High sibling correlation on methylphenidate response but no association with DAT1-10R homozygosity in Dutch sibpairs with ADHD.

Contains fulltext : 47717.pdf (publisher's version ) (Closed access)BACKGROUND: A minority of patients with attention-deficit hyperactivity disorder (ADHD) do not respond favorably to methylphenidate. This has been partially associated with homozygosity for the Dopamine transporter (DAT1) 10-repeat allele and the presence of one or two Dopamine D4 receptor (DRD4) 7-repeat alleles. This study examined the sibling correlation of methylphenidate response rate and the possible association between response rate and these risk alleles. METHODS: A sample of 82 Dutch children with ADHD, from 54 families, (including 30 singletons and 28 sib pairs), who used methylphenidate, was phenotyped according to DSM-IV criteria. Patients were members of affected sib pairs and were genotyped for DAT1 and DRD4. The sibling Intraclass Correlation Coefficient for methylphenidate response rate was calculated. The association between individual response rates and the risk alleles was examined using linear regression techniques. RESULTS: The Intraclass Correlation Coefficient was significant (r=.563, p=.001). No evidence was found establishing an association between methylphenidate response and DAT1-homozygosity. There was a positive trend towards association with the presence of one or two DRD4-7R alleles. CONCLUSIONS: The sibling correlation may indicate a familial clustering of methylphenidate response. This response is possibly associated with the presence of one or two alleles at the DRD4-7R locus, but not with DAT1-10R homozygosity in the Dutch population

User-Centered Innovation and Regulatory Framework: Energy Prosumerss Market Access in EU Regulation

European energy consumers who previously had a rather passive, consuming role, and were confronted with top-down determined energy supply options, services, as well as prices, are now assuming a more proactive role, in some cases becoming prosumers of energy. Originally the focus of both individual and collective prosumers has been on local sustainable energy production. However currently the focus is slowly shifting to both own production and own consumption of local sustainable energy, as well as to participation in the local and national market (e.g. supplying energy to one’s neighbors or to one’s family residing in a different region). As technology progresses and the formats of market design evolve, the problem of ‘regulatory disconnection’ could arise, meaning that the existent regulatory framework might not be ‘fit for purpose’ any longer due to its disconnection from rapidly developing innovation. In such cases the existing regulatory framework (perhaps unintentionally) represent obstacles for (further) development of the local energy in Europe. In the current research we focus on the specific type of innovation, and namely user-centered innovation by the local sustainable energy collectives, illustrated by the transactions between individual and collective prosumers of the local energy, be it peer-to-peer transactions or interaction with national energy market players, e.g. energy suppliers. In order to perform such transactions, prosumers necessitate market access. The issue of prosumers’ market access is used as a case study in order to test current degree of ‘fit’ between the European regulatory framework on one hand and innovation in the energy sector on the other hand

Smart design rules for smart grids: analysing local smart grid development through an empirico-legal institutional lens

Background This article entails an innovative approach to smart grid technology implementation, as it connects governance research with legal analysis. We apply the empirico-legal ‘ILTIAD framework’, which combines Elinor Ostrom’s Institutional Analysis and Development (IAD) framework with institutional legal theory (ILT), to an empirical case study of a local smart grid project. Methods Empirical data were collected in an exploratory, descriptive example study of a single case, focusing on the Action Situation and interactions towards establishing a local Smart Grid. The case was chosen because of its complexity, following the ‘logic of intensity sampling’. Data triangulation took place combining participatory observation, semi-structured interviews, and document analysis. Results Through an exploratory case study, we showed how the ILTIAD framework can help reduce complexity in local decision-making processes on smart grid implementation, as it allows for analytical description and prescriptive design of local smart grid systems. In the analysis we addressed ownership arrangements and contracts and identified barriers and opportunities for realizing a local smart grid system. The design part includes a scenario which revealed the prescribed patterns of behaviour (liberties and abilities) and the consequential aspects that apply to each situation. Conclusions Analysing and designing normative alignment ex ante to the planning and implementation of a smart grid system provides clarity to stakeholders about their current opportunities. For this reason, the ILTIAD framework can be used as a design guideline for establishing new and integrated smart grid projects

A Practical Approach to the Treatment of Low-Risk Childhood Fever

Fever is a common symptom of childhood infections that in itself does not require treatment. The UK’s National Institute for Health and Care Excellence (NICE) advises home-based antipyretic treatment for low-risk feverish children only if the child appears distressed. The recommended antipyretics are ibuprofen or paracetamol (acetaminophen). They are equally recommended for the distressed, feverish child; therefore, healthcare professionals, parents and caregivers need to decide which of these agents to administer if the child is distressed. This narrative literature review examines recent data on ibuprofen and paracetamol in feverish children to determine any clinically relevant differences between these agents. The data suggest that these agents have similar safety profiles in this setting and in the absence of underlying health issues, ibuprofen seems to be more effective than paracetamol at reducing NICE’s treatment criterion, ‘distress’ (as assessed by discomfort levels, symptom relief, and general behavior)

The challenging paradigm of interrelated energy systems towards a more sustainable future

This paper brings together several contemporary topics in energy systems aiming to provide a literature review based reflection on how several interrelated energy systems can contribute together to a more sustainable world. Some directions are discussed, such as the improvement of the energy efficiency and environmental performance of systems, the development of new technologies, the increase of the use of renewable energy sources, the promotion of holistic and multidisciplinary studies, and the implementation of new management rules and "eco-friendly and sustainable" oriented policies at different scales. The interrelations of the diverse energy systems are also discussed in order to address their main social, economic and environmental impacts. The subjects covered include the assessment of the electricity market and its main players (demand, supply, distribution), the evaluation of urban systems (buildings, transportation, commuting), the analysis of the implementation of renewable energy cooperatives, the discussion of the diffusion of the electric vehicle and the importance of new bioenergy systems. This paper also presents relevant research carried out in the framework of the Energy for Sustainability (EfS) Initiative of the University of Coimbra, linking the reviewed areas to the multidisciplinary approach adopted by the EfS Initiative. To conclude, several research topics that should be addressed in the near future are proposed