Synthetic strategies for the enhancement of Mg(OH)2 thermochemical performances as heat storage material

Abstract This work deals with the study of influence of multi walled carbon nanotubes (CNTs) characteristics on thermochemical performance of hybrid materials based on Mg(OH) 2 (M) as heat storage medium. Two different functionalized CNTs samples are investigated, separated curly tubes (SN) and bundles of straight nanotubes (BN). Hybrids were synthesized by reverse deposition precipitation method and their structure was characterized by X-ray analysis and scanning electron microscopy. The heat storage performance was studied through a thermogravimetric apparatus, simulating heat storage/release cycles. It is demonstrated that separated CNTs owning mainly carboxylic groups increase the interaction with precipitated magnesium hydroxide, improving the reacted fraction during dehydration/hydration cycle. In terms of dehydration/hydration conversion the samples' rank is SN-M>Mg(OH) 2 >BN-M. SN-M exhibits higher heat storage/output capacity (~1250 kJ/kg Mg(OH)2 , ~350 MJ/m 3 )

Effects of sports experience on children's gross motor coordination level

Background: Gross motor coordination (GMC) development could be influenced by age, gender, weight status, geographical area, living setting, home environment, socio-economic status, sports practice. Purpose: To verify whether practicing sports and practicing different sports could influence children's GMC level. Methods: A total of 295 children aged 8-11 years were involved in the study and divided into 5 groups in relation to the sport they practiced: gymnastics group (n = 67; 51F, 16M), cycling group (n = 64; 15F, 49M), athletics group (n = 47; 22F, 25M), swimming group (n = 35; 20F, 15M), control group (n = 82; 42F, 40M). The four subtests of the Körperkoordinations Test für Kinder (KTK) assessed children's GMC level. The scores from each of the four subtests were summed into the KTK total raw score (RS) and then converted into a gender- and age-specific motor quotient (MQ). Results: Children practicing sports showed significantly higher RS and MQ score than children of control group (203.14 ± 38.55 vs. 163.63 ± 43.50 and 98.56 ± 15.79 vs. 83.01 ± 16.71, respectively; p < 0.001). Children practicing gymnastics had a significantly higher RS and MQ than children of cycling, swimming, and control groups (p < 0.05), children of control group had a significantly lower RS and MQ than children of all other groups (p < 0.05). Children practicing gymnastics performed better walking backwards subtest than all other children's groups (p < 0.001). Children of control group performed worse jumping sideways subtest than children of gymnastics, athletics and swimming groups (p < 0.01). Children practicing gymnastics performed better moving sideways subtest than children of athletics, cycling and control groups (p < 0.01); children of control group performed worse than children of all other groups (p < 0.01). Children of control group performed worse hopping for height subtest than children of gymnastics, athletics and cycling groups (p < 0.05); children practicing gymnastics performed better than children of swimming and control groups (p < 0.05). Conclusions: The performance model and therefore the specialized training that each sport discipline required, could justified the differences in children's GMC level among sports groups. Thus, coaches should plan individualized interventions and choose activity contents to support children's GMC development

Körperkoordinations test für Kinder: A short form is not fully satisfactory

Assessment of motor competence (MC) is crucial to finding deficiencies in children's motor development. Because of the need to ensure validity, reliability, and feasibility, the selection of contemporary testing batteries is a difficult task. Many papers report the validity of the KTK test in describing MC in school aged children. KTK consists of 4 four separate items: walking back, jumping sideways, moving sideways, and hopping for height. Some authors suggested the use of a short version of KTK that includes 3 items excluding one subtest: hopping for height. This study aimed to evaluate the effectiveness of short versions of Körperkoordinationstest für Kinder (KTK). A sample of 2,231 participants (boys: n=1,188; girls: n = 1,043; age range: 6–12 years) were recruited from Italian schools between January 2019 and February 2020 and they performed the complete version of KTK. Stepwise linear regression was performed on the dataset to evaluate the ideal number of variables to describe the KTK short form version. Data for both the sexes and all ages indicated that considering the item combinations of each short version, the highest R squares were obtained in those that included exactly the deleted subtest (ranging from 0.881–0.979). The adoption of a short form does not seem to provide a fully satisfactory condition for measuring MC in children 6–12 years

The prevalence of peripheral and central hearing impairment and its relation to cognition in older adults.

Age-related hearing loss (ARHL) and dementia are two highly prevalent conditions in the adult population. Recent studies have suggested that hearing loss is independently associated with poorer cognitive functioning. The aim of this study was to evaluate the prevalence of ARHL and cognitive impairment in a large sample of subjects older than 65 years and to correlate hearing function with cognitive function. A total of 488 subjects older than 65 years (mean age 72.8 years) participating in the Great Age Study underwent a complete audiological, neurological and neuropsychological evaluation as part of a multidisciplinary assessment. The prevalence of a hearing loss greater than 25 dB HL was 64.1%, of Central Auditory Processing Disorder (CAPD) was 14.3 and 25.3% of the subjects reported a hearing handicap as reported on the Hearing Handicap Inventory for the Elderly Screening Version questionnaire. Multiple logistic regression analysis corrected for gender, age and education duration showed that mild cognitive impairment (MCI) was significantly associated with hearing impairment (CAPD and hearing threshold; odds ratio 1.6, p = 0.05) and that Alzheimer's disease (AD) was significantly associated with CAPD (odds ratio 4.2, p = 0.05). Given that up to 80% of patients affected by MCI convert to AD, adding auditory tests to a screening cognitive battery might have value in the early diagnosis of cognitive decline

Interrelationship between age, gender, and weight status on motor coordination in Italian children and early adolescents aged 6-13 years old

Although numerous evidences reported a negative correlation between motor coordination (MC) and overweight/obesity in children and adolescents, the interrelationship between age, gender, and weight status is still debatable. Hence, the aim of this cross-sectional study was to examine the association between MC and weight status according to age and gender across childhood and early adolescence in a large sample of Italian elementary and middle school students. A number of 1961 Italian school students (1,026 boys, 935 girls) was stratified in three consecutive age groups (6-7, 8-10, and 11-13 years) and four weight status categories (underweight, normal weight, overweight, and obese) according to Cole's body mass index (BMI) cut-off points for children. MC performance was assessed measuring motor quotient (MQ) with the Körperkoordinationstest für Kinder (KTK). Results showed significantly lower MQ levels in children in overweight (OW) and with obesity (OB) in both sexes for all age groups than peers in normal weight (NW), except in 6-7-year-old boys. Girls in OW and with OB had similar MQ levels across all age groups, while younger boys in OW and with OB showed higher MQ levels than older ones (p < 0.05). The 6-7-year-old boys showed better MQ levels than girls peers in NW, OW, and with OB, while 8-10-year-old boys in underweight (UW), NW, and OW; and 11-13-year-old boys only in NW (p < 0.05). No interaction effect was found between age, gender, and weight status on MQ levels. These outcomes showed the negative impact of higher weight status on MC performance according to age and gender, pointing out the importance of planning targeted motor programs that consider these variables to improve MC performance

Therapeutic Targeting of Acute Myeloid Leukemia by Gemtuzumab Ozogamicin

Simple Summary Gemtuzumab Ozogamicin (GO) is a drug approved for the treatment of acute myeloid leukemia (AML). It targets leukemic cells that express the CD33 molecule on their surface and brings the toxic agent calicheamicin inside the cell to kill it. Several studies have shown that AML patients can benefit of the addition of GO to chemotherapy during induction regimens, pre- and post-transplantation. Moreover, some disease features have been addressed or are under investigation for their capacity to predict response to GO, with the future aim of selecting AML patients that can mostly benefit of GO treatment. Acute myeloid leukemia (AML) is a complex hematological malignancy characterized by genetic and clinical heterogeneity and high mortality. Despite the recent introduction of novel pharmaceutical agents in hemato-oncology, few advancements have been made in AML for decades. In the last years, the therapeutic options have rapidly changed, with the approval of innovative compounds that provide new opportunities, together with new challenges for clinicians: among them, on 1 September, 2017 the Food and Drug Administration granted approval for Gemtuzumab Ozogamicin (GO) in combination with daunorubicin and cytarabine for the treatment of adult patients affected by newly diagnosed CD33(+) AML. Benefits of GO-based regimens were also reported in the pre- and post-transplantation settings. Moreover, several biomarkers of GO response have been suggested, including expression of CD33 and multidrug resistance genes, cytogenetic and molecular profiles, minimal residual disease and stemness signatures. Among them, elevated CD33 expression on blast cells and non-adverse cytogenetic or molecular risk represent largely validated predictors of good response

Método de análise da suscetibilidade a movimentos de massa aplicado a obras viárias / Method for analysis of the susceptibility to mass movements applied to road works

A execução de intervenções na malha rodoviária para sua ampliação ou para sua melhoria implicam interferências em diversos tipos de relevos, incluindo os ondulados e os montanhosos. Considerando a grande variedade de fatores físicos e antrópicos coexistentes ao longo dos traçados de interesse e ressaltando-se a ocorrência de eventos extremos de precipitações pluviométricas, a necessidade de se avaliar previamente a suscetibilidade a movimentos de massa nas encostas que margeiam as vias torna-se cada vez mais alta. A existência de estudos para identificação de áreas instáveis visa prevenir a ocorrência de transtornos aos usuários devido a interdições no tráfego, danos à infraestrutura e, até mesmo, a vítimas fatais. Na presente pesquisa, analisaram-se os deslizamentos translacionais rasos e rotacionais para um trecho da rodovia BR-280, localizado em Corupá e em São Bento do Sul, no norte de Santa Catarina. Para isso, foram levantados mapas da identificação do meio físico, bem como foram realizados ensaios de laboratório para a obtenção dos parâmetros de resistência dos solos. Com os dados obtidos, fez-se a interpretação dos deslizamentos translacionais e rotacionais, por meio dos modelos SHALSTAB e Bishop, respectivamente, os quais foram aplicados espacialmente em um Sistema de Informação Geográfica (SIG). Assim, adotou-se um padrão semafórico para a união dos resultados de deslizamentos translacionais e rotacionais, o qual indica, no mapa, as zonas de maior instabilidade, que requerem maior atenção, conduzindo à aplicação de medidas preventivas, como obras de contenção e de drenagem

Metodologia aplicada na análise de suscetibilidade a movimentos de massa em obras viárias / Methodology applied to the analysis of susceptibility to mass movements in road works

A previsão e a remediação de problemas gerados pela ocorrência de movimentos de massa em taludes rodoviários têm ganhado repercussão e, por isso, têm sido alvos de estudos. O alto impacto ambiental, o elevado custo de manutenção e de recuperação e, também, as interdições no tráfego são exemplos de efeitos ocasionados pelos deslizamentos de encostas. Nesse contexto, o presente trabalho tem por objetivo apresentar o estudo e a análise de deslizamentos translacionais rasos e rotacionais para um trecho da rodovia BR-101, localizado na região sudoeste do Estado do Rio de Janeiro, entre os municípios de Paraty, de Angra dos Reis e de Mangaratiba. A metodologia utilizada para a previsão desses eventos baseou-se tanto no levantamento de mapas envolvendo os fatores físicos da região quanto em parâmetros de resistência dos solos, obtidos em ensaios de campo e de laboratório. Após a obtenção desses dados, realizou-se a análise da instabilidade dos taludes em questão. No caso de deslizamentos translacionais rasos, utilizou-se o modelo Shallow Slope Stability Model (SHALSTAB) e, por sua vez, no que diz respeito aos deslizamentos rotacionais, utilizou-se o método de Bishop, ambos aplicados sobre o Modelo Digital do Terreno (MDT). Dessa forma, através da união dos resultados de deslizamentos translacionais rasos e rotacionais, elaborou-se um mapa de padrão semafórico contendo zonas de maior e de menor instabilidade existentes ao longo do corpo estradal. Ao final, foram analisadas as áreas de maior instabilidade que requerem atenção e a posterior aplicação de soluções geotécnicas pertinentes.

Early and extended erythropoietin monotherapy after hypoxic ischaemic encephalopathy:a multicentre double-blind pilot randomised controlled trial

Objective: To examine the feasibility of early and extended erythropoietin monotherapy after hypoxic ischaemic encephalopathy (HIE). Design: Double-blind pilot randomised controlled trial.Setting: Eight neonatal units in South Asia. Patients: Neonates (≥36 weeks) with moderate or severe HIE admitted between 31 December 2022 and 3 May 2023. Interventions: Erythropoietin (500 U/kg daily) or to the placebo (sham injections using a screen) within 6 hours of birth and continued for 9 days. MRI at 2 weeks of age. Main outcomes and measures: Feasibility of randomisation, drug administration and assessment of brain injury using MRI. Results: Of the 154 neonates screened, 56 were eligible; 6 declined consent and 50 were recruited; 43 (86%) were inborn. Mean (SD) age at first dose was 4.4 (1.2) hours in erythropoietin and 4.1 (1.0) hours in placebo. Overall mortality at hospital discharge occurred in 5 (19%) vs 11 (46%) (p=0.06), and 3 (13%) vs 9 (40.9%) (p=0.04) among those with moderate encephalopathy in the erythropoietin and placebo groups. Moderate or severe injury to basal ganglia, white matter and cortex occurred in 5 (25%) vs 5 (38.5%); 14 (70%) vs 11 (85%); and 6 (30%) vs 2 (15.4%) in the erythropoietin and placebo group, respectively. Sinus venous thrombosis was seen in two (10%) neonates in the erythropoietin group and none in the control group. Conclusions: Brain injury and mortality after moderate or severe HIE are high in South Asia. Evaluation of erythropoietin monotherapy using MRI to examine treatment effects is feasible in these settings. Trial registration number: NCT05395195

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements