300 research outputs found
Multiple and Precessing Collimated Outflows in the Planetary Nebula IC 4634
With its remarkable double-S shape, IC 4634 is an archetype of
point-symmetric planetary nebulae (PN). In this paper, we present a detailed
study of this PN using archival HST WFPC2 and ground-based narrow-band images
to investigate its morphology, and long-slit spectroscopic observations to
determine its kinematics and to derive its physical conditions and excitation.
The data reveal new structural components, including a distant string of knots
distributed along an arc-like feature 40"-60" from the center of the nebula, a
skin of enhanced [O III]/H-alpha ratio enveloping the inner shell and the
double-S feature, and a triple-shell structure. The spatio-kinematical study
also finds an equatorial component of the main nebula that is kinematically
independent from the bright inner S-shaped arc. We have investigated in detail
the bow shock-like features in IC 4634 and found that their morphological,
kinematical and emission properties are consistent with the interaction of a
collimated outflow with surrounding material. Indeed, the morphology and
kinematics of some of these features can be interpreted using a 3D numerical
simulation of a collimated outflow precessing at a moderate, time-dependent
velocity. Apparently, IC 4634 has experienced several episodes of
point-symmetric ejections oriented at different directions with the outer
S-shaped feature being related to an earlier point-symmetric ejection and the
outermost arc-like string of knots being the relic of an even much earlier
point-symmetric ejection. There is tantalizing evidence that the action of
these collimated outflows has also taken part in the shaping of the innermost
shell and inner S-shaped arc of IC 4634.Comment: 16 pages, 11 figures, accepted for publication in The Astrophysical
Journa
Critical Behavior of the Three-Dimensional Ising Spin Glass
We have simulated, using parallel tempering, the three dimensional Ising spin
glass model with binary couplings in a helicoidal geometry. The largest lattice
(L=20) has been studied using a dedicated computer (the SUE machine). We have
obtained, measuring the correlation length in the critical region, a strong
evidence for a second-order finite temperature phase transition ruling out
other possible scenarios like a Kosterlitz-Thouless phase transition. Precise
values for the and critical exponents are also presented.Comment: RevTex; 12 pages plus 5 ps figures. Final version to be published in
PR
SOCS3 deregulation contributes to aberrant activation of the JAK/STAT pathway in precursor T-cell neoplasms
Despite the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway being frequently altered in T-ALL/LBL, no specific therapy has been approved for T-ALL/LBL patients with constitutive signalling by JAK/STAT, so there is an urgent need to identify pathway members that may be potential therapeutic targets. In the present study, we searched for JAK/STAT pathway members potentially modulated through aberrant methylation and identified SOCS3 hypermethylation as a recurrent event in T-ALL/LBL. Additionally, we explored the implications of SOCS3 deregulation in T-ALL/LBL and demonstrated that SOCS3 counteracts the constitutive activation of the JAK/STAT pathway through different molecular mechanisms. Therefore, SOCS3 emerges as a potential therapeutic target in T-ALL/LBLComunidad de Madrid, Grant/Award
Number: B2017/BMD-3778; LINFOMAS-CM;
Fundación Científica Asociación Española
Contra el Cáncer, Grant/Award Number:
PROYE18054PIRI; Fundación Ramón
Areces, Grant/Award Number: CIVP19S7917;
Instituto de Investigación Sanitaria
Fundación Jiménez Díaz; Ministerio de
Ciencia, Innovación y Universidades, Grant/
Award Number: RTI2018- 093330-B-I00
and MCIU/FEDER; Ministerio de Economía
y Competitividad, Grant/Award Number:
SAF2015-70561-R and MINECO/FEDE
Mapping the ionised gas around the luminous QSO HE 1029-1401: Evidence for minor merger events?
We present VIMOS integral field spectroscopy of the brightest radio-quiet QSO
on the southern sky HE 1029-1401 at a redshift of z=0.086. Standard
decomposition techniques for broad-band imaging are extended to integral field
data in order to deblend the QSO and host emission. We perform a tentative
analysis of the stellar continuum finding a young stellar population (<100Myr)
or a featureless continuum embedded in an old stellar population (10Gyr)
typical for a massive elliptical galaxy. The stellar velocity dispersion of
sigma_*=320\pm90 km/s and the estimated black hole mass
log(M_BH/M_sun)=8.7\pm0.3 are consistent with the local M_BH-sigma_* relation
within the errors. For the first time we map the two-dimensional ionised gas
distribution and the gas velocity field around HE 1029-1401. While the stellar
host morphology is purely elliptical we find a highly structured distribution
of ionised gas out to 16 kpc from the QSO. The gas is highly ionised solely by
the QSO radiation and has a significantly lower metallicity than would be
expected for the stellar mass of the host, indicating an external origin of the
gas most likely due to minor mergers. We find a rotating gas disc around the
QSO and a dispersion-dominated non-rotating gas component within the central 3
kpc. At larger distances the velocity field is heavily disturbed, which could
be interpreted as another signature of past minor merger events. Alternatively,
the arc-like structure seen in the ionised gas might also be indicative of a
large-scale expanding bubble, centred on and possibly driven by the active
nucleus.Comment: 13 pages, 13 figures, 1 table, accepted for publication in A&
First Light LBT AO Images of HR 8799 bcde at 1.65 and 3.3 Microns: New Discrepancies between Young Planets and Old Brown Dwarfs
As the only directly imaged multiple planet system, HR 8799 provides a unique
opportunity to study the physical properties of several planets in parallel. In
this paper, we image all four of the HR 8799 planets at H-band and 3.3 microns
with the new LBT adaptive optics system, PISCES, and LBTI/LMIRCam. Our images
offer an unprecedented view of the system, allowing us to obtain H and 3.3$
micron photometry of the innermost planet (for the first time) and put strong
upper-limits on the presence of a hypothetical fifth companion. We find that
all four planets are unexpectedly bright at 3.3 microns compared to the
equilibrium chemistry models used for field brown dwarfs, which predict that
planets should be faint at 3.3 microns due to CH4 opacity. We attempt to model
the planets with thick-cloudy, non-equilibrium chemistry atmospheres, but find
that removing CH4 to fit the 3.3 micron photometry increases the predicted L'
(3.8 microns) flux enough that it is inconsistent with observations. In an
effort to fit the SED of the HR 8799 planets, we construct mixtures of cloudy
atmospheres, which are intended to represent planets covered by clouds of
varying opacity. In this scenario, regions with low opacity look hot and
bright, while regions with high opacity look faint, similar to the patchy cloud
structures on Jupiter and L/T transition brown-dwarfs. Our mixed cloud models
reproduce all of the available data, but self-consistent models are still
necessary to demonstrate their viability.Comment: Accepted to Ap
Impact of uterine manipulator on oncological outcome in endometrial cancer surgery
Background: There are limited data available to indicate whether oncological outcomes might be influenced by the uterine manipulator, which is used at the time of hysterectomy for minimally invasive surgery in patients with endometrial cancer. The current evidence derives from retrospective studies with limited sample sizes. Without substantial evidence to support its use, surgeons are required to make decisions about its use based only on their personal choice and surgical experience.
Objective: To evaluate the use of the uterine manipulator on oncological outcomes after minimally invasive surgery, for apparent early-stage endometrial cancer. Study Design: We performed a retrospective multicentric study to assess the oncological safety of uterine manipulator use in patients with apparent early-stage endometrial cancer, treated with minimally invasive surgery. The type of manipulator, surgical staging, histology, lymphovascular space invasion, International Federation of Gynecology and Obstetrics stage, adjuvant treatment, recurrence, and pattern of recurrence were evaluated. The primary objective was to determine the relapse rate. The secondary objective was to determine recurrence-free survival, overall survival, and the pattern of recurrence.
Results: A total of 2661 women from 15 centers were included; 1756 patients underwent hysterectomy with a uterine manipulator and 905 without it. Both groups were balanced with respect to histology, tumor grade, myometrial invasion, International Federation of Gynecology and Obstetrics stage, and adjuvant therapy. The rate of recurrence was 11.69% in the uterine manipulator group and 7.4% in the no-manipulator group (P<.001). The use of the uterine manipulator was associated with a higher risk of recurrence (hazard ratio, 2.31; 95% confidence interval, 1.27–4.20; P=.006). The use of uterine manipulator in uterus-confined endometrial cancer (International Federation of Gynecology and Obstetrics [FIGO] I–II) was associated with lower disease-free survival (hazard ratio, 1.74; 95% confidence interval, 0.57–0.97; P=.027) and higher risk of death (hazard ratio, 1.74; 95% confidence interval, 1.07–2.83; P=.026). No differences were found regarding the pattern of recurrence between both groups (chi-square statistic, 1.74; P=.63).
Conclusion: In this study, the use of a uterine manipulator was associated with a worse oncological outcome in patients with uterus-confined endometrial cancer (International Federation of Gynecology and Obstetrics I–II) who underwent minimally invasive surgery. Prospective trials are essential to confirm these results
Truncating FLNC Mutations Are Associated With High-Risk Dilated and Arrhythmogenic Cardiomyopathies
BACKGROUND: Filamin C (encoded by the FLNC gene) is essential for sarcomere attachment to the plasmatic membrane. FLNC mutations have been associated with myofibrillar myopathies, and cardiac involvement has been reported in some carriers. Accordingly, since 2012, the authors have included FLNC in the genetic screening of patients with inherited cardiomyopathies and sudden death. OBJECTIVES: The aim of this study was to demonstrate the association between truncating mutations in FLNC and the development of high-risk dilated and arrhythmogenic cardiomyopathies. METHODS: FLNC was studied using next-generation sequencing in 2,877 patients with inherited cardiovascular diseases. A characteristic phenotype was identified in probands with truncating mutations in FLNC. Clinical and genetic evaluation of 28 affected families was performed. Localization of filamin C in cardiac tissue was analyzed in patients with truncating FLNC mutations using immunohistochemistry. RESULTS: Twenty-three truncating mutations were identified in 28 probands previously diagnosed with dilated, arrhythmogenic, or restrictive cardiomyopathies. Truncating FLNC mutations were absent in patients with other phenotypes, including 1,078 patients with hypertrophic cardiomyopathy. Fifty-four mutation carriers were identified among 121 screened relatives. The phenotype consisted of left ventricular dilation (68%), systolic dysfunction (46%), and myocardial fibrosis (67%); inferolateral negative T waves and low QRS voltages on electrocardiography (33%); ventricular arrhythmias (82%); and frequent sudden cardiac death (40 cases in 21 of 28 families). Clinical skeletal myopathy was not observed. Penetrance was >97% in carriers older than 40 years. Truncating mutations in FLNC cosegregated with this phenotype with a dominant inheritance pattern (combined logarithm of the odds score: 9.5). Immunohistochemical staining of myocardial tissue showed no abnormal filamin C aggregates in patients with truncating FLNC mutations. CONCLUSIONS: Truncating mutations in FLNC caused an overlapping phenotype of dilated and left-dominant arrhythmogenic cardiomyopathies complicated by frequent premature sudden death. Prompt implantation of a cardiac defibrillator should be considered in affected patients harboring truncating mutations in FLNC.Instituto de Salud Carlos III [PI11/0699, PI14/0967, PI14/01477, RD012/0042/0029, RD012/0042/0049, RD012/0042/0066, RD12/0042/0069]; Spanish Ministry of Economy and Competitiveness [SAF2015-71863-REDT]; Plan Nacional de I+D+I; Plan Estatalde I+D+I, European Regional Development Fund; Health in Code SLS
The Mice at play in the CALIFA survey: A case study of a gas-rich major merger between first passage and coalescence
We present optical integral field spectroscopy (IFS) observations of the
Mice, a major merger between two massive (>10^11Msol) gas-rich spirals NGC4676A
and B, observed between first passage and final coalescence. The spectra
provide stellar and gas kinematics, ionised gas properties and stellar
population diagnostics, over the full optical extent of both galaxies. The Mice
provide a perfect case study highlighting the importance of IFS data for
improving our understanding of local galaxies. The impact of first passage on
the kinematics of the stars and gas has been significant, with strong bars
likely induced in both galaxies. The barred spiral NGC4676B exhibits a strong
twist in both its stellar and ionised gas disk. On the other hand, the impact
of the merger on the stellar populations has been minimal thus far: star
formation induced by the recent close passage has not contributed significantly
to the global star formation rate or stellar mass of the galaxies. Both
galaxies show bicones of high ionisation gas extending along their minor axes.
In NGC4676A the high gas velocity dispersion and Seyfert-like line ratios at
large scaleheight indicate a powerful outflow. Fast shocks extend to ~6.6kpc
above the disk plane. The measured ram pressure and mass outflow rate
(~8-20Msol/yr) are similar to superwinds from local ULIRGs, although NGC4676A
has only a moderate infrared luminosity of 3x10^10Lsol. Energy beyond that
provided by the mechanical energy of the starburst appears to be required to
drive the outflow. We compare the observations to mock kinematic and stellar
population maps from a merger simulation. The models show little enhancement in
star formation during and following first passage, in agreement with the
observations. We highlight areas where IFS data could help further constrain
the models.Comment: 23 pages, 13 figures, accepted to A&A. A version with a complete set
of high resolution figures is available here:
http://www-star.st-and.ac.uk/~vw8/resources/mice_v8_astroph.pd
Potentially pathogenic Acanthamoeba genotype T4 isolated from dental units and emergency combination showers
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