Är det inte dokumenterat är det inte gjort!

SAMMANFATTNING Detta examensarbete syftar till att kvalitetssäkra omvårdnaden av hästar med medicinsk kolik på djursjukhusens stationärvårdsavdelning. Genom att bidra med ett förslag till standardvårdplan för hästar med medicinsk kolik vill vi optimera hästens vård och omvårdnad under sjukhusvistelsen. Syftet med att arbeta med standardvårdplaner (SVP) är att skapa högkvalitativ omvårdnad, underlätta dokumentationsarbetet och i förlängningen kunna få mer tid till att se och vårda den enskilde patienten. Kolik är en åkomma med många olika samverkande faktorer, både miljöbetingade och eventuellt ärftliga Kolik i matsmältningskanalen delas ofta in i medicinsk- och kirurgisk kolik och i detta arbete läggs vikten på medicinsk kolik. Huvuddelen (~90 %) av all kolik kräver ingen kirurgi och tillhör därmed gruppen medicinsk kolik. Kolikavsnittet i arbetet är tänkt som en kunskapsöversikt över sjukdomstillståndet och ska användas som ett styrdokument för att trygga en kvalitativ basnivå på omvårdnaden. I standardvårdplanen har ett antal riskområden identifierats och därefter har riskdiagnoser, mål och åtgärder för att uppnå huvudmålet - en kolikfri patient, utarbetats. Därpå utvecklades kryssprotokoll för parametrar vid observation av kolikhäst och för smärtbedömning vid medicinsk kolik. Nyckelord: dokumentation, medicinsk kolik, omvårdnad, standardvårdplan SUMMARY This diploma work aims to assure the quality care of horses with medical colic on the veterinary hospital's stationary ward. By contributing this proposal of a standard care plan for horses with medical colic we intend to optimize the horse's medical and nursing care during the hospital stay. The aim of working with standard care plans is to create high-quality nursing care, facilitate documentation and in the extension have more time to tend to the individual patient. Colic is a disease with many different interacting factors, both environmental and possibly hereditary. Colic in the gastrointestinal canal is often divided into medical - and surgical colic and in this essay the main emphasis is on medical colic. The main part (~90%) of all colic cases are non surgical and therefore belong to the medical colic cases. The colic chapter in this essay is intended as a knowledge overview over the illness and should be used as a governing document to pursue a safe and high quality-based level of nursing care. In the standard care plan a number of risk areas have been identified. Following this, risk diagnoses, objectives and measures were compiled in order to achieve the main objective - a colic free patient. Subsequently, diagrams for observing the symptoms of colic and pain in horses were developed. Key words: care, documentation, medical colic, standard care planSAMMANFATTNING Detta examensarbete syftar till att kvalitetssäkra omvårdnaden av hästar med medicinsk kolik på djursjukhusens stationärvårdsavdelning. Genom att bidra med ett förslag till standardvårdplan för hästar med medicinsk kolik vill vi optimera hästens vård och omvårdnad under sjukhusvistelsen. Syftet med att arbeta med standardvårdplaner (SVP) är att skapa högkvalitativ omvårdnad, underlätta dokumentationsarbetet och i förlängningen kunna få mer tid till att se och vårda den enskilde patienten. Kolik är en åkomma med många olika samverkande faktorer, både miljöbetingade och eventuellt ärftliga Kolik i matsmältningskanalen delas ofta in i medicinsk- och kirurgisk kolik och i detta arbete läggs vikten på medicinsk kolik. Huvuddelen (~90 %) av all kolik kräver ingen kirurgi och tillhör därmed gruppen medicinsk kolik. Kolikavsnittet i arbetet är tänkt som en kunskapsöversikt över sjukdomstillståndet och ska användas som ett styrdokument för att trygga en kvalitativ basnivå på omvårdnaden. I standardvårdplanen har ett antal riskområden identifierats och därefter har riskdiagnoser, mål och åtgärder för att uppnå huvudmålet - en kolikfri patient, utarbetats. Därpå utvecklades kryssprotokoll för parametrar vid observation av kolikhäst och för smärtbedömning vid medicinsk kolik. Nyckelord: dokumentation, medicinsk kolik, omvårdnad, standardvårdplan SUMMARY This diploma work aims to assure the quality care of horses with medical colic on the veterinary hospital's stationary ward. By contributing this proposal of a standard care plan for horses with medical colic we intend to optimize the horse's medical and nursing care during the hospital stay. The aim of working with standard care plans is to create high-quality nursing care, facilitate documentation and in the extension have more time to tend to the individual patient. Colic is a disease with many different interacting factors, both environmental and possibly hereditary. Colic in the gastrointestinal canal is often divided into medical - and surgical colic and in this essay the main emphasis is on medical colic. The main part (~90%) of all colic cases are non surgical and therefore belong to the medical colic cases. The colic chapter in this essay is intended as a knowledge overview over the illness and should be used as a governing document to pursue a safe and high quality-based level of nursing care. In the standard care plan a number of risk areas have been identified. Following this, risk diagnoses, objectives and measures were compiled in order to achieve the main objective - a colic free patient. Subsequently, diagrams for observing the symptoms of colic and pain in horses were developed. Key words: care, documentation, medical colic, standard care pla

Revealing electronic state-switching at conical intersections in alkyl iodides by ultrafast XUV transient absorption spectroscopy

Conical intersections between electronic states often dictate the chemistry of photoexcited molecules. Recently developed sources of ultrashort extreme ultraviolet (XUV) pulses tuned to element-specific transitions in molecules allow for the unambiguous detection of electronic state-switching at a conical intersection. Here, the fragmentation of photoexcited iso-propyl iodide and tert-butyl iodide molecules (i-C$_{3}$H$_{7}$I and t-C$_{4}$H$_{9}$I) through a conical intersection between $^{3}$Q$_{0}$/$^{1}$Q$_{1}$ spin-orbit states is revealed by ultrafast XUV transient absorption measuring iodine 4d core-to-valence transitions. The electronic state-sensitivity of the technique allows for a complete mapping of molecular dissociation from photoexcitation to photoproducts. In both molecules, the sub-100 fs transfer of a photoexcited wave packet from the $^{3}$Q$_{0}$ state into the $^{1}$Q$_{1}$ state at the conical intersection is captured. The results show how differences in the electronic state-switching of the wave packet in i-C$_{3}$H$_{7}$I and t-C$_{4}$H$_{9}$I directly lead to differences in the photoproduct branching ratio of the two systems

High-resolution VLA low radio frequency observations of the Perseus cluster: radio lobes, mini-halo and bent-jet radio galaxies

We present the first high-resolution 230-470 MHz map of the Perseus cluster obtained with the Karl G. Jansky Very Large Array. The high dynamic range and resolution achieved has allowed the identification of previously-unknown structures in this nearby galaxy cluster. New hints of sub-structures appear in the inner radio lobes of the brightest cluster galaxy NGC 1275. The spurs of radio emission extending into the outer X-ray cavities, inflated by past nuclear outbursts, are seen for the first time at these frequencies, consistent with spectral aging. Beyond NGC 1275, we also analyze complex radio sources harbored in the cluster. Two new distinct, narrowly-collimated jets are visible in IC 310, consistent with a highly-projected narrow-angle tail radio galaxy infalling into the cluster. We show how this is in agreement with its blazar-like behavior, implying that blazars and bent-jet radio galaxies are not mutually exclusive. We report the presence of filamentary structures across the entire tail of NGC 1265, including two new pairs of long filaments in the faintest bent extension of the tail. Such filaments have been seen in other cluster radio sources such as relics and radio lobes, indicating that there may be a fundamental connection between all these radio structures. We resolve the very narrow and straight tail of CR 15 without indication of double jets, so that the interpretation of such head-tail sources is yet unclear. Finally, we note that only the brightest western parts of the mini-halo remain, near NGC 1272 and its bent double jets.Comment: 17 pages, 12 figures, Accepted for publication in MNRA

Longitudinal Examination of Everyday Executive Functioning in Children With ASD: Relations With Social, Emotional, and Behavioral Functioning Over Time

Executive functioning (EF) deficits are well-documented in Autism Spectrum Disorder (ASD), yet little is known about the longitudinal trajectory of “everyday” EF and links to social, emotional and behavioral outcomes in ASD. This study examined the profile of everyday EF utilizing parent-reported measures over 2 years, and explored whether prior estimates of EF were related to later co-morbid psychopathology and social functioning in 39 children with ASD and 34 typically developing (TD) children (ages 7–14 years). According to parent reports, children with ASD had impaired scores of EF in all domains at both time points, and showed no significant improvement across 2 years, compared to controls. Regression analyses showed that prior estimates of behavior regulation difficulties at time 1 uniquely predicted later emotional (i.e., symptoms of anxiety/depression) and behavioral (i.e., oppositionality/aggressiveness) problems in children with ASD 2 years later. Furthermore, an improvement of metacognitive skills predicted a reduction of social difficulties over 2 years in ASD. These results imply that EF may be a potential target of intervention for preventing and reducing co-morbid psychopathology and promoting social competence in youth with ASD. Furthermore, the findings that EF related to behavior is more critical for later emotional and behavioral functioning, whereas EF related to cognition is more critical for social functioning, indicates that it may be beneficial to tailor treatment. Future studies investigating the effectiveness of EF-based interventions in improving the cognitive, psychological and social outcomes in ASD are of high priority

Therapeutic Implications of GIPC1 Silencing in Cancer

GIPC1 is a cytoplasmic scaffold protein that interacts with numerous receptor signaling complexes, and emerging evidence suggests that it plays a role in tumorigenesis. GIPC1 is highly expressed in a number of human malignancies, including breast, ovarian, gastric, and pancreatic cancers. Suppression of GIPC1 in human pancreatic cancer cells inhibits in vivo tumor growth in immunodeficient mice. To better understand GIPC1 function, we suppressed its expression in human breast and colorectal cancer cell lines and human mammary epithelial cells (HMECs) and assayed both gene expression and cellular phenotype. Suppression of GIPC1 promotes apoptosis in MCF-7, MDA-MD231, SKBR-3, SW480, and SW620 cells and impairs anchorage-independent colony formation of HMECs. These observations indicate GIPC1 plays an essential role in oncogenic transformation, and its expression is necessary for the survival of human breast and colorectal cancer cells. Additionally, a GIPC1 knock-down gene signature was used to interrogate publically available breast and ovarian cancer microarray datasets. This GIPC1 signature statistically correlates with a number of breast and ovarian cancer phenotypes and clinical outcomes, including patient survival. Taken together, these data indicate that GIPC1 inhibition may represent a new target for therapeutic development for the treatment of human cancers

Heliophysics and Amateur Radio:Citizen Science Collaborations for Atmospheric, Ionospheric, and Space Physics Research and Operations

The amateur radio community is a global, highly engaged, and technical community with an intense interest in space weather, its underlying physics, and how it impacts radio communications. The large-scale observational capabilities of distributed instrumentation fielded by amateur radio operators and radio science enthusiasts offers a tremendous opportunity to advance the fields of heliophysics, radio science, and space weather. Well-established amateur radio networks like the RBN, WSPRNet, and PSKReporter already provide rich, ever-growing, long-term data of bottomside ionospheric observations. Up-and-coming purpose-built citizen science networks, and their associated novel instruments, offer opportunities for citizen scientists, professional researchers, and industry to field networks for specific science questions and operational needs. Here, we discuss the scientific and technical capabilities of the global amateur radio community, review methods of collaboration between the amateur radio and professional scientific community, and review recent peer-reviewed studies that have made use of amateur radio data and methods. Finally, we present recommendations submitted to the U.S. National Academy of Science Decadal Survey for Solar and Space Physics (Heliophysics) 2024–2033 for using amateur radio to further advance heliophysics and for fostering deeper collaborations between the professional science and amateur radio communities. Technical recommendations include increasing support for distributed instrumentation fielded by amateur radio operators and citizen scientists, developing novel transmissions of RF signals that can be used in citizen science experiments, developing new amateur radio modes that simultaneously allow for communications and ionospheric sounding, and formally incorporating the amateur radio community and its observational assets into the Space Weather R2O2R framework. Collaborative recommendations include allocating resources for amateur radio citizen science research projects and activities, developing amateur radio research and educational activities in collaboration with leading organizations within the amateur radio community, facilitating communication and collegiality between professional researchers and amateurs, ensuring that proposed projects are of a mutual benefit to both the professional research and amateur radio communities, and working towards diverse, equitable, and inclusive communities

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead