El uso de técnicas computacionales para mejorar el cumplimiento de técnicas del recuerdo en entornos inteligentes (REMIND)

El proyecto “El Uso de Técnicas Computacionales para Mejorar el Cumplimiento de Técnicas del Recuerdo en Entornos Inteligentes” o por su título original “The Use of Computational Techniques to Improve Compliance to Reminders within Smarts Environments (REMIND)” tiene por objetivo general crear una red internacional e intersectorial para desarrollar el marco de intercambio de conocimiento y masa crítica necesario para avanzar en el desarrollo de técnicas del recuerdo que se implementarán en entornos inteligentes orientado a resolver problemas de recuerdo o personas con demencia. Para lograr este objetivo, el enfoque se centra en el desarrollo de tecnología basada en la ciencia del comportamiento y mejores técnicas computacionales orientadas a soluciones apropiadas del recuerdo.Eje: Redes de cooperación científica internacionales.Red de Universidades con Carreras en Informátic

Relaxation time for the alignment between quark spin and angular velocity in a rotating QCD medium

We compute the relaxation times for massive quarks and anti-quarks to align their spins with the angular velocity in a rigidly rotating medium at finite temperature and baryon density. The rotation effects are implemented using a fermion propagator immersed in a cylindrical rotating environment. The relaxation time is computed as the inverse of the interaction rate to produce an asymmetry between the quark (anti-quark) spin components along and opposite to the angular velocity. For conditions resembling heavy-ion collisions, the relaxation times for quarks are smaller than for anti-quarks. For semi-central collisions the relaxation time is within the possible life-time of the QGP for all collision energies. However, for anti-quarks this happens only for collision energies $\sqrt{s_{NN}}\gtrsim 50$ GeV. The results are quantified in terms of the intrinsic quark and anti-quark polarizations, namely, the probability to build the spin asymmetry as a function of time. Our results show that these intrinsic polarizations tend to 1 with time at different rates given by the relaxation times with quarks reaching a sizable asymmetry at a faster pace. These are key results to further elucidate the mechanisms of hyperon polarization in relativistic heavy-ion collisions.Comment: 9 pages, 10 figure

UTILIZACIÓN DE STREPTOMYCES SP. RL8 COMO AGENTE PROBIÓTICO EN POLLOS DE LA RAZA LEGHORN

Durante sus primeras semanas de vida los pollos de las instalaciones avícolas están sometidos a situaciones de estrés que ocasionan desbalances en la microbiota intestinal, que hacen a su vez que sean susceptibles a la incidencia de microorganismos patógenos. El uso de antibióticos de amplio espectro para contrarrestar los efectos de dichos patógenos ha originado problemas de resistencia bacteriana y de inocuidad alimentaria. Se ha propuesto la utilización de probióticos como un medio para la reducción de patógenos intestinales y aumento de indicadores bioproductivos. En el presente trabajo se evaluó la actividad probiótica de Streptomyces sp. cepa RL8 en indicadores fisiológicos y productivos en pollos de la raza Leghorn. Se demostró que no hubo diferencias significativas entre el grupo tratado y el grupo control en cuanto a los parámetros productivos y de salud. Sin embargo, se encontraron diferencias significativas entre ambos grupos para algunos componentes hematológicos e inmunológicos. Por tanto, la cepa de Streptomyces sp. RL8 puede ser una alternativa para mejorar el estado de salud de los pollos, a través de la estimulación de parámetros hematológicos y modulación del sistema inmune de las aves

Planeación, gobernanza y sustentabilidad Retos y desafíos desde el enfoque territorial

Frente a la compleja realidad actual, resulta ineludible el desarrollo de la investigación científica de los fenómenos y procesos urbanos, territoriales y ambientales, que contribuya a su comprensión y la construcción de alternativas de solución a los retos y desafíos vigentes. En este contexto, el abordaje de las ciudades y regiones metropolitanas, el ordenamiento del territorio y la ocupación del espacio, así como la relación sociedad-naturaleza y la complejidad ambiental, precisa la generación de metodologías y procesos de investigación multi e inter disciplinarios que contribuyan a la comprensión de los procesos socioterritoriales, el mejoramiento de las condiciones de vida y la conservación ambiental.Programa de Fortalecimiento de la Calidad Educativa PFCE-2016 proyecto K0313101

Systematics and diversification of the Ichthyomyini (Cricetidae, Sigmodontinae) revisited: evidence from molecular, morphological, and combined approaches

Ichthyomyini, a morphologically distinctive group of Neotropical cricetid rodents, lacks an integrative study of its systematics and biogeography. Since this tribe is a crucial element of the Sigmodontinae, the most speciose subfamily of the Cricetidae, we conducted a study that includes most of its recognized diversity (five genera and 19 species distributed from southern Mexico to northern Bolivia). For this report we analyzed a combined matrix composed of four molecular markers (RBP3, GHR, RAG1, Cytb) and 56 morphological traits, the latter including 15 external, 14 cranial, 19 dental, five soft-anatomical and three postcranial features. A variety of results were obtained, some of which are inconsistent with the currently accepted classification and understanding of the tribe. Ichthyomyini is retrieved as monophyletic, and it is divided into two main clades that are here recognized as subtribes: one to contain the genus Anotomys and the other composed by the remaining genera. Neusticomys (as currently recognized) was found to consist of two well supported clades, one of which corresponds to the original concept of Daptomys. Accordingly, we propose the resurrection of the latter as a valid genus to include several species from low to middle elevations and restrict Neusticomys to several highland forms. Numerous other revisions are necessary to reconcile the alpha taxonomy of ichthyomyines with our phylogenetic results, including placement of the Cajas Plateau water rat (formerly Chibchanomys orcesi) in the genus Neusticomys (sensu stricto), and the recognition of at least two new species (one in Neusticomys, one in Daptomys). Additional work is necessary to confirm other unanticipated results, such as the non-monophyletic nature of Rheomys and the presence of a possible new genus and species from Peru. Our results also suggest that ichthyomyines are one of the main Andean radiations of sigmodontine cricetids, with an evolutionary history dating to the Late Miocene and subsequent cladogenesis during the Pleistocene

El abrigo y la cueva de Benzú en la Prehistoria de Ceuta. Aproximación al estudio de las sociedades cazadoras-recolectoras y tribales comunitarias en el ámbito norteafricano del Estrecho de Gibraltar.

Extensa obra sobre los métodos, antecedentes y objetivos; observaciones preliminares y estudios anteriores, excavación y análisis de los resultados del Proyecto Benzú.Consejería de Educación, Cultura y Deporte de la Ciudad Autónoma de Ceuta. Universidad Española de Educación a Distancia. Universidad de Cádiz.419 página

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research