1,380 research outputs found
Quantum Computing in Molecular Magnets
Shor and Grover demonstrated that a quantum computer can outperform any
classical computer in factoring numbers and in searching a database by
exploiting the parallelism of quantum mechanics. Whereas Shor's algorithm
requires both superposition and entanglement of a many-particle system, the
superposition of single-particle quantum states is sufficient for Grover's
algorithm. Recently, the latter has been successfully implemented using Rydberg
atoms. Here we propose an implementation of Grover's algorithm that uses
molecular magnets, which are solid-state systems with a large spin; their spin
eigenstates make them natural candidates for single-particle systems. We show
theoretically that molecular magnets can be used to build dense and efficient
memory devices based on the Grover algorithm. In particular, one single crystal
can serve as a storage unit of a dynamic random access memory device. Fast
electron spin resonance pulses can be used to decode and read out stored
numbers of up to 10^5, with access times as short as 10^{-10} seconds. We show
that our proposal should be feasible using the molecular magnets Fe8 and Mn12.Comment: 13 pages, 2 figures, PDF, version published in Nature, typos
correcte
Quantum enhanced positioning and clock synchronization
A wide variety of positioning and ranging procedures are based on repeatedly
sending electromagnetic pulses through space and measuring their time of
arrival. This paper shows that quantum entanglement and squeezing can be
employed to overcome the classical power/bandwidth limits on these procedures,
enhancing their accuracy. Frequency entangled pulses could be used to construct
quantum positioning systems (QPS), to perform clock synchronization, or to do
ranging (quantum radar): all of these techniques exhibit a similar enhancement
compared with analogous protocols that use classical light. Quantum
entanglement and squeezing have been exploited in the context of
interferometry, frequency measurements, lithography, and algorithms. Here, the
problem of positioning a party (say Alice) with respect to a fixed array of
reference points will be analyzed.Comment: 4 pages, 2 figures. Accepted for publication by Natur
Quantum simulation of the wavefunction to probe frustrated Heisenberg spin systems
Quantum simulators are controllable quantum systems that can reproduce the
dynamics of the system of interest, which are unfeasible for classical
computers. Recent developments in quantum technology enable the precise control
of individual quantum particles as required for studying complex quantum
systems. Particularly, quantum simulators capable of simulating frustrated
Heisenberg spin systems provide platforms for understanding exotic matter such
as high-temperature superconductors. Here we report the analog quantum
simulation of the ground-state wavefunction to probe arbitrary Heisenberg-type
interactions among four spin-1/2 particles . Depending on the interaction
strength, frustration within the system emerges such that the ground state
evolves from a localized to a resonating valence-bond state. This spin-1/2
tetramer is created using the polarization states of four photons. The
single-particle addressability and tunable measurement-induced interactions
provide us insights into entanglement dynamics among individual particles. We
directly extract ground-state energies and pair-wise quantum correlations to
observe the monogamy of entanglement
Trial baseline characteristics of a cluster randomised controlled trial of a school-located obesity prevention programme; the Healthy Lifestyles Programme (HeLP) trial
This is the final version of the article. Available from BioMed Central via the DOI in this record.Background
We have developed a healthy lifestyles programme (HeLP) for primary school aged children (9–10 years), currently being evaluated in a definitive cluster randomised controlled trial. This paper descriptively presents the baseline characteristics of trial children (BMI, waist circumference, % body fat, diet and physical activity) by gender, cluster level socio-economic status, school size and time of recruitment into the trial.
Methods
Schools were recruited from across the South West of England and allocated 1:1 to either intervention (HeLP) or control (usual practice) stratified by the proportion of children eligible for free school meals (FSM, 1 Year 5 class). The primary outcome is change in body mass index standard deviation score (BMI sds) at 24 months post-randomisation. Secondary outcomes are BMI sds at 18 months, waist circumference and percentage body fat sds at 18 and 24 months, proportion of children classified as underweight, overweight and obese at 18 and 24 months, physical activity (for a sub-sample) and food intake at 18 months.
Results
At baseline 11.4% and 13.6% of children were categorised as overweight or obese respectively. A higher percentage of girls than boys (25.3% vs 24.8%) and children from schools in FSM category 2 (28.2% vs 23.2%) were overweight or obese. Children were consuming a mean (range) of 4.15 (0–13) energy dense snacks (EDS) and 3.23 (0–9) healthy snacks (HS) per day with children from schools in FSM category 2 consuming more EDS and negative food markers and less HS and positive food markers. Children spent an average 53.6 min per day (11.9 to 124.8) in MVPA and thirteen hours (779.3 min) per day (11 h to 15 h) doing less than ‘light’ intensity activity. Less than 5% of children achieved the Departments of Health’s recommendation of 60 min of MVPA every day.
Conclusion
We have excellent completeness of baseline data for all measures and have achieved compliance to accelerometry not seen before in other large scale studies. Our anthropometric baseline data is representative of local and national data for children this age and reflects the gender and socio-economic variations expected of children this age in relation to physical activity and weight status.The definitive trial of HeLP is funded by the UK National Institute for Health Research (NIHR) Public Health Research Programme (10/3010/01) and a full report will be published on the NIHR website. Intervention materials and delivery was funded by the Peninsula College of Medicine and Dentistry. PenCLAHRC provided methodological support during the transition from the exploratory trial to the definitive evaluation
Root causes for delayed hospital discharge in patients with ST-segment Myocardial Infarction (STEMI): a qualitative analysis
Coevolved mutations reveal distinct architectures for two core proteins in the bacterial flagellar motor
Switching of bacterial flagellar rotation is caused by large domain movements of the FliG protein triggered by binding of the signal protein CheY to FliM. FliG and FliM form adjacent multi-subunit arrays within the basal body C-ring. The movements alter the interaction of the FliG C-terminal (FliGC) "torque" helix with the stator complexes. Atomic models based on the Salmonella entrovar C-ring electron microscopy reconstruction have implications for switching, but lack consensus on the relative locations of the FliG armadillo (ARM) domains (amino-terminal (FliGN), middle (FliGM) and FliGC) as well as changes during chemotaxis. The generality of the Salmonella model is challenged by the variation in motor morphology and response between species. We studied coevolved residue mutations to determine the unifying elements of switch architecture. Residue interactions, measured by their coevolution, were formalized as a network, guided by structural data. Our measurements reveal a common design with dedicated switch and motor modules. The FliM middle domain (FliMM) has extensive connectivity most simply explained by conserved intra and inter-subunit contacts. In contrast, FliG has patchy, complex architecture. Conserved structural motifs form interacting nodes in the coevolution network that wire FliMM to the FliGC C-terminal, four-helix motor module (C3-6). FliG C3-6 coevolution is organized around the torque helix, differently from other ARM domains. The nodes form separated, surface-proximal patches that are targeted by deleterious mutations as in other allosteric systems. The dominant node is formed by the EHPQ motif at the FliMMFliGM contact interface and adjacent helix residues at a central location within FliGM. The node interacts with nodes in the N-terminal FliGc α-helix triad (ARM-C) and FliGN. ARM-C, separated from C3-6 by the MFVF motif, has poor intra-network connectivity consistent with its variable orientation revealed by structural data. ARM-C could be the convertor element that provides mechanistic and species diversity.JK was supported by Medical Research Council grant U117581331. SK was supported by seed funds from Lahore University of Managment Sciences (LUMS) and the Molecular Biology Consortium
Leaf-level photosynthetic capacity in lowland Amazonian and high elevation, Andean tropical moist forests of Peru
We examined whether variations in photosynthetic capacity are linked to variations in theenvironment and/or associated leaf traits for tropical moist forests (TMFs) in the Andes/west-ern Amazon regions of Peru. We compared photosynthetic capacity (maximal rate of carboxylation of Rubisco (Vcmax),and the maximum rate of electron transport (Jmax)), leaf mass, nitrogen (N) and phosphorus(P) per unit leaf area (Ma,Naand Pa, respectively), and chlorophyll from 210 species at 18field sites along a 3300-m elevation gradient. Western blots were used to quantify the abun-dance of the CO₂-fixing enzyme Rubisco. Area- and N-based rates of photosynthetic capacity at 25°C were higher in upland than low-land TMFs, underpinned by greater investment of N in photosynthesis in high-elevation trees. Soil [P] and leaf Pa were key explanatory factors for models of area-based Vcmax and Jmax but did not account for variations in photosynthetic N-use efficiency. At any given Na and Pa, the fraction of N allocated to photosynthesis was higher in upland than lowland species. For a smallsubset of lowland TMF trees examined, a substantial fraction of Rubisco was inactive. These results highlight the importance of soil- and leaf-P in defining the photosyntheticcapacity of TMFs, with variations in N allocation and Rubisco activation state further influenc-ing photosynthetic rates and N-use efficiency of these critically important forests
First-passage times in complex scale-invariant media
How long does it take a random walker to reach a given target point? This
quantity, known as a first passage time (FPT), has led to a growing number of
theoretical investigations over the last decade1. The importance of FPTs
originates from the crucial role played by first encounter properties in
various real situations, including transport in disordered media, neuron firing
dynamics, spreading of diseases or target search processes. Most methods to
determine the FPT properties in confining domains have been limited to
effective 1D geometries, or for space dimensions larger than one only to
homogeneous media1. Here we propose a general theory which allows one to
accurately evaluate the mean FPT (MFPT) in complex media. Remarkably, this
analytical approach provides a universal scaling dependence of the MFPT on both
the volume of the confining domain and the source-target distance. This
analysis is applicable to a broad range of stochastic processes characterized
by length scale invariant properties. Our theoretical predictions are confirmed
by numerical simulations for several emblematic models of disordered media,
fractals, anomalous diffusion and scale free networks.Comment: Submitted version. Supplementary Informations available on Nature
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Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
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