Regional tourism opportunities in the Andalusian coast

At the School of Architecture of Granada, within the research line on Coastal Architecture, the uniqueness and variability of the different development cases arising in the Andalusian coast have been analysed, all of which were approached from the particularization of their fragmentary condition and establishing comparative relationships between them to help understand the complexity of the phenomenon. All studied aspects have been contrasted in various fields thanks to the graphic treatment of the information. To achieve this goal, specific techniques associated with the selected parameters have been used. All of this is used to provide new evidence for the future in order to propose alternatives and remedies for environmental imbalances, infrastructures based on the use of public transport and public facilities related to the landscape. These elements can achieve, as a whole, the recovery of the coastline understood as a strip of land full of valuable heritage providing, with the correct alignment, social cohesion to the territorial structure.Peer Reviewe

A Alhambra na obra de Rogelio Salmona: Ecos da experiência nazarí

The influence of the Alhambra upon contemporary architecture is recognized worldwide, hence the Latin-American case is not an exception. This architectonic relation, attractive and full of creative strength, is especially evocative in the works of Rogelio Salmona who, among other architects like the Mexican Luis Barragan, applied Hispanic-Islamic principles to his works. This investigation does not propose a map of influences or a compilation of past research, but an approach based on Salmona’s own travels and living experiences. Its first step is a general description of the Alhambra influence on occidental architecture between XV and XX centuries. This is followed by an explanation of the essential typological principles in Islamic architecture. After that, we present a record of Salmona’s travel through Spain, which shows how the Alhambra became its main protagonist, and concludes with a tracking of what composition strategies inspired on the Alhambra were applied by Rogelio Salmona. This paper uses Salmona’s own photographic work as a key for discovering the emotivity of his projects, in a way that shows a clear connection between architectures apparently separated in space and time.La Alhambra ha ejercido una gran influencia en la arquitectura contemporánea y el caso latinoamericano no es ajeno a este fenómeno. Esa relación, atractiva y a la vez llena de potencia creadora, resulta especialmente evocadora en la obra de Rogelio Salmona, que junto a otros arquitectos como Luis Barragán aplicaron los principios de la arquitectura hispano-islámica. Más allá del trazado de un mapa sobre estas influencias, o de la recopilación de autores que han abordado esta cuestión en sus investigaciones, se propone un acercamiento desde la experiencia vivencial de Rogelio Salmona siguiendo la huella de sus viajes en contacto con la arquitectura islámica. Para ello se ha realizado una primera descripción general sobre la influencia de la Alhambra en la arquitectura occidental a partir del siglo XV. En segundo lugar, se expone una descripción de los principios tipológicos esenciales de la arquitectura Islámica. A continuación, se presenta un seguimiento del viaje de Rogelio Salmona a España, en el que se enfatiza la visita del arquitecto a la Alhambra, para finalmente concluir con un rastreo de estrategias compositivas alhambrescas en la obra construida de Salmona a través de fotografías originales del arquitecto. Se descubre así, desde la emotividad y de un modo natural, cómo surge esta conexión en arquitecturas aparentemente alejadas en la distancia temporal y física.A Alhambra tem exercido uma grande influência na arquitetura contemporânea, e o caso latino-americano não está alheio a esse fenômeno. Essa relação, atraente e ao mesmo tempo repleta de poder criativo, é especialmente evocativa na obra de Rogelio Salmona que, junto a outros arquitetos como Luis Barragán, aplicou os princípios da arquitetura hispano-islâmica. Além de desenhar um mapa sobre essas influências, ou do estudo de autores que abordaram essa questão em suas pesquisas, propõe-se uma abordagem a partir da experiência de Rogelio Salmona seguindo o traçado de suas viagens em contato com a arquitetura islâmica. Para este fim, faz-se uma primeira descrição geral sobre a influência da Alhambra na arquitetura ocidental desde o século XV. Em segundo lugar, apresenta-se a continuação da viagem de Rogelio Salmona à Espanha, enfatizando-se a visita do arquiteto à Alhambra. Segue-se uma descrição dos princípios tipológicos essenciais da arquitetura islâmica e, finalmente, conclui-se com um levantamento de estratégias composicionais da Alhambra no trabalho construído de Salmona através de fotografias originais do arquiteto. Assim se constata, com o emprego da sensibilidade, e de maneira natural, como essa conexão surge em arquiteturas aparentemente distintas fisicamente e no que diz respeito à noção de tempo

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Changing geographical patterns and trends in cancer incidence in children and adolescents in Europe, 1991–2010 (Automated Childhood Cancer Information System): a population-based study

Background: A deceleration in the increase in cancer incidence in children and adolescents has been reported in several national and regional studies in Europe. Based on a large database representing 1·3 billion person-years over the period 1991–2010, we provide a consolidated report on cancer incidence trends at ages 0–19 years. Methods: We invited all population-based cancer registries operating in European countries to participate in this population-based registry study. We requested a listing of individual records of cancer cases, including sex, age, date of birth, date of cancer diagnosis, tumour sequence number, primary site, morphology, behaviour, and the most valid basis of diagnosis. We also requested population counts in each calendar year by sex and age for the registration area, from official national sources, and specific information about the covered area and registration practices. An eligible registry could become a contributor if it provided quality data for all complete calendar years in the period 1991–2010. Incidence rates and the average annual percentage change with 95% CIs were reported for all cancers and major diagnostic groups, by region and overall, separately for children (age 0–14 years) and adolescents (age 15–19 years). We examined and quantified the stability of the trends with joinpoint analyses. Findings: For the years 1991–2010, 53 registries in 19 countries contributed a total of 180 335 unique cases. We excluded 15 162 (8·4%) of 180 335 cases due to differing practices of registration, and considered the quality indicators for the 165 173 cases included to be satisfactory. The average annual age-standardised incidence was 137·5 (95% CI 136·7–138·3) per million person-years and incidence increased significantly by 0·54% (0·44–0·65) per year in children (age 0–14 years) with no change in trend. In adolescents, the combined European incidence was 176·2 (174·4–178·0) per million person-years based on all 35 138 eligible cases and increased significantly by 0·96% (0·73–1·19) per year, although recent changes in rates among adolescents suggest a deceleration in this increasing trend. We observed temporal variations in trends by age group, geographical region, and diagnostic group. The combined age-standardised incidence of leukaemia based on 48 458 cases in children was 46·9 (46·5–47·3) per million person-years and increased significantly by 0·66% (0·48–0·84) per year. The average overall incidence of leukaemia in adolescents was 23·6 (22·9–24·3) per million person-years, based on 4702 cases, and the average annual change was 0·93% (0·49–1·37). We also observed increasing incidence of lymphoma in adolescents (average annual change 1·04% [0·65–1·44], malignant CNS tumours in children (average annual change 0·49% [0·20–0·77]), and other tumours in both children (average annual change 0·56 [0·40–0·72]) and adolescents (average annual change 1·17 [0·82–1·53]). Interpretation: Improvements in the diagnosis and registration of cancers over time could partly explain the observed increase in incidence, although some changes in underlying putative risk factors cannot be excluded. Cancer incidence trends in this young population require continued monitoring at an international level. Funding: Federal Ministry of Health of the Federal German Government, the European Union's Seventh Framework Programme, and International Agency for Research on Cancer