. This is due to lepton flavor conservation. If this
conservation law is broken by some non-standard interactions, electron
neutrinos are converted to muon and tau-neutrinos, and electrons - to muons.
This affects the supernova dynamics and the supernova neutrino signal. We
consider lepton flavor violating interactions mediated by scalar bileptons,
i.e. heavy scalars with lepton number 2. It is shown that in case of TeV-mass
bileptons the electron fermi gas is equilibrated with non-electron species
inside the inner supernova core at a time-scale of order of (1-100) ms. In
particular, a scalar triplet which generates neutrino masses through the
see-saw type II mechanism is considered. It is found that supernova core is
sensitive to yet unprobed values of masses and couplings of the triplet.Comment: accepted to Eur.Phys.J.
Large Extra Dimensions and Decaying KK Recurrences
We suggest the possibility that in ADD type brane-world scenarios, the higher
KK excitations of the graviton may decay to lower ones owing to a breakdown of
the conservation of extra dimensional ``momenta'' and study its implications
for astrophysics and cosmology. We give an explicit realization of this idea
with a bulk scalar field , whose nonzero KK modes acquire vacuum
expectation values. This scenario helps to avoid constraints on large extra
dimensions that come from gamma ray flux bounds in the direction of nearby
supernovae as well as those coming from diffuse cosmological gamma ray
background. It also relaxes the very stringent limits on reheat temperature of
the universe in ADD models.Comment: 16 pages, late
Pulsar-wind nebulae and magnetar outflows: observations at radio, X-ray, and gamma-ray wavelengths
We review observations of several classes of neutron-star-powered outflows:
pulsar-wind nebulae (PWNe) inside shell supernova remnants (SNRs), PWNe
interacting directly with interstellar medium (ISM), and magnetar-powered
outflows. We describe radio, X-ray, and gamma-ray observations of PWNe,
focusing first on integrated spectral-energy distributions (SEDs) and global
spectral properties. High-resolution X-ray imaging of PWNe shows a bewildering
array of morphologies, with jets, trails, and other structures. Several of the
23 so far identified magnetars show evidence for continuous or sporadic
emission of material, sometimes associated with giant flares, and a few
possible "magnetar-wind nebulae" have been recently identified.Comment: 61 pages, 44 figures (reduced in quality for size reasons). Published
in Space Science Reviews, "Jets and Winds in Pulsar Wind Nebulae, Gamma-ray
Bursts and Blazars: Physics of Extreme Energy Release
Search for Doubly-Charged Higgs Boson Production at HERA
A search for the single production of doubly-charged Higgs bosons H^{\pm \pm}
in ep collisions is presented. The signal is searched for via the Higgs decays
into a high mass pair of same charge leptons, one of them being an electron.
The analysis uses up to 118 pb^{-1} of ep data collected by the H1 experiment
at HERA. No evidence for doubly-charged Higgs production is observed and mass
dependent upper limits are derived on the Yukawa couplings h_{el} of the Higgs
boson to an electron-lepton pair. Assuming that the doubly-charged Higgs only
decays into an electron and a muon via a coupling of electromagnetic strength
h_{e \mu} = \sqrt{4 \pi \alpha_{em}} = 0.3, a lower limit of 141 GeV on the
H^{\pm\pm} mass is obtained at the 95% confidence level. For a doubly-charged
Higgs decaying only into an electron and a tau and a coupling h_{e\tau} = 0.3,
masses below 112 GeV are ruled out.Comment: 15 pages, 3 figures, 1 tabl
Magnetic Field Generation in Stars
Enormous progress has been made on observing stellar magnetism in stars from
the main sequence through to compact objects. Recent data have thrown into
sharper relief the vexed question of the origin of stellar magnetic fields,
which remains one of the main unanswered questions in astrophysics. In this
chapter we review recent work in this area of research. In particular, we look
at the fossil field hypothesis which links magnetism in compact stars to
magnetism in main sequence and pre-main sequence stars and we consider why its
feasibility has now been questioned particularly in the context of highly
magnetic white dwarfs. We also review the fossil versus dynamo debate in the
context of neutron stars and the roles played by key physical processes such as
buoyancy, helicity, and superfluid turbulence,in the generation and stability
of neutron star fields.
Independent information on the internal magnetic field of neutron stars will
come from future gravitational wave detections. Thus we maybe at the dawn of a
new era of exciting discoveries in compact star magnetism driven by the opening
of a new, non-electromagnetic observational window.
We also review recent advances in the theory and computation of
magnetohydrodynamic turbulence as it applies to stellar magnetism and dynamo
theory. These advances offer insight into the action of stellar dynamos as well
as processes whichcontrol the diffusive magnetic flux transport in stars.Comment: 41 pages, 7 figures. Invited review chapter on on magnetic field
generation in stars to appear in Space Science Reviews, Springe
Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector
A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results
T-cell regulation in Erythema Nodosum Leprosum.
Leprosy is a disease caused by Mycobacterium leprae where the clinical spectrum correlates with the patient immune response. Erythema Nodosum Leprosum (ENL) is an immune-mediated inflammatory complication, which causes significant morbidity in affected leprosy patients. The underlying cause of ENL is not conclusively known. However, immune-complexes and cell-mediated immunity have been suggested in the pathogenesis of ENL. The aim of this study was to investigate the regulatory T-cells in patients with ENL. Forty-six untreated patients with ENL and 31 non-reactional lepromatous leprosy (LL) patient controls visiting ALERT Hospital, Ethiopia were enrolled to the study. Blood samples were obtained before, during and after prednisolone treatment of ENL cases. Peripheral blood mononuclear cells (PBMCs) were isolated and used for immunophenotyping of regulatory T-cells by flow cytometry. Five markers: CD3, CD4 or CD8, CD25, CD27 and FoxP3 were used to define CD4+ and CD8+ regulatory T-cells. Clinical and histopathological data were obtained as supplementary information. All patients had been followed for 28 weeks. Patients with ENL reactions had a lower percentage of CD4+ regulatory T-cells (1.7%) than LL patient controls (3.8%) at diagnosis of ENL before treatment. After treatment, the percentage of CD4+regulatory T-cells was not significantly different between the two groups. The percentage of CD8+ regulatory T-cells was not significantly different in ENL and LL controls before and after treatment. Furthermore, patients with ENL had higher percentage of CD4+ T-ells and CD4+/CD8+ T-cells ratio than LL patient controls before treatment. The expression of CD25 on CD4+ and CD8+ T-cells was not significantly different in ENL and LL controls suggesting that CD25 expression is not associated with ENL reactions while FoxP3 expression on CD4+ T-cells was significantly lower in patients with ENL than in LL controls. We also found that prednisolone treatment of patients with ENL reactions suppresses CD4+ T-cell but not CD8+ T-cell frequencies. Hence, ENL is associated with lower levels of T regulatory cells and higher CD4+/CD8+ T-cell ratio. We suggest that this loss of regulation is one of the causes of ENL
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