23 research outputs found

    Recent developments in the genetics of childhood epileptic encephalopathies: impact in clinical practice

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    Multi-messenger observations of a binary neutron star merger

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    On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta

    Arthropod Infection Models for Francisella tularensis

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    Purpose of Review Little is known about the interactions between Francisella tularensis and arthropods. The advent of next-generation sequencing led to a better knowledge of the genetic diversity of F. tularensis, which is associated with macrogeographical areas. These findings, coupled with precise methods to follow bacteria within arthropods, brought a renewed interest in this field. The scope of this review is to present the most recent literature describing experimental infections of arthropod vectors with F. tularensis. Recent Findings The latest data show the importance to test relevant lineages of F. tularensis and also emphasize the importance to improve arthropod infection models. Summary Many gaps still need to be filled to better understand the role of arthropods in the transmission and maintenance of F. tularensis. However, significant advancements were made in the last years. Future research will likely contribute to unravel the interconnections between F. tularensis, host, vector, and the environment
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