1,442 research outputs found
Between the Barrio and the City: Pathways of Work among Scavenging Families
In this article, I will reconstruct, through brief stories, some of the traits that characterize the way of life of families in the El Salvador neighborhood, in Buenos Aires, Argentina, go scavenging everyday in Buenos Aires city. These stories will not only tell us who they are and how they arrived at the El Salvador neighborhood, from where, and in what manner they began to salir con la carreta, but will also permit us to move closer to the day-to-day existence of these families in relationship to their life in the barrio and the activities they engage in, thereby giving us a fuller understanding of family dynamics. In the research that originated this paper, I followed an ethnographical perspective to study and analyze the way of life of those families living from the recyclable waste they recollect in Buenos Aires city.Fil: Gorban, Debora. Universidad Nacional de San MartĂn. Instituto de Altos Estudios Sociales; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentin
Inference of analytical thermodynamic models for biological networks
We present an automated algorithm for inferring analytical models of closed reactive biochemical mixtures, on the basis of standard approaches borrowed from thermodynamics and kinetic theory of gases. As an input, the method requires a number of steady states (i.e. an equilibria cloud in the phase-space), and at least one time series of measurements for each species. Validations are discussed for both the Michaelis-Menten mechanism (four species, two conservation laws) and the mitogen-activated protein kinase - MAPK - mechanism (eleven species, three conservation laws
Systems with inheritance: dynamics of distributions with conservation of support, natural selection and finite-dimensional asymptotics
If we find a representation of an infinite-dimensional dynamical system as a nonlinear kinetic system with {\it conservation of supports} of distributions, then (after some additional technical steps) we can state that the asymptotics is finite-dimensional. This conservation of support has a {\it quasi-biological interpretation, inheritance} (if a gene was not presented initially in a isolated population without mutations, then it cannot appear at later time). These quasi-biological models can describe various physical, chemical, and, of course, biological
systems. The finite-dimensional asymptotic demonstrates effects of {\it ``natural" selection}. The estimations of asymptotic dimension are presented. The support of an individual limit distribution is almost always small. But the union of such supports can be the whole space even for one solution. Possible are such situations: a solution is a finite set of narrow peaks getting in time more and more narrow, moving slower and slower. It is possible that these peaks do not tend to fixed positions, rather they continue moving, and the path covered tends to infinity at . The {\it drift equations} for peaks motion are obtained. Various types of stability are studied.
In example, models of cell division self-synchronization are
studied. The appropriate construction of notion of typicalness in infinite-dimensional spaces is discussed, and the ``completely thin" sets are introduced
Entropy: The Markov Ordering Approach
The focus of this article is on entropy and Markov processes. We study the
properties of functionals which are invariant with respect to monotonic
transformations and analyze two invariant "additivity" properties: (i)
existence of a monotonic transformation which makes the functional additive
with respect to the joining of independent systems and (ii) existence of a
monotonic transformation which makes the functional additive with respect to
the partitioning of the space of states. All Lyapunov functionals for Markov
chains which have properties (i) and (ii) are derived. We describe the most
general ordering of the distribution space, with respect to which all
continuous-time Markov processes are monotonic (the {\em Markov order}). The
solution differs significantly from the ordering given by the inequality of
entropy growth. For inference, this approach results in a convex compact set of
conditionally "most random" distributions.Comment: 50 pages, 4 figures, Postprint version. More detailed discussion of
the various entropy additivity properties and separation of variables for
independent subsystems in MaxEnt problem is added in Section 4.2.
Bibliography is extende
Maxallent: Maximizers of all Entropies and Uncertainty of Uncertainty
The entropy maximum approach (Maxent) was developed as a minimization of the
subjective uncertainty measured by the Boltzmann--Gibbs--Shannon entropy. Many
new entropies have been invented in the second half of the 20th century. Now
there exists a rich choice of entropies for fitting needs. This diversity of
entropies gave rise to a Maxent "anarchism". Maxent approach is now the
conditional maximization of an appropriate entropy for the evaluation of the
probability distribution when our information is partial and incomplete. The
rich choice of non-classical entropies causes a new problem: which entropy is
better for a given class of applications? We understand entropy as a measure of
uncertainty which increases in Markov processes. In this work, we describe the
most general ordering of the distribution space, with respect to which all
continuous-time Markov processes are monotonic (the Markov order). For
inference, this approach results in a set of conditionally "most random"
distributions. Each distribution from this set is a maximizer of its own
entropy. This "uncertainty of uncertainty" is unavoidable in analysis of
non-equilibrium systems. Surprisingly, the constructive description of this set
of maximizers is possible. Two decomposition theorems for Markov processes
provide a tool for this description.Comment: 23 pages, 4 figures, Correction in Conclusion (postprint
Monotonically equivalent entropies and solution of additivity equation
Generalized entropies are studied as Lyapunov functions for the Master
equation (Markov chains). Three basic properties of these Lyapunov functions
are taken into consideration: universality (independence of the kinetic
coefficients), trace-form (the form of sum over the states), and additivity
(for composition of independent subsystems). All the entropies, which have all
three properties simultaneously and are defined for positive probabilities, are
found. They form a one-parametric family.
We consider also pairs of entropies , , which are connected by
the monotonous transformation (equivalent entropies). All
classes of pairs of universal equivalent entropies, one of which has a
trace-form, and another is additive (these entropies can be different one from
another), were found. These classes consist of two one-parametric families: the
family of entropies, which are equivalent to the additive trace-form entropies,
and the family of Renyi-Tsallis entropies.Comment: elsart-LaTeX2e, 11 page
Kinetic Path Summation, Multi--Sheeted Extension of Master Equation, and Evaluation of Ergodicity Coefficient
We study the Master equation with time--dependent coefficients, a linear
kinetic equation for the Markov chains or for the monomolecular chemical
kinetics. For the solution of this equation a path summation formula is proved.
This formula represents the solution as a sum of solutions for simple kinetic
schemes (kinetic paths), which are available in explicit analytical form. The
relaxation rate is studied and a family of estimates for the relaxation time
and the ergodicity coefficient is developed. To calculate the estimates we
introduce the multi--sheeted extensions of the initial kinetics. This approach
allows us to exploit the internal ("micro")structure of the extended kinetics
without perturbation of the base kinetics.Comment: The final journal versio
PCA and K-Means decipher genome
In this paper, we aim to give a tutorial for undergraduate students studying
statistical methods and/or bioinformatics. The students will learn how data
visualization can help in genomic sequence analysis. Students start with a
fragment of genetic text of a bacterial genome and analyze its structure. By
means of principal component analysis they ``discover'' that the information in
the genome is encoded by non-overlapping triplets. Next, they learn how to find
gene positions. This exercise on PCA and K-Means clustering enables active
study of the basic bioinformatics notions. Appendix 1 contains program listings
that go along with this exercise. Appendix 2 includes 2D PCA plots of triplet
usage in moving frame for a series of bacterial genomes from GC-poor to GC-rich
ones. Animated 3D PCA plots are attached as separate gif files. Topology
(cluster structure) and geometry (mutual positions of clusters) of these plots
depends clearly on GC-content.Comment: 18 pages, with program listings for MatLab, PCA analysis of genomes
and additional animated 3D PCA plot
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