Stratigraphic Column of the Kope and Fairview Formations, Kentucky 445, Brent, Kentucky

The Upper Ordovician Kope Formation is exposed over a broad area of southwestern Ohio, southeastern Indiana, and northern Kentucky (Weir and others, 1984). Roadcuts along Ky. 445 near Brent (Figs. 2-3) and adjacent roadcuts along Interstate 275 expose a nearly complete section of the Kope Formation as well as the overlying Fairview Formation

On the Impact of Link Layer Retransmissions on TCP for Aeronautical Communications

In this article, we evaluate the impact of link layer retransmissions on the performance of TCP in the context of aeronautical communications.We present the architecture of aeronautical networks, which is manly driven by an important channel access delay, and the various retransmission strategies that can be implemented at both link and transport layers. We consider a worst case scenario to illustrate the benefits provided by the ARQ scheme at the link layer in terms of transmission delay.We evaluate the trade-off between allowing a fast data transmission and a low usage of satellite capacity by adjusting link layer parameters

Impact of model resolution for on-shelf heat transport along the West Antarctic Peninsula

The flux of warm deep water onto Antarctic continental shelves plays a vital role in determining water mass properties adjacent to the continent. A regional model, with two different grid resolutions, has been used to simulate ocean processes along the West Antarctic Peninsula. At both 4 km and 1.5 km resolution, the model reproduces the locations of warm intrusions, as shown through comparison with observations from instrumented seals. However, the 1.5 km simulation shows greater on‐shelf heat transport, leading to improved representation of heat content on the shelf. This increased heat transport is associated with increased eddy activity, both at the shelf‐break and in the deep ocean off‐shore. Cross‐shelf troughs are key locations of on‐shelf heat transport. Comparison of two troughs, Belgica and Marguerite, shows differing responses to increased resolution. At higher resolution, there is an increased on‐shelf volume transport at Belgica Trough, but not at Marguerite Trough. This is likely related to the differing structure of the shelf‐break jet between these two locations. The increased heat flux at Marguerite Trough is attributed to increased heat content in the on‐shelf transport. Increased eddy activity off‐shelf may lead to greater cross‐front heat transport, and therefore increased heat available above the continental slope. While these simulations differ in their magnitude of heat transport, both show similar patterns of variability. Variations in wind stress lead to variations in speed of the shelf‐break jet, and therefore on‐shelf heat transport. These results demonstrate the importance of model resolution for understanding cross‐shelf transport around Antarctica

Potential impacts on ecosystem services of land use transitions to second-generation bioenergy crops in GB

We present the first assessment of the impact of land use change (LUC) to second-generation (2G) bioenergy crops on ecosystem services (ES) resolved spatially for Great Britain (GB). A systematic approach was used to assess available evidence on the impacts of LUC from arable, semi-improved grassland or woodland/forest, to 2G bioenergy crops, for which a quantitative ‘threat matrix’ was developed. The threat matrix was used to estimate potential impacts of transitions to either Miscanthus, short-rotation coppice (SRC, willow and poplar) or short-rotation forestry (SRF). The ES effects were found to be largely dependent on previous land uses rather than the choice of 2G crop when assessing the technical potential of available biomass with a transition from arable crops resulting in the most positive effect on ES. Combining these data with constraint masks and available land for SRC and Miscanthus (SRF omitted from this stage due to lack of data), south-west and north-west England were identified as areas where Miscanthus and SRC could be grown, respectively, with favourable combinations of economic viability, carbon sequestration, high yield and positive ES benefits. This study also suggests that not all prospective planting of Miscanthus and SRC can be allocated to agricultural land class (ALC) ALC 3 and ALC 4 and suitable areas of ALC 5 are only minimally available. Beneficial impacts were found on 146 583 and 71 890 ha when planting Miscanthus or SRC, respectively, under baseline planting conditions rising to 293 247 and 91 318 ha, respectively, under 2020 planting scenarios. The results provide an insight into the interplay between land availability, original land uses, bioenergy crop type and yield in determining overall positive or negative impacts of bioenergy cropping on ecosystems services and go some way towards developing a framework for quantifying wider ES impacts of this important LUC

A correlation between the intrinsic brightness and average decay rate of Swift/UVOT gamma-ray burst optical/ultraviolet light curves

We examine a sample of 48 Swift/UVOT long gamma-ray burst light curves and find a correlation between the logarithmic luminosity at 200 s and average decay rate determined from 200 s onwards, with a Spearman rank coefficient of −0.58 at a significance of 99.998 per cent (4.2σ). We discuss the causes of the log L200 s–α>200 s correlation, finding it to be an intrinsic property of long gamma-ray bursts, and not resulting from the selection criteria. We find two ways to produce the correlation. One possibility is that there is some property of the central engine, outflow or external medium that affects the rate of energy release so that the bright afterglows release their energy more quickly and decay faster than the fainter afterglows. Alternatively, the correlation may be produced by variation of the observer’s viewing angle, with observers at large viewing angles observing fainter and slower decaying light curves

Female Burying Beetles Benefit from Male Desertion: Sexual Conflict and Counter-Adaptation over Parental Investment

Sexual conflict drives the coevolution of sexually antagonistic traits, such that an adaptation in one sex selects an opposing coevolutionary response from the other. Although many adaptations and counteradaptations have been identified in sexual conflict over mating interactions, few are known for sexual conflict over parental investment. Here we investigate a possible coevolutionary sequence triggered by mate desertion in the burying beetle Nicrophorus vespilloides, where males commonly leave before their offspring reach independence. Rather than suffer fitness costs as a consequence, our data suggest that females rely on the male's absence to recoup some of the costs of larval care, presumably because they are then free to feed themselves on the carcass employed for breeding. Consequently, forcing males to stay until the larvae disperse reduces components of female fitness to a greater extent than caring for young singlehandedly. Therefore we suggest that females may have co-evolved to anticipate desertion by their partners so that they now benefit from the male's absence

Impact of UV Radiation from Giant Spirals on the Evolution of Dwarf Galaxies

We show that ultraviolet radiation, with wavelengths shorter than 2000 A, escaping from the disks of giant spirals could be one of the principal factors affecting the evolution of low mass satellite galaxies. We demonstrate, using a semi-qualitative model, that the Lyman continuum part of the radiation field can lead to ionization of the ISM of the dwarf galaxies through the process of photoevaporation, making the ISM virtually unobservable. The FUV part (912 < lambda < 2000 A) is shown to dominate over the internal sources of radiation for most of the Galactic dwarf spheroidals. The proposed environmental factor could be at least partially responsible for the bifurcation of the low mass proto-galaxies into two sequences - dwarf irregulars and dwarf spheroidals. We discuss many peculiarities of the Local Group early-type dwarfs which can be accounted for by the impact of the UV radiation from the host spiral galaxy (Milky Way or M31).Comment: 15 pages, 12 figures. Accepted for publication in MNRAS. More consistent photoionization model is used in Sect. 2. All main results stay unchange

Implantable cardioverter defibrillators for the treatment of arrhythmias and cardiac resynchronisation therapy for the treatment of heart failure: systematic review and economic evaluation

Background This assessment updates and expands on two previous technology assessments that evaluated implantable cardioverter defibrillators (ICDs) for arrhythmias and cardiac resynchronisation therapy (CRT) for heart failure (HF). Objectives To assess the clinical effectiveness and cost-effectiveness of ICDs in addition to optimal pharmacological therapy (OPT) for people at increased risk of sudden cardiac death (SCD) as a result of ventricular arrhythmias despite receiving OPT; to assess CRT with or without a defibrillator (CRT-D or CRT-P) in addition to OPT for people with HF as a result of left ventricular systolic dysfunction (LVSD) and cardiac dyssynchrony despite receiving OPT; and to assess CRT-D in addition to OPT for people with both conditions. Data sources Electronic resources including MEDLINE, EMBASE and The Cochrane Library were searched from inception to November 2012. Additional studies were sought from reference lists, clinical experts and manufacturers’ submissions to the National Institute for Health and Care Excellence. Review methods Inclusion criteria were applied by two reviewers independently. Data extraction and quality assessment were undertaken by one reviewer and checked by a second. Data were synthesised through narrative review and meta-analyses. For the three populations above, randomised controlled trials (RCTs) comparing (1) ICD with standard therapy, (2) CRT-P or CRT-D with each other or with OPT and (3) CRT-D with OPT, CRT-P or ICD were eligible. Outcomes included mortality, adverse events and quality of life. A previously developed Markov model was adapted to estimate the cost-effectiveness of OPT, ICDs, CRT-P and CRT-D in the three populations by simulating disease progression calculated at 4-weekly cycles over a lifetime horizon. Results A total of 4556 references were identified, of which 26 RCTs were included in the review: 13 compared ICD with medical therapy, four compared CRT-P/CRT-D with OPT and nine compared CRT-D with ICD. ICDs reduced all-cause mortality in people at increased risk of SCD, defined in trials as those with previous ventricular arrhythmias/cardiac arrest, myocardial infarction (MI) > 3 weeks previously, non-ischaemic cardiomyopathy (depending on data included) or ischaemic/non-ischaemic HF and left ventricular ejection fraction ≤ 35%. There was no benefit in people scheduled for coronary artery bypass graft. A reduction in SCD but not all-cause mortality was found in people with recent MI. Incremental cost-effectiveness ratios (ICERs) ranged from £14,231 per quality-adjusted life-year (QALY) to £29,756 per QALY for the scenarios modelled. CRT-P and CRT-D reduced mortality and HF hospitalisations, and improved other outcomes, in people with HF as a result of LVSD and cardiac dyssynchrony when compared with OPT. The rate of SCD was lower with CRT-D than with CRT-P but other outcomes were similar. CRT-P and CRT-D compared with OPT produced ICERs of £27,584 per QALY and £27,899 per QALY respectively. The ICER for CRT-D compared with CRT-P was £28,420 per QALY. In people with both conditions, CRT-D reduced the risk of all-cause mortality and HF hospitalisation, and improved other outcomes, compared with ICDs. Complications were more common with CRT-D. Initial management with OPT alone was most cost-effective (ICER £2824 per QALY compared with ICD) when health-related quality of life was kept constant over time. Costs and QALYs for CRT-D and CRT-P were similar. The ICER for CRT-D compared with ICD was £27,195 per QALY and that for CRT-D compared with OPT was £35,193 per QALY. Limitations Limitations of the model include the structural assumptions made about disease progression and treatment provision, the extrapolation of trial survival estimates over time and the assumptions made around parameter values when evidence was not available for specific patient groups. Conclusions In people at risk of SCD as a result of ventricular arrhythmias and in those with HF as a result of LVSD and cardiac dyssynchrony, the interventions modelled produced ICERs of < £30,000 per QALY gained. In people with both conditions, the ICER for CRT-D compared with ICD, but not CRT-D compared with OPT, was < £30,000 per QALY, and the costs and QALYs for CRT-D and CRT-P were similar. A RCT comparing CRT-D and CRT-P in people with HF as a result of LVSD and cardiac dyssynchrony is required, for both those with and those without an ICD indication. A RCT is also needed into the benefits of ICD in non-ischaemic cardiomyopathy in the absence of dyssynchrony. Study registration This study is registered as PROSPERO number CRD42012002062. Funding The National Institute for Health Research Health Technology Assessment programme