66 research outputs found
β-hCG resolution times during expectant management of tubal ectopic pregnancies
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Evolution of MicroRNA Genes in Oryza sativa and Arabidopsis thaliana: An Update of the Inverted Duplication Model
- Author
- AC Mallory
- AH Paterson
- AK Leung
- AR van der Krol
- B Bartel
- BC Meyers
- C Maher
- C Napoli
- CC Mello
- CD Malone
- CI Wu
- E Allen
- E Berezikov
- E Hornstein
- EJ Devor
- F Vazquez
- FF Felippes
- G Zeller
- GC Conant
- H Grosshans
- J Li
- J Lu
- J Masel
- J Piriyapongsa
- J Piriyapongsa
- J Yu
- J Yu
- JA Birchler
- JM Franco-Zorrilla
- JT Cuperus
- K Naito
- L Wu
- Li-zhi Gao
- M Dewannieux
- M Ghildiyal
- M Ha
- N Fahlgren
- NM Kopelman
- NR Smalheiser
- NR Smalheiser
- O Voinnet
- PA Sharp
- QJ Luo
- QW Niu
- R Sasidharan
- RK Jansen
- S Takuno
- SA Smith
- VL Chandler
- VN Kim
- W Hennig
- W Zhang
- Wen-kai Jiang
- X Dai
- X Guo
- X Guo
- Y Jiao
- Ying Xu
- Yun Zhang
- YY Li
- Z Gu
- Z Ma
- Publication venue
- Public Library of Science
- Publication date
- 14/12/2011
- Field of study
The origin and evolution of microRNA (miRNA) genes, which are of significance in tuning and buffering gene expressions in a number of critical cellular processes, have long attracted evolutionary biologists. However, genome-wide perspectives on their origins, potential mechanisms of their de novo generation and subsequent evolution remain largely unsolved in flowering plants. Here, genome-wide analyses of Oryza sativa and Arabidopsis thaliana revealed apparently divergent patterns of miRNA gene origins. A large proportion of miRNA genes in O. sativa were TE-related and MITE-related miRNAs in particular, whereas the fraction of these miRNA genes much decreased in A. thaliana. Our results show that the majority of TE-related and pseudogene-related miRNA genes have originated through inverted duplication instead of segmental or tandem duplication events. Based on the presented findings, we hypothesize and illustrate the four likely molecular mechanisms to de novo generate novel miRNA genes from TEs and pseudogenes. Our rice genome analysis demonstrates that non-MITEs and MITEs mediated inverted duplications have played different roles in de novo generating miRNA genes. It is confirmed that the previously proposed inverted duplication model may give explanations for non-MITEs mediated duplication events. However, many other miRNA genes, known from the earlier proposed model, were rather arisen from MITE transpositions into target genes to yield binding sites. We further investigated evolutionary processes spawned from de novo generated to maturely-formed miRNA genes and their regulatory systems. We found that miRNAs increase the tunability of some gene regulatory systems with low gene copy numbers. The results also suggest that gene balance effects may have largely contributed to the evolution of miRNA regulatory systems
A multi-centre, double-blind, placebo-controlled, randomised trial of combination methotrexate and gefitinib versus methotrexate alone to treat tubal ectopic pregnancies (GEM3): trial protocol
- Author
- Alexandra Peace-Gadsby
- Andrew W Horne
- Andrew W. Horne
- Ann Doust
- Arri Coomarasamy
- Ben Mol
- Catherine Hewitt
- Cecilia Bottomley
- Colin Duncan
- D Mavrelos
- Davor Jurkovic
- F Mol
- James May
- Jane Daniels
- L Say
- LB Krag Moeller
- Lee Middleton
- M Skubisz
- MH Cohen
- MM Skubisz
- NM van Mello
- R Cantwell
- RS Herbst
- Siladitya Bhattacharya
- SN Avcioglu
- Stephen Tong
- Tom Bourne
- UW Nilsson
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background Tubal ectopic pregnancy (tEP) is the most common life-threatening condition in gynaecology. Treatment options include surgery and medical management. Stable women with tEPs with pre-treatment serum human chorionic gonadotrophin (hCG) levels 1000 IU/L can take significant time to resolve with methotrexate and require multiple outpatient monitoring visits. In pre-clinical studies, we found that tEP implantation sites express high levels of epidermal growth factor receptor. In early-phase trials, we found that combination therapy with gefitinib, an orally active epidermal growth factor receptor antagonist, and methotrexate resolved tEPs without the need for surgery in over 70% of cases, did not cause significant toxicities, and was well tolerated. We describe the protocol of a randomised trial to assess the efficacy of combination gefitinib and methotrexate, versus methotrexate alone, in reducing the need for surgical intervention for tEPs. Methods and analysis We propose to undertake a multi-centre, double-blind, placebo-controlled, randomised trial (around 70 sites across the UK) and recruit 328 women with tEPs (with pre-treatment serum hCG of 1000–5000 IU/L). Women will be randomised in a 1:1 ratio by a secure online system to receive a single dose of intramuscular methotrexate (50 mg/m2) and either oral gefitinib or matched placebo (250 mg) daily for 7 days. Participants and healthcare providers will remain blinded to treatment allocation throughout the trial. The primary outcome is the need for surgical intervention for tEP. Secondary outcomes are the need for further methotrexate treatment, time to resolution of the tEP (serum hCG ≤ 15 IU/L), number of hospital visits associated with treatment (until resolution or scheduled/emergency surgery), and the return of menses by 3 months after resolution. We will also assess adverse events and reactions until day of resolution or surgery, and participant-reported acceptability at 3 months. Discussion A medical intervention that reduces the need for surgery and resolves tEP faster would be a favourable treatment alternative. If effective, we believe that gefitinib and methotrexate could become standard care for stable tEPs
Avaliação morfométrica do tendão de Aquiles por ultra-sonografia
- Author
- Adler RS
- Alair Augusto S.M.D. dos Santos
- Beltran J
- Bock E
- Chandnani VP
- Cheung Y
- Ebeling T
- Edson Marchiori
- Erickson SJ
- Fessell DP
- Gilberto Torres Neto
- Jacobson JA
- Jacobson JA
- Jacobson JA
- Józsa L
- Kainberger F
- Kallinen M
- Koivunen-Niemelä T
- Kujala UM
- Liem MS
- Lin J
- Lin J
- Maffulli N
- Martinoli C
- Mathieson JR
- Neuhold A
- Primack SJ
- Ptasznik R
- Rawool NM
- Reinherz RP
- Ricardo Andrade Fernandes de Mello
- Steinmetz A
- van Holsbeeck MT
- Yuzawa K
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Prospective surveillance study of acute respiratory infections, influenza-like illness and seasonal influenza vaccine in a cohort of juvenile idiopathic arthritis patients
- Author
- A Heim
- A Hu
- American Academy of Pediatrics Committee on Infectious Diseases
- BE van Ewijk
- C Deffernez
- C Ogimi
- CA Wallace
- Committee for Proprietary Medicinal Products
- Committee for Proprietary Medicinal Products
- EH Giannini
- Estratégia de Vacinação contra Influenza Pandêmica (H1N1)
- Eurico Arruda
- F Kanakoudi-Tsakalidou
- F Neske
- Flávia E de Paula
- HI Brunner
- J Garbino
- J Kuypers
- J Kuypers
- J Kuypers
- JL Proenca-Modena
- K Nystrom
- L Dell’Era
- LJ van Elden
- LM Thomazelli
- LS Souza
- Luciana M Carvalho
- Luciana R Roberti
- M Koskenvuo
- MC Albuquerque
- MH Pritchard
- Ministry of Health
- N Bellei
- N Bruck
- N Toplak
- NE Aikawa
- NM Graham
- NM Smith
- NY Olson
- PN Malleson
- RE Petty
- Rodrigo V D Silvestre
- SB Lambert
- SC Mazin
- T Shinoki
- TB Gagliardi
- Virginia P L Ferriani
- WHO Collaborating Center for the surveillance eacoI
- Wyller A Mello
- Y Lu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
- Ackley K
- Adams C
- Adams J
- Adams SM
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
- Agarwal B
- Agathos M
- Agatsuma K
- Aggarwal N
- Aglietta M
- Agliozzo C
- Agudo I
- Aguiar OD
- Aguilar JA
- Aharonian F
- Ahlers M
- Ahrens M
- Aiello L
- Ain A
- Ajith P
- Akras S
- Al Samarai I
- Albert A
- Albert A
- Albuquerque IFM
- Albury JM
- Alcaniz JS
- Alexander KD
- Alfaro R
- Alighieri S Di Serego
- Allam S
- Allekotte I
- Allen B
- Allen G
- Allison J
- Allison JR
- Allocca A
- Almela A
- Altin PA
- Altmann D
- Alvarez C
- Alvarez JD
- Alvarez M Dovale
- Alvarez-Muiz J
- Amati L
- Amato A
- An T
- Ananyeva A
- Anastasi GA
- Anchordoqui L
- Andeen K
- Anderson JP
- Anderson SB
- Anderson T
- Anderson WG
- Andrada B
- Andre M
- Andreoni I
- Andreoni I
- Andringa S
- Angelova SV
- Anghinolfi M
- Angner EO
- Angus CR
- Annis J
- Ansseau I
- Antier S
- Anton G
- Antonelli LA
- Antonelli LA
- Anupama GC
- Aoki K
- Aoki W
- Appert S
- Aptekar RL
- Arai K
- Arakawa M
- Aramo C
- Araya MC
- Arcavi I
- Arceo R
- Ardid M
- Areeda JS
- Aresu G
- Argan A
- Argelles C
- Arnaud N
- Array LWA Long Wavelength
- Array MWA Murchison Widefield
- Arrieta M
- Arsene N
- Arteaga-Velzquez JC
- Artola R
- Arun KG
- Asakura Y
- Asaoka Y
- Ascenzi S
- Ashall C
- Ashley MCB
- Ashton G
- Asorey H
- Assis P
- Ast M
- Aston SM
- Astone P
- Atallah DV
- ATLAS
- Atwood WB
- Aubert J-J
- Aubert P
- Aublin J
- Auffenberg J
- Aufmuth P
- Aulbert C
- AultONeal K
- Austin C
- Avgitas T
- Avila G
- Avila-Alvarez A
- Awad A Kuotb
- Axani S
- Baar S
- Babak S
- Bachetti M
- Backes M
- Bacon P
- Bader MKM
- Badescu AM
- Bae S
- Bagherpour H
- Bai X
- Bailes M
- Baker PT
- Balaceanu A
- Balanutsa PV
- Balasubramanian A
- Balbinot E
- Baldaccini F
- Baldini L
- Ballardin G
- Ballmer SW
- Bally J
- Balzer A
- Banagiri S
- Banerji M
- Bannister KW
- Barayoga JC
- Barbarino C
- Barbato F
- Barber AS
- Barbiellini G
- Barbiellini G
- Barclay SE
- Baret B
- Barish BC
- Barker D
- Barkett K
- Barnard M
- Barnes J
- Barone F
- Barr B
- Barrios-Marti J
- Barron JP
- Barsotti L
- Barsuglia M
- Barta D
- Barthelmy SD
- Bartlett J
- Bartos I
- Barway S
- Barway S
- Barwick SW
- Basa S
- Bassiri R
- Basti A
- Bastieri D
- Batch JC
- Bauer FE
- Bauer FE
- Baum V
- Bawaj M
- Bay R
- Bayley JC
- Bazzan M
- Bazzano A
- Bchele M
- Beardmore AP
- Beardsley A
- Beatty JJ
- Becerril A
- Becherini Y
- Bechtol K
- Becker KH
- Becsy B
- Beer C
- Bejger M
- Belahcene I
- Belhorma B
- Bell AS
- Bellazzini R
- Bellido JA
- Bellm E
- Belmont-Moreno E
- Benetti S
- Benkhali F Ait
- Benoit-Levy A
- BenZvi SY
- Berat C
- Berenji B
- Berge D
- Berger BK
- Berger E
- Bergmann G
- Berisso M Gomez
- Berley D
- Bernal A
- Bernardini E
- Bernardini MG
- Bernhard S
- Bernrhr K
- Bero JJ
- Beroiz M
- Berry CPL
- Bersanetti D
- Bertaina ME
- Bertin E
- Bertin V
- Bertolini A
- Berton M
- Bertou X
- Bessell MS
- Besson DZ
- Beswick R
- Betzwieser J
- Bhagwat S
- Bhalerao V
- Bhandare R
- Bhattacharya D
- Biagi S
- Biermann PL
- Bilenko IA
- Billingsley G
- Billman CR
- Binder G
- Bindig D
- Birch J
- Birney R
- Birnholtz O
- Biscans S
- Biscoveanu S
- Bisht A
- Bissaldi E
- Bissaldi E
- Biteau J
- Bitossi M
- Biwer C
- Bizouard MA
- Blackburn JK
- Blackburn L
- Blackman J
- Blackwell R
- Blaess SG
- Blagorodnova N
- Blair CD
- Blair DG
- Blair RM
- Blanchard P
- Blanco A
- Bland PA
- Blandford RD
- Blaufuss E
- Blazek J
- Bleve C
- Bloemen S
- Bloom ED
- Blot S
- Bock O
- Bode N
- Boer M
- Bogaert G
- Bohacova M
- Bohe A
- Bohm C
- Boisson C
- Bolmont J
- Bond IA
- Bondu F
- Bonifazi C
- Bonilla E
- Bonino R
- Bonnand R
- Bonnefoy S
- Bonoli S
- Booler T
- Boom BA
- Bordas P
- Bork R
- Bormuth R
- Borner M
- Borodai N
- Bos F
- Boschi V
- Bose D
- Bose S
- Boser S
- Bossie K
- Botner O
- Bottacini E
- Bottcher M
- Botti AM
- Botticella MT
- Bouffanais Y
- Bourbeau E
- Bourbeau J
- Bourret S
- Bouwhuis MC
- Bozzi A
- Bozzo E
- Brack J
- Bradaschia C
- Bradascio F
- Brady PR
- Branchesi M
- Brancus I
- Brandt S
- Brau JE
- Braun J
- Braun J
- Bravo O Martinez
- Brayeur L
- Breeveld AA
- Bregeon J
- Bregeon J
- Brenzke M
- Bretz H-P
- Bretz T
- Briant T
- Bridgeman A
- Briechle FL
- Briggs MS
- Brillet A
- Brinkmann M
- Brisbois C
- Brisson V
- Brnzas H
- Brocato E
- Brockill P
- Broderick JW
- Broida JE
- Bron S
- Brooks AF
- Brooks D
- Brostean-Kaiser J
- Brout D
- Brown DA
- Brown DD
- Brown IS
- Bruijn R
- Brun F
- Brun P
- Brunett S
- Brunner J
- Bruun SH
- Bryan M
- Buchanan CC
- Buchholz P
- Buckley DAH
- Buckley-Geer E
- Budnev NM
- Buehler R
- Bueno A
- Bufano F
- Buffa F
- Buikema A
- Buitink S
- Bulgarelli A
- Bulger J
- Bulik T
- Bulik T
- Bulla M
- Bulten HJ
- Buonanno A
- Burgay M
- Burgess JM
- Burgman A
- Burhonov O
- Burke DL
- Burns E
- Burrows DN
- Buscemi M
- Buskulic D
- Buson S
- Bustillo J Caldern
- Busto J
- Butler NR
- Butler RE
- Buttu M
- Buy C
- Byer RL
- Caballero-Garcia MD
- Caballero-Mora KS
- Caballero-Mora KS
- Cabero M
- Cabral J
- Caccianiga L
- Cadonati L
- Cagnoli G
- Cahillane C
- Callister TA
- Calloni E
- CALTECH GROWTH JAGWAR
- Cameron RA
- Camilo F
- Camp JB
- Campana S
- Camuccio R
- Cancio A
- Canepa M
- Canfora F
- Canizares P
- Cannella C
- Cannizzaro G
- Cannon KC
- Cano Z
- Cao H
- Cao J
- Cao XL
- Capaccioli M
- Capano CD
- Capasso M
- Capistrn T
- Capocasa E
- Capone A
- Capozzi D
- Cappellaro E
- Caputo R
- Caramete L
- Caraveo P
- Caraveo PA
- Carbognani F
- Carboni G
- Cardenas B Vargas
- Cardillo M
- Caria T
- Caride S
- Carlin JL
- Carney MF
- Caroff S
- Carosi A
- Carr J
- Carramiana A
- Carretti E
- Cartier R
- Caruso R
- Carver T
- Casadio C
- Casado A Lopez
- Casanova S
- Casanova S
- Casasola V
- Casella P
- Casentini C
- Casey J
- Casier M
- Castander FJ
- Castangia P
- Castellina A
- Castellon A
- Castellon JL Nilo
- Castillo J Alvarez
- Castillo M
- Castro JM Gonzalez
- Castro ML Diaz
- Castro-Tirado AJ
- Casu S
- Catalani F
- Cataldi G
- Cattaneo PW
- Caudill S
- Cavagli M
- Cavalier F
- Cavalieri R
- Cavazzuti E
- Cazon L
- Cella G
- Celli S
- Cenko SB
- Cepeda CB
- Cerd-Durn P
- Ceron JM Castro
- Cerretani G
- Cerruti M
- Cerutti AC Cobos
- Cesarini E
- Chakraborty N
- Chamberlin SJ
- Chambers KC
- Chan M
- Chandra P
- Chang S-W
- Chang Z
- Chao S
- Charlton P
- Chase E
- Chassande-Mottin E
- Chatterjee D
- Chatterjee D
- Chatziioannou K
- Chaves RCG
- Chavez AG
- Chavushyan V
- Cheeseboro BD
- Chekhtman A
- Chen A
- Chen G
- Chen HY
- Chen L
- Chen T-W
- Chen TX
- Chen X
- Chen Y
- Chen Y
- Chen YB
- Chen YP
- Chenevez J
- Cheng H-P
- Cherry ML
- Cheung CC
- Cheung E
- Chevalier J
- Chia H
- Chiang J
- Chiarusi T
- Chincarini A
- Chinellato JA
- Chirkin D
- Chiummo A
- Chmiel T
- Cho HS
- Cho M
- Choi C
- Choi J-S
- Chornock R
- Chow JH
- Christensen N
- Christov A
- Chu Q
- Chua AJK
- Chua S
- Chudoba J
- Chung AKW
- Chung S
- Ciani G
- Cikota A
- Ciolfi R
- Ciprini S
- Circella M
- Cirelli CE
- Cirone A
- Clara F
- Clark JA
- Clark K
- Clark P
- Clarke TE
- Classen L
- Clay RW
- Clearwater P
- Cleva F
- Cleveland WH
- Cline T
- Cobb BE
- Cocchieri C
- Coccia E
- Coelho JAB
- Coelho P
- Coenders S
- Cohadon P-F
- Cohen D
- Cohen-Tanugi J
- Colafrancesco S
- Colafrancesco S
- Colalillo R
- Colazo C
- Coleiro A
- Coleman A
- Colla A
- Collaboration ALMA
- Collaboration ANTARES
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- Collaboration CALET
- Collaboration DLT40
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- Collaboration IKI-GW Follow-up
- Collaboration Insight-Hxmt
- Collaboration IPN
- Collaboration KU
- Collaboration LOFAR
- Collaboration MASTER
- Collaboration Pi Sky
- Collaboration Pierre Auger
- Collaboration Swift
- Collaboration VINROUGE
- Collette CG
- Collica L
- Collin GH
- Colmenero E Romero
- Coluccia MR
- Cominsky LR
- Cominsky LR
- Conceicao R
- Concu R
- Condon B
- Coniglione R
- Connaughton V
- Conrad J
- Conrad JM
- Consolati G
- Consortium TZAC
- Constancio M
- Conti L
- Contreras F
- Cook DO
- Cook ER
- Cooke J
- Cooper MJ
- Cooper SJ
- Copperwheat C
- Corban P
- Corbitt TR
- Cordero-Carrion I
- Corley KR
- Cornish N
- Corongiu A
- Corral-Santana JM
- Corsi A
- Cortese S
- Costa CA
- Costa CF Da Silva
- Costa E
- Costa-Duarte MV
- Costantin D
- Costantini H
- Cotti U
- Cotzomi J
- Coughlin M
- Coughlin MW
- Coughlin SB
- Coulon J-P
- Coulter DA
- Countryman ST
- Courvoisier TJ-L
- Coutu S
- Couvares P
- Covas PB
- Covault CE
- Covino S
- Cowan EE
- Coward DM
- Coward DM
- Cowart MJ
- Cowen DF
- Cowperthwaite P
- Coyle P
- Coyne DC
- Coyne R
- Crawford S
- Creighton JDE
- Creighton TD
- Creusot A
- Cripe J
- Crisp H
- Crocce M
- Cronin J
- Cross R
- Crosse B
- Crowder SG
- Cucchiara A
- Cui W
- Cui WW
- Cullen TJ
- Cumming A
- Cunha CE
- Cunniffe R
- Cunningham L
- Cuoco A
- Cuoco E
- Cusumano G
- Cutter R
- Cwiek A
- Cwiok M
- Czyrkowski H
- D'Al A
- D'Amico F
- D'Amico S
- D'Ammando F
- D'Andrea CB
- D'Antonio S
- D'Avanzo P
- D'Elia V
- D'Olivo JC
- Da Costa LN
- Dabrowski R
- Dadina M
- Dal Canton T
- Daniel B
- Danilishin SL
- Danzmann K
- Dasgupta A
- Dasso S
- Dattilo V
- Daumiller K
- Dave I
- Davids ID
- Davier M
- Davis C
- Davis D
- Daw EJ
- Dawson BR
- Day B
- Day JA
- Day M
- De Almeida RM
- De Andre JPAM
- De Bonis G
- De Carvalho W Rodrigues
- De Cesare G
- De Cia A
- De Clercq C
- De Gois JS
- De Gregorio-Monsalvo I
- De Jong M
- De Jong SJ
- De la Fuente E
- De laurentis M
- De Leon C
- De Leon S Coutio
- De Mauro G
- De Mitri I
- De Naurois M
- de Oliveira C Mendes
- De Oliveira J
- De Oliveira MA Leigui
- de Oliveira R Lopes
- De Palma F
- De Pasquale M
- De Pietri R
- De Ridder S
- De Rosa R
- De Rossi C
- De Souza V
- De Ugarte-Postigo A
- De Varona O
- De Vries KD
- De Wasseige G
- De With M
- De K
- De S
- Debatin J
- Debra D
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- Drlica-Wagner A
- Drouhin D
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- Piro AL
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- Zywucka N
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Severe maternal morbidity and near misses in tertiary hospitals, Kelantan, Malaysia: a cross-sectional study
- Author
- A Halder
- A Mehrabadi
- A Pandey
- A Rana
- AJ Pacheco
- AS Parys Van
- BA Lawton
- DK Kaye
- DS Santana
- E Nelissen
- E Zanette
- EA Rocha Filho
- EA Rocha Filho
- EV Kuklina
- FA Lotufo
- FR Shen
- G Lobato
- GG Zeeman
- JG Cecatti
- JG Cecatti
- JL Shaw
- JP Souza
- JP Souza
- K Hill
- KE Fitzpatrick
- L Say
- L Say
- LP Galvao
- M Jabir
- M Knight
- M Tikkanen
- MAB Dias
- ML Morse
- Mohd Noor Norhayati
- Mohd Yacob Azman
- Nik Hussain Nik Hazlina
- NM Mello van
- O Tuncalp
- O Tuncalp
- OT Oladapo
- P Luexay
- R Ps
- RC Pacagnella
- RC Pattinson
- SB Mazhar
- SE Geller
- T Chaiworapongsa
- WM Callaghan
- WW Daniel
- Zaharah Sulaiman
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
- A Abou-Raya
- A Aljandali
- A Ambesi-Impiombato
- A Aydin
- A Balcerczyk
- A Besarab
- A Brzezinski
- A Campbell
- A Carrillo-Vico
- A Cavalli
- A Chattopadhyay
- A Chattopadhyay
- A Cherubini
- A Dey
- A Doms
- A Donovan
- A Donovan
- A Dávalos
- A Gaeta
- A Garny
- A Gnjec
- A Gomes
- A Gopalakrishnan
- A Hald
- A Henney
- A Hirayama
- A Hoffmann
- A Huber
- A Hugman
- A Iannetti
- A Ide-Ektessabi
- A Jacobs
- A Jeyabalan
- A Kahvejian
- A Karrar
- A Kasztler
- A Kibel
- A Kocyigit
- A Kotha
- A Kumral
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- A Lewén
- A Lotery
- A Maggio
- A Malek
- A Malik
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- A Matsuzawa
- A Mitra
- A Monge
- A Murakami
- A Murakami
- A Murakami
- A Murakami
- A Mutti
- A Nijnik
- A Nunomura
- A Nunomura
- A Patt
- A Persson
- A Pietrangelo
- A Piga
- A Pirat
- A Post
- A Pradhan
- A Protti
- A Rattner
- A Ravati
- A Rehman
- A Reynolds
- A Richmond
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- A Roetto
- A Rostom
- A Rumbold
- A Russo
- A Rötig
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- A Saltelli
- A Sandek
- A Sassano
- A Scalbert
- A Scalbert
- A Scalbert
- A Sica
- A Smahi
- A Sola
- A Stintzi
- A Szewczyk
- A Taguchi
- A Tedgui
- A Terman
- A Terman
- A Terman
- A Undas
- A Virdis
- A Wagner
- A Wagner
- A Wagner
- A Wagner
- A Wojas-Pelc
- A Wong
- A Xu
- A Yoritaka
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- Ad hoc committee on systemic lupus erythematosus response criteria for fatigue
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- T Amit
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- The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
- TJ Gibson
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- TK Kvien
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- U Eckstein-Ludwig
- U Heinz
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- U Schönbeck
- UN Das
- V Adam-Vizi
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- V Braun
- V Calabrese
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- V Campuzano
- V Curcin
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- XP Huang
- Y Almog
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- Y Wu
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- Y Zhao
- Y Zheng
- YE Henrotin
- YF Chu
- YH Lee
- YH Suh
- YH Wei
- YJ Surh
- YJ Surh
- YJ Surh
- YK Wu
- YM Kim
- YS Keum
- YS Sohn
- YX Ma
- YZ Fang
- Z Cai
- Z Cai
- Z Cheng
- Z Pei
- Z Serdar
- Z Tong
- Z Tong
- Z Yu
- Z Zhang
- ZD Liu
- ZD Liu
- ZE Karanjawala
- ZE Suntres
- ZI Cabantchik
- ZZ Chong
- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Ectopic pregnancy secondary to in vitro fertilisation-embryo transfer: pathogenic mechanisms and management strategies
- Author
- A Audebert
- A Baxi
- A Cohen
- A Cohen
- A Daponte
- A Karaer
- A Lass
- A Lass
- A Lass
- A Nazari
- A Pacchiarotti
- A Petrides
- A Revel
- A Wiser
- AA Milki
- AJ Headley
- AJ Stephens
- AL Waylen
- AR Hagemann
- AS Kathiresan
- AW Horne
- AW Horne
- AW Horne
- B Almog
- B Asimakopoulos
- B Coroleu
- B Huang
- B Kumbak
- B Oriol
- B Refaat
- B Refaat
- Bassem Refaat
- BE Friedman
- BP Katz
- BS Shapiro
- BS Shapiro
- C Chojenta
- C Li
- C Mitchell
- C Schippert
- C Shen
- CB Benson
- CC Lawler
- CE Boots
- CJ Stern
- CJ Wang
- CM Howles
- CR Givens
- D Desai
- D Galliano
- D Jurkovic
- D Mavrelos
- DA Keegan
- DM Kissin
- E Khalifa
- E Kirk
- E Kirk
- E Kirk
- E Kirk
- E Kirk
- E Newbatt
- EA Bachman
- EA El Hakim
- EA El Hakim
- ED Na
- Elizabeth Dalton
- F Azem
- F Mol
- F Mol
- F Uysal
- FG Ugurlucan
- FS Karipcin
- G Bogdanskiene
- G Ertzeid
- G Lockwood
- G Nargund
- G Oron
- G Wu
- GM Chambers
- GN Cecchino
- GS Ghazeeri
- H Fernandez
- H Kaur
- H Murray
- HB Clayton
- HB Clayton
- HJ Chang
- HR Park
- I Casikar
- I Uyar
- IE Timor-Tritsch
- IM Usta
- J Chai
- J Nathorst-Boos
- J Tal
- J Wang
- J Yeh
- JF McLaren
- JF McLaren
- JH Cho
- JL Allison
- JL Pouly
- JL Shaw
- JL Shaw
- JM Eom
- JW Kim
- K Hancke
- K Litwicka
- K Litwicka
- K Singh
- K Talbot
- KE Dillon
- KM Perkins
- KS Khan
- KT Barnhart
- KV Newby
- L Ni
- L Qin
- L Savelli
- L Sentilhes
- L Stadtmauer
- L Wang
- L Zhu
- L Zhu
- LA Wallace
- LC Demirel
- LL Wang
- LP Smith
- LY Kao
- M Agdi
- M Alvarez
- M Eftekhar
- M Epee-Bekima
- M Gradison
- M Kazandi
- M Malak
- M Patil
- M Prorocic
- M Sezik
- M Skubisz
- M Weigert
- MH Addar
- MJ Hill
- MM Skubisz
- MN Mascarenhas
- MS Hendricks
- MS Kamath
- MV Hjordt Hansen
- N Job-Spira
- N Johnson
- N Low
- NM Van Mello
- NM Van Mello
- O Eytan
- O Ishihara
- O Yoshino
- P Chaudhary
- P Dar
- P Lesny
- P Lesny
- P Rana
- P Talbot
- PC Steptoe
- PC Steptoe
- PO Cenksoy
- Q Zhang
- R Grady
- R Malhotra
- R Orvieto
- R Orvieto
- R Shao
- R Shao
- R Shao
- R Shao
- R Yamamoto
- RR Li
- S Al-Hasani
- S Guha
- S Jakus
- S Parashi
- S Sahin
- S Tong
- SA Bora
- SF Marcus
- SH Jun
- SL Fisher
- SP Rodrigues
- SS Wang
- T Allersma
- T Aust
- T Fukuda
- T Krishnan
- T Maltaris
- TA Gelbaya
- U Verma
- V Akande
- V Knutzen
- V Rovei
- VL Baker
- VN Sivalingam
- W Xi
- William L Ledger
- WL Risser
- X Luo
- XH Li
- XJ Yang
- XP Ye
- Y Wang
- Y Yu
- YJ Lin
- YL Zhang
- YL Zhang
- Z Jia-Rong
- Z Khan
- Z OuYang
- Z Pandian
- Z Wu
- ZY Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Diminishing benefits of urban living for children and adolescents’ growth and development
- Author
- Abarca-Gómez L
- Abdeen ZA
- Abdrakhmanova S
- Abdul Rahim HF
- Abdurrahmonova Z
- Abril GL
- Abu-Rmeileh NM
- Acosta-Cazares B
- Adam I
- Adamczyk M
- Adams RJ
- Adu-Afarwuah S
- Aekplakorn W
- Afsana K
- Afzal S
- Agbor VN
- Agdeppa IA
- Aghazadeh-Attari J
- Aguenaou H
- Aguilar-Salinas CA
- Agyemang C
- Ahmad MH
- Ahmad NA
- Ahmadi A
- Ahmadi N
- Ahmadi N
- Ahmed I
- Ahmed SH
- Ahrens W
- Aitmurzaeva G
- Ajlouni K
- Al Hourani HM
- Al Qaoud NM
- Al-Hazzaa HM
- Al-Lahou B
- Al-Raddadi R
- Alarouj M
- AlBuhairan F
- AlDhukair S
- Aldwairji MA
- Alexius S
- Ali MM
- Alkandari A
- Alkerwi A
- Alkhatib BM
- Allin K
- Alvarez-Pedrerol M
- Aly E
- Amarapurkar DN
- Amoah J
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- Amouyel P
- Andersen LB
- Anderssen SA
- Androutsos O
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- Aseffa N
- Aspelund T
- Assah FK
- Assembekov B
- Assunção MCF
- Aung MS
- Auvinen J
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- Azizi F
- Azmin M
- Babu BV
- Baharudin A
- Bahijri S
- Bakacs M
- Baker JL
- Balakrishna N
- Balanova Y
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- Banach M
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- Bao TQ
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- Barceló A
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- Batista AP
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- Bere E
- Bergh IH
- Berhane Y
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- Bernabe-Ortiz A
- Bernotiene G
- Bettiol H
- Beutel ME
- Beybey AF
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- Bhargava SK
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- Bista B
- Bixby H
- Bjelica DJ
- Bjerregaard AA
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- Boddy LM
- Boehm BO
- Boer JMA
- Boggia JG
- Bogova E
- Boissonnet CP
- Bojesen SE
- Boker LK
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- Bongard V
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- Bovet P
- Boymatova K
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- Braeckman L
- Bragt MCE
- Brajkovich I
- Branca F
- Braunerová RT
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- Breda J
- Brenner H
- Brewster LM
- Brian GR
- Briceño Y
- Brinduse L
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- Cacciottolo J
- Cadena LH
- Cai H
- Caixeta RB
- Cama T
- Cameron C
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- Capuano E
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- Cheng C-Y
- Cheng YJ
- Cheraghian B
- Chetrit A
- Chikova-Iscener E
- Chinapaw MJM
- Chinnock A
- Chiolero A
- Chiou S-T
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- Christofaro DG
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AbstractOptimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.</jats:p
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