11 research outputs found
Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation : Data From ROCKET AF
- Author
- Abadier R.
- Abelson M.
- Abhyankar A.
- Abram N.
- Achimastos A.
- Agacdiken Agir A.
- Agah R.
- Agamasu J.
- Aganauskiene J.
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- Agnelli G.
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- Aidietiene S.
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- Akyea Djamson A.
- Al Saghir Y.
- Al Zoebi A.
- Albina G.
- Albirini A.
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- Alekseeva N.
- Alessi S.
- Alexeeva O.
- Alfieri A.
- Almaguer E.
- Almquist A.
- Altunkeser B.
- Alvarado O.
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M. Kaste on työryhmÀn ROCKET AF Steering Comm jÀsen.Background-Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. Methods and Results-In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose-adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all-cause mortality in the 14 171 participants in the intention-to-treat population. The median age was 73 years, and the mean CHADS(2) score was 3.5. Over 1.9 years of median follow-up, 1214 (8.6%) patients died. Kaplan-Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all-cause mortality was observed between the rivaroxaban and warfarin arms (P=0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33-1.70, P= 75 years (hazard ratio 1.69, 95% CI 1.51-1.90, P Conclusions-In a large population of patients anticoagulated for nonvalvular atrial fibrillation, approximate to 7 in 10 deaths were cardiovascular, whereasPeer reviewe
Disorder Detection in Tomato Plant Using Deep Learning
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- 'Elsevier BV'
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- Field of study
Synergy of two human endogenous retroviruses in multiple myeloma
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- BjĂžrn A. NexĂž
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- Sara B. Jensen
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- Vachon
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- Weinhold
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- 'Elsevier BV'
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- Field of study
In-vitro hemolytic activity and free radical scavenging by sol-gel synthesized Fe3O4 stabilized ZrO2 nanoparticles
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- Abinaya
- Anjum N. Sabri
- Balaji
- Bashir
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- 'Elsevier BV'
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- Field of study
Effects of celery powder on wheat dough properties and textural, antioxidant and starch digestibility properties of bread
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- U Gawlik-Dziki
- W Kooti
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- 'Springer Science and Business Media LLC'
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A comparison of two-dimensional prediction tracing and a virtual reality patient methods for diagnosis and treatment planning of orthognathic cases in dental students: a randomized preliminary study
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- Field of study
Partial root-zone drying (PRD), its effects and agricultural significance: a review
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- A Alkhaldi
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- A Shahnazari
- A Shahnazari
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- AR Sepaskhah
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- BG Leib
- BJ Pandias
- BR Loveys
- C Gencoglan
- C Kirda
- C Kirda
- DM Mingo
- DW Grimes
- DZ Gong
- E Fereres
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- F Li
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Enhanced infection prophylaxis reduces mortality in severely immunosuppressed HIV-infected adults and older children initiating antiretroviral therapy in Kenya, Malawi, Uganda and Zimbabwe: the REALITY trial
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- Publication venue
- 'International AIDS Society'
- Publication date
- 01/01/2016
- Field of study
Meeting abstract FRAB0101LB from 21st International AIDS Conference 18â22 July 2016, Durban, South Africa.
Introduction: Mortality from infections is high in the first 6 months of antiretroviral therapy (ART) among HIVâinfected adults and children with advanced disease in subâSaharan Africa. Whether an enhanced package of infection prophylaxis at ART initiation would reduce mortality is unknown.
Methods:
The REALITY 2Ă2Ă2 factorial openâlabel trial (ISRCTN43622374) randomized ARTânaĂŻve HIVâinfected adults and children >5 years with CD4 <100 cells/mm3. This randomization compared initiating ART with enhanced prophylaxis (continuous cotrimoxazole plus 12 weeks isoniazid/pyridoxine (antiâtuberculosis) and fluconazole (antiâcryptococcal/candida), 5 days azithromycin (antiâbacterial/protozoal) and singleâdose albendazole (antiâhelminth)), versus standardâofâcare cotrimoxazole. Isoniazid/pyridoxine/cotrimoxazole was formulated as a scored fixedâdose combination. Two other randomizations investigated 12âweek adjunctive raltegravir or supplementary food. The primary endpoint was 24âweek mortality.
Results:
1805 eligible adults (n = 1733; 96.0%) and children/adolescents (n = 72; 4.0%) (median 36 years; 53.2% male) were randomized to enhanced (n = 906) or standard prophylaxis (n = 899) and followed for 48 weeks (3.8% lossâtoâfollowâup). Median baseline CD4 was 36 cells/mm3 (IQR: 16â62) but 47.3% were WHO Stage 1/2. 80 (8.9%) enhanced versus 108(12.2%) standard prophylaxis died before 24 weeks (adjusted hazard ratio (aHR) = 0.73 (95% CI: 0.54â0.97) p = 0.03; Figure 1) and 98(11.0%) versus 127(14.4%) respectively died before 48 weeks (aHR = 0.75 (0.58â0.98) p = 0.04), with no evidence of interaction with the two other randomizations (p > 0.8). Enhanced prophylaxis significantly reduced incidence of tuberculosis (p = 0.02), cryptococcal disease (p = 0.01), oral/oesophageal candidiasis (p = 0.02), deaths of unknown cause (p = 0.02) and (marginally) hospitalisations (p = 0.06) but not presumed severe bacterial infections (p = 0.38). Serious and grade 4 adverse events were marginally less common with enhanced prophylaxis (p = 0.06). CD4 increases and VL suppression were similar between groups (p > 0.2).
Conclusions:
Enhanced infection prophylaxis at ART initiation reduces early mortality by 25% among HIVâinfected adults and children with advanced disease. The pill burden did not adversely affect VL suppression. Policy makers should consider adopting and implementing this lowâcost broad infection prevention package which could save 3.3 lives for every 100 individuals treated
Cause of death and predictors of all-cause mortality in anticoagulated patients with nonvalvular atrial fibrillation: Data from ROCKET AF
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- Yu B.
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- Yusof Z.
- Zadionchenko V.
- Zakhary B.
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- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2015
- Field of study
Background-Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. Methods and Results-In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose-adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all-cause mortality in the 14 171 participants in the intentionto- treat population. The median age was 73 years, and the mean CHADS2 score was 3.5. Over 1.9 years of median follow-up, 1214 (8.6%) patients died. Kaplan-Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all-cause mortality was observed between the rivaroxaban and warfarin arms (P=0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33-1.70, P<0.0001) and age 6575 years (hazard ratio 1.69, 95% CI 1.51-1.90, P<0.0001) were associated with higher all-cause mortality. Multiple additional characteristics were independently associated with higher mortality, with decreasing creatinine clearance, chronic obstructive pulmonary disease, male sex, peripheral vascular disease, and diabetes being among the most strongly associated (model C-index 0.677). Conclusions-In a large population of patients anticoagulated for nonvalvular atrial fibrillation, 487 in 10 deaths were cardiovascular, whereas <1 in 10 deaths were caused by nonhemorrhagic stroke or systemic embolism. Optimal prevention and treatment of heart failure, renal impairment, chronic obstructive pulmonary disease, and diabetes may improve survival
Beyond a neurotransmitter: The role of serotonin in inflammation and immunity
- Author
- Abbas
- Ahlman
- Ahmadi
- Aiello
- Akahoshi
- Amadori
- Ameisen
- Amin
- Andersen
- Andrews
- Ashkenazy-Shahar
- Assouline-Cohen
- Atarashi
- Aune
- Aune
- Aune
- Badovinac
- Banchereau
- Banks
- Barnes
- Basu
- Bauer
- Beikmann
- Bensinger
- Bertrand
- Beurel
- Bhat
- Bianchi
- Bonnet
- Bonnet
- Bopp
- Branco-de-Almeida
- Brenner
- Brunk
- Bull
- Byram
- Byrne
- Capuron
- Carabotti
- Cathcart
- Cerrito
- Chabbi-Achengli
- Chaitidis
- Chase
- Chen
- Chen
- Chen
- Choi
- Ciorba
- Ciorba
- Clemons
- Costedio
- Cserr
- Dantzer
- Dantzer
- Dantzer
- Dantzer
- Dash
- Davami
- Davi
- Davies
- Davydova
- de las Casas-Engel
- de Las Casas-Engel
- Deaglio
- Di Rosso
- Dienz
- Dowlati
- Duerschmied
- Durk
- Edgar
- El Aidy
- Epelman
- Eskelinen
- Fazzino
- Fazzino
- Ferjan
- Ford
- Frank
- Freire-Garabal
- Fung
- Gandolfo
- Ge
- Gerriets
- Gerriets
- Gerriets
- Gershon
- Gershon
- Gershon
- Gershon
- Ghia
- Giacovazzo
- Ginhoux
- Glass
- Gobin
- Gobin
- Gordon
- Graff
- Greeson
- Grigoleit
- Grosse
- Grosse
- Gurgel
- Gurtner
- Gutierrez
- Hamilton
- Hera Wu
- Herr
- Heusel
- Hickey
- Holinstat
- Holst
- Hong
- Howard
- Idzko
- Inoue
- Ivanov
- Ivanov
- Iyengar
- Jackson
- Jakubzick
- Jordan N. Storkersen
- Josefowicz
- Khan
- Kim
- Kim
- Kim
- Kim
- Klein
- Kohler
- Kohler
- Kopschina Feltes
- Kritas
- Kuo
- Kurd
- Kushnir-Sukhov
- Kushnir-Sukhov
- Kut
- Lahti
- Lang
- Lazarevic
- Li
- Li
- Li
- Liao
- Lima
- Lisman
- Liu
- Lorentz
- Louveau
- Lutz
- Macintyre
- Maes
- Maes
- Maes
- Malaguarnera
- Marshall
- Mbongue
- McNicol
- Mercado
- Metcalfe
- Michalek
- Miller
- Mosmann
- Motomura
- Muller
- Munn
- Murata
- Mustard
- Myint
- Nakajima
- Nakamura
- Namkung
- Nautiyal
- Nikolaus
- Nowak
- Olson
- Owens
- OâConnell
- Palmer
- Park
- Park
- Pasare
- Perruzza
- Powell
- Puri
- Raison
- Ransohoff
- Reichenberg
- Reinhard
- Rhee
- Ridge
- Ringvall
- Rosenblat
- Roumestan
- Rybka
- Said
- Sander
- Sant
- Santhanam
- Schaefer
- Shenoy
- Spengler
- Stefulj
- Steinman
- Sternberg
- Subramaniam
- Sutcigil
- Talaat
- Taler
- Tanaka
- Tanaka
- Tang
- Travis H. Denna
- Tyring
- Urbina
- Valent
- Valerie A. Gerriets
- Vega
- Vitalis
- Vollmar
- Walker
- Walker
- Walther
- Walther
- Wang
- Wang
- Wang
- Weaver
- Weaver
- Wernersson
- Wichers
- Williams
- Wong
- Xu
- Yadav
- Yang
- Yano
- Yen
- Yin
- Yu PL
- Yuan
- Zeiser
- Zhang
- Zhang
- Zhou
- Zhu
- Ziu
- Zorrilla
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study