Interrelationships between human capital and social capital in small and medium sized firms: The effect of age and sector of activity

This study explores the interconnection between human factors and social factors and analyses the relations influenced by the specific activity and age of firms. A statistical approach is implemented which applies factor analysis techniques, based on a sample of small and medium sized firms from four sectors of activity which are between four and fifteen years old, and are split into three time periods. It is found that there are interconnected groups of human capital and social capital factors, although a sizeable proportion of the literature conceptually separates these factors and deals with them individually. It is also ascertained that this relationship is influenced by the field of activity and the age of the firms.Entrepreneurship, Factor analysis, Human capital, Management, Social capital

The influence of factors characterizing the performance of ports, measured by operational, financial and efficiency indicators

This paper aims to study the performance of ports by characterization factors and understand its importance. The methods used are data envelopment analysis (DEA), factor analysis and linear regression. The sample consists of 43 European ports. The results indicate the existence of a relationship between performance and several variables that characterize the port and confirm the impact of location, governance, size, infrastructure, port specialisation, logistics integration and maritime services in the operational and financial performance and efficiency of ports .Portos, desempenho, factores de caracterização

A influência dos factores de caracterização dos portos no desempenho, medido por indicadores operacionais, financeiros e de eficiência

This paper aims to study the performance of ports by characterization factors and understand its importance. The methods used are data envelopment analysis (DEA), factor analysis and linear regression. The sample consists of 43 European ports. The results indicate the existence of a relationship between performance and several variables that characterize the port and confirm the impact of location, governance, size, infrastructure, port specialisation, logistics integration and maritime services in the operational and financial performance and efficiency of ports

Was the GLE on May 17, 2012 linked with the M5.1-class flare the first in the 24th solar cycle?

On May 17, 2012 an M5.1-class flare exploded from the sun. An O-type coronal mass ejection (CME) was also associated with this flare. There was an instant increase in proton flux with peak at $\geq 100$ MeV, leading to S2 solar radiation storm level. In about 20 minutes after the X-ray emission, the solar particles reached the Earth.It was the source of the first (since December 2006) ground level enhancement (GLE) of the current solar cycle 24. The GLE was detected by neutron monitors (NM) and other ground based detectors. Here we present an observation by the Tupi muon telescopes (Niteroi, Brazil, $22^{0}.9 S$, $43^{0}.2 W$, 3 m above sea level) of the enhancement of muons at ground level associated with this M5.1-class solar flare. The Tupi telescopes registered a muon excess over background $\sim 20\%$ in the 5-min binning time profile. The Tupi signal is studied in correlation with data obtained by space-borne detectors (GOES, ACE), ground based neutron monitors (Oulu) and air shower detectors (the IceTop surface component of the IceCube neutrino observatory). We also report the observation of the muon signal possibly associated with the CME/sheath striking the Earth magnetosphere on May 20, 2012. We show that the observed temporal correlation of the muon excess observed by the Tupi muon telescopes with solar transient events suggests a real physical connection between them. Our observation indicates that combination of two factors, the low energy threshold of the Tupi muon telescopes and the location of the Tupi experiment in the South Atlantic Anomaly region, can be favorable in the study and detection of the solar transient events. Our experiment provides new data complementary to other techniques (space and ground based) in the study of solar physics.Comment: 9 pages, 10 figure

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes. Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. We enrolled adults aged 18–85 years with type 2 diabetes, estimated glomerular filtration rate (eGFR)25–75 mL/min per 1·73 m 2 of body surface area, and a urine albumin-to-creatinine ratio (UACR)of 300–5000 mg/g who had received maximum labelled or tolerated renin–angiotensin system inhibition for at least 4 weeks. Participants were given atrasentan 0·75 mg orally daily during an enrichment period before random group assignment. Those with a UACR decrease of at least 30% with no substantial fluid retention during the enrichment period (responders)were included in the double-blind treatment period. Responders were randomly assigned to receive either atrasentan 0·75 mg orally daily or placebo. All patients and investigators were masked to treatment assignment. The primary endpoint was a composite of doubling of serum creatinine (sustained for ≥30 days)or end-stage kidney disease (eGFR <15 mL/min per 1·73 m 2 sustained for ≥90 days, chronic dialysis for ≥90 days, kidney transplantation, or death from kidney failure)in the intention-to-treat population of all responders. Safety was assessed in all patients who received at least one dose of their assigned study treatment. The study is registered with ClinicalTrials.gov, number NCT01858532. Findings: Between May 17, 2013, and July 13, 2017, 11 087 patients were screened; 5117 entered the enrichment period, and 4711 completed the enrichment period. Of these, 2648 patients were responders and were randomly assigned to the atrasentan group (n=1325)or placebo group (n=1323). Median follow-up was 2·2 years (IQR 1·4–2·9). 79 (6·0%)of 1325 patients in the atrasentan group and 105 (7·9%)of 1323 in the placebo group had a primary composite renal endpoint event (hazard ratio [HR]0·65 [95% CI 0·49–0·88]; p=0·0047). Fluid retention and anaemia adverse events, which have been previously attributed to endothelin receptor antagonists, were more frequent in the atrasentan group than in the placebo group. Hospital admission for heart failure occurred in 47 (3·5%)of 1325 patients in the atrasentan group and 34 (2·6%)of 1323 patients in the placebo group (HR 1·33 [95% CI 0·85–2·07]; p=0·208). 58 (4·4%)patients in the atrasentan group and 52 (3·9%)in the placebo group died (HR 1·09 [95% CI 0·75–1·59]; p=0·65). Interpretation: Atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease who were selected to optimise efficacy and safety. These data support a potential role for selective endothelin receptor antagonists in protecting renal function in patients with type 2 diabetes at high risk of developing end-stage kidney disease. Funding: AbbVie

Measuring the health-related Sustainable Development Goals in 188 countries : a baseline analysis from the Global Burden of Disease Study 2015

Background In September, 2015, the UN General Assembly established the Sustainable Development Goals (SDGs). The SDGs specify 17 universal goals, 169 targets, and 230 indicators leading up to 2030. We provide an analysis of 33 health-related SDG indicators based on the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015). Methods We applied statistical methods to systematically compiled data to estimate the performance of 33 health-related SDG indicators for 188 countries from 1990 to 2015. We rescaled each indicator on a scale from 0 (worst observed value between 1990 and 2015) to 100 (best observed). Indices representing all 33 health-related SDG indicators (health-related SDG index), health-related SDG indicators included in the Millennium Development Goals (MDG index), and health-related indicators not included in the MDGs (non-MDG index) were computed as the geometric mean of the rescaled indicators by SDG target. We used spline regressions to examine the relations between the Socio-demographic Index (SDI, a summary measure based on average income per person, educational attainment, and total fertility rate) and each of the health-related SDG indicators and indices. Findings In 2015, the median health-related SDG index was 59.3 (95% uncertainty interval 56.8-61.8) and varied widely by country, ranging from 85.5 (84.2-86.5) in Iceland to 20.4 (15.4-24.9) in Central African Republic. SDI was a good predictor of the health-related SDG index (r(2) = 0.88) and the MDG index (r(2) = 0.2), whereas the non-MDG index had a weaker relation with SDI (r(2) = 0.79). Between 2000 and 2015, the health-related SDG index improved by a median of 7.9 (IQR 5.0-10.4), and gains on the MDG index (a median change of 10.0 [6.7-13.1]) exceeded that of the non-MDG index (a median change of 5.5 [2.1-8.9]). Since 2000, pronounced progress occurred for indicators such as met need with modern contraception, under-5 mortality, and neonatal mortality, as well as the indicator for universal health coverage tracer interventions. Moderate improvements were found for indicators such as HIV and tuberculosis incidence, minimal changes for hepatitis B incidence took place, and childhood overweight considerably worsened. Interpretation GBD provides an independent, comparable avenue for monitoring progress towards the health-related SDGs. Our analysis not only highlights the importance of income, education, and fertility as drivers of health improvement but also emphasises that investments in these areas alone will not be sufficient. Although considerable progress on the health-related MDG indicators has been made, these gains will need to be sustained and, in many cases, accelerated to achieve the ambitious SDG targets. The minimal improvement in or worsening of health-related indicators beyond the MDGs highlight the need for additional resources to effectively address the expanded scope of the health-related SDGs.Peer reviewe

Olfactory Heterogeneity in LRRK2 Related Parkinsonism

LRRK2 mutations can cause familial and sporadic Parkinson's disease (PD) with Lewy-body pathology at post-mortem. Studies of olfaction in LRRK2 are sparse and incongruent. We applied a previously validated translation of the 16 item smell identification test from Sniffin' Sticks (SS-16) to 14 parkinsonian carriers of heterozygous G2019S LRRK2 mutation and compared with 106 PD patients and 118 healthy controls. the mean SS-16 score in LRRK2 was higher than in PD (p < 0.001, 95% CI for beta = -4.7 to -1.7) and lower than in controls (p = 0.007, 95% CI for beta = +0.6 to +3.6). in the LRRK2 group, subjects with low scores had significantly more dyskinesia. They also had younger age of onset, longer disease duration, and reported less frequently a family history of PD, but none of these other differences reached significance. Odor identification is diminished in LRRK2 parkinsonism but not to the same extent as in idiopathic PD. (C) 2010 Movement Disorder SocietyReta Lila Weston Trust for Medical Research and Foundation Philantropique Edmond SafraUCL, Inst Neurol, Reta Lila Weston Inst Neurol Studies, London WC1N 1PJ, EnglandUniv Fed Parana, Hosp Clin, Dept Internal Med, Neurol Serv,Movement Disorders Unit, Curitiba, Parana, BrazilUniv São Paulo, Sch Med, Dept Neurol, São Paulo, BrazilUniv Toronto, Ctr Res Neurodegenerat Dis, Toronto, ON, CanadaHosp Israelita Albert Einstein, Inst Israelita Ensino & Pesquisa Albert Einstein, Inst Cerebro, São Paulo, BrazilUniversidade Federal de São Paulo, Universidade Federal de São Paulo, LiNC, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, São Paulo, BrazilErasmus MC, Dept Clin Genet, Rotterdam, NetherlandsUniversidade Federal de São Paulo, Universidade Federal de São Paulo, LiNC, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, São Paulo, BrazilWeb of Scienc

NEOTROPICAL ALIEN MAMMALS: a data set of occurrence and abundance of alien mammals in the Neotropics

Biological invasion is one of the main threats to native biodiversity. For a species to become invasive, it must be voluntarily or involuntarily introduced by humans into a nonnative habitat. Mammals were among first taxa to be introduced worldwide for game, meat, and labor, yet the number of species introduced in the Neotropics remains unknown. In this data set, we make available occurrence and abundance data on mammal species that (1) transposed a geographical barrier and (2) were voluntarily or involuntarily introduced by humans into the Neotropics. Our data set is composed of 73,738 historical and current georeferenced records on alien mammal species of which around 96% correspond to occurrence data on 77 species belonging to eight orders and 26 families. Data cover 26 continental countries in the Neotropics, ranging from Mexico and its frontier regions (southern Florida and coastal-central Florida in the southeast United States) to Argentina, Paraguay, Chile, and Uruguay, and the 13 countries of Caribbean islands. Our data set also includes neotropical species (e.g., Callithrix sp., Myocastor coypus, Nasua nasua) considered alien in particular areas of Neotropics. The most numerous species in terms of records are from Bos sp. (n = 37,782), Sus scrofa (n = 6,730), and Canis familiaris (n = 10,084); 17 species were represented by only one record (e.g., Syncerus caffer, Cervus timorensis, Cervus unicolor, Canis latrans). Primates have the highest number of species in the data set (n = 20 species), partly because of uncertainties regarding taxonomic identification of the genera Callithrix, which includes the species Callithrix aurita, Callithrix flaviceps, Callithrix geoffroyi, Callithrix jacchus, Callithrix kuhlii, Callithrix penicillata, and their hybrids. This unique data set will be a valuable source of information on invasion risk assessments, biodiversity redistribution and conservation-related research. There are no copyright restrictions. Please cite this data paper when using the data in publications. We also request that researchers and teachers inform us on how they are using the data