Effectiveness of Negative Pressure Wound Therapy in Burns in Pediatric and Adolescent Patients: A Systematic Review and Meta-Analysis

Background: Burns represent a public health problem because they generate both physical and psychological damage, especially in the child and adolescent population, and high costs, especially due to the management of scars. Advances in burn care have improved survival and quality of life for this population. New clinical trials have been conducted on the benefits of negative pressure wound therapy (NPWT), showing that it improves the healing of burns and the appearance of scars. Therefore, this study aims to analyze the efficacy of NPWT both alone and as an adjunct to conventional dressings in pediatric and adolescent patients compared with conventional treatments. Methodology: A systematic search was carried out between December 2023 and the last quarter of 2025 in databases such as PubMed, Scopus, CINAHL, and the Cochrane Library. This meta-analysis was performed following the PRISMA statement (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) and was registered in PROSPERO with registration number CRD42024597293. The risk of bias 2 (RoB2) tool was used to assess the risk of bias in the studies. Quantitative meta-analyses using random-model effects were performed only for variables with sufficient comparable data among studies. For other outcomes, where meta-analysis was not feasible due to lack of comparable data or control groups, results were synthesized qualitatively. Results: A total of seven articles (three clinical trials and four retrospective studies), in which a total of 323 subjects participated, were included. The main results demonstrate the efficacy of NPWT, as it decreases the re-epithelialization time, improves the appearance of scars (MD = -1.25 (95% CI between -1.80 and -0.70)), reduces the probability of skin grafts (OR = 0.17 (95% CI between 0.06 and 0.46)), and therefore, as there is less need for surgery and fewer dressing changes, reduces costs. Conclusions: NPWT offers significant clinical benefits in the treatment of burns in children and adolescents. Although a meta-analysis could not be performed due to the lack of a control group in some studies, studies with larger samples and multicenter designs will be necessary to better assess the relevant clinical outcomes. However, the results of this study show that NPWT is effective in treating burns in children and adolescents and that its use in clinical practice may represent a promising adjunctive therapy

Evaluation of the new role of the invasive species (Procambarus clarkii) as an environmental indicator in polluted watersheds.

Procambarus clarkii represents an invasive species of crayfish common in the rivers of the Iberian Peninsula, which replaced a previous invasive species of crayfish (Austropotamobius pallipes) and is now being replaced by a new invasive species (Pacifastacus leniusculus) in northern rivers. Leaving aside the ecological problems that these invasive species can cause, these organisms can be excellent candidates to act as environmental indicators in pollution processes that involves the interface water–sediment.In this work, the potential role of Procambarus clarkii as a bioindicator of pollution processes of mining origin is evaluated. Unlike previous research, which often focuses on snapshot assessments of contamination levels, our approach integrates historical data and continuous monitoring to provide adynamic perspective on the impact of Hg and other metals on biotic and abiotic media over an extended period. A total of 330 crayfish were collected from 10 sites in Valdeazogues river, grouped by size, and analyzed for Hg, Pb, Cd, Cu, Zn, As, and Sb in abdominal muscle and hepatopancreas, with a complete characterization of sediment and water media.Crayfish data have shown that hepatopancreas and muscle present the highest average content of Zn (1,325 and 377 mg kg-1, respectively) and Cu (1,297 and 179 mg kg-1 respectively). Levels of Hg were higher in muscle (1.6 mg kg-1) than hepatopancreas (1.0 mg kg-1), with all muscle samples exceeding the EU maximum permissible level of 0.5 mg kg-1 for food. The sensitivity of P. clarkii has been sufficient to identify different sources of Hg, Pb and Zn contamination in the drainage system, and even agricultural sources of Cd downstream of the mining district.This versatile capability can be of application to large mining areas in the south of the Iberian Peninsula, especially throughout the Iberian Pyrite Belt

Analyzing STEM video characteristics on viewer engagement for dissemination and exercise contents: a data-driven approach

Educational videos are increasingly used to enhance learning and disseminate scientific and technical knowledge. However, optimizing their design is essential to maintain viewer attention and maximize their educational impact. This study analyzes user engagement with exercise and dissemination videos on a Spanish-speaking YouTube channel focused on STEM education, particularly physics and engineering. The research examines how video characteristics, such as length, narration speed, and the presence of a fixed channel introduction, affect attention retention. Using YouTube analytics, data from 124 videos published between 2019 and 2025 were analyzed through metrics such as average view duration and audience retention after the first 30 s. Results show that dissemination videos achieve higher attention retention than exercise videos. Shorter videos, especially those under eight minutes, are significantly more effective, while narration speed has little influence. The first 30 s are critical for maintaining engagement, particularly in dissemination videos. Conversely, the inclusion of a fixed introduction reduces attention and should be avoided as it adds no educational value. These findings provide evidence-based recommendations for educators and content creators to improve the design and impact of educational videos, contributing to the broader understanding of effective communication strategies in STEM education on digital platforms

The potential of glycerine as a fuel in the synthesis of highly active nickel-based perovskites for ammonia decomposition

The development of non-noble metal perovskites as catalytic precursors for ammonia decomposition presents a promising route for sustainable hydrogen production. In this work, the influence of the organic fuel (citric acid, urea, glycerine, and oxalic acid) used to synthesize a non-conventional La0.1Mg0.9NiO3 perovskite by the self-combustion method was systematically investigated. Comprehensive structural, morphological, and textural characterization was conducted to establish correlations with the catalytic activity in the ammonia decomposition reaction. Among the evaluated fuels, glycerine yielded a highly porous nickel-based perovskite with enhanced surface area, well-dispersed Ni0 crystallites of optimal size, and favourable reducibility and basicity. Consequently, this material reached 84.1 % ammonia conversion at 350 °C, approaching the performance of Ru-based systems. It also exhibited excellent thermal stability underscoring its potential as a robust catalyst for ammonia decomposition. Therefore, the use of glycerine, a low-cost and widely available industrial by-product, enhances the economic and environmental sustainability of the synthesis process. These findings provide valuable insights into the rational design of highly active, efficient, and stable nickel-based perovskites as catalytic precursors for scalable hydrogen generation from ammonia decomposition

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#6 El material introduce una reflexión sobre la relación entre la luz y la presencia. La iluminación no sólo determina qué elementos captan la atención del observador, sino que también define y materializa su existencia. El cambio de estado drástico que aquello expuesto experimenta se insinúa a través de la condición también inestable de un público que lo celebra. Todo ocurre en el interior de una habitación, donde el enigma no radica en la naturaleza del cambio, sino en el momento en que este acontece, enfatizando así la relevancia de la temporalidad en la construcción de la experiencia

Feasible Solutions for the Implementation and Analysis of Commercial High-Performance Interconnection Network Architectures

Interconnection networks play a fundamental role in High-Performance Computing (HPC) and Data Center (DC) systems. These systems consist of thousands of compute and storage nodes that work cooperatively and jointly, acting as a single unit. Therefore, they require an interconnection network that offers high bandwidth and low latency to avoid becoming the system’s bottleneck. Within this context, this thesis focuses specifically on networks that utilize Remote Direct Memory Access (RDMA) technology. Initially implemented in HPC systems, the adoption of RDMA has accelerated significantly in DCs. The increase in services that handle large volumes of data, such as the development of Artificial Intelligence (AI) applications, Big Data, and distributed storage, demands the same high-performance characteristics (high bandwidth and low latency) that RDMA offers. Given all the above, network performance depends on several key factors. One of these is the topology, which defines how these nodes are interconnected. New topologies are continuously being proposed to efficiently interconnect a large number of nodes at a low cost. These topologies require efficient routing algorithms to balance the network load. The challenge is that while many of these topologies are often proposed theoretically, they are rarely implemented in a real system due to the technical difficulties involved. However, topology is only one factor among many. The massive amount of data traffic handled by these networks is so high that congestion is a frequent occurrence, degrading the overall system performance. To address this, various Congestion Control (CC) methods exist that seek to eliminate congestion or, failing that, reduce its adverse effects. The problem is that these mechanisms are often very complex to configure effectively. Furthermore, the mechanisms most commonly used in commercial networks were designed for needs and technologies different from those of today. Since the behavior of congestion has changed, it is crucial to update existing mechanisms and propose new solutions capable of addressing these new situations and technologies. Ultimately, simulators play a crucial role in the development of new solutions. They are highly useful in the early stages of development, as they enable design errors to be quickly identified and corrected. They also make it possible to study whether solutions are viable before implementing them on a large scale in real systems. Additionally, they enable the evaluation of new network architectures that are not yet available in real devices, as well as the proposal of new solutions for them. In this thesis, viable solutions are proposed to improve the performance of these interconnection networks. The work spans from the implementation of novel topologies and their routing algorithms in real systems, the enhancement of CC mechanisms through network state monitoring, to the modeling and evaluation of new architectures using an interconnection network simulator

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# 1 El audio comienza con un ascenso orbital que transporta al oyente a un entorno remoto mediante una compleja red de señales espaciales. Las frecuencias captadas del exterior se combinan con emisiones del satélite Sputnik, ecos de radares lunares e interferencias de equipos radiofónicos, conformando un paisaje acústico que evoca la circulación por una base o enclave distante. El desarrollo sonoro que se produce está vinculado al tránsito desde un punto de ingreso hasta una salida estratosférica, donde la interrupción de la información genera una sensación de distanciamiento respecto a lo reconocible

The association of environmentally sustainable healthy dietary patterns and risk of neurological and psychiatric disorders: A systematic review and meta-analysis of 28 cohorts

PurposeThe current burden of neurological and psychiatric disorders is a major issue in public health. We aimed to explore how adherence to healthy diets with low environmental impact (HDLE)—Mediterranean, EAT-Lancet and Healthy Provegetarian diets—are associated with neurological and psychiatric outcomes (depression, anxiety, cognitive impairment, and dementia) in prospective cohort studies of adults.MethodsWe systematically searched four databases until March 2025. Pooled risk ratios (pRRs) with 95% confidence intervals (CIs) along with prediction intervals (PIs) were estimated. Our meta-analyses compared the incidence of mental outcomes between individuals with the highest vs. lowest (reference category = 1) adherence to HDLE. The certainty of evidence was assessed with the GRADE framework.ResultsThis systematic review included 39 articles involving 472,125 adults (mean age 63y,52% female) from 28 unique cohorts with a mean follow-up of 10y. The highest (vs. the lowest) adherence to HDLE was associated with a lower risk of depression (pRR: 0.80; 95%CI:0.75–0.85; PI:0.68–0.93; k = 12/n = 333,218), cognitive impairment (pRR:0.66; 95%CI:0.60–0.72; PI:0.57–0.76; k = 5; n = 27,338), and dementia (pRR: 0.87; 95%CI:0.76–0.99; PI:0.63–1.20; k = 11/n = 235,863). A meta-analysis for incident anxiety was not conducted due to the scarcity of studies (k = 2). Certainty of evidence was rated as low for depression and very low for cognitive impairment and dementia.ConclusionA higher adherence to HDLE was associated with a lower risk of depression (20%), cognitive impairment (34%) and dementia (13%)