Time-integrated luminosity recorded by the BABAR detector at the PEP-II e+e- collider

This article is the Preprint version of the final published artcile which can be accessed at the link below.We describe a measurement of the time-integrated luminosity of the data collected by the BABAR experiment at the PEP-II asymmetric-energy e+e- collider at the ϒ(4S), ϒ(3S), and ϒ(2S) resonances and in a continuum region below each resonance. We measure the time-integrated luminosity by counting e+e-→e+e- and (for the ϒ(4S) only) e+e-→μ+μ- candidate events, allowing additional photons in the final state. We use data-corrected simulation to determine the cross-sections and reconstruction efficiencies for these processes, as well as the major backgrounds. Due to the large cross-sections of e+e-→e+e- and e+e-→μ+μ-, the statistical uncertainties of the measurement are substantially smaller than the systematic uncertainties. The dominant systematic uncertainties are due to observed differences between data and simulation, as well as uncertainties on the cross-sections. For data collected on the ϒ(3S) and ϒ(2S) resonances, an additional uncertainty arises due to ϒ→e+e-X background. For data collected off the ϒ resonances, we estimate an additional uncertainty due to time dependent efficiency variations, which can affect the short off-resonance runs. The relative uncertainties on the luminosities of the on-resonance (off-resonance) samples are 0.43% (0.43%) for the ϒ(4S), 0.58% (0.72%) for the ϒ(3S), and 0.68% (0.88%) for the ϒ(2S).This work is supported by the US Department of Energy and National Science Foundation, the Natural Sciences and Engineering Research Council (Canada), the Commissariat à l’Energie Atomique and Institut National de Physique Nucléaire et de Physiquedes Particules (France), the Bundesministerium für Bildung und Forschung and Deutsche Forschungsgemeinschaft (Germany), the Istituto Nazionale di Fisica Nucleare (Italy), the Foundation for Fundamental Research on Matter (The Netherlands), the Research Council of Norway, the Ministry of Education and Science of the Russian Federation, Ministerio de Ciencia e Innovación (Spain), and the Science and Technology Facilities Council (United Kingdom). Individuals have received support from the Marie-Curie IEF program (European Union) and the A.P. Sloan Foundation (USA)

Am J Prev Med

CC999999/Intramural CDC HHS/United States2017-02-19T00:00:00Z26456878PMC531651

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape : A Large-Scale Genome-Wide Interaction Study

Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age-and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to similar to 2.8M SNPs with BMI and WHRadjBMI in four strata (men 50y, women 50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR= 50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may providefurther insights into the biology that underlies weight change with age or the sexually dimorphism of body shape.Peer reviewe

A micromechanical approach for the micropolar modeling of heterogeneous periodic media

Computational homogenization is adopted to assess the homogenized two-dimensional response of periodic composite materials where the typical microstructural dimension is not negligible with respect to the structural sizes. A micropolar homogenization is, therefore, considered coupling a Cosserat medium at the macro-level with a Cauchy medium at the micro-level, where a repetitive Unit Cell (UC) is selected. A third order polynomial map is used to apply deformation modes on the repetitive UC consistent with the macro-level strain components. Hence, the perturbation displacement field arising in the heterogeneous medium is characterized. Thus, a newly defined micromechanical approach, based on the decomposition of the perturbation fields in terms of functions which depend on the macroscopic strain components, is adopted. Then, to estimate the effective micropolar constitutive response, the well known identification procedure based on the Hill-Mandel macro-homogeneity condition is exploited. Numerical examples for a specific composite with cubic symmetry are shown. The influence of the selection of the UC is analyzed and some critical issues are outlined

Analisi multi-scala dei pannelli in muratura basata su formulazioni agli elementi finiti miste

A first order multi-scale model for regular masonry based on a periodic homogenization technique is presented. In particular, a two-field mixed finite element formulation is proposed for the solution of the boundary value problem at the macroscopic level, aiming at improving the accuracy of the macroscopic field evaluation. Some applications on simple 2D structures are shown both in the field of linear elastic and elastic-plastic behavior

Coarse-graining approaches for particulate composites as micropolar continua

A multitude of composite materials ranging from polycrystals up to concrete and masonry-like materials overwhelmingly display random morphologies. In this work we propose a statistically-based multiscale procedure which allow us to simulate the actual microstructure of a two-dimensional and two-phase random medium and to estimate the elastic moduli of the energy equivalent homogeneous micropolar continuum. This procedure uses finite-size scaling of Statistical Volume Elements (SVEs) and approaches the so-called Representative Volume Element (RVE) through two hierarchies of constitutive bounds, respectively stemming from the numerical solution of Dirichlet and Neumann non-classical boundary value problems, set up on mesoscale material cells. The results of the performed numerical simulations point out the worthiness of accounting spatial randomness as well as the additional degrees of freedom of the Cosserat continuum

Composizione di rivestimento con attivita’ antimicrobica e antisalina, e procedimento per la sua preparazione

Viene descritta una composizione di rivestimento contenente una sospensione acquosa a base di un acido policarbossilico, preferibilmente acido fosfocitrico, micro- e/o nano-bastoncini di ossido di zinco. E’ descritto inoltre un procedimento per la sua preparazione, che comprende la preparazione di una sospensione acquosa mediante la dispersione di micro-bastoncini di ossido di zinco e/o nano-bastoncini di ossido di zinco in una soluzione acquosa contenente un acido policarbossilico, preferibilmente acido fosfocitrico. La composizione di rivestimento secondo la presente invenzione è particolarmente adatta per rivestire materiali porosi e possiede un’elevata attività antimicrobica e antisalina