Potential automorphy of certain non self-dual 3-dimensional Galois representations

In a series of papers, van Geemen and Top have defined a family of surfaces $S_z$ indexed by a nonzero integer parameter $z$, and a compatible family of 3-dimensional Galois representations over \Q(i) attached to each surface. In this note we use recent advancements in potential automorphy and automorphy lifting to show that these compatible families are potentially automophic for all values of $z$, and hence that their L-functions have analytic continuation and a functional equation

Tumor-derived exosomes confer antigen-specific immunosuppression in a murine delayed-type hypersensitivity model

Exosomes are endosome-derived small membrane vesicles that are secreted by most cell types including tumor cells. Tumor-derived exosomes usually contain tumor antigens and have been used as a source of tumor antigens to stimulate anti-tumor immune responses. However, many reports also suggest that tumor-derived exosomes can facilitate tumor immune evasion through different mechanisms, most of which are antigen-independent. In the present study we used a mouse model of delayed-type hypersensitivity (DTH) and demonstrated that local administration of tumor-derived exosomes carrying the model antigen chicken ovalbumin (OVA) resulted in the suppression of DTH response in an antigen-specific manner. Analysis of exosome trafficking demonstrated that following local injection, tumor-derived exosomes were internalized by CD11c+ cells and transported to the draining LN. Exosome-mediated DTH suppression is associated with increased mRNA levels of TGF-β1 and IL-4 in the draining LN. The tumor-derived exosomes examined were also found to inhibit DC maturation. Taken together, our results suggest a role for tumor-derived exosomes in inducing tumor antigen-specific immunosuppression, possibly by modulating the function of APCs. © 2011 Yang et al

The Beyond the Standard Model Working Group: Summary Report

Report of the "Beyond the Standard Model" working group for the Workshop `Physics at TeV Colliders', Les Houches, France, 21 May - 1 June 2001. It consists of 18 separate parts: 1. Preface; 2. Theoretical Discussion; 3. Numerical Calculation of the mSUGRA and Higgs Spectrum; 4. Theoretical Uncertainties in Sparticle Mass Predictions; 5. High Mass Supersymmetry with High Energy Hadron Colliders; 6. SUSY with Heavy Scalars at LHC; 7. Inclusive Study of MSSM in CMS; 8. Establishing a No-Lose Theorem for NMSSM Higgs Boson Discovery at the LHC; 9. Effects of Supersymmetric Phases on Higgs Production in Association with Squark Pairs in the Minimal Supersymmetric Standard Model; 10. Study of the Lepton Flavour Violating Decays of Charged Fermions in SUSY GUTs; 11. Interactions of the Goldstino Supermultiplet with Standard Model Fields; 12. Attempts at Explaining the NuTeV Observation of Di-Muon Events; 13. Kaluza-Klein States of the Standard Model Gauge Bosons: Constraints From High Energy Experiments; 14. Kaluza-Klein Excitations of Gauge Bosons in the ATLAS Detector; 15. Search for the Randall Sundrum Radion Using the ATLAS Detector; 16. Radion Mixing Effects on the Properties of the Standard Model Higgs Boson; 17. Probing Universal Extra Dimensions at Present and Future Colliders; 18. Black Hole Production at Future Colliders.Report of the Beyond the Standard Model working group for the Workshop `Physics at TeV Colliders', Les Houches, France, 21 May - 1 June 2001. It consists of 18 separate parts: 1. Preface: 2. Theoretical Discussion: 3. Numerical Calculation of the mSUGRA and Higgs Spectrum: 4. Theoretical Uncertainties in Sparticle Mass Predictions: 5. High Mass Supersymmetry with High Energy Hadron Colliders: 6. SUSY with Heavy Scalars at LHC: 7. Inclusive Study of MSSM in CMS: 8. Establishing a No-Lose Theorem for NMSSM Higgs Boson Discovery at the LHC: 9. Effects of Supersymmetric Phases on Higgs Production in Association with Squark Pairs in the Minimal Supersymmetric Standard Model: 10. Study of the Lepton Flavour Violating Decays of Charged Fermions in SUSY GUTs: 11. Interactions of the Goldstino Supermultiplet with Standard Model Fields: 12. Attempts at Explaining the NuTeV Observation of Di-Muon Events: 13. Kaluza-Klein States of the Standard Model Gauge Bosons: Constraints From High Energy Experiments: 14. Kaluza-Klein Excitations of Gauge Bosons in the ATLAS Detector: 15. Search for the Randall Sundrum Radion Using the ATLAS Detector: 16. Radion Mixing Effects on the Properties of the Standard Model Higgs Boson: 17. Probing Universal Extra Dimensions at Present and Future Colliders: 18. Black Hole Production at Future Colliders

IκBβ acts to inhibit and activate gene expression during the inflammatory response

The activation of pro-inflammatory gene programs by nuclear factor-κB (NF-κB) is primarily regulated through cytoplasmic sequestration of NF-κB by the inhibitor of κB (IκB) family of proteins1. IκBβ, a major isoform of IκB, can sequester NF-κB in the cytoplasm2, although its biological role remains unclear. Although cells lacking IκBβ have been reported3, 4, in vivo studies have been limited and suggested redundancy between IκBα and IκBβ5. Like IκBα, IκBβ is also inducibly degraded; however, upon stimulation by lipopolysaccharide (LPS), it is degraded slowly and re-synthesized as a hypophosphorylated form that can be detected in the nucleus6, 7, 8, 9, 10, 11. The crystal structure of IκBβ bound to p65 suggested this complex might bind DNA12. In vitro, hypophosphorylated IκBβ can bind DNA with p65 and c-Rel, and the DNA-bound NF-κB:IκBβ complexes are resistant to IκBα, suggesting hypophosphorylated, nuclear IκBβ may prolong the expression of certain genes9, 10, 11. Here we report that in vivo IκBβ serves both to inhibit and facilitate the inflammatory response. IκBβ degradation releases NF-κB dimers which upregulate pro-inflammatory target genes such as tumour necrosis factor-α (TNF-α). Surprisingly, absence of IκBβ results in a dramatic reduction of TNF-α in response to LPS even though activation of NF-κB is normal. The inhibition of TNF-α messenger RNA (mRNA) expression correlates with the absence of nuclear, hypophosphorylated-IκBβ bound to p65:c-Rel heterodimers at a specific κB site on the TNF-α promoter. Therefore IκBβ acts through p65:c-Rel dimers to maintain prolonged expression of TNF-α. As a result, IκBβ^(−/−) mice are resistant to LPS-induced septic shock and collagen-induced arthritis. Blocking IκBβ might be a promising new strategy for selectively inhibiting the chronic phase of TNF-α production during the inflammatory response

Riittääkö, että opettaja on motivoitunut?

Tämän tutkimuksen tarkoituksena oli selvittää, mitkä asiat vaikuttavat varhaiskasvatuksen opettajien motivaatioon ja millä tavalla varhaiskasvatuksen opettajien psykologiset perustarpeet täyttyvät heidän työssään. Tässä tutkimuksessa varsinaisia tutkimuskysymyksiä oli kaksi: 1. Mikä varhaiskasvatuksen opettajia motivoi työssään? ja 2. Millä tavalla varhaiskasvatuksen opettajien psykologiset perustarpeet täyttyvät työssä? Tämän tutkimuksen teoreettisena viitekehyksenä toimivat Decin ja Ryanin itsemääräämisteoria ja Maslow’n tarvehierarkia. Tutkimus toteutettiin puolistrukturoiduilla yksilöhaastatteluilla. Haastateltavana oli neljä varhaiskasvatuksen opettajaa, jotka työskentelivät samassa yksikössä, mutta olivat keskenään erilaisissa ryhmissä. Haastatteluvastaukset analysoitiin teorialähtöisellä analyysillä. Tulosten mukaan varhaiskasvatuksen opettajien motivaation orientaatiolaji oli autonominen motivaatio. Varhaiskasvatuksen opettajat pitivät työnsä sisältöä mielekkäänä, mikä edesauttoi arvoihin ja tavoitteisiin sitoutumista. Motivaatiota heikentäviksi tekijöiksi sanoitettiin sellaisia asioita, kuten vajaavaiset resurssit niin henkilöstössä, kuin materiaalissakin, yhteiskunnallisen ja rahallisen arvostuksen puute, sekä yksikön arvojen piiloon jääminen. Varhaiskasvatuksen opettajien psykologiset perustarpeet täyttyivät vaihtelevasti. Haastateltavat eivät kyenneet luomaan turvallisuudentunnetta itselleen työstä saatavalla rahallisella korvauksella, elleivät olleet erityisen säästäväisiä. Jokainen haastateltavista koki me-henkeä oman tiiminsä kanssa, mutta ei koko yksikön kesken. Suurin osa haastateltavista tunsi saavansa tarpeeksi arvostusta työstänsä, mutta samalla enemmistö myös tunsi, ettei heidän täysi potentiaalinsa toteudu heidän nykyisessä työssään. Tämä tutkimus toi esiin sen, millä tasolla varhaiskasvatuksen opettajien motivaatio oli, ja miten heidän psykologiset perustarpeensa täyttyvät työssään. Tämän tutkimuksen tulokset eivät kuitenkaan ole yleistettävissä pienen otannan takia

Search for light bosons in decays of the 125 GeV Higgs boson in proton-proton collisions at root s=8 TeV

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Search for heavy gauge W ' bosons in events with an energetic lepton and large missing transverse momentum at root s=13TeV

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Search for massive resonances decaying in to WW,WZ or ZZ bosons in proton-proton collisions at root s=13 TeV

Peer reviewe

Search for narrow resonances in dilepton mass spectra in proton-proton collisions at sqrt(s) = 13 TeV and combination with 8 TeV data

A search for narrow resonances in dielectron and dimuon invariant mass spectra has been performed using data obtained from proton–proton collisions at View the MathML sources=13 TeV collected with the CMS detector. The integrated luminosity for the dielectron sample is 2.7 fb−1 and for the dimuon sample 2.9 fb−1. The sensitivity of the search is increased by combining these data with a previously analyzed set of data obtained at View the MathML sources=8 TeV and corresponding to a luminosity of 20 fb−1. No evidence for non-standard-model physics is found, either in the 13 TeV data set alone, or in the combined data set. Upper limits on the product of production cross section and branching fraction have also been calculated in a model-independent manner to enable interpretation in models predicting a narrow dielectron or dimuon resonance structure. Limits are set on the masses of hypothetical particles that could appear in new-physics scenarios. For the View the MathML sourceZSSM′ particle, which arises in the sequential standard model, and for the superstring inspired View the MathML sourceZψ′ particle, 95% confidence level lower mass limits for the combined data sets and combined channels are found to be 3.37 and 2.82 TeV, respectively. The corresponding limits for the lightest Kaluza–Klein graviton arising in the Randall–Sundrum model of extra dimensions with coupling parameters 0.01 and 0.10 are 1.46 and 3.11 TeV, respectively. These results significantly exceed the limits based on the 8 TeV LHC data

Search for Evidence of the Type-III Seesaw Mechanism in Multilepton Final States in Proton-Proton Collisions at root s=13 TeV

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