The 1996 research assessment exercise : the library and information management panel

Reports on the 1996 Research Assessment Exercise (RAE), the fourth such exercise aimed at providing funding councils of UK universities (including former polytechnics) with the necessary data to rate the quality of UK academic research for predetermined units of assessment in order to fund research selectively. Previous RAEs were conducted in 1986, 1989, and 1992 (for a report of the 1992 RAE see JOLIS 26 (3) Sep 94, 141-7 (LISA ref. 9409765)). Reports generally on the work of the Library and Information Management Panel in agreeing criteria specific to their assessment task, particularly the five principal modes of publication: research monographs; articles in scholarly periodicals; refereed conference papers; published research reports; and book chapters. Discusses the methodology used by the Panel, research submissions received and the overall results

Creating a new Harvard referencing guide at the University of Lincoln

Development of a Harvard referencing guide and app by the Library at the University of Lincol

Referencing handbook: Harvard

University of Lincoln approved guide to Harvard referencing. Providing guidelines on how to reference 75 sources of information. The second edition includes extended guidance on how to reference, all new examples, additional annotated diagrams and an index to help you locate sources

Accessing humanities research in a digital environment

AbstractContract law co-exists with copyright law in the publishing world often blurring the lines between authors and publishers in the dissemination of scholarly research. Technology has further obscured the traditional publishing model creating complications for academics as uncertainties about access to their published research arise. The goal of authors in publishing their scholarly research is to make an impact, to contribute to the global discussion and to disseminate knowledge to others. Making research available through open access (OA) may assist with the increased circulation of research, thereby potentially increasing its impact. OA research is seemingly more accepted and developed as a publishing model in science, technology and medicine, but evidence suggests less so in the humanities. The development of digital humanities represents a potential means by which OA may become more widely accepted as a publishing model in the humanities in general. This paper explores the role of open access in scholarly publication, and its influence on publishing contracts and the copyright of authors

Overweight or Obesity: Serum Lipids in a University Population of Barranquilla Colombia

Introduction: According to the World Health Organization, overweight and obesity occur due to an abnormal or excessive accumulation of body fat that is harmful to health. During childhood and adolescence, risk factors such as dyslipidemia or obesity are detected, the maintenance of which in the adult stage has been verified, indicating that detection should be started as early as possible. It is necessary to carry out an anthropometric <- nutritional evaluation to detect a deficit or excess weight in time. A study on the topic of chronic non-communicable diseases in Colombia indicated that in 2014 more than 100,000 people died with ischemic and hemorrhagic cerebrovascular diseases (CVDs), cancer, DM and chronic obstructive pulmonary disease (COPD), by being able to carry out early detections that will allow adequate prevention of secondary complications. Methodology: An observational, descriptive, cross-sectional study was carried out with a population - sample of 36 university students of both sexes. After informed consent, those who met the inclusion criteria demanded by Bioimpedance included: weight, height, visceral fat, body fat, In addition to abdominal or waist circumference, hip and lipid profile: total cholesterol (CT), triglycerides (TG), HDLc, VLDLc. LDLc. Results: Overweight and obesity in the results of (BMI, Gf and FV)), found in young male and female sex with prevalence in the male sex group, and hyperlipidemias mainly in the female sex studied. Conclusion: High prevalence of CVD risk factors such as overweight, obesity, and hyperlipidemia in the female sex group

Clinical effectiveness of usual care with or without antidepressant medication for primary care patients with minor or mild-major depression: a randomized equivalence trial

<p>Abstract</p> <p>Background</p> <p>Minor and mild-major depression are highly prevalent in primary care. There is insufficient evidence for the effectiveness of antidepressants in the treatment of minor and mild-major depression. We compared the effectiveness of usual primary care treatment, with or without antidepressants, in minor and mild-major depression.</p> <p>Methods</p> <p>A pragmatic patient-randomized equivalence trial with 52 weeks follow-up was conducted in The Netherlands. In total, 59 primary care physicians (PCPs) recruited and treated 181 adult patients with minor or mild-major depression. Patients were randomized to four consultations within 3 months of usual care plus antidepressants (UCandAD) or usual care alone (UCnoAD). The Montgomery Åsberg Depression Rating Scale (MADRS) was used to assess changes in severity of depressive symptoms. The predefined equivalence margin was set at five points. Multilevel analysis was used to analyze the data. Secondary outcome measures were the Short-Form 36 (SF-36), and the Client Satisfaction Questionnaire (CSQ-8).</p> <p>Results</p> <p>Patients received on average 3.0 (SD 1.4) 15-min consultations within 3 months with (n = 85) or without paroxetine (n = 96). Equivalence of UCandAD and UCnoAD was demonstrated in the intention-to-treat analyses as well as the per-protocol analysis after 6 weeks, but not at 13, 26 and 52 weeks follow-up. No statistical differences in effectiveness between treatment groups were found in the intention-to-treat analysis. No differences in the physical and mental functioning (SF-36) were found between the treatment groups. Patients allocated to UCandAD were slightly more satisfied with their treatment at 13 weeks follow-up (but not at 52 weeks follow-up) than patients allocated to UCnoAD. Preliminary analyses suggested that subgroups such as patients with mild-major (instead of a minor) depression might benefit from antidepressant treatment. Patients who were assigned to their preferred treatment (in particular to UCnoAD) were more often compliant and had better clinical outcomes.</p> <p>Conclusion</p> <p>UCandAD was as effective as UCnoAD over the first 6 weeks, but not at 13, 26, and 52 weeks. However, superiority of either treatment could not be demonstrated either. The question whether antidepressants add any clinical effect to usual care remains unresolved. We recommend future studies to look for subgroups of patients who may benefit from antidepressants.</p> <p>Trial registration</p> <p>Dutch Trial Registry ISRCN03007807.</p

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility to more common diseases than any other region of the human genome, including almost all disorders classified as autoimmune. In type 1 diabetes the major genetic susceptibility determinants have been mapped to the MHC class II genes HLA-DQB1 and HLA-DRB1 (refs 1-3), but these genes cannot completely explain the association between type 1 diabetes and the MHC region. Owing to the region's extreme gene density, the multiplicity of disease-associated alleles, strong associations between alleles, limited genotyping capability, and inadequate statistical approaches and sample sizes, which, and how many, loci within the MHC determine susceptibility remains unclear. Here, in several large type 1 diabetes data sets, we analyse a combined total of 1,729 polymorphisms, and apply statistical methods - recursive partitioning and regression - to pinpoint disease susceptibility to the MHC class I genes HLA-B and HLA-A (risk ratios >1.5; Pcombined = 2.01 × 10-19 and 2.35 × 10-13, respectively) in addition to the established associations of the MHC class II genes. Other loci with smaller and/or rarer effects might also be involved, but to find these, future searches must take into account both the HLA class II and class I genes and use even larger samples. Taken together with previous studies, we conclude that MHC-class-I-mediated events, principally involving HLA-B*39, contribute to the aetiology of type 1 diabetes. ©2007 Nature Publishing Group

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic.

The COVID-19 pandemic has increased negative emotions and decreased positive emotions globally. Left unchecked, these emotional changes might have a wide array of adverse impacts. To reduce negative emotions and increase positive emotions, we tested the effectiveness of reappraisal, an emotion-regulation strategy that modifies how one thinks about a situation. Participants from 87 countries and regions (n = 21,644) were randomly assigned to one of two brief reappraisal interventions (reconstrual or repurposing) or one of two control conditions (active or passive). Results revealed that both reappraisal interventions (vesus both control conditions) consistently reduced negative emotions and increased positive emotions across different measures. Reconstrual and repurposing interventions had similar effects. Importantly, planned exploratory analyses indicated that reappraisal interventions did not reduce intentions to practice preventive health behaviours. The findings demonstrate the viability of creating scalable, low-cost interventions for use around the world