Expression of the ErbB Family of Receptor Tyrosine Kinases and Toll-like Receptor 4 on Oral Squamous Cell Carcinoma Cells: A Preliminary Study

Epidermal growth factor receptor (EGFR) and its three related proteins are collectively known as an ErbB family of receptor tyrosine kinases (RTKs). It comprises of four distinct receptors: the EGFR (ErbB1/Her1), ErbB2 (neu/Her2), ErbB3 (Her3) and ErbB4 (Her4). It plays a critical function in the homeostasis of epithelial cells. It also drives cancer development. Oral squamous cell carcinoma (OSCC) is considered the sixth most common cancer. It has been reported that an overexpression of EGFR correlated with progression and poor prognosis in SCC of the tongue. Therefore, targeted inhibition of EGFR is a promising approach to suppress signal transduction pathways which control tumor cell growth, proliferation, and resistance to apoptosis. The role of bacteria in cancer, in particular initiation and progression, is well known. It has been reported that TLR4 activation by lipopolysaccharide (LPS) results in resistance to EGFR-targeted therapy in OSCC. The overall goal of the study is to elucidate how oral bacteria influence the clinical outcome of the EGFR-targeted therapy in OSCC since the oral cavity harbors a diverse and complex microbial community. In this presentation, we reported an expression of ErbB family of RTKs and TLR 4 on OSCC cells

Expression of the ErbB Family of Receptor Tyrosine Kinases and Toll-like Receptor 4 on Oral Squamous Cell Carcinoma Cells: A Preliminary Study

Epidermal growth factor receptor (EGFR) and its three related proteins are collectively known as an ErbB family of receptor tyrosine kinases (RTKs). It comprises of four distinct receptors: the EGFR (ErbB1/Her1), ErbB2 (neu/Her2), ErbB3 (Her3) and ErbB4 (Her4). It plays a critical function in the homeostasis of epithelial cells. It also drives cancer development. Oral squamous cell carcinoma (OSCC) is considered the sixth most common cancer. It has been reported that an overexpression of EGFR correlated with progression and poor prognosis in SCC of the tongue. Therefore, targeted inhibition of EGFR is a promising approach to suppress signal transduction pathways which control tumor cell growth, proliferation, and resistance to apoptosis. The role of bacteria in cancer, in particular initiation and progression, is well known. It has been reported that TLR4 activation by lipopolysaccharide (LPS) results in resistance to EGFR-targeted therapy in OSCC. The overall goal of the study is to elucidate how oral bacteria influence the clinical outcome of the EGFR-targeted therapy in OSCC since the oral cavity harbors a diverse and complex microbial community. In this presentation, we reported an expression of ErbB family of RTKs and TLR 4 on OSCC cells

Patient selection for left ventricular assist devices

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102692/1/ejhfhfq006.pd

Influence of deposition strategies on tensile and fatigue properties in a wire + arc additive manufactured Ti-6Al-4V

This paper investigates the influence of two different deposition strategies, oscillation and parallel pass, on the tensile and high cycle fatigue properties of a wire + arc additive manufactured Ti-6Al-4V alloy in the as-built condition. In the oscillation build, the plasma torch and the wire feeder continuously oscillated across the wall thickness direction. In contrast, four single layers were deposited consecutively in the same direction along the wall length in the parallel pass build. Test specimens were manufactured in horizontal and vertical orientation with respect to the deposited layers. Compared with the parallel pass build, the oscillation build had lower static strength due to its coarser transformation microstructure. However, the elongation values were similar. The presence of columnar primary β grains has resulted in anisotropic elongation values. The vertical samples with loading axis parallel to the primary β grains showed 40% higher elongation than the horizontal samples. The fatigue strength was comparable with its wrought counterpart and greater than typical material by casting. At 107 cycles, fatigue strength of 600 MPa was achieved for the oscillation build vertical samples and the parallel pass build in both orientations. Only the oscillation build horizontal samples had lower fatigue strength of 500 MPa. Fractography analysis showed that most of the samples (about 70%) had crack initiation from pores, about 20% samples had crack initiated from microstructural features and the rest did not failed (runouts at 107 cycles)

Tract-specific white matter structural disruption in patients with bipolar disorder

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Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV

The performance of muon reconstruction, identification, and triggering in CMS has been studied using 40 inverse picobarns of data collected in pp collisions at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection criteria covering a wide range of physics analysis needs have been examined. For all considered selections, the efficiency to reconstruct and identify a muon with a transverse momentum pT larger than a few GeV is above 95% over the whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4, while the probability to misidentify a hadron as a muon is well below 1%. The efficiency to trigger on single muons with pT above a few GeV is higher than 90% over the full eta range, and typically substantially better. The overall momentum scale is measured to a precision of 0.2% with muons from Z decays. The transverse momentum resolution varies from 1% to 6% depending on pseudorapidity for muons with pT below 100 GeV and, using cosmic rays, it is shown to be better than 10% in the central region up to pT = 1 TeV. Observed distributions of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO

Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV

The performance of muon reconstruction, identification, and triggering in CMS has been studied using 40 inverse picobarns of data collected in pp collisions at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection criteria covering a wide range of physics analysis needs have been examined. For all considered selections, the efficiency to reconstruct and identify a muon with a transverse momentum pT larger than a few GeV is above 95% over the whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4, while the probability to misidentify a hadron as a muon is well below 1%. The efficiency to trigger on single muons with pT above a few GeV is higher than 90% over the full eta range, and typically substantially better. The overall momentum scale is measured to a precision of 0.2% with muons from Z decays. The transverse momentum resolution varies from 1% to 6% depending on pseudorapidity for muons with pT below 100 GeV and, using cosmic rays, it is shown to be better than 10% in the central region up to pT = 1 TeV. Observed distributions of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO

X-ray emission from the Sombrero galaxy: discrete sources

We present a study of discrete X-ray sources in and around the bulge-dominated, massive Sa galaxy, Sombrero (M104), based on new and archival Chandra observations with a total exposure of ~200 ks. With a detection limit of L_X = 1E37 erg/s and a field of view covering a galactocentric radius of ~30 kpc (11.5 arcminute), 383 sources are detected. Cross-correlation with Spitler et al.'s catalogue of Sombrero globular clusters (GCs) identified from HST/ACS observations reveals 41 X-rays sources in GCs, presumably low-mass X-ray binaries (LMXBs). We quantify the differential luminosity functions (LFs) for both the detected GC and field LMXBs, whose power-low indices (~1.1 for the GC-LF and ~1.6 for field-LF) are consistent with previous studies for elliptical galaxies. With precise sky positions of the GCs without a detected X-ray source, we further quantify, through a fluctuation analysis, the GC LF at fainter luminosities down to 1E35 erg/s. The derived index rules out a faint-end slope flatter than 1.1 at a 2 sigma significance, contrary to recent findings in several elliptical galaxies and the bulge of M31. On the other hand, the 2-6 keV unresolved emission places a tight constraint on the field LF, implying a flattened index of ~1.0 below 1E37 erg/s. We also detect 101 sources in the halo of Sombrero. The presence of these sources cannot be interpreted as galactic LMXBs whose spatial distribution empirically follows the starlight. Their number is also higher than the expected number of cosmic AGNs (52+/-11 [1 sigma]) whose surface density is constrained by deep X-ray surveys. We suggest that either the cosmic X-ray background is unusually high in the direction of Sombrero, or a distinct population of X-ray sources is present in the halo of Sombrero.Comment: 11 figures, 5 tables, ApJ in pres

Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV

A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7 TeV is presented. The data were collected at the LHC, with the CMS detector, and correspond to an integrated luminosity of 4.6 inverse femtobarns. No significant excess is observed above the background expectation, and upper limits are set on the Higgs boson production cross section. The presence of the standard model Higgs boson with a mass in the 270-440 GeV range is excluded at 95% confidence level.Comment: Submitted to JHE

Measurement of the Z/gamma* + b-jet cross section in pp collisions at 7 TeV

The production of b jets in association with a Z/gamma* boson is studied using proton-proton collisions delivered by the LHC at a centre-of-mass energy of 7 TeV and recorded by the CMS detector. The inclusive cross section for Z/gamma* + b-jet production is measured in a sample corresponding to an integrated luminosity of 2.2 inverse femtobarns. The Z/gamma* + b-jet cross section with Z/gamma* to ll (where ll = ee or mu mu) for events with the invariant mass 60 < M(ll) < 120 GeV, at least one b jet at the hadron level with pT > 25 GeV and abs(eta) < 2.1, and a separation between the leptons and the jets of Delta R > 0.5 is found to be 5.84 +/- 0.08 (stat.) +/- 0.72 (syst.) +(0.25)/-(0.55) (theory) pb. The kinematic properties of the events are also studied and found to be in agreement with the predictions made by the MadGraph event generator with the parton shower and the hadronisation performed by PYTHIA.Comment: Submitted to the Journal of High Energy Physic