528 research outputs found
Risk Factors and Outcomes of Candidemia Caused by Biofilm-Forming Isolates in a Tertiary Care Hospital
- Author
- AL Lazzell
- Alessio De Luca
- Angela Raffaella Losito
- B Fiori
- Barbara Fiori
- Brunella Posteraro
- CG Pierce
- CW Craver
- D Andes
- DG Maki
- DL Horn
- DM Kuhn
- DM Kuhn
- EM Kojic
- Enrico Maria Trecarichi
- F Hasan
- Floyd L. Wormley
- G Ramage
- Giovanni Fadda
- J Morgan
- JE Nett
- JH Shin
- K Swindell
- KW Garey
- LJ Douglas
- M Bassetti
- M Morrell
- M Tumbarello
- M Tumbarello
- MA Pfaller
- Mario Tumbarello
- Maurizio Sanguinetti
- MD Zilberberg
- NP O'Grady
- O Leroy
- P Uppuluri
- P Uppuluri
- P Uppuluri
- Patrizia Posteraro
- PG Pappas
- PK Mukherjee
- R Rajendran
- Roberto Cauda
- S Kucharíková
- TE Zaoutis
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
Very few data exist on risk factors for developing biofilm-forming Candida bloodstream infection (CBSI) or on variables associated with the outcome of patients treated for this infection.
METHODS AND FINDINGS: We identified 207 patients with CBSI, from whom 84 biofilm-forming and 123 non biofilm-forming Candida isolates were recovered. A case-case-control study to identify risk factors and a cohort study to analyze outcomes were conducted. In addition, two sub-groups of case patients were analyzed after matching for age, sex, APACHE III score, and receipt of adequate antifungal therapy. Independent predictors of biofilm-forming CBSI were presence of central venous catheter (odds ratio [OR], 6.44; 95% confidence interval [95% CI], 3.21-12.92) or urinary catheter (OR, 2.40; 95% CI, 1.18-4.91), use of total parenteral nutrition (OR, 5.21; 95% CI, 2.59-10.48), and diabetes mellitus (OR, 4.47; 95% CI, 2.03-9.83). Hospital mortality, post-CBSI hospital length of stay (LOS) (calculated only among survivors), and costs of antifungal therapy were significantly greater among patients infected by biofilm-forming isolates than those infected by non-biofilm-forming isolates. Among biofilm-forming CBSI patients receiving adequate antifungal therapy, those treated with highly active anti-biofilm (HAAB) agents (e.g., caspofungin) had significantly shorter post-CBSI hospital LOS than those treated with non-HAAB antifungal agents (e.g., fluconazole); this difference was confirmed when this analysis was conducted only among survivors. After matching, all the outcomes were still favorable for patients with non-biofilm-forming CBSI. Furthermore, the biofilm-forming CBSI was significantly associated with a matched excess risk for hospital death of 1.77 compared to non-biofilm-forming CBSI.
CONCLUSIONS: Our data show that biofilm growth by Candida has an adverse impact on clinical and economic outcomes of CBSI. Of note, better outcomes were seen for those CBSI patients who received HAAB antifungal therapy
Search for Kaluza-Klein Graviton Emission in ppˉ Collisions at s=1.8 TeV using the Missing Energy Signature
- Author
- Acosta D
- Affolder T
- Akimoto H
- Albrow MG
- Ambrose D
- Amidei D
- Anikeev K
- Antos J
- Apollinari G
- Arisawa T
- Artikov A
- Asakawa T
- Ashmanskas W
- Azfar F
- Azzi-Bacchetta P
- Bacchetta N
- Bachacou H
- Badgett W
- Bailey S
- Barbaro-Galtieri A
- Barnes VE
- Barnett BA
- Baroiant S
- Barone M
- Bauer G
- Bedeschi F
- Behari S
- Belforte S
- Bell WH
- Bellettini G
- Bellinger J
- Benjamin D
- Bensinger J
- Beretvas A
- Berryhill J
- Bhatti A
- Binkley M
- Bisello D
- Bishai M
- Blair RE
- Blocker C
- Bloom K
- Blumenfeld B
- Blusk SR
- Bocci A
- Bodek A
- Bolla G
- Bolshov A
- Bonushkin Y
- Bortoletto D
- Boudreau J
- Brandl A
- Bromberg C
- Brozovic M
- Brubaker E
- Bruner N
- Budagov J
- Budd HS
- Burkett K
- Busetto G
- Byrum KL
- Cabrera S
- Calafiura P
- Campbell M
- Carithers W
- Carlsmith D
- Carlson J
- Caskey W
- Castro A
- Cauz D
- Cecco SD
- Cerri A
- Cerrito L
- Chan AW
- Chang PS
- Chang PT
- Chapman J
- Chen C
- Chen YC
- Cheng MT
- Chertok M
- Chiarelli G
- Chirikov-Zorin I
- Chlachidze G
- Chlebana F
- Christofek L
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- Chung JY
- Chung WH
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- Clark AG
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- Connolly A
- Convery M
- Conway J
- Cordelli M
- Cranshaw J
- Culbertson R
- D'Auria S
- D'Onofrio M
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- Dittmann JR
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- Engels E
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- Errede D
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- Fan Q
- Farrington S
- Feild RG
- Fernandez JP
- Ferretti C
- Field RD
- Fiori I
- Flaugher B
- Flores-Castillo LR
- Foster GW
- Franklin M
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- Fukui Y
- Furic I
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- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2004
- Field of study
We report on a search for direct Kaluza-Klein graviton production in a data
sample of 84 pb−1 of \ppb collisions at s = 1.8 TeV, recorded
by the Collider Detector at Fermilab. We investigate the final state of large
missing transverse energy and one or two high energy jets. We compare the data
with the predictions from a 3+1+n-dimensional Kaluza-Klein scenario in which
gravity becomes strong at the TeV scale. At 95% confidence level (C.L.) for
n=2, 4, and 6 we exclude an effective Planck scale below 1.0, 0.77, and 0.71
TeV, respectively.Comment: Submitted to PRL, 7 pages 4 figures/Revision includes 5 figure
Measurement of the average time-integrated mixing probability of b-flavored hadrons produced at the Tevatron
- Author
- Acosta D
- Affolder T
- Akimoto H
- Albrow MG
- Ambrose D
- Amidei D
- Anikeev K
- Antos J
- Apollinari G
- Arisawa T
- Artikov A
- Asakawa T
- Ashmanskas W
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- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 08/09/2003
- Field of study
We have measured the number of like-sign (LS) and opposite-sign (OS) lepton
pairs arising from double semileptonic decays of b and bˉ-hadrons,
pair-produced at the Fermilab Tevatron collider. The data samples were
collected with the Collider Detector at Fermilab (CDF) during the 1992-1995
collider run by triggering on the existence of μμ and eμ candidates
in an event. The observed ratio of LS to OS dileptons leads to a measurement of
the average time-integrated mixing probability of all produced b-flavored
hadrons which decay weakly, χˉ=0.152±0.007 (stat.) ±0.011
(syst.), that is significantly larger than the world average χˉ=0.118±0.005.Comment: 47 pages, 10 figures, 15 tables Submitted to Phys. Rev.
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
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- Abbiendi G
- Abbrescia M
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- Zanetti M
- Zang J
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- Zeinali M
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- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
The performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
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- Acosta MV
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- Xiao H
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- Yazgan E
- Yelton J
- Yetkin T
- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
- Yoon AS
- York A
- Yu I
- Yu SS
- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zang SL
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
- Zhu RY
- Zhukov V
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- Ziebarth EB
- Ziegler J
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- Zoeller MH
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
The performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
X-ray emission from the Sombrero galaxy: discrete sources
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
- Adam N
- Adam W
- Adams MR
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- Adiguzel A
- Adler V
- Adzic P
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahuja S
- Akchurin N
- Akgun B
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- Akin IV
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- Albayrak EA
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- Anderson J
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- Andreev V
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- Andreev Y
- Andrews W
- Anghel IM
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- Apollinari G
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- Bauerdick LAT
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- Breedon R
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- Brigliadori L
- Brigljevic V
- Broccolo G
- Brom JM
- Brona G
- Brooke JJ
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- Brun H
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- Bryer AG
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- Butler PH
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- Caballero IG
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- Cabrillo IJ
- Caebergs T
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- Calderon A
- Cali IA
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- Caminada L
- Campagnari C
- Campbell A
- Campderros JD
- Camporesi T
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- Chang YH
- Chang YH
- Chang YW
- Chanon N
- Chao Y
- Charaf O
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- Chasco M
- Chatterjee A
- Chauhan S
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- Chen GM
- Chen HS
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- Choudhary BC
- Choudhury RK
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- Chuang SH
- Chung J
- Chung YS
- Chwalek T
- Ciesielski R
- Cifuentes JAB
- Cihangir S
- Cimmino A
- Cirino G
- Cittolin S
- Ciulli V
- Civinini C
- Claes DR
- Clare R
- Clarida W
- Clement E
- Clerbaux B
- Cline D
- CMS Collaboration
- Cockerill DJA
- Codispoti G
- Colafranceschi S
- Colaleo A
- Cole JE
- Cole P
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- Collard C
- Colling D
- Conetti S
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- Conway J
- Cooper SI
- Cortabitarte RV
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- Costantini S
- Coughlan JA
- Cousins R
- Covarelli R
- Cox B
- Cox PT
- Creanza D
- Cremaldi LM
- Cripps N
- Cuevas J
- Cuffiani M
- Cumalat JP
- Cuplov V
- Cure B
- Cushman P
- Cussans D
- Cutajar M
- Cutts D
- Cwiok M
- Czellar S
- D'Agnolo RT
- D'Alessandro R
- D'Alfonso M
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- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2010
- Field of study
We present a study of discrete X-ray sources in and around the
bulge-dominated, massive Sa galaxy, Sombrero (M104), based on new and archival
Chandra observations with a total exposure of ~200 ks. With a detection limit
of L_X = 1E37 erg/s and a field of view covering a galactocentric radius of ~30
kpc (11.5 arcminute), 383 sources are detected. Cross-correlation with Spitler
et al.'s catalogue of Sombrero globular clusters (GCs) identified from HST/ACS
observations reveals 41 X-rays sources in GCs, presumably low-mass X-ray
binaries (LMXBs). We quantify the differential luminosity functions (LFs) for
both the detected GC and field LMXBs, whose power-low indices (~1.1 for the
GC-LF and ~1.6 for field-LF) are consistent with previous studies for
elliptical galaxies. With precise sky positions of the GCs without a detected
X-ray source, we further quantify, through a fluctuation analysis, the GC LF at
fainter luminosities down to 1E35 erg/s. The derived index rules out a
faint-end slope flatter than 1.1 at a 2 sigma significance, contrary to recent
findings in several elliptical galaxies and the bulge of M31. On the other
hand, the 2-6 keV unresolved emission places a tight constraint on the field
LF, implying a flattened index of ~1.0 below 1E37 erg/s. We also detect 101
sources in the halo of Sombrero. The presence of these sources cannot be
interpreted as galactic LMXBs whose spatial distribution empirically follows
the starlight. Their number is also higher than the expected number of cosmic
AGNs (52+/-11 [1 sigma]) whose surface density is constrained by deep X-ray
surveys. We suggest that either the cosmic X-ray background is unusually high
in the direction of Sombrero, or a distinct population of X-ray sources is
present in the halo of Sombrero.Comment: 11 figures, 5 tables, ApJ in pres
Search for new physics with same-sign isolated dilepton events with jets and missing transverse energy
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Adair A
- Adam N
- Adam W
- Adams JR
- Adams MR
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- Adiguzel A
- Adler V
- Adzic P
- Agram JL
- Aguilar-Benitez M
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- Ahmad M
- Ahmad WH
- Ahuja S
- Akchurin N
- Akgun B
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- Akin IV
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- CMS Collaboration
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- Xiao H
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- Yazgan E
- Yelton J
- Yetkin T
- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
- Yoon AS
- York A
- Yu I
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- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
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- Zielinski M
- Zito G
- Zou W
- Zucchetta A
- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
A search for new physics is performed in events with two same-sign isolated
leptons, hadronic jets, and missing transverse energy in the final state. The
analysis is based on a data sample corresponding to an integrated luminosity of
4.98 inverse femtobarns produced in pp collisions at a center-of-mass energy of
7 TeV collected by the CMS experiment at the LHC. This constitutes a factor of
140 increase in integrated luminosity over previously published results. The
observed yields agree with the standard model predictions and thus no evidence
for new physics is found. The observations are used to set upper limits on
possible new physics contributions and to constrain supersymmetric models. To
facilitate the interpretation of the data in a broader range of new physics
scenarios, information on the event selection, detector response, and
efficiencies is provided.Comment: Published in Physical Review Letter
Compressed representation of a partially defined integer function over multiple arguments
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
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- Abdullin S
- Abdulsalam A
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- d'Enterria D
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- Da Costa EM
- Dabrowski A
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- Dallavalle GM
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- Daubie E
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- de Barbaro P
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- de Cassagnac RG
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- Publication venue
- Publication date
- 01/01/2013
- Field of study
In OLAP (OnLine Analitical Processing) data are analysed in an n-dimensional cube. The cube may be represented as a partially defined function over n arguments. Considering that often the function is not defined everywhere, we ask: is there a known way of representing the function or the points in which it is defined, in a more compact manner than the trivial one
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
- Author
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2009
- Field of study
The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
in the CMS endcaps. Their performance has been evaluated using data taken
during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
Selectivity control in Pt-catalyzed cinnamaldehyde hydrogenation
- Author
- A Silva
- AA Christy
- AJ Plomp
- AK Prashar
- AL Ankudinov
- AS Barnard
- BM Trost
- C Poupin
- CJ Kliewer
- CMA Parlett
- D Zhao
- DE Ramaker
- E Bailon-Garcia
- F Baletto
- F Delbecq
- G Neri
- G Szöllösi
- GA Attard
- H Mistry
- HU Blaser
- I Lee
- J Magano
- JC de Jesús
- JH Clark
- JP Breen
- K An
- KR Kahsar
- KW Fiori
- LA Saudan
- M Abid
- M Englisch
- M Hakamada
- M Hellal
- M Vasiur Rahaman
- MA Keane
- ML Toebes
- MS Ide
- O Isaienko
- P Gallezot
- P Gallezot
- P Lara
- P Maki-Arvela
- R Zheng
- RA Sheldon
- S Galvagno
- S Handjani
- S Kaneko
- S Laref
- S Li
- S Santiago-Pedro
- SC Tsang
- SM Senthil Kumar
- ST Marshall
- T Vergunst
- WO Oduro
- Y Isobe
- Y Lei
- Y Nitta
- Y Xia
- Y Zhu
- Zhiyong Guo
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Chemoselectivity is a cornerstone of catalysis, permitting the targeted modification of specific functional groups within complex starting materials. Here we elucidate key structural and electronic factors controlling the liquid phase hydrogenation of cinnamaldehyde and related benzylic aldehydes over Pt nanoparticles. Mechanistic insight from kinetic mapping reveals cinnamaldehyde hydrogenation is structure-insensitive over metallic platinum, proceeding with a common Turnover Frequency independent of precursor, particle size or support architecture. In contrast, selectivity to the desired cinnamyl alcohol product is highly structure sensitive, with large nanoparticles and high hydrogen pressures favoring C=O over C=C hydrogenation, attributed to molecular surface crowding and suppression of sterically-demanding adsorption modes. In situ vibrational spectroscopies highlight the role of support polarity in enhancing C=O hydrogenation (through cinnamaldehyde reorientation), a general phenomenon extending to alkyl-substituted benzaldehydes. Tuning nanoparticle size and support polarity affords a flexible means to control the chemoselective hydrogenation of aromatic aldehydes
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