15,817 research outputs found
Study of Molecular Mechanism of Antibiotic susceptibility against Polymicrobial Oral infection
Abstract

Introduction- Antibiotic to treat dental caries infection are routinely prescribed. Bacteria have increased resistance to the currently recommended antibiotics. The purpose of this investigation was to perform antibiotic susceptibility on a panel pathogenic strain of bacteria isolated step by step from dental caries infection. 
Materials and Methods-Bacteria were isolated from caries site of patients and cultivated identified at the species level. Each of 150 species of bacteria was tested for antibiotics susceptibility to a five antibiotics using Etest. Antibiotic used were Amoxicillin, Cloxocillin, Erythromycin, Tetracycline, Penicillin-V.
Results- The percentages of Resistance in treatment for each antibiotic in this study were penicillin V: 72/150 (48%), Tetracycline: 99/150 (66%), amoxicillin: 135/150 (90%), Cloxocillin: 117/150 (78%), and Erythromycin: 90/150 (60%) (Table 1). If combination antibiotic therapy had been used to treat the bacteria isolated from dental caries, the percentage of Resistance for the combination of penicillin V/Amoxicillin would have been 39/150 (26%), and the combination of amoxicillin/ Erythromycin would have been 45/150 (30%).
Conclusion- This study demonstrated the Molecular Mechanism of antibiotic resistance and susceptibility pattern, of bacteria causing dental caries. The comprehensive results data obtained will allow in investigating spatial distribution of pathogenic antibiotic resistant bacteria in patients of dental caries. In turn this will allow the development of novel diagnostic and treatment methods. 

GCD Computation of n Integers
Greatest Common Divisor (GCD) computation is one of the most important
operation of algorithmic number theory. In this paper we present the algorithms
for GCD computation of integers. We extend the Euclid's algorithm and
binary GCD algorithm to compute the GCD of more than two integers.Comment: RAECS 201
Computing Multiplicative Order and Primitive Root in Finite Cyclic Group
Multiplicative order of an element of group is the least positive
integer such that , where is the identity element of . If the
order of an element is equal to , it is called generator or primitive
root. This paper describes the algorithms for computing multiplicative order
and primitive root in , we also present a logarithmic
improvement over classical algorithms.Comment: 8 page
Photon redshift and the appearance of a naked singularity
In this paper we analyze the redshift as observed by an external observer
receiving photons which terminate in the past at the naked singularity formed
in a Tolman-Bondi dust collapse. Within the context of models considered here
it is shown that photons emitted from a weak curvature naked singularity are
always finitely redshifted to an external observer. Certain cases of strong
curvature naked singularities, including the self-similar one, where the
photons are infinitely redshifted are also pointed out.Comment: Latex file, 14 pages, no figures, one change in the reference.
Accepted for publication in Phys. Rev.
Studies on fatigue behaviour of weld-bonds of Al-Mn-Mg alloy
In the present paper, fatigue and metallurgical behaviour of weld-bonds and adhesive bonds developed using 2 mm thick aluminium alloys namely 5052 alloy have been reported. Weld-bonds were prepared using structural adhesive (Epoxy resin) and spot welding (20 kA welding current for 6 cycles welding time at welding pressure of 0.5 MPa). Curing after applying Epoxy resin for developing adhesive bonds and weld bonds was performed at a temperature of 100 oC for 90 min. Fatigue tests were conducted under tension–shear loading pattern with stress ratio of 0.5 and loading frequency of 5 Hz. The maximum tensile shear load for fatigue test was kept at different level i.e. 90%, 80%, 70% and 50% of the ultimate shear tensile strength of weld bond and adhesive bonds. The fatigue lives of both adhesive bond and weld-bond joints decreased with increase in maximum tensile shear load. Fatigue performance of weld bond was higher than adhesive bond especially at high load
Anti-HIV therapy: pipeline approaches and future directions
Human immunodeficiency virus (HIV), with about 30 million deaths and double infections (in developing countries), is an open challenge today for global scientists. Developing safe and effective measurements against it has become the prime need of hour. Though, putting it at health priority, various efforts like chemotherapy, vaccines and others are attempted globally over last decade. Consequently, highly active antiretroviral therapy was introduced but fails to completely block the viral replication due to drug resistance and various other severe side effects. The antigenic variability and lack of appropriate experimental models is the major obstacle in the development of an ever effective treatment against HIV. However, to overcome the present hurdles and to emerge a preventive HIV vaccine efforts at various platforms are done. A renewed, coordinated research, preclinical studies, clinical trials together with sufficient long term scientific and commercial commitments are made. Few of the therapeutic efforts viz. RNA interference (RNAi) based replication arrest of HIV, viral enzymes’ inhibitors, nanotechnology based HIV control and various preclinically trialed vaccines are reviewed in this paper. Also, the observed toxicity of existing therapeutic regimen, key challenges and future prospects for the development of better tolerated prophylactic HIV-1 vaccine are discussed
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Morphing Based Approach for Process Planning for Fabrication of Geometries and the Control of Material Composition
The inherent limitation of most of the solid freeform fabrication is the deposition in form
of layers. Artificial imposition of the process for the desired geometric morphology and
the functional gradience of material limits the accuracy of the workpiece. Mathematical
morphing of geometry and the material gradience allows a smooth variation across the
part geometry and the material composition of the part. The paper describes a framework
for process planning and implementation of fabrication of geometries and control of the
material composition. Simulation results for the suggested approach are described in the
paper.Mechanical Engineerin
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