40 research outputs found
New method to characterize a machining system: application in turning
Many studies simulates the machining process by using a single degree of
freedom spring-mass sytem to model the tool stiffness, or the workpiece
stiffness, or the unit tool-workpiece stiffness in modelings 2D. Others impose
the tool action, or use more or less complex modelings of the efforts applied
by the tool taking account the tool geometry. Thus, all these models remain
two-dimensional or sometimes partially three-dimensional. This paper aims at
developing an experimental method allowing to determine accurately the real
three-dimensional behaviour of a machining system (machine tool, cutting tool,
tool-holder and associated system of force metrology six-component
dynamometer). In the work-space model of machining, a new experimental
procedure is implemented to determine the machining system elastic behaviour.
An experimental study of machining system is presented. We propose a machining
system static characterization. A decomposition in two distinct blocks of the
system "Workpiece-Tool-Machine" is realized. The block Tool and the block
Workpiece are studied and characterized separately by matrix stiffness and
displacement (three translations and three rotations). The Castigliano's theory
allows us to calculate the total stiffness matrix and the total displacement
matrix. A stiffness center point and a plan of tool tip static displacement are
presented in agreement with the turning machining dynamic model and especially
during the self induced vibration. These results are necessary to have a good
three-dimensional machining system dynamic characterization
Design, Performance, and Calibration of CMS Hadron Endcap Calorimeters
Detailed measurements have been made with the CMS hadron calorimeter endcaps (HE) in response to beams of muons, electrons, and pions. Readout of HE with custom electronics and hybrid photodiodes (HPDs) shows no change of performance compared to readout with commercial electronics and photomultipliers. When combined with lead-tungstenate crystals, an energy resolution of 8\% is achieved with 300 GeV/c pions. A laser calibration system is used to set the timing and monitor operation of the complete electronics chain. Data taken with radioactive sources in comparison with test beam pions provides an absolute initial calibration of HE to approximately 4\% to 5\%
Tight Junction Proteins and Signaling Pathways in Cancer and Inflammation: A Functional Crosstalk.
The ability of epithelial cells to organize through cell-cell adhesion into a functioning epithelium serves the purpose of a tight epithelial protective barrier. Contacts between adjacent cells are made up of tight junctions (TJ), adherens junctions (AJ), and desmosomes with unique cellular functions and a complex molecular composition. These proteins mediate firm mechanical stability, serves as a gatekeeper for the paracellular pathway, and helps in preserving tissue homeostasis. TJ proteins are involved in maintaining cell polarity, in establishing organ-specific apical domains and also in recruiting signaling proteins involved in the regulation of various important cellular functions including proliferation, differentiation, and migration. As a vital component of the epithelial barrier, TJs are under a constant threat from proinflammatory mediators, pathogenic viruses and bacteria, aiding inflammation and the development of disease. Inflammatory bowel disease (IBD) patients reveal loss of TJ barrier function, increased levels of proinflammatory cytokines, and immune dysregulation; yet, the relationship between these events is partly understood. Although TJ barrier defects are inadequate to cause experimental IBD, mucosal immune activation is changed in response to augmented epithelial permeability. Thus, the current studies suggest that altered barrier function may predispose or increase disease progression and therapies targeted to specifically restore the barrier function may provide a substitute or supplement to immunologic-based therapies. This review provides a brief introduction about the TJs, AJs, structure and function of TJ proteins. The link between TJ proteins and key signaling pathways in cell proliferation, transformation, and metastasis is discussed thoroughly. We also discuss the compromised intestinal TJ integrity under inflammatory conditions, and the signaling mechanisms involved that bridge inflammation and cancer
Analyses on ex-vessel debris formation and coolability in SARNET frame
International audienceThe major aim of work in the SARNET2 European project on ex-vessel debris formation and coolability was to get an overall perspective on coolability of melt released from a failed reactor pressure vessel and falling into a water-filled cavity. Especially, accident management concepts for BWRs, dealing with deep water pools below the reactor vessel, are addressed, but also shallower pools in existing PWRs, with questions about partial cooling and time delay of molten corium concrete interaction. The subject can be divided into three main topics (i) Debris bed formation by breakup of melt, (ii) Coolability of debris and (iii) Coupled treatment of the processes. Accompanied by joint collaborations of the partners, the performed work comprises theoretical, experimental and modelling activities. Theoretical work was done by KTH on the melt outflow conditions from a RPV and on the quantification of the probability of yielding a non-coolable ex-vessel bed by use of probabilistic assessment. IKE introduced a theoretical concept to improve debris bed coolability. A large amount of experimental work was done by partners (KTH, VTT, IKE) on the coolability of debris beds using different bed geometries, particles, heating methods and water feeds, yielding a valuable base for code validation. Modelling work was mainly done by IKE, IRSN, RSE and VTT concerning jet breakup and/or debris bed formation and cooling in 2D and 3D geometries. A benchmark for the DEFOR-A experiment of KTH was performed. Important progress was reached for several tasks and aspects and important insights are given, enabling to focus the view on possible key aspects of future activities. © 2014 Elsevier Ltd. All rights reserved
Synthesis of 13-vertex dimetallacarboranes by electrophilic insertion into 12-vertex ruthenacarboranes
The electrophilic insertion of organometallic species into metallacarboranes was studied in detail for the model compound-the 12-vertex closo-ruthenacarborane anion [CpâRu(C2B9H11)]- (1). Reactions of the anion 1 with the 12-electron cationic species [M(ring)]+ (M(ring) = RuCp, RuCpâ and Co(C4Me4)) gave the 13-vertex closo-dimetallacarboranes CpâRu(C2B9H11)M(ring). Similar reactions of the neutral ruthenacarborane CpâRu(Me2S-C2B9H10) produce the cationic dimetallacarboranes [CpâRu(Me2S-C2B9H10)M(ring)]+. The symmetrical 13-vertex diruthenacarboranes (C5R5)Ru(R2C2B9H9)Ru(C5R5) can be prepared by the direct reactions of Tl2[7,8-R2-7,8-C2B9H9] (R = H and Me) with two equivalents of [CpRu(MeCN)3]+ or [CpâRuCl]4. The insertions of the 14-electron cationic species [M(ring)]+ (M(ring) = NiCp, NiCpâ and Co(C6Me6)) into 1 gave the 13-vertex dimetallacarboranes CpâRu(C2B9H11)M(ring), which have a distorted framework with one open face. The structures of CpâRu(C2B9H11)Co(C4Me4) and CpâRu(C2B9H11)NiCp were established by X-ray diffraction. Some of the 13-vertex dimetallacarboranes have two electrons less than required by Wade's rules. This violation is explained by the absence of the appropriate pathway for the distortion of the framework
Status of steam explosion understanding and modelling
International audienceThe main results of the major international activities related to fuel-coolant interactions (FCI) of the last 4-year period are presented and a summary of the knowledge gained regarding understanding and the improvements of modelling is provided. At first, the major outcomes of the OECD SERENA-2 program are presented and discussed. Important clarifications were obtained on the so-called material effect and on FCI code capabilities. We then summarise complementary analytical analyses and experimental programs performed in the frame of the SARNET community. The focus was put on the role of melt fragmentation and solidification, the impact of void on the intensity of an explosion and the triggering mechanisms. As a conclusion, tables summarising the improvements are proposed as well as research priorities. © 2014 Elsevier Ltd