Reducing the Risk of Pesticide Residues in the Groundwater: A Case Study of Punjab

The objective of this study was to reduce the risks of pesticide residues in groundwater, through the use of Good Agriculture Practices (Gaps) the data (primary) were collected with the help of two pretested questionnaires. SQC (Statistical Quality Control) tools and Hazard Identification Based System were used on data, for the determination of the risk from different activities, related to pesticide usage. It was observed that induction of risk assessment and the principle of quality management at an early stage of the food supply chain which would increase the efficiency of farming and also decreased the different types of hazards, related to the agricultural activit

Reducing the Risk of Pesticide Residues in the Groundwater: A Case Study of Punjab

The objective of this study was to reduce the risks of pesticide residues in groundwater, through the use of Good Agriculture Practices (Gaps) the data (primary) were collected with the help of two pretested questionnaires. SQC (Statistical Quality Control) tools and Hazard Identification Based System were used on data, for the determination of the risk from different activities, related to pesticide usage. It was observed that induction of risk assessment and the principle of quality management at an early stage of the food supply chain which would increase the efficiency of farming and also decreased the different types of hazards, related to the agricultural activit

Enhancement of aerodynamic performance of high speed train through nose profile design: A computational fluid dynamics approach

Aerodynamic drag of fast-moving train has significant impact on its fuel consumption and design safety. To improve aerodynamic performance, the drag forces on the train surfaces must be reduced. Train’s front-end nose design has boundless geometrical variations that can be applied for improved performance. Three geometric characteristics were used in present research: A-pillar roundness, nose length that controls its shrinking, and nose bluntness. Latin-Hypercube based random sampling method was used to determine appropriate values of these parameters for specific range. Using Computational Fluid Dynamics (CFD), a numerical approach was used to analyze train aerodynamic performance based on selected factors and operating conditions. Comparisons based on analysis of the base design and proposed design models were made and evaluated for enhanced performance. CFD analysis of the base design and iterative improvements in modified designs indicate drag reduction through change in A-pillar roundness and bluntness of nose to be 10% and 22%, respectively. The increase in nose length which controls nose shrinkage causes the drag to increase by 35%. Similarly, the boundary layer and pressure distribution on the front end of train were also considered and analyzed for performance improvement. It was concluded that the length controlling nose shrinkage of proposed train design is the key factor among the selected geometric parameters that has more influence on drag on high-speed train surface in comparison to other parameters considered. This research effort offers a modification, analysis and comparison of front-end nose geometry of high-speed train to improve aerodynamic performance and consequently fuel consumption

Analisis penerapan prinsip 5C pada produk pembiayaan iB Griya Bank Jateng Syariah : studi kasus pada Bank Jateng Syariah Cabang Semarang

Kegiatan usaha yang dijalankan Bank Jateng Syariah terutama dalam kegiatan usaha lending (pembiayaan) dimaksudkan untuk memenuhi kebutuhan hidup masyarakat berupa penyediaan modal usaha untuk pembelian barang-barang produksi, modal kerja, pengembangan bisnis, pembangunan atau pembelian rumah, dan pembelian barang-barang konsumtif. Dalam pemenuhan kebutuhan masyarakat berupa hunian Bank Jateng Syariah hadir dengan produk pembiayaan berupa iB Griya Bank Jateng Syariah. Dalam memenuhi kebutuhan masyarakat tidak serta merta Bank Jateng Syariah merealisasikannya, terdapat beberapa aspek yang perlu diperhatikan. Untuk itu Bank Jateng Syariah menerapkan prinsip 5C untuk menjadi tolak ukur dari realisasi pembiayaan yang diajukan nasabah. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana penerapan prinsip 5C yang dilakukan Bank Jateng Syariah Cabang Semarang terhadap penilaian produk pembiayaan iB Griya. Penelitian ini menggunakan metode penelitian kualitatif. Dimana penelitian tersebut di dapat dari hasil observasi, wawancara, dan dokumentasi terkait dengan objek yang diteliti. Selain itu penelitian ini ditunjang dengan adanya data primer dan sekunder dari beberapa literatur. Dari hasil penelitian diketahui bahwa dalam menilai seluruh pembiayaan yang diajukan debitur terutama dalam penilaian pembiayaan iB Griya Bank Jateng Syariah menggunakan dan mengaplikasikan alat analisis 5C tersebut dan disesuaikan dengan ketentuan yang dimiliki Bank Jateng Syariah dalam hal penilaian pembiayaan

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Funding: F Carvalho and E Fernandes acknowledge support from Fundação para a Ciência e a Tecnologia, I.P. (FCT), in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy i4HB; FCT/MCTES through the project UIDB/50006/2020. J Conde acknowledges the European Research Council Starting Grant (ERC-StG-2019-848325). V M Costa acknowledges the grant SFRH/BHD/110001/2015, received by Portuguese national funds through Fundação para a Ciência e Tecnologia (FCT), IP, under the Norma Transitória DL57/2016/CP1334/CT0006.proofepub_ahead_of_prin

Global injury morbidity and mortality from 1990 to 2017 : results from the Global Burden of Disease Study 2017

Correction:Background Past research in population health trends has shown that injuries form a substantial burden of population health loss. Regular updates to injury burden assessments are critical. We report Global Burden of Disease (GBD) 2017 Study estimates on morbidity and mortality for all injuries. Methods We reviewed results for injuries from the GBD 2017 study. GBD 2017 measured injury-specific mortality and years of life lost (YLLs) using the Cause of Death Ensemble model. To measure non-fatal injuries, GBD 2017 modelled injury-specific incidence and converted this to prevalence and years lived with disability (YLDs). YLLs and YLDs were summed to calculate disability-adjusted life years (DALYs). Findings In 1990, there were 4 260 493 (4 085 700 to 4 396 138) injury deaths, which increased to 4 484 722 (4 332 010 to 4 585 554) deaths in 2017, while age-standardised mortality decreased from 1079 (1073 to 1086) to 738 (730 to 745) per 100 000. In 1990, there were 354 064 302 (95% uncertainty interval: 338 174 876 to 371 610 802) new cases of injury globally, which increased to 520 710 288 (493 430 247 to 547 988 635) new cases in 2017. During this time, age-standardised incidence decreased non-significantly from 6824 (6534 to 7147) to 6763 (6412 to 7118) per 100 000. Between 1990 and 2017, age-standardised DALYs decreased from 4947 (4655 to 5233) per 100 000 to 3267 (3058 to 3505). Interpretation Injuries are an important cause of health loss globally, though mortality has declined between 1990 and 2017. Future research in injury burden should focus on prevention in high-burden populations, improving data collection and ensuring access to medical care.Peer reviewe

The global burden of adolescent and young adult cancer in 2019 : a systematic analysis for the Global Burden of Disease Study 2019

Background In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults. Findings There were 1.19 million (95% UI 1.11-1.28) incident cancer cases and 396 000 (370 000-425 000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59.6 [54.5-65.7] per 100 000 person-years) and high-middle SDI countries (53.2 [48.8-57.9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14.2 [12.9-15.6] per 100 000 person-years) and middle SDI (13.6 [12.6-14.8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23.5 million (21.9-25.2) DALYs to the global burden of disease, of which 2.7% (1.9-3.6) came from YLDs and 97.3% (96.4-98.1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. Interpretation Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe

The global burden of cancer attributable to risk factors, 2010-19 : a systematic analysis for the Global Burden of Disease Study 2019

Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.Peer reviewe