1,363 research outputs found
5G Radio Access Network Architecture for Terrestrial Broadcast Services
The 3rd Generation Partnership Project (3GPP) has defined based on the Long
Term Evolution (LTE) enhanced Multicast Broadcast Multimedia Service (eMBMS) a
set of new features to support the distribution of Terrestrial Broadcast
services in Release 14. On the other hand, a new 5th Generation (5G) system
architecture and radio access technology, 5G New Radio (NR), are being
standardised from Release 15 onwards, which so far have only focused on unicast
connectivity. This may change in Release 17 given a new Work Item set to
specify basic Radio Access Network (RAN) functionalities for the provision of
multicast/broadcast communications for NR. This work initially excludes some of
the functionalities originally supported for Terrestrial Broadcast services
under LTE e.g. free to air, receive-only mode, large-area single frequency
networks, etc. This paper proposes an enhanced Next Generation RAN architecture
based on 3GPP Release 15 with a series of architectural and functional
enhancements, to support an efficient, flexible and dynamic selection between
unicast and multicast/broadcast transmission modes and also the delivery of
Terrestrial Broadcast services. The paper elaborates on the Cloud-RAN based
architecture and proposes new concepts such as the RAN Broadcast/Multicast
Areas that allows a more flexible deployment in comparison to eMBMS. High-level
assessment methodologies including complexity analysis and inspection are used
to evaluate the feasibility of the proposed architecture design and compare it
with the 3GPP architectural requirements.Comment: 12 pages, 10 figures, 2 tables, IEEE Trans. Broadcastin
Demonstrating Immersive Media Delivery on 5G Broadcast and Multicast Testing Networks
This work presents eight demonstrators and one showcase developed within the
5G-Xcast project. They experimentally demonstrate and validate key technical
enablers for the future of media delivery, associated with multicast and
broadcast communication capabilities in 5th Generation (5G). In 5G-Xcast, three
existing testbeds: IRT in Munich (Germany), 5GIC in Surrey (UK), and TUAS in
Turku (Finland), have been developed into 5G broadcast and multicast testing
networks, which enables us to demonstrate our vision of a converged 5G
infrastructure with fixed and mobile accesses and terrestrial broadcast,
delivering immersive audio-visual media content. Built upon the improved
testing networks, the demonstrators and showcase developed in 5G-Xcast show the
impact of the technology developed in the project. Our demonstrations
predominantly cover use cases belonging to two verticals: Media & Entertainment
and Public Warning, which are future 5G scenarios relevant to multicast and
broadcast delivery. In this paper, we present the development of these
demonstrators, the showcase, and the testbeds. We also provide key findings
from the experiments and demonstrations, which not only validate the technical
solutions developed in the project, but also illustrate the potential technical
impact of these solutions for broadcasters, content providers, operators, and
other industries interested in the future immersive media delivery.Comment: 16 pages, 22 figures, IEEE Trans. Broadcastin
Custom human endogenous retroviruses dedicated microarray identifies self-induced HERV-W family elements reactivated in testicular cancer upon methylation control
Endogenous retroviruses (ERVs) are an inherited part of the eukaryotic genomes, and represent ∼400 000 loci in the human genome. Human endogenous retroviruses (HERVs) can be divided into distinct families, composed of phylogenetically related but structurally heterogeneous elements. The majority of HERVs are silent in most physiological contexts, whereas a significant expression is observed in pathological contexts, such as cancers. Owing to their repetitive nature, few of the active HERV elements have been accurately identified. In addition, there are no criteria defining the active promoters among HERV long-terminal repeats (LTRs). Hence, it is difficult to understand the HERV (de)regulation mechanisms and their implication on the physiopathology of the host. We developed a microarray to specifically detect the LTR-containing transcripts from the HERV-H, HERV-E, HERV-W and HERV-K(HML-2) families. HERV transcriptome was analyzed in the placenta and seven normal/tumoral match-pair samples. We identified six HERV-W loci overexpressed in testicular cancer, including a usually placenta-restricted transcript of ERVWE1. For each locus, specific overexpression was confirmed by quantitative RT-PCR, and comparison of the activity of U3 versus U5 regions suggested a U3-promoted transcription coupled with 5′R initiation. The analysis of DNA from tumoral versus normal tissue revealed that hypomethylation of U3 promoters in tumors is a prerequisite for their activation
Characterisation of retroviruses in the horse genome and their transcriptional activity via transcriptome sequencing
The recently released draft horse genome is incompletely characterised in terms of its repetitive
element profile. This paper presents characterisation of the endogenous retrovirus (ERVs) of the horse
genome based on a data-mining strategy using murine leukaemia virus proteins as queries. 978 ERV
gene sequences were identified. Sequences were identified from the gamma, epsilon and betaretrovirus
genera. At least one full length gammaretroviral locus was identified, though the gammaretroviral
sequences are very degenerate. Using these data the RNA expression of these ERVs were derived from
RNA transcriptome data from a variety of equine tissues. Unlike the well studied human and murine
ERVs there do not appear to be particular phylogenetic groups of equine ERVs that are more
transcriptionally active. Using this novel approach provided a more technically feasible method to
characterise ERV expression than previous studies
Defending the genome from the enemy within:mechanisms of retrotransposon suppression in the mouse germline
The viability of any species requires that the genome is kept stable as it is transmitted from generation to generation by the germ cells. One of the challenges to transgenerational genome stability is the potential mutagenic activity of transposable genetic elements, particularly retrotransposons. There are many different types of retrotransposon in mammalian genomes, and these target different points in germline development to amplify and integrate into new genomic locations. Germ cells, and their pluripotent developmental precursors, have evolved a variety of genome defence mechanisms that suppress retrotransposon activity and maintain genome stability across the generations. Here, we review recent advances in understanding how retrotransposon activity is suppressed in the mammalian germline, how genes involved in germline genome defence mechanisms are regulated, and the consequences of mutating these genome defence genes for the developing germline
Climate driven life histories: the case of the Mediterranean Storm petrel
Seabirds are affected by changes in the marine ecosystem. The influence of climatic factors on marine food webs can be reflected in long-term seabird population changes. We modelled the survival and recruitment of the Mediterranean storm petrel (Hydrobates pelagicus melitensis) using a 21-year mark-recapture dataset involving almost 5000 birds. We demonstrated a strong influence of prebreeding climatic conditions on recruitment age and of rainfall and breeding period
conditions on juvenile survival. The results suggest that the juvenile survival rate of the Mediterranean subspecies may not be negatively affected by the predicted features of climate change, i.e., warmer summers and lower rainfall. Based on
considerations of winter conditions in different parts of the Mediterranean, we were able to draw inferences about the wintering areas of the species for the first time
A systematic evaluation of expression of HERV-W elements; influence of genomic context, viral structure and orientation
<p>Abstract</p> <p>Background</p> <p>One member of the W family of human endogenous retroviruses (HERV) appears to have been functionally adopted by the human host. Nevertheless, a highly diversified and regulated transcription from a range of HERV-W elements has been observed in human tissues and cells. Aberrant expression of members of this family has also been associated with human disease such as multiple sclerosis (MS) and schizophrenia. It is not known whether this broad expression of HERV-W elements represents transcriptional leakage or specific transcription initiated from the retroviral promoter in the long terminal repeat (LTR) region. Therefore, potential influences of genomic context, structure and orientation on the expression levels of individual HERV-W elements in normal human tissues were systematically investigated.</p> <p>Results</p> <p>Whereas intronic HERV-W elements with a pseudogene structure exhibited a strong anti-sense orientation bias, intronic elements with a proviral structure and solo LTRs did not. Although a highly variable expression across tissues and elements was observed, systematic effects of context, structure and orientation were also observed. Elements located in intronic regions appeared to be expressed at higher levels than elements located in intergenic regions. Intronic elements with proviral structures were expressed at higher levels than those elements bearing hallmarks of processed pseudogenes or solo LTRs. Relative to their corresponding genes, intronic elements integrated on the sense strand appeared to be transcribed at higher levels than those integrated on the anti-sense strand. Moreover, the expression of proviral elements appeared to be independent from that of their corresponding genes.</p> <p>Conclusions</p> <p>Intronic HERV-W provirus integrations on the sense strand appear to have elicited a weaker negative selection than pseudogene integrations of transcripts from such elements. Our current findings suggest that the previously observed diversified and tissue-specific expression of elements in the HERV-W family is the result of both directed transcription (involving both the LTR and internal sequence) and leaky transcription of HERV-W elements in normal human tissues.</p
Observation of associated near-side and away-side long-range correlations in √sNN=5.02 TeV proton-lead collisions with the ATLAS detector
Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02 TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1 μb-1 of data as a function of transverse momentum (pT) and the transverse energy (ΣETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∼0) correlation that grows rapidly with increasing ΣETPb. A long-range “away-side” (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos2Δϕ modulation for all ΣETPb ranges and particle pT
Measurement of the cross-section of high transverse momentum vector bosons reconstructed as single jets and studies of jet substructure in pp collisions at √s = 7 TeV with the ATLAS detector
This paper presents a measurement of the cross-section for high transverse momentum W and Z bosons produced in pp collisions and decaying to all-hadronic final states. The data used in the analysis were recorded by the ATLAS detector at the CERN Large Hadron Collider at a centre-of-mass energy of √s = 7 TeV;{\rm Te}{\rm V}4.6\;{\rm f}{{{\rm b}}^{-1}}{{p}_{{\rm T}}}\gt 320\;{\rm Ge}{\rm V}|\eta |\lt 1.9{{\sigma }_{W+Z}}=8.5\pm 1.7$ pb and is compared to next-to-leading-order calculations. The selected events are further used to study jet grooming techniques
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
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