Nuevas aportaciones sobre el escultor Cosme Velázquez (1755-1837)

El escultor logroñés Cosme Velázquez fue una figura destacadas del arte en Cádiz entre los siglos XVIII y XIX. Fue un artista fecundo que participó en muchas obras realizadas en la ciudad y trabajó como profesor de escultura de la Escuela de Nobles Artes de Cádiz, transmitiendo el estilo academicista que él había adquirido en la Real Academia de Bellas Artes de San Fernando. Este artículo añade nuevos datos sobre su infancia y juventud, así como la atribución de una nueva obra en la localidad riojana de Navarrete, que ayuda a perfilar aún más el estilo artístico de este escultor.

New contributions to the sculptor Cosme Velázquez (1755-1837)

El escultor logroñés Cosme Velázquez fue una figura destacadas del arte en Cádiz entre los siglos XVIII y XIX. Fue un artista fecundo que participó en muchas obras realizadas en la ciudad y trabajó como profesor de escultura de la Escuela de Nobles Artes de Cádiz, transmitiendo el estilo academicista que él había adquirido en la Real Academia de Bellas Artes de San Fernando. Este artículo añade nuevos datos sobre su infancia y juventud, así como la atribución de una nueva obra en la localidad riojana de Navarrete, que ayuda a perfilar aún más el estilo artístico de este escultor.The sculptor Cosme Velázquez, born in Logroño (La Rioja), was an important artist who lived in Cádiz during the XVIIIth and XIXth centuries. He worked in a large number of sculptures of that city and he taught at the Fine Arts School of Cádiz, where he transmitted the academic style that he has learned in the Royal Academy of Fine Arts of Madrid. This article adds new information about his childhood and youth. Besides, it introduces a new work placed in Navarrete (La Rioja), which helps to know better the artistic style of this sculptor

La biblioteca del arquitecto Francisco Alejo de Aranguren (1739-1785)

Francisco Alejo de Aranguren fue un arquitecto en activo en La Rioja, País Vasco, Navarra y Burgos durante la segunda mitad del siglo XVIII. Los libros que poseía fueron inventariados, consignándose noventa libros, de los que un 36% se corresponden con cuestiones de su oficio (tanto arquitectura como matemáticas), un 30% son libros religiosos y el resto muestran intereses variados que van desde la literatura o la esgrima a las ciencias o la economía. Además, en ella conviven un incipiente interés por autores extranjeros y obras académicas con tendencias de carácter aún conservador

Las tres defensas de Logroño (1335, 1521 y 1808)

Logroño ha vivido a lo largo de su historia tres defensas significativas frente a tropas atacantes: en 1335, 1521 y 1808. De ellas, la más conocida es la de 1521, cuya conmemoración se sigue celebrando anualmente cada 11 de junio. Sin embargo, en 1805, la defensa de 1335, protagonizada por Rui Díaz de Gaona, fue propuesta como tema en el concurso de la Real Academia de San Fernando. En este artículo analizamos las causas de esta elección para, a continuación, rastrear en la prensa de Logroño los motivos por los que este suceso acabó cayendo casi en el olvido ante la fama del sitio de 1521. La conclusión será que este último, por su carácter comunitario y popular, era un modelo cívico más apropiado que el ejemplo de valor individual del Capitán Gaona

Implementación del método del caso en docencia virtual para asignaturas prácticas y teóricas del Grado en Química y del Grado en Ingeniería Química de la Facultad de Ciencias Químicas

Memoria ID-0073. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2014-2015

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Funder: Funder: Fundación bancaria ‘La Caixa’ Number: LCF/PR/PR16/51110003 Funder: Grifols SA Number: LCF/PR/PR16/51110003 Funder: European Union/EFPIA Innovative Medicines Initiative Joint Number: 115975 Funder: JPco-fuND FP-829-029 Number: 733051061Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Combined searches for the production of supersymmetric top quark partners in proton-proton collisions at root s=13 TeV

A combination of searches for top squark pair production using proton-proton collision data at a center-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 137 fb(-1) collected by the CMS experiment, is presented. Signatures with at least 2 jets and large missing transverse momentum are categorized into events with 0, 1, or 2 leptons. New results for regions of parameter space where the kinematical properties of top squark pair production and top quark pair production are very similar are presented. Depending on themodel, the combined result excludes a top squarkmass up to 1325 GeV for amassless neutralino, and a neutralinomass up to 700 GeV for a top squarkmass of 1150 GeV. Top squarks with masses from 145 to 295 GeV, for neutralino masses from 0 to 100 GeV, with a mass difference between the top squark and the neutralino in a window of 30 GeV around the mass of the top quark, are excluded for the first time with CMS data. The results of theses searches are also interpreted in an alternative signal model of dark matter production via a spin-0 mediator in association with a top quark pair. Upper limits are set on the cross section for mediator particle masses of up to 420 GeV

Measurement of the W gamma Production Cross Section in Proton-Proton Collisions at root s=13 TeV and Constraints on Effective Field Theory Coefficients

A fiducial cross section for W gamma production in proton-proton collisions is measured at a center-of-mass energy of 13 TeV in 137 fb(-1) of data collected using the CMS detector at the LHC. The W -> e nu and mu nu decay modes are used in a maximum-likelihood fit to the lepton-photon invariant mass distribution to extract the combined cross section. The measured cross section is compared with theoretical expectations at next-to-leading order in quantum chromodynamics. In addition, 95% confidence level intervals are reported for anomalous triple-gauge couplings within the framework of effective field theory.Peer reviewe