142 research outputs found

    Interviews with Burt Brumfield, Maxine Querbach, Roy Stanbaugh, Ed Hershler, Katie Schnetzer, Pat Halling, Barbara Howe, The Benishes, Emma Folck, William R. McFarland, and Brenda Greenwood

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    Interviews with Burt Brumfield, Maxine Querbach, Roy Stanbaugh, Ed Hershler, Katie Schnetzer, Pat Halling, Barbara Howe, The Benishes, Emma Folck, William R. McFarland, and Brenda Greenwood. 00:00:00 - Introduction, Burt Brumfield of Jetmore, KS on November 30, 1963 00:00:17 - Kissing pigeon fashion. 00:00:50 - Horse races 00:01:30 - Decoration Day (Memorial Day) 00:03:03 - School activities 00:03:26 - A blizzard hits during a literary 00:05:10 - Prairie fire 00:05:29 - Poem, A Poor Married Man 00:06:07 - Grandfather\u27s work on the sabbath in Indiana and the resulting death of a cow 00:07:25 - Father\u27s work on the sabbath and a subsequent cyclone 00:08:16 - Introduction, Maxine Querbach of Hanston, KS on December 21, 1963 00:08:30 - Story about an old bachelor 00:10:20 - Introduction, Roy Stanbaugh of Hanston, KS on December 30, 1963 00:10:36 - Story about the Dust Bowl 00:10:50 - Story about windy Kansas 00:11:14 - Story about Louie the Robber a modern day Robin Hood 00:12:18 - Story about older students chasing off the teacher 00:16:17 - Early smallpox treatments 00:17:22 - Introduction, Ed Herschler of Hanston, KS on January 4, 1963 00:17:44 - Blizzard of 1886 00:22:11 - Story of the Purple family murders in November of 1886 00:28:22 - Prairie fires 00:31:17 - Story about a 16-year-old female teacher being assaulted by local men 00:33:54 - Introduction, Katie Schnetzer, Pat Halling, and Barbara Howe of Hanston, KS on January 3, 1963 00:34:36 - Description of children\u27s games. Some description is in German 00:39:19 - Ghost stories 00:41:25 - Song, untitled, vocal 00:41:59 - Song, He Asked Me For a Date , vocal duet 00:43:17 - Song, Sippin\u27 Cider Through a Straw , vocal duet 00:46:37 - Song, Let\u27s Go Bowling on Bowling Green , vocal duet 00:47:36 - Introduction, Maxine Querbach of Hanston, KS 00:48:00 - Grasshopper swarms of the late 1800s 00:48:32 - Introduction, The Benishes , a musical group playing in Orwell, KS on January 5, 1963 00:49:23 - Song, untitled squaredance, fiddle and piano 01:06:13 - Introduction, Emma Folck of Little River, KS on January 1, 1964 01:06:30 - History of the Rhodes family in Rice County, KS in 1880 01:07:49 - Farm production in 1875 in Rice County, KS and the first courthouse 01:08:27 - Mother is bitten by a rattlesnake in 1879 01:09:38 - Pawnee Rock 01:10:00 - Story, John Brown\u27s Buddy 01:11:14 - Staying overnight in Lindsborg, KS in 1905 01:12:29 - Early agricultural practices 01:13:15 - Introduction, William R. McFarland of Cimmaron, KS on November 29, 1963 01:13:37 - Song, The Early Days , vocal and piano 01:17:56 - Song, Fifty Years Ago, vocal and piano 01:22:50 - Song, Oh, Those Christmas Days , vocal and piano 01:26:54 - Song, Arkansas Valley to the tune of Red River Valley , vocal and piano 01:30:10 - Introduction, Brenda Greenwood and friends of Cimmaron, KS on November 29, 1963 01:30:31 - Song, Cimmaron Schools to the tune of The Marine Hymn , vocalhttps://scholars.fhsu.edu/sackett/1084/thumbnail.jp

    Sex Pheromone Evolution Is Associated with Differential Regulation of the Same Desaturase Gene in Two Genera of Leafroller Moths

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    Chemical signals are prevalent in sexual communication systems. Mate recognition has been extensively studied within the Lepidoptera, where the production and recognition of species-specific sex pheromone signals are typically the defining character. While the specific blend of compounds that makes up the sex pheromones of many species has been characterized, the molecular mechanisms underpinning the evolution of pheromone-based mate recognition systems remain largely unknown. We have focused on two sets of sibling species within the leafroller moth genera Ctenopseustis and Planotortrix that have rapidly evolved the use of distinct sex pheromone blends. The compounds within these blends differ almost exclusively in the relative position of double bonds that are introduced by desaturase enzymes. Of the six desaturase orthologs isolated from all four species, functional analyses in yeast and gene expression in pheromone glands implicate three in pheromone biosynthesis, two Δ9-desaturases, and a Δ10-desaturase, while the remaining three desaturases include a Δ6-desaturase, a terminal desaturase, and a non-functional desaturase. Comparative quantitative real-time PCR reveals that the Δ10-desaturase is differentially expressed in the pheromone glands of the two sets of sibling species, consistent with differences in the pheromone blend in both species pairs. In the pheromone glands of species that utilize (Z)-8-tetradecenyl acetate as sex pheromone component (Ctenopseustis obliquana and Planotortrix octo), the expression levels of the Δ10-desaturase are significantly higher than in the pheromone glands of their respective sibling species (C. herana and P. excessana). Our results demonstrate that interspecific sex pheromone differences are associated with differential regulation of the same desaturase gene in two genera of moths. We suggest that differential gene regulation among members of a multigene family may be an important mechanism of molecular innovation in sex pheromone evolution and speciation

    Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

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    A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

    Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

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    Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes. Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. We enrolled adults aged 18–85 years with type 2 diabetes, estimated glomerular filtration rate (eGFR)25–75 mL/min per 1·73 m 2 of body surface area, and a urine albumin-to-creatinine ratio (UACR)of 300–5000 mg/g who had received maximum labelled or tolerated renin–angiotensin system inhibition for at least 4 weeks. Participants were given atrasentan 0·75 mg orally daily during an enrichment period before random group assignment. Those with a UACR decrease of at least 30% with no substantial fluid retention during the enrichment period (responders)were included in the double-blind treatment period. Responders were randomly assigned to receive either atrasentan 0·75 mg orally daily or placebo. All patients and investigators were masked to treatment assignment. The primary endpoint was a composite of doubling of serum creatinine (sustained for ≥30 days)or end-stage kidney disease (eGFR <15 mL/min per 1·73 m 2 sustained for ≥90 days, chronic dialysis for ≥90 days, kidney transplantation, or death from kidney failure)in the intention-to-treat population of all responders. Safety was assessed in all patients who received at least one dose of their assigned study treatment. The study is registered with ClinicalTrials.gov, number NCT01858532. Findings: Between May 17, 2013, and July 13, 2017, 11 087 patients were screened; 5117 entered the enrichment period, and 4711 completed the enrichment period. Of these, 2648 patients were responders and were randomly assigned to the atrasentan group (n=1325)or placebo group (n=1323). Median follow-up was 2·2 years (IQR 1·4–2·9). 79 (6·0%)of 1325 patients in the atrasentan group and 105 (7·9%)of 1323 in the placebo group had a primary composite renal endpoint event (hazard ratio [HR]0·65 [95% CI 0·49–0·88]; p=0·0047). Fluid retention and anaemia adverse events, which have been previously attributed to endothelin receptor antagonists, were more frequent in the atrasentan group than in the placebo group. Hospital admission for heart failure occurred in 47 (3·5%)of 1325 patients in the atrasentan group and 34 (2·6%)of 1323 patients in the placebo group (HR 1·33 [95% CI 0·85–2·07]; p=0·208). 58 (4·4%)patients in the atrasentan group and 52 (3·9%)in the placebo group died (HR 1·09 [95% CI 0·75–1·59]; p=0·65). Interpretation: Atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease who were selected to optimise efficacy and safety. These data support a potential role for selective endothelin receptor antagonists in protecting renal function in patients with type 2 diabetes at high risk of developing end-stage kidney disease. Funding: AbbVie

    Search for single production of vector-like quarks decaying into Wb in pp collisions at s=8\sqrt{s} = 8 TeV with the ATLAS detector

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    Measurements of top-quark pair differential cross-sections in the eμe\mu channel in pppp collisions at s=13\sqrt{s} = 13 TeV using the ATLAS detector

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    Measurement of the W boson polarisation in ttˉt\bar{t} events from pp collisions at s\sqrt{s} = 8 TeV in the lepton + jets channel with ATLAS

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    Measurement of the charge asymmetry in top-quark pair production in the lepton-plus-jets final state in pp collision data at s=8TeV\sqrt{s}=8\,\mathrm TeV{} with the ATLAS detector

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    Measurement of the bbb\overline{b} dijet cross section in pp collisions at s=7\sqrt{s} = 7 TeV with the ATLAS detector

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    Search for dark matter in association with a Higgs boson decaying to bb-quarks in pppp collisions at s=13\sqrt s=13 TeV with the ATLAS detector

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