Real-time monitoring and control for efficient management of drinking water networks: Barcelona case study

Drinking water utilities in urban areas are facing new challenges in their real-time operation: limited water resources, intensive energy requirements, a growing population, a costly and ageing infrastructure, increasingly stringent regulations, and increased attention towards the environmental impact of water use. The efficient use of resources is becoming a priority for water managers and the recent advances in ICT technologies can provide solutions to this end. Real-time management in water networks may be considered as a process comprising two different levels: (i) Monitoring, which is concerned with the observation and estimation of the current state of a system and the detection/diagnosis of abnormal situations. It is achieved through sensors and communications technology, together with mathematical models; and (ii) Control, related to computing and applying the best admissible control strategies for network actuators. Optimal control seeks to optimize a given set of operational goals related to the network performance, such as efficiency in resource use, environmental impact, etc. Real-time monitoring and control techniques can significantly improve the use of water and energy resources in water networks. This paper addresses the developments of the European project EFFINET, which proposes a novel integrated water resource management system based on advanced ICT technologies of automation and telecommunications for improving the efficiency of drinking water networks in terms of water use, energy consumption, water loss minimization, and water quality guarantees by addressing the real-time monitoring and control levels.Peer ReviewedPostprint (author’s final draft

Leakage detection and localization method based on a hybrid inverse/direct modelling approach suitable for handling multiple-leak scenarios

When an accurate hydraulic network model is available, direct modeling techniques are very straightforward and reliable for on-line leakage detection and localization applied to large class of water distribution networks. Nonetheless, the assumption of single-leak scenarios is usually considered and may not hold in real applications. This paper presents a leakage detection and localization method suitable for multiple-leak scenarios in a large class of water distribution networks. This method can be seen as an upgrade of a direct-modeling approach in which a global search method based on Genetic Algorithms (GAs) has been integrated in order to estimate the water loss hotspots and their size. This is an inverse / direct modelling method which seeks to take benefit from both approaches: the exploration capability of GAs and the straightforwardness and reliability offered by the availability of an accurate hydraulic model. The application of the resulting method in a district metered area of the Barcelona water distribution network is provided and discussed.Peer ReviewedPostprint (author's final draft

Life cycle assessment of olive pomace valorisation through pyrolysis

A life cycle assessment (LCA) of the olive pomace valorisation by means of a pyrolysis system has been performed. The environmental impacts associated with three different stages were evaluated. The first stage is the olive production, the second stage is the olive oil extraction, where the by-product olive pomace is used as a raw material for the pyrolysis system. An LCA screening of the ecological versus the conventional route has been complementary evaluated. The pyrolysis system yields char, gases and tar, involving the following stages: biomass drying and grinding, pyrolysis, separation of gases and char, gas cooling by consecutively using an air heat exchanger followed of a water one, and the separation of gases and tar. For this study, 14 mid-point and 3 end-point impact categories were selected. The functional unit (FU) of 100 kg olive pomace was considered as an overall bench-mark approach. The obtained results reveal that the most environmental-friendly option was the ecological scenario. Therefore, only the biomass produced by this scenario was considered for a further pyrolysis system. The results showed the pyrolysis system can be considered an ecological tool for the valorisation of olive pomace, using energy-efficient equipment together with the water and airSe ha realizado un análisis del ciclo de vida (ACV) de la valorización del orujo de aceituna mediante un sistema de pirólisis . Se evaluaron los impactos ambientales asociados a tres etapas diferentes. La primera etapa es la producción de aceitunas, la segunda etapa es la extracción de aceite de oliva, donde el orujo de oliva subproducto se utiliza como materia prima para el sistema de pirólisis. Se ha evaluado complementariamente un cribado LCA de la vía ecológica frente a la convencional. El sistema de pirólisis produce carbonilla, gases y alquitrán, involucrando las siguientes etapas: secado y molienda de biomasa, pirólisis, separación de gases y carbonilla, enfriamiento de gas mediante el uso consecutivo de un intercambiador de calor de aire seguido de uno de agua, y la separación de gases y alquitrán. . Para este estudio, se seleccionaron 14 categorías de impacto de punto medio y 3 de punto final. La unidad funcional (UF) de 100 kg de orujo de aceituna se consideró como un enfoque de referencia general. Los resultados obtenidos revelan que la opción más amigable con el medio ambiente fue el escenario ecológico. Por lo tanto, solo la biomasa producida por este escenario se consideró para un sistema de pirólisis adicional. Los resultados mostraron que el sistema de pirólisis puede considerarse una herramienta ecológica para la valorización del orujo de aceituna, utilizando equipos energéticamente eficientes junto con la reutilización de agua y aire

COVID-19 Impact: A Case Study at the School of Agricultural Engineering and Environment of the Universitat Politècnica de València

[EN] To study the first impact of the COVID-19 crisis on the results obtained by students belonging to the School of Agricultural Engineering and Environment at the Universitat Politecnica de Valencia (Spain), the average of the marks corresponding to three academic years (2016-2019) was compared to those obtained in 2019-2020 for a total of four bachelor's degrees and two semesters. Our results suggest a positive effect on the marks obtained during the activation of emergency remote teaching during the spring semester of 2019-2020 in three out of the four degrees, with these differences being significant for the whole study. Moreover, just at the end of that period, instructors and students were surveyed regarding teaching methodologies, evaluation modalities, and difficulties found throughout the process of adapting to distance teaching. Our results allow us to sensibly think about that exceptional situation in order to propose a set of counterweighting measures which could improve the implementation of distance learning in engineering colleges.Clemente Polo, G.; Garcia-Prats, A.; Lisón, P.; Rubio Michavila, C.; Vidal-Puig, S.; Ricarte Benedito, B.; Estruch-Guitart, V.... (2022). COVID-19 Impact: A Case Study at the School of Agricultural Engineering and Environment of the Universitat Politècnica de València. Sustainability. 14(17):1-14. https://doi.org/10.3390/su141710607114141

Distance Learning In Time Of Crisis: A Case Study At The School Of Agricultural Engineering And Environment Of Universitat Politècnica De València

[EN] Higher education is continuously evolving to keep up with the challenges posed by the introduction of information and communication technologies (ICT) to education. In this sense, distance learning is booming, with an increasing number of higher education students taking advantage of the flexibility remote learning provides. The School of Agricultural Engineering and Environment (ETSIAMN) of Universitat Politècnica de València (UPV) has been gradually incorporating ICT tools in its bachelor and master degrees for the last two decades. As a result, many college students and university instructors are familiar with ICT techniques. However, the unprecedented COVID-19 crisis has put distance learning in the spotlight like never before, forcing students, faculty, and staff to adapt to the new situation with hardly any preparation time. For that reason, it is convenient to analyse in depth the results and impact of the teaching and evaluation methodologies developed and applied during this critical period, as a way to detect and amend potential inefficiencies in the learning process. The specific goal of this study was to analyse the teaching period during the COVID-19 crisis in ETSIAMN, which covered the spring semester of the academic year 2019-2020. To this purpose, 114 instructors and 274 students were surveyed in July 2020, belonging to four bachelor degrees (agricultural and biological engineering; forestry engineering; food engineering; and biotechnology), and three master degrees (agricultural and biological engineering; forestry engineering, and oenology). Regarding the experimental design for the survey, three main blocks were identified: the first block corresponds to teaching methodologies, comparing students and faculty preferences for distance lecturing; the second block focuses on evaluation modalities and exam configurations; and the final block centers on the difficulties found by both students and lecturers along the adaptation process from conventional to distance teaching. Results showed that instructors and students preferred a combination of live streaming with recorded lectures, being multiple choice the favourite examination type, although many students rated first a project-based evaluation. Overall, students rejected tests with no possibilities to go back on already answered questions, and instructors mostly preferred limiting the time to complete the on-line tests. The lack of motivation was the main barrier encountered by students to achieve an effective learning. Finally, a set of counterweighting measures to improve and promote the successful implementation of distance learning in engineering colleges is proposed.Clemente Polo, G.; Garcia-Prats, A.; Lisón, P.; Rubio Michavila, C.; Ricarte Benedito, B.; Estruch-Guitart, V.; Fenollosa Ribera, ML.... (2020). Distance Learning In Time Of Crisis: A Case Study At The School Of Agricultural Engineering And Environment Of Universitat Politècnica De València. IATED Academy. 3938-3945. https://doi.org/10.21125/iceri.2020.0889S3938394

The direct and indirect effects of COVID‐19 pandemic in a real‐life hematological setting

Background: Clinical outcomes of novel coronavirus 2019 disease (COVID-19) in onco-hematological patients are unknown. When compared to non-immunocompromised patients, onco-hematological patients seem to have higher mortality rates. Aims: We describe the characteristics and outcomes of a consecutive cohort of 24 onco-hematological patients with COVID-19 during the first month of the pandemic. We also describe variations in healthcare resource utilization within our hematology department. Methods and results: Data from patients between the first month of the pandemic were retrospectively collected. Clinical and logistic data were also collected and compared with the average values from the prior 3 months of activity. Prevalence of COVID-19 in our hematological population was 0.4%. Baseline characteristics were as follows: male sex: 83%, lymphoid diseases: 46%, median age: 69 (22-82) years. Median follow-up in survivors was 14 (9-28) days and inpatient mortality rate was 46%. Average time to moderate/severe respiratory insufficiency and death were 3 (1-10) and 10 (3-18) days, respectively. Only 1 out of every 12 patients who developed moderate to severe respiratory insufficiency recovered. Upon univariate analysis, the following factors were associated with higher mortality: age ≥ 70 years (P = .01) and D-dimer ≥900 mcg/L (P = .04). With respect to indirect effects during the COVID-19 pandemic, and when compared with the prior 3 months of activity, inpatient mortality (excluding patients with COVID-19 included in the study) increased by 56%. This was associated with a more frequent use of vasoactive drugs (+300%) and advanced respiratory support (+133%) in the hematology ward. In the outpatient setting, there was a reduction in initial visits (-55%) and chemotherapy sessions (-19%). A significant increase in phone visits was reported (+581%). Conclusion: COVID-19 pandemic is associated with elevated mortality in hematological patients. Negative indirect effects are also evident within this setting

In silico Analyses of Immune System Protein Interactome Network, Single-Cell RNA Sequencing of Human Tissues, and Artificial Neural Networks Reveal Potential Therapeutic Targets for Drug Repurposing Against COVID-19

Background: There is pressing urgency to identify therapeutic targets and drugs that allow treating COVID-19 patients effectively.Methods: We performed in silico analyses of immune system protein interactome network, single-cell RNA sequencing of human tissues, and artificial neural networks to reveal potential therapeutic targets for drug repurposing against COVID-19.Results: We screened 1,584 high-confidence immune system proteins in ACE2 and TMPRSS2 co-expressing cells, finding 25 potential therapeutic targets significantly overexpressed in nasal goblet secretory cells, lung type II pneumocytes, and ileal absorptive enterocytes of patients with several immunopathologies. Then, we performed fully connected deep neural networks to find the best multitask classification model to predict the activity of 10,672 drugs, obtaining several approved drugs, compounds under investigation, and experimental compounds with the highest area under the receiver operating characteristics.Conclusion: After being effectively analyzed in clinical trials, these drugs can be considered for treatment of severe COVID-19 patients. Scripts can be downloaded at

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Cabbage and fermented vegetables : From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19

Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT(1)R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT(1)R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity.Peer reviewe

Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies

There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR gamma:Peroxisome proliferator-activated receptor, NF kappa B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2 alpha:Elongation initiation factor 2 alpha). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT(1)R axis (AT(1)R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity