38 research outputs found
RISCO DE ÚLCERAS DE MEMBROS INFERIORES NOS DIABÉTICOS DE UM AMBULATÓRIO UNIVERSITÁRIO
OBJETIVO: Estratificar o risco de ulceração de membros inferiores em pacientes diabéticos tipo 2 do Ambulatório de Endocrinologia da Santa Casa de Misericóidia de Curitiba – PR. MÉTODO: A amostra foi composta por 100 pacientes diabéticos e maiores de 18 anos, submetidos a um questionário e ao exame físico dos pés, para a verificação de Fatores de Risco para ulceração, Presença de Sinais e Sintomas Neuropáticos, verificação de Perda da Sensibilidade Protetora (PSP) e Doença Arterial Periférica (DAP). A partir destes dados, calculou-se a estratificação do risco de ulceração e avaliou-se a correlação das variáveis sexo, idade, tempo de doença, tipo de terapia, presença de outras complicações crônicas e controle do diabetes (DM) com esta estratificação de risco. RESULTADOS: 26% dos pacientes apresentaram PSP e 63% risco de DAP. Além disso, 15% apresentaram risco 3 (alto risco) e 23 % risco 2 (risco moderado). Houve correlação positiva entre a estratificação do risco e a presença de outras complicações crônicas do DM (p=0,003) e maior tempo médio de doença (p=0,009). CONCLUSÃO: 38% foram classificados como risco 2 e 3 para ulceração de membros inferiores (alto risco). Houve uma correlação entre a classificação de risco do pé diabético e as variáveis tempo médio de DM e complicações crônicas do DM, o que sugere a necessidade de acompanhamento desta população. O exame dos pés faz-se necessário para quantificar o risco de úlceras de membros inferiores em pacientes diabéticos sintomáticos ou não, a fim de melhorar as estratégias de tratamento e prevenção desta complicação
Pervasive gaps in Amazonian ecological research
Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4
While the increasing availability of global databases on ecological communities has advanced our knowledge
of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In
the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of
Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus
crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced
environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian
Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by
2050. This means that unless we take immediate action, we will not be able to establish their current status,
much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio
Minimal information for studies of extracellular vesicles 2018 (MISEV2018):a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points
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Climate seasonality limits leaf carbon assimilation and wood productivity in tropical forests
The seasonal climate drivers of the carbon cycle in tropical forests remain poorly known, although these forests account for more carbon assimilation and storage than any other terrestrial ecosystem. Based on a unique combination of seasonal pan-tropical data sets from 89 experimental sites (68 include aboveground wood productivity measurements and 35 litter productivity measurements), their associated canopy photosynthetic capacity (enhanced vegetation index, EVI) and climate, we ask how carbon assimilation and aboveground allocation are related to climate seasonality in tropical forests and how they interact in the seasonal carbon cycle. We found that canopy photosynthetic capacity seasonality responds positively to precipitation when rainfall is < 2000 mm yr⁻¹ (water-limited forests) and to radiation otherwise (light-limited forests). On the other hand, independent of climate limitations, wood productivity and litterfall are driven by seasonal variation in precipitation and evapotranspiration, respectively. Consequently, light-limited forests present an asynchronism between canopy photosynthetic capacity and wood productivity. First-order control by precipitation likely indicates a decrease in tropical forest productivity in a drier climate in water-limited forest, and in current light-limited forest with future rainfall < 2000 mm yr⁻¹