Phenotypic and genotypic characterization of lumbosacral stenosis in Labrador retrievers

Lumbosacral stenosis (LS) is a structural narrowing of the spinal canal in the canine lumbosacral spine. Large-sized working and sporting dog breeds such as Labrador retrievers are predisposed for reasons that are incompletely understood. Early diagnosis is essential for maximizing the quality of life, and minimizing the likelihood of early retirement in working dogs. Lumbosacral stenosis is usually considered to be a condition associated with degenerative changes observed with normal aging, however presence of the disease in young and middle aged working dogs has also been reported. This leads to the probable theory that some dogs in large breeds like Labrador retrievers might be genetically pre-disposed to LS.;Radiographic screening is common practice for agencies that purchase, train, and use working dogs. Dogs with morphologic traits such as canine hip dysplasia, canine elbow dysplasia, and transitional lumbosacral vertebrae are commonly rejected. However radiographs are insensitive for detecting LS. Advanced imaging methods such as computed tomography (CT) and magnetic resonance imaging (MRI) and the current standard diagnostic tests for detection of LS. These modalities are considered to be complimentary, with each offering different strengths for visualization of bony and soft tissue structures. For working dogs, computed tomography offers advantages of greater availability and the faster scanning times that allow the use of reversible sedation. Qualitative CT phenotyping is a standard method for clinical diagnosis of LS in dogs. However, for research purposes, a method for quantitative phenotyping of LS would also be beneficial. There is a lack of published evidence for a consensus on any such quantitative CT phenotypic traits in humans or dogs. In the first study, we developed one such quantitative trait using CT imaging in a sample of 25 Labrador retrievers---fat area ratio or FAR (ratio of the vertebral canal fat area content in a transverse slice to the vertebral body area in the same transverse slice). This measurement was found to have good agreement with the standard qualitative assessment of LS (as made by a certified veterinary radiologist); and we propose that FAR can be used to quantify LS especially in a research capacity.;Lumbar spinal stenosis (LSS) is a human condition that is often considered to be orthologous to canine LS. Genetic studies in humans have shown promise in identification of possible genetic factors that might be associated with LSS. The predominant genetic approach for research in canine LS has been pedigree analysis especially in the German shepherds; but no genetic association studies have been reported in any breed. The second study of the project was an attempt at the investigation into the genetic characteristics of LS in Labrador retrievers. To do so we analyzed the exome of 8 young Labrador retrievers---4 positive for LS and 4 negative for LS, from a pool of 40 Labrador retrievers in the US military working dog (MWD) program. The FAR measurement (from previous retrospective study in 25 dogs) was used for quantitative phenotyping of the 40 dogs (as well as qualitative CT phenotyping); followed by the selection of 8 dogs best representing the extremes of the phenotype---LS affected and LS unaffected. We were able to identify 3 genes---TTR (Transthyretin), FOLR2 (Folate Receptor 2) and USP9X (Ubiquitin Specific Peptidase 9, X-linked)---that could possibly be associated with canine LS. However, follow-up analysis is necessary to determine the true nature of the relationship between these genes and LS in Labrador retrievers. These 3 genes could potentially be new candidate genes for canine LS---not just in Labrador retrievers but also in other affected breeds. Further studies are also needed to investigate the role of these candidate genes in human LSS. The inability of LS in getting detected by simple radiographs is a major disadvantage for the agencies that procure, train and employ working dogs like the military and transportation safety authority. This necessitates the identification of genetic marker/s of LS that could then possibly be developed into simple diagnostic tests. And if certain breeds are indeed genetically predisposed, these diagnostic tests could perhaps even become standard screening protocol during the acquisition of these dogs. Labrador retrievers are loyal, kind, and intelligent breed of dogs; with greatly versatile applications beneficial to humans. Even though other breeds are used as working dogs around the world, Labrador retrievers cannot be easily replaced and the demand for this breed has been steadily increasing. A possible genetic test that can identify genetic predisposition to LS in young Labrador retrievers that might become working dogs can significantly improve the procurement process. And if reasons behind early occurrence of LS were premature degenerative changes instead, early detection would mean preventative conditioning training protocols and better therapeutic treatments. (Abstract shortened by UMI.)

Modelling observable signatures of jet-ISM interaction: thermal emission and gas kinematics

Relativistic jets are believed to have a substantial impact on the gas dynamics and evolution of the interstellar medium (ISM) of their host galaxies. In this paper, we aim to draw a link between the simulations and the observable signatures of jet-ISM interactions by analyzing the emission morphology and gas kinematics resulting from jet-induced shocks in simulated disc and spherical systems. We find that the jet-induced laterally expanding forward shock of the energy bubble sweeping through the ISM causes large-scale outflows, creating shocked emission and high-velocity dispersion in the entire nuclear regions ($\sim2$ kpcs) of their hosts. The jetted systems exhibit larger velocity widths (> 800 km/s), broader Position-Velocity maps and distorted symmetry in the disc's projected velocities than systems without a jet. We also investigate the above quantities at different inclination angles of the observer with respect to the galaxy. Jets inclined to the gas disc of its host are found to be confined for longer times, and consequently couple more strongly with the disc gas. This results in prominent shocked emission and high-velocity widths, not only along the jet's path, but also in the regions perpendicular to them. Strong interaction of the jet with a gas disc can also distort its morphology. However, after the jets escape their initial confinement, the jet-disc coupling is weakened, thereby lowering the shocked emission and velocity widths.Comment: Matches the Published versio

Anticipatory anti-colonial writing in R.K. Narayan's Swami and Friends and Mulk Raj Anand's Untouchable

This article uses the term “anticipatory anti-colonial writing” to discuss the workings of time in R.K. Narayan’s Swami and Friends and Mulk Raj Anand’s Untouchable. Both these first novels were published in 1935 with the support of British literary personalities (Graham Greene and E.M. Forster respectively) and both feature young protagonists who, in contrasting ways, are engaged in Indian resistance to colonial rule. This study examines the difference between Narayan’s local, though ironical, resistance to the homogenizing temporal demands of empire and Anand’s awkwardly modernist, socially committed vision. I argue that a form of anticipation that explicitly looks forward to decolonization via new and transnational literary forms is a crucial feature of Untouchable that is not found in Swami and Friends, despite the latter’s anti-colonial elements. Untouchable was intended to be a “bridge between the Ganges and the Thames” and anticipates postcolonial negotiations of time that critique global inequalities and rely upon the multidirectional global connections forged by modernism

May Measurement Month 2018: a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension

Aims Raised blood pressure (BP) is the biggest contributor to mortality and disease burden worldwide and fewer than half of those with hypertension are aware of it. May Measurement Month (MMM) is a global campaign set up in 2017, to raise awareness of high BP and as a pragmatic solution to a lack of formal screening worldwide. The 2018 campaign was expanded, aiming to include more participants and countries. Methods and results Eighty-nine countries participated in MMM 2018. Volunteers (≥18 years) were recruited through opportunistic sampling at a variety of screening sites. Each participant had three BP measurements and completed a questionnaire on demographic, lifestyle, and environmental factors. Hypertension was defined as a systolic BP ≥140 mmHg or diastolic BP ≥90 mmHg, or taking antihypertensive medication. In total, 74.9% of screenees provided three BP readings. Multiple imputation using chained equations was used to impute missing readings. 1 504 963 individuals (mean age 45.3 years; 52.4% female) were screened. After multiple imputation, 502 079 (33.4%) individuals had hypertension, of whom 59.5% were aware of their diagnosis and 55.3% were taking antihypertensive medication. Of those on medication, 60.0% were controlled and of all hypertensives, 33.2% were controlled. We detected 224 285 individuals with untreated hypertension and 111 214 individuals with inadequately treated (systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg) hypertension. Conclusion May Measurement Month expanded significantly compared with 2017, including more participants in more countries. The campaign identified over 335 000 adults with untreated or inadequately treated hypertension. In the absence of systematic screening programmes, MMM was effective at raising awareness at least among these individuals at risk

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good

Juxtaposing BTE and ATE – on the role of the European insurance industry in funding civil litigation

One of the ways in which legal services are financed, and indeed shaped, is through private insurance arrangement. Two contrasting types of legal expenses insurance contracts (LEI) seem to dominate in Europe: before the event (BTE) and after the event (ATE) legal expenses insurance. Notwithstanding institutional differences between different legal systems, BTE and ATE insurance arrangements may be instrumental if government policy is geared towards strengthening a market-oriented system of financing access to justice for individuals and business. At the same time, emphasizing the role of a private industry as a keeper of the gates to justice raises issues of accountability and transparency, not readily reconcilable with demands of competition. Moreover, multiple actors (clients, lawyers, courts, insurers) are involved, causing behavioural dynamics which are not easily predicted or influenced. Against this background, this paper looks into BTE and ATE arrangements by analysing the particularities of BTE and ATE arrangements currently available in some European jurisdictions and by painting a picture of their respective markets and legal contexts. This allows for some reflection on the performance of BTE and ATE providers as both financiers and keepers. Two issues emerge from the analysis that are worthy of some further reflection. Firstly, there is the problematic long-term sustainability of some ATE products. Secondly, the challenges faced by policymakers that would like to nudge consumers into voluntarily taking out BTE LEI