ORGANIZATION AND ECONOMICS RESULTS OF LAMBS PRODUCTION ON FAMILY FARM ANTE URSIĆ

Ovčarska proizvodnja je gospodarska grana koja se sve više razvija u Republici Hrvatskoj, zbog velikog broja autohtonih, ali i inozemnih pasmina. Merinolandschaf pasmina je jedna od najvažnijih pasmina ovaca u svijetu, nastala križanjem njemačkih autohtonih pasmina s merino pasminama, te se uzgaja zbog proizvodnje mesa i vune. OPG Ante Ursić bavi se ovčarskom proizvodnjom od 1999. godine s orijentacijom na proizvodnju janjadi. Analitičkim kalkulacijama je utvrđena dobit u proizvodnji janjadi kroz tri godine. Najveća dobit ostvarena je u 2013. godini u iznosu od 48.200 kuna, u 2014. godini iznosila je 11.479 kuna, a u 2015. godini samo 6.681 kuna. Najveću stavku u strukturi prihoda ima prodana janjad, a u strukturi troškova hrana. Rentabilnost koja je jedan od pokazatelja uspješnosti proizvodnje, na OPG-u Ante Ursić iznosila je od 28,55% u prvoj godini do 6% u zadnjoj, a ekonomičnost se kretala također silaznim trendom od 1,4 do 1,06. Iako su ekonomski pokazatelji pozitivni, zabrinjavajući je njihov trend smanjenjaSheep production is the industry that is expanding in Croatia, due to the large number of indigenous as well as foreign breeds. Merinolandschaf breed is one of the most important breeds of sheep in the world, created by crossing the German indigenous breeds with merino breeds and are raised for their meat and wool production. Family farm Ante Ursić engaged in sheep production in 1999 and is oriented to the production of lambs. Analytical calculations is determined income in the production of lambs for three years. The biggest gain was recorded in 2013 in the amount of 48.200 kuna in 2014 amounted to 11.479 kuna, and in 2015 only 6.681 kuna. The biggest item in the income structure has sold lambs and the cost structure of the food. Profitability, which is one of the performance indicators of production, on the family farm Ante Ursić was of 28.55% in the first year to 6% in the last, and economy also moved downward trend from 1.4 to 1.06. Although economic indicators are positive, their declining trend is worrying

ASSOCIATION BETWEEN DURATION OF DIALYSIS AND HELICOBACTER PYLORI INFECTION IN DIALYSIS PATIENTS AT THE UNIVERSITY CLINICAL HOSPITAL MOSTAR

Introduction: Association of Helicobacter pylori (HP) infection with the length of dialysis in dialysis patients is contradictory. This study was conducted in order to determine the association between the duration of dialysis and the HP infection status in the dialysis patients. Furthemore, biochemical parameters were monitored in two subject groups that were included in this study. Subjects and methods: The study included 51 patients on chronic hemodialysis program who had gastrointestinal symptoms. The subjects were divided in two groups per the length of dialysis treatment. In this study we analyzed age, gender, the time period since the onset of the chronic hemodialysis program, body mass index, biochemical parameters, and whether the patients have arterial hypertension and/or diabetes. The presence of HP antigen was determined in the stool samples with use of he UlcoGnost AG test plate. Results: The incidence of HP infection in hemodialysis patients, with some of the gastrointestinal symptoms, was 25.5%. Patients on hemodialysis for less than 24 months had lower incidence of HP infection than those on hemodialysis program for more than 24 months. HP positive and HP negative subjects were also compared by gender, age, biochemical parameters and body mass index. There was no statistical significant difference between the groups in any of those characteristics. When comparing the HP status of the subjects with the presence of arterial hypertension and diabetes, no statistically significant difference was found between the groups. Conclusion: This study showed negative correlation between HP infection and the length of hemodialysis program. Analysis of age, gender, body mass index, biochemical parameters, presence of arterial hypertension and/or diabetes showed no statistically significant difference was found between the hemodialysis patients who were HP positive and those who were HP negative. Additional studies are needed to elucidate the correlation mechanism between the HP infection and the duration of dialysis, in order to examine how long the dialysis time period is the most susceptible to HP infection, and then to improve the prognosis of patients with renal disease

ASSOCIATION BETWEEN DURATION OF DIALYSIS AND HELICOBACTER PYLORI INFECTION IN DIALYSIS PATIENTS AT THE UNIVERSITY CLINICAL HOSPITAL MOSTAR

Introduction: Association of Helicobacter pylori (HP) infection with the length of dialysis in dialysis patients is contradictory. This study was conducted in order to determine the association between the duration of dialysis and the HP infection status in the dialysis patients. Furthemore, biochemical parameters were monitored in two subject groups that were included in this study. Subjects and methods: The study included 51 patients on chronic hemodialysis program who had gastrointestinal symptoms. The subjects were divided in two groups per the length of dialysis treatment. In this study we analyzed age, gender, the time period since the onset of the chronic hemodialysis program, body mass index, biochemical parameters, and whether the patients have arterial hypertension and/or diabetes. The presence of HP antigen was determined in the stool samples with use of he UlcoGnost AG test plate. Results: The incidence of HP infection in hemodialysis patients, with some of the gastrointestinal symptoms, was 25.5%. Patients on hemodialysis for less than 24 months had lower incidence of HP infection than those on hemodialysis program for more than 24 months. HP positive and HP negative subjects were also compared by gender, age, biochemical parameters and body mass index. There was no statistical significant difference between the groups in any of those characteristics. When comparing the HP status of the subjects with the presence of arterial hypertension and diabetes, no statistically significant difference was found between the groups. Conclusion: This study showed negative correlation between HP infection and the length of hemodialysis program. Analysis of age, gender, body mass index, biochemical parameters, presence of arterial hypertension and/or diabetes showed no statistically significant difference was found between the hemodialysis patients who were HP positive and those who were HP negative. Additional studies are needed to elucidate the correlation mechanism between the HP infection and the duration of dialysis, in order to examine how long the dialysis time period is the most susceptible to HP infection, and then to improve the prognosis of patients with renal disease

SENSITIVE SKIN IN THE POPULATION OF HERZEGOVINA-NERETVA COUNTY: PREVALENCEAND CLINICAL DATA

Introduction: Sensitive skin has been described as a syndrome defined by the occurrence of unpleasant sensations (stinging, burning, pain, pruritus, and tingling sensations) in response to stimuli that normally should not provoke such sensations. Although often transient, and in many cases unaccompanied by visual dermatological responses, sensitive skin affects the quality of life. The aim of this survey was to assess the prevalence of sensitive skin and collect clinical data on sensitive skin in the population of Herzegovina-Neretva County. Subjects and methods: The survey included a total of 73 participants, 45 female and 28 male, aged 20 years and above, with a diagnosis of sensitive skin syndrome (SSS) confirmed by physicians. A dermatological exam assessing skin type, phototype and skin sensitivity was performed. The survey collected an assortment of information including demographics and included customized standardized questionnaires that closely examine skin sensitivity and the burden of sensitive skin. Results: Findings concurred with existing evidence that individuals with sensitive skin represent almost half the examined population. The prevalence of perceived sensitive skin was significantly higher in females than in males. The main skin symptom was itching, followed by prickling, warmth and numbness. Our results clearly show that there is a burden of sensitive skin. Conclusion: This study investigated the prevalence of sensitive skin and the burden of sensitive skin in the population of Herzegovina-Neretva County. It is the first to focus on sensitive skin among Herzegovina-Neretva County population. Further studies are needed to bolster epidemiological data and physiological pathways of sensitive skin syndrome

SENSITIVE SKIN IN THE POPULATION OF HERZEGOVINA-NERETVA COUNTY: PREVALENCEAND CLINICAL DATA

Introduction: Sensitive skin has been described as a syndrome defined by the occurrence of unpleasant sensations (stinging, burning, pain, pruritus, and tingling sensations) in response to stimuli that normally should not provoke such sensations. Although often transient, and in many cases unaccompanied by visual dermatological responses, sensitive skin affects the quality of life. The aim of this survey was to assess the prevalence of sensitive skin and collect clinical data on sensitive skin in the population of Herzegovina-Neretva County. Subjects and methods: The survey included a total of 73 participants, 45 female and 28 male, aged 20 years and above, with a diagnosis of sensitive skin syndrome (SSS) confirmed by physicians. A dermatological exam assessing skin type, phototype and skin sensitivity was performed. The survey collected an assortment of information including demographics and included customized standardized questionnaires that closely examine skin sensitivity and the burden of sensitive skin. Results: Findings concurred with existing evidence that individuals with sensitive skin represent almost half the examined population. The prevalence of perceived sensitive skin was significantly higher in females than in males. The main skin symptom was itching, followed by prickling, warmth and numbness. Our results clearly show that there is a burden of sensitive skin. Conclusion: This study investigated the prevalence of sensitive skin and the burden of sensitive skin in the population of Herzegovina-Neretva County. It is the first to focus on sensitive skin among Herzegovina-Neretva County population. Further studies are needed to bolster epidemiological data and physiological pathways of sensitive skin syndrome

INAPPROPRIATE USE OF TOPICAL CORTICOSTEROIDES IN THE DERMATOLOGY OUTPATIENT

Introduction: Topical corticosteroids are group of drugs which have anti-immuno-suppressive, anti-proliferative and vasoconstrictive effects and are among the most commonly prescribed medication, important and efficacious for management of various dermatological disorders. Strict implementation of the existing regulations is the need of the hour to prevent their widespread abuse. Aim of the study was to investigate the usage of topical corticosteroids therapy with the recipe of a doctor and without it. Subjects and methods: The subjects were patients who visited Pharmacies in Mostar from April to July 2020 and were buying topical corticosteroids with or without a recipe or medical report from the doctor. 80 subjects completed a questionnaire themselves included: the way of buying a topical corticosteroids, the information about using topical corticosteroids earlier, the information about subject\u27s visits to the doctor; the length of time using topical corticosteroids, the type of topical corticosteroids used, the part of body the topical corticosteroids was applied on. Results: A total of 80 subjects were treated in the observed period, 58.8% were female. 72.5% subjects had already used local corticosteroids, 62.50% purchased the drug at the recommendation of the pharmacist, 66.30% had no recent diagnosis or no diagnosed disease at all, 21.25% used the drug for more than a month, the most often purchased one was moderate potent local corticosteroid Betamethasone diproprionate 0.05 %. Most commonly subjects applied local corticosteroids on arms (50%). Conclusion: Strict regulations regarding only prescription-based dispensing of local corticosteroids must be put into practice. This will hopefully bring down both the extremes of ever increasing cases of steroid-induced dermatoses in everyday dermatology practise on one hand and the irrational fears of using TCs in well justified indications on the other

INAPPROPRIATE USE OF TOPICAL CORTICOSTEROIDES IN THE DERMATOLOGY OUTPATIENT

Introduction: Topical corticosteroids are group of drugs which have anti-immuno-suppressive, anti-proliferative and vasoconstrictive effects and are among the most commonly prescribed medication, important and efficacious for management of various dermatological disorders. Strict implementation of the existing regulations is the need of the hour to prevent their widespread abuse. Aim of the study was to investigate the usage of topical corticosteroids therapy with the recipe of a doctor and without it. Subjects and methods: The subjects were patients who visited Pharmacies in Mostar from April to July 2020 and were buying topical corticosteroids with or without a recipe or medical report from the doctor. 80 subjects completed a questionnaire themselves included: the way of buying a topical corticosteroids, the information about using topical corticosteroids earlier, the information about subject\u27s visits to the doctor; the length of time using topical corticosteroids, the type of topical corticosteroids used, the part of body the topical corticosteroids was applied on. Results: A total of 80 subjects were treated in the observed period, 58.8% were female. 72.5% subjects had already used local corticosteroids, 62.50% purchased the drug at the recommendation of the pharmacist, 66.30% had no recent diagnosis or no diagnosed disease at all, 21.25% used the drug for more than a month, the most often purchased one was moderate potent local corticosteroid Betamethasone diproprionate 0.05 %. Most commonly subjects applied local corticosteroids on arms (50%). Conclusion: Strict regulations regarding only prescription-based dispensing of local corticosteroids must be put into practice. This will hopefully bring down both the extremes of ever increasing cases of steroid-induced dermatoses in everyday dermatology practise on one hand and the irrational fears of using TCs in well justified indications on the other

Presentation of Graves' orbitopathy within European Group On Graves' Orbitopathy (EUGOGO) centres from 2012 to 2019 (PREGO III)

Background: Graves' orbitopathy (GO) is subject to epidemiological and care-related changes. Aim of the survey was to identify trends in presentation of GO to the European Group On Graves' Orbitopathy (EUGOGO) tertiary referral centres and initial management over time. Methods: Prospective observational multicentre study. All new referrals with diagnosis of GO within September-December 2019 were included. Clinical and demographic characteristics, referral timelines and initial therapeutic decisions were recorded. Data were compared with a similar EUGOGO survey performed in 2012. Results: Besides age (mean age: 50.5±13 years vs 47.7±14 years; p 0.007), demographic characteristics of 432 patients studied in 2019 were similar to those in 2012. In 2019, there was a decrease of severe cases (9.8% vs 14.9; p<0.001), but no significant change in proportion of active cases (41.3% vs 36.6%; p 0.217). After first diagnosis of GO, median referral time to an EUGOGO tertiary centre was shorter (2 (0-350) vs 6 (0-552) months; p<0.001) in 2019. At the time of first visit, more patients were already on antithyroid medications (80.2% vs 45.0%; p<0.001) or selenium (22.3% vs 3.0%; p<0.001). In 2019, the initial management plans for GO were similar to 2012, except for lid surgery (2.4% vs 13.9%; p<0.001) and prescription of selenium (28.5% vs 21.0%; p 0.027). Conclusion: GO patients are referred to tertiary EUGOGO centres in a less severe stage of the disease than before. We speculate that this might be linked to a broader awareness of the disease and faster and adequate delivered treatment

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements