Yos9p assists in the degradation of certain non-glycosylated proteins from the endoplasmic reticulum

The HRD ubiquitin ligase recognizes and ubiquitylates proteins of the endoplasmic reticulum that display structural defects. Here, we apply quantitative proteomics to characterize the substrate spectrum of the HRD complex. Among the identified substrates is Erg3p, a glycoprotein involved in sterol-synthesis. We characterize Erg3p and demonstrate that the elimination of Erg3p requires Htm1p and Yos9p, two proteins that partake in the glycan-dependent turnover of aberrant proteins. We further show that the HRD ligase also mediates the breakdown of Erg3p and CPY* engineered to lack N-glycans. The degradation of these non-glycosylated substrates is enhanced by a mutant variant of Yos9p that has lost its affinity for oligosaccharides, indicating that Yos9p has a previously unrecognized role in the quality control of non-glycosylated proteins

The optimal sink and the best source in a Markov chain

It is well known that the distributions of hitting times in Markov chains are quite irregular, unless the limit as time tends to infinity is considered. We show that nevertheless for a typical finite irreducible Markov chain and for nondegenerate initial distributions the tails of the distributions of the hitting times for the states of a Markov chain can be ordered, i.e., they do not overlap after a certain finite moment of time. If one considers instead each state of a Markov chain as a source rather than a sink then again the states can generically be ordered according to their efficiency. The mechanisms underlying these two orderings are essentially different though.Comment: 12 pages, 1 figur

Psychometric assessment of the short-form Child Perceptions Questionnaire: an international collaborative study.

OBJECTIVE: To examine the factor structure and other psychometric characteristics of the most commonly used child oral-health-related quality-of-life (OHRQoL) measure (the 16-item short-form CPQ11-14 ) in a large number of children (N = 5804) from different settings and who had a range of caries experience and associated impacts. METHODS: Secondary data analyses used subnational epidemiological samples of 11- to 14-year-olds in Australia (N = 372), New Zealand (three samples: 352, 202, 429), Brunei (423), Cambodia (244), Hong Kong (542), Malaysia (439), Thailand (220, 325), England (88, 374), Germany (1055), Mexico (335) and Brazil (404). Confirmatory factor analysis (CFA) was used to examine the factor structure of the CPQ11-14 across the combined sample and within four regions (Australia/NZ, Asia, UK/Europe and Latin America). Item impact and internal reliability analysis were also conducted. RESULTS: Caries experience varied, with mean DMFT scores ranging from 0.5 in the Malaysian sample to 3.4 in one New Zealand sample. Even more variation was noted in the proportion reporting only fair or poor oral health; this was highest in the Cambodian and Mexican samples and lowest in the German sample and one New Zealand sample. One in 10 reported that their oral health had a marked impact on their life overall. The CFA across all samples revealed two factors with eigenvalues greater than 1. The first involved all items in the oral symptoms and functional limitations subscales; the second involved all emotional well-being and social well-being items. The first was designated the 'symptoms/function' subscale, and the second was designated the 'well-being' subscale. Cronbach's alpha scores were 0.72 and 0.84, respectively. The symptoms/function subscale contained more of the items with greater impact, with the item 'Food stuck in between your teeth' having greatest impact; in the well-being subscale, the 'Felt shy or embarrassed' item had the greatest impact. Repeating the analyses by world region gave similar findings. CONCLUSION: The CPQ11-14 performed well cross-sectionally in the largest analysis of the scale in the literature to date, with robust and mostly consistent psychometric characteristics, albeit with two underlying factors (rather than the originally hypothesized four-factor structure). It appears to be a sound, robust measure which should be useful for research, practice and policy

Explicit formulae in probability and in statistical physics

We consider two aspects of Marc Yor's work that have had an impact in statistical physics: firstly, his results on the windings of planar Brownian motion and their implications for the study of polymers; secondly, his theory of exponential functionals of Levy processes and its connections with disordered systems. Particular emphasis is placed on techniques leading to explicit calculations.Comment: 14 pages, 2 figures. To appear in Seminaire de Probabilites, Special Issue Marc Yo

Comparative Study of Multifragmentation of Gold Nuclei Induced by Relativistic Protons, 4^4He, and 12^{12}C

Multiple emission of intermediate-mass fragments has been studied for the collisions of p, $^4$He and $^{12}$C on Au with the $4\pi$ setup FASA. The mean IMF multiplicities (for the events with at least one IMF) are saturating at the value of $2.2\pm0.2$ for the incident energies above 6 GeV. The observed IMF multiplicities cannot be described in a two-stage scenario, a fast cascade followed by a statistical multifragmentation. Agreement with the measured IMF multiplicities is obtained by introducing an intermediate phase and modifying empirically the excitation energies and masses of the remnants. The angular distributions and energy spectra from the p-induced collisions are in agreement with the scenario of ``thermal'' multifragmentation of a hot and diluted target spectator. In the case of $^{12}$C+Au(22.4 GeV) and $^4$He(14.6 GeV)+Au collisions, deviations from a pure thermal break-up are seen in the energy spectra of the emitted fragments, which are harder than those both from model calculations and from the measured ones for p-induced collisions. This difference is attributed to a collective flow.Comment: 33 pages 15 figures, accepted in Nucl. Phys.

Bounds on the tau and muon neutrino vector and axial vector charge radius

A Majorana neutrino is characterized by just one flavor diagonal electromagnetic form factor: the anapole moment, that in the static limit corresponds to the axial vector charge radius . Experimental information on this quantity is scarce, especially in the case of the tau neutrino. We present a comprehensive analysis of the available data on the single photon production process $e^+ e^- -> \nu \bar\nu \gamma$ off Z-resonance, and we discuss the constraints that these measurements can set on for the tau neutrino. We also derive limits for the Dirac case, when the presence of a vector charge radius is allowed. Finally, we comment on additional experimental data on $\nu_\mu$ scattering from the NuTeV, E734, CCFR and CHARM-II collaborations, and estimate the limits implied for and for the muon neutrino.Comment: 20 pages, 2 eps figures. CCFR data included in the analysis. Conclusion unchange

A Biased Review of Sociophysics

Various aspects of recent sociophysics research are shortly reviewed: Schelling model as an example for lack of interdisciplinary cooperation, opinion dynamics, combat, and citation statistics as an example for strong interdisciplinarity.Comment: 16 pages for J. Stat. Phys. including 2 figures and numerous reference

Existence, uniqueness, and nondegeneracy of positive solutions of semilinear elliptic equations

We study positive solutions of the Dirichlet problem: Δ u ( x )+ f ( u ( x ))=0, x ∈ D n , u ( x )=0, x ∈∂ D n , where D n is an n -ball. We find necessary and sufficient conditions for solutions to be nondegenerate. We also give some new existence and uniqueness theorems.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46528/1/220_2005_Article_BF01468138.pd

Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector

A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results

Jet size dependence of single jet suppression in lead-lead collisions at sqrt(s(NN)) = 2.76 TeV with the ATLAS detector at the LHC

Measurements of inclusive jet suppression in heavy ion collisions at the LHC provide direct sensitivity to the physics of jet quenching. In a sample of lead-lead collisions at sqrt(s) = 2.76 TeV corresponding to an integrated luminosity of approximately 7 inverse microbarns, ATLAS has measured jets with a calorimeter over the pseudorapidity interval |eta| < 2.1 and over the transverse momentum range 38 < pT < 210 GeV. Jets were reconstructed using the anti-kt algorithm with values for the distance parameter that determines the nominal jet radius of R = 0.2, 0.3, 0.4 and 0.5. The centrality dependence of the jet yield is characterized by the jet "central-to-peripheral ratio," Rcp. Jet production is found to be suppressed by approximately a factor of two in the 10% most central collisions relative to peripheral collisions. Rcp varies smoothly with centrality as characterized by the number of participating nucleons. The observed suppression is only weakly dependent on jet radius and transverse momentum. These results provide the first direct measurement of inclusive jet suppression in heavy ion collisions and complement previous measurements of dijet transverse energy imbalance at the LHC.Comment: 15 pages plus author list (30 pages total), 8 figures, 2 tables, submitted to Physics Letters B. All figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HION-2011-02