On the Discovery of Success Trajectories of Authors

Understanding the qualitative patterns of research endeavor of scientific authors in terms of publication count and their impact (citation) is important in order to quantify success trajectories. Here, we examine the career profile of authors in computer science and physics domains and discover at least six different success trajectories in terms of normalized citation count in longitudinal scale. Initial observations of individual trajectories lead us to characterize the authors in each category. We further leverage this trajectory information to build a two-stage stratification model to predict future success of an author at the early stage of her career. Our model outperforms the baseline with an average improvement of 15.68% for both the datasets.Comment: 2 pages, 1 figure in 25rd International World Wide Web Conference WWW 201

IDENTIFICATION OF POTENTIAL SALMONELLA TYPHI BETA-LACTAMASE TEM 1 INHIBITORS USING PEPTIDOMIMETICS, VIRTUAL SCREENING, AND MOLECULAR DYNAMICS SIMULATIONS

Objective: The purpose of this study was to identify a potential peptidomimetic S. typhi Beta-lactamase TEM 1 inhibitor to tackle the antibiotic resistance among S. typhi.Methods: The potential peptidomimetic inhibitor was identified by in silico docking of the small peptide WFRKQLKW with S. typhi Beta-lactamase TEM 1. The 3D coordinate geometry of the residues of small peptide interacting with the active site of the receptor was generated and mimics were identified using PEP: MMs: MIMIC server. All the identified mimics were docked at the active site of the receptor using Autodock 4.2 and the best-docked complex was selected on the basis of binding energy and number of H-bonds. The complex was then subjected to molecular dynamics simulations of 30 ns using AMBER 12 software package. The stereochemical stability of the Beta-lactamase TEM 1-WFRKQLKW complex was estimated with the help of Ramachandran plot using PROCHECK tool.Results: In the present study, a new potential peptidomimetic inhibitor (ZINC05839264) of Beta-lactamase TEM 1 has been identified based on antimicrobial peptide WFRKQLKW by virtual screening of the MMsINC database. The docking and molecular simulation studies revealed that the mimic binds more tightly to the active site of the receptor than the peptide. The Ramachandran plot also shows that the Beta-lactamase TEM 1-mimic complex is stereo chemically more stable than Beta-lactamase TEM 1-WFRKQLKW complex as more number of residues (93.6%) are falling under the core region of the plot in case of the former.Conclusion: The study shows that the peptidomimetic compound can act as a potential inhibitor of S. typhi Beta-lactamase TEM 1 and further it can be developed into more effective therapeutic to tackle the problem of antibiotic resistance

PULSAR DETECTION SYSTEM USING RADIO TELESCOPE

Radio astronomers and Researchers have detected numerous neutron stars in our galaxy, and they also predicted the Existence of many more neutron stars in space. Pulsars are very peculiar, yet almost inscrutable celestial objects. This is an object which is impelling radiation into space closest to the speed of light. Neutron stars are the most interesting galactic bodies to mankind. The things that hold us during the whole study are the fascinating properties of pulsar i.e. high density, a small diameter, strong gravity, and strong magnetic field. As the peculiar properties and the extreme nature of pulsar continue to disclose this catches the attention of Astronomers. Pulsars are distant objects. So, it is very tedious job to capture the radiations coming from it for this we have designed a system which consist of an Antenna, Filters, Amplifiers and Receiver. The signal we capture through the antenna will undergo signal processing to extract the Pulse which is buried in noise. The techniques used here are the fast-folding algorithm (FFA) and Fast Fourier transform (FFT) are explained along. By this whole study to building a system and performed signal processing and obtained the Pulse

Ex situ conservation and qualitative characterization of traditional cultivars of rice (Oryza sativa L.)

168-179Genetic diversity of rice cultivars offers adequate opportunity for added advantage for rice improvement. Current study with 132 traditional rice cultivars had been collected from West Bengal, Manipur and Assam. Those cultivars are being preserved at repository of Uttar Banga Krishi Viswavidyalaya since 2009. Few of them had used in breeding programme to develop new desirable variety with unique characteristics. Those traditional cultivars were phenotypically characterized using PPV&FRA descriptor. In this piece of work, 44 traits were considered to record the morphological differences among the traditional cultivars. All the traditional cultivars showed one or few distinctive features that made different from each other. Finally the traditional cultivars were classified based few anticipated distinctive characters. Amylose content in endosperm was very low in ten, low in twelve, medium in 61 and high in 49 traditional cultivars. Amylose content of milled rice is a significant parameter in respect of consumer preference. Under Indian context, consumers prefer rice with medium amylose content (20-25%) in the endosperm. Strong aroma was emitted by 25, mild aroma by 23 and no aroma in 84 cultivar

The COVID‐19 Pandemic Not Only Poses Challenges, but Also Opens Opportunities for Sustainable Transformation

The COVID-19 pandemic has impacted social, economic, and environmental systems worldwide, slowing down and reversing the progress made in achieving the Sustainable Development Goals (SDGs). SDGs belong to the 2030 Agenda to transform our world by tackling humankind's challenges to ensure well-being, economic prosperity, and environmental protection. We explore the potential impacts of the pandemic on SDGs for Nepal. We followed a knowledge co-creation process with experts from various professional backgrounds, involving five steps: online survey, online workshop, assessment of expert's opinions, review and validation, and revision and synthesis. The pandemic has negatively impacted most SDGs in the short term. Particularly, the targets of SDG 1, 4, 5, 8, 9, 10, 11, and 13 have and will continue to have weakly to moderately restricting impacts. However, a few targets of SDG 2, 3, 6, and 11 could also have weakly promoting impacts. The negative impacts have resulted from impeding factors linked to the pandemic. Many of the negative impacts may subside in the medium and long terms. The key five impeding factors are lockdowns, underemployment and unemployment, closure of institutions and facilities, diluted focus and funds for non-COVID-19-related issues, and anticipated reduction in support from development partners. The pandemic has also opened a window of opportunity for sustainable transformation, which is short-lived and narrow. These opportunities are lessons learned for planning and action, socio-economic recovery plan, use of information and communication technologies and the digital economy, reverse migration and “brain gain,” and local governments' exercising authorities

The use of plants in the traditional management of diabetes in Nigeria: Pharmacological and toxicological considerations

Ethnopharmacological relevance: The prevalence of diabetes is on a steady increase worldwide and it is now identified as one of the main threats to human health in the 21st century. In Nigeria, the use of herbal medicine alone or alongside prescription drugs for its management is quite common. We hereby carry out a review of medicinal plants traditionally used for diabetes management in Nigeria. Based on the available evidence on the species׳ pharmacology and safety, we highlight ways in which their therapeutic potential can be properly harnessed for possible integration into the country׳s healthcare system. Materials and methods: Ethnobotanical information was obtained from a literature search of electronic databases such as Google Scholar, Pubmed and Scopus up to 2013 for publications on medicinal plants used in diabetes management, in which the place of use and/or sample collection was identified as Nigeria. ‘Diabetes’ and ‘Nigeria’ were used as keywords for the primary searches; and then ‘Plant name – accepted or synonyms’, ‘Constituents’, ‘Drug interaction’ and/or ‘Toxicity’ for the secondary searches. Results: The hypoglycemic effect of over a hundred out of the 115 plants reviewed in this paper is backed by preclinical experimental evidence, either in vivo or in vitro. One-third of the plants have been studied for their mechanism of action, while isolation of the bioactive constituent(s) has been accomplished for twenty three plants. Some plants showed specific organ toxicity, mostly nephrotoxic or hepatotoxic, with direct effects on the levels of some liver function enzymes. Twenty eight plants have been identified as in vitro modulators of P-glycoprotein and/or one or more of the cytochrome P450 enzymes, while eleven plants altered the levels of phase 2 metabolic enzymes, chiefly glutathione, with the potential to alter the pharmacokinetics of co-administered drugs. Conclusion: This review, therefore, provides a useful resource to enable a thorough assessment of the profile of plants used in diabetes management so as to ensure a more rational use. By anticipating potential toxicities or possible herb–drug interactions, significant risks which would otherwise represent a burden on the country׳s healthcare system can be avoided

Thermodynamic model for hydrothermal sulfide deposition in the paleoproterozoic granite ore system at Malanjkhand, India

1697-1711Malanjkhand fossil hydrothermal deposit is a Paleoproterozoic metallogeny associated with the Malanjkhand Granitoid represents an ideal granite ore system. It is formed by mixing of two distinct compositions of hydrothermal fluids in variable proportion derived from two different sources and results in the deposition of primary sulfide ores which comprises of chalcopyrite + pyrite ± bornite. Primary sulfide ores alters to secondary sulfides (chalcocite + chovellite) and oxides (cuprite + tenorite) ores because of extensive hydrothermal activities. Occurrence of two distinct varieties of ore assemblages (primary and secondary ores) indicates broadly two stages of sulfide deposition. Thermodynamic modeling suggests that hydrothermal alteration brings change in the physico-chemical environment from reduced to oxidized zone in the Malanjkhand granite ore system. The primary sulfide ores occurs in reduction zone whereas secondary ores found in the oxidation zone which forms of a cap on the primary ores. Change in the physico-chemical environment caused change in the composition of the ore minerals which favors enrichment in Cu along with the depletion of Fe and S content

Reduction of postoperative pain after infiltration of local anesthetic at the port site and subdiaphragmatic space in laparoscopic cholecystectomy: A cross-sectional study

Introduction: Port site and subdiaphragmatic infiltration of local anesthetics during laparoscopic cholecystectomy (LC) is preferred by surgeons to decrease postoperative pain. LC with local anesthetics infiltration as well as without any local anesthetic both have been standard surgical practice. However, the difference in the reduction of postoperative pain in these two groups is not well known. The objective of the study was to compare the postoperative pain with and without infiltration of local anesthetic at the port site and subdiaphragmatic space in LC.   Methods: A hospital-based cross-sectional study was conducted from 25 April 2021 to 25 October 2021 among 60 patients who underwent elective LC.  The patients were divided into two equal groups. The study group received infiltration of 20 ml of bupivacaine (0.5%) at the port site and the subdiaphragmatic space, while the control group did not receive any local anesthetic. The primary outcome measure was the visual analog pain score at 6, 12, 24 and 48hrs postoperatively.   Results: Among 60 patients, the majority were female- 40(66.7%); and 40-50 years age group. The two groups were comparable in terms of age, sex, ASA, BMI and duration of pneumoperitoneum and surgery. Infiltration of a local anesthetic agent produced effective postoperative analgesia in the immediate postoperative hours  (6, 12 and 24 hours) and was found to be statistically significant when compared to the no-local anesthesia group.   Conclusion: The intraoperative port site and subdiaphragmatic local infiltration is effective at reducing postoperative pain in the first 12 hours without any adverse events

Reduction of postoperative pain after infiltration of local anesthetic at the port site and subdiaphragmatic space in laparoscopic cholecystectomy: A cross-sectional study

Introduction: Port site and subdiaphragmatic infiltration of local anesthetics during laparoscopic cholecystectomy (LC) is preferred by surgeons to decrease postoperative pain. LC with local anesthetics infiltration as well as without any local anesthetic both have been standard surgical practice. However, the difference in the reduction of postoperative pain in these two groups is not well known. The objective of the study was to compare the postoperative pain with and without infiltration of local anesthetic at the port site and subdiaphragmatic space in LC.   Methods: A hospital-based cross-sectional study was conducted from 25 April 2021 to 25 October 2021 among 60 patients who underwent elective LC.  The patients were divided into two equal groups. The study group received infiltration of 20 ml of bupivacaine (0.5%) at the port site and the subdiaphragmatic space, while the control group did not receive any local anesthetic. The primary outcome measure was the visual analog pain score at 6, 12, 24 and 48hrs postoperatively.   Results: Among 60 patients, the majority were female- 40(66.7%); and 40-50 years age group. The two groups were comparable in terms of age, sex, ASA, BMI and duration of pneumoperitoneum and surgery. Infiltration of a local anesthetic agent produced effective postoperative analgesia in the immediate postoperative hours  (6, 12 and 24 hours) and was found to be statistically significant when compared to the no-local anesthesia group.   Conclusion: The intraoperative port site and subdiaphragmatic local infiltration is effective at reducing postoperative pain in the first 12 hours without any adverse events