A Business Model Assessment and Evaluation Framework for City Logistics Collaborative Strategic Decision Support

Several City Logistics (CL) initiatives have emerged in the last two decades with the aim to reduce the negative externalities of freight distribution in urban areas. Such initiatives can be public and/or private but need to not break or impeach current operations efficiency so to not hinder their profitability. In order to provide business value to CL initiatives and thus fostering their long-term success, it is necessary to understand the decision-making of private companies operating in the urban freight ecosystem. This paper proposes an ex-ante assessment and evaluation framework built around the concept of an ecosystem business modelling that includes the decision-making by CL stakeholders. A theoretical framework previously developed is extended to evaluate a collaborative business model of an Urban Consolidation Centre (UCC). Cost-Benefit analysis (CBA is used estimate the impact of the business model configuration. Finally, research and practice implications are also addressed

Smart and sustainable urban logistic applications aided by intelligent techniques

[EN] CO2-free urban logistics is one of the 10 objectives to reach by 2030 as part of transport policy. What technologies can help to accomplish it? In this paper, we discuss the very complex situation that today¿s big and modern cities are facing with a tremendous environment of many urban logistics companies running in the same city. In the majority of cases, there is less or none coordination among them worsening traffic congestions. We believe that intelligent techniques are one of the key approaches that can aid to support smart and sustainable urban logistic applications. There are large open problems in the field of cooperative urban logistics that can greatly improve with the help of artificial intelligence. Some solutions are cited in this paper, but the overall conclusion is that there is still much work to be done.Giret Boggino, AS. (2019). Smart and sustainable urban logistic applications aided by intelligent techniques. Service Oriented Computing and Applications (Online). 13(3):185-186. https://doi.org/10.1007/s11761-019-00271-zS185186133Market reports (2019) Global last mile delivery market size, status and forecast 2019–2025. The Market reports. Report code : 1362721, pp 1–114Xiao Z, Wang JJ, Lenzer J, Sun Y (2017) Understanding the diversity of final delivery solutions for online retailing: a case of Shenzhen, China. In: World conference on transport research—WCTR 2016 Shanghai. Transportation Research Procedia, vol 25, pp 985–998, 2017. 10–15 July 2016Gonzalez-Feliu J, Semet F, Routhier JL (2014) Sustainable urban logistics: concepts, methods and information systems. Springer, BerlinMacharis C, Melo S (2011) City distribution and urban freight transport: multiple perspectives. Edward Elgar Publishing, CheltenhamPagell M, Wu Z (2009) Building a more complete theory of sustainable supply chain management using case studies of 10 exemplars. J Supply Chain Manag 45:37–56Morana J, Gonzalez-Feliu J (2015) A sustainable urban logistics dashboard from the perspective of a group of operational managers. Manag Res Rev 38(10):1068–1085Gunasekaran A, Kobu B (2007) Performance measures and metrics in logistics and supply chain management: a review of recent literature (1995–2004) for research and applications. Int J Prod Res 45:2819–2840Griffis SE, Goldsby TJ, Cooper M, Closs DJ (2007) Aligning logistics performance measures to the information needs of the firm. J Bus Logist 48:35–56Alonso-Mora J, Samaranayake S, Wallar A, Frazzoli E, Rus D (2017) On-demand high-capacity ride-sharing via dynamic trip-vehicle assignment. Proc Natl Acad Sci 114(3):462–467Gentile G, Noekel K (2016) Modeling public transport passenger flows in the era of intelligent transport systems. Springer, BerlinNeirotti P, De Marco A, Cagliano AC, Mangano G, Scorrano F (2014) Current trends in smart city initiatives: some stylised facts. Cities 38:25–36Chatterjee R (2016) Optimizing last mile delivery using public transport with multiagent based control. Master thesis, pp 1–59Skiver RL, Godfrey M (2017) Crowdserving: a last mile delivery method for brickand—mortar retailers. Glob J Bus Res 11(2):67–77Brüning M, Schönewolf W (2011) Freight transport system for urban shipment and delivery. In: IEEE forum on integrated and sustainable transportation systems, Vienna, pp 136–14

Quantitative uptake of colloidal particles by cell cultures

The use of nanotechnologies involving nano- and microparticles has increased tremendously in the recent past. There are various beneficial characteristics that make particles attractive for a wide range of technologies. However, colloidal particles on the other hand can potentially be harmful for humans and environment. Today, complete understanding of the interaction of colloidal particles with biological systems still remains a challenge. Indeed, their uptake, effects, and final cell cycle including their life span fate and degradation in biological systems are not fully understood. This is mainly due to the complexity of multiple parameters which need to be taken in consideration to perform the nanosafety research. Therefore, we will provide an overview of the common denominators and ideas to achieve universal metrics to assess their safety. The review discusses aspects including how biological media could change the physicochemical properties of colloids, how colloids are endocytosed by cells, how to distinguish between internalized versus membrane-attached colloids, possible correlation of cellular uptake of colloids with their physicochemical properties, and how the colloidal stability of colloids may vary upon cell internalization. In conclusion three main statements are given. First, in typically exposure scenarios only part of the colloids associated with cells are internalized while a significant part remain outside cells attached to their membrane. For quantitative uptake studies false positive counts in the form of only adherent but not internalized colloids have to be avoided. pH sensitive fluorophores attached to the colloids, which can discriminate between acidic endosomal/lysosomal and neutral extracellular environment around colloids offer a possible solution. Second, the metrics selected for uptake studies is of utmost importance. Counting the internalized colloids by number or by volume may lead to significantly different results. Third, colloids may change their physicochemical properties along their life cycle, and appropriate characterization is required during the different stages.This work was supported by the European Commission (grant FutureNanoNeeds) grant agreement no. 604602 to WJP. NF acknowledges funding from the Lars Hiertas Minne Fundation (Sweden), SA, BP and IC acknowledge a fellowship from the Alexander von Humboldt Fundation (Germany). AE acknowledges Junta de Andalucía (Spain) for a Talentia Postdoc Fellowship, co-financed by the European Union Seventh Framework Programme, grant agreement no 267226. AHS acknowledges the Egyptian government (Ministry of Higher Education, Mission). The project was also supported by the Dr. Dorka-Stiftung (Germany) to PJ

Evaluation of appendicitis risk prediction models in adults with suspected appendicitis

Background Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis. Methods A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis). Results Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent). Conclusion Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified

Integration of oncology and palliative care : a Lancet Oncology Commission

Full integration of oncology and palliative care relies on the specific knowledge and skills of two modes of care: the tumour-directed approach, the main focus of which is on treating the disease; and the host-directed approach, which focuses on the patient with the disease. This Commission addresses how to combine these two paradigms to achieve the best outcome of patient care. Randomised clinical trials on integration of oncology and palliative care point to health gains: improved survival and symptom control, less anxiety and depression, reduced use of futile chemotherapy at the end of life, improved family satisfaction and quality of life, and improved use of health-care resources. Early delivery of patient-directed care by specialist palliative care teams alongside tumour-directed treatment promotes patient-centred care. Systematic assessment and use of patient-reported outcomes and active patient involvement in the decisions about cancer care result in better symptom control, improved physical and mental health, and better use of health-care resources. The absence of international agreements on the content and standards of the organisation, education, and research of palliative care in oncology are major barriers to successful integration. Other barriers include the common misconception that palliative care is end-of-life care only, stigmatisation of death and dying, and insufficient infrastructure and funding. The absence of established priorities might also hinder integration more widely. This Commission proposes the use of standardised care pathways and multidisciplinary teams to promote integration of oncology and palliative care, and calls for changes at the system level to coordinate the activities of professionals, and for the development and implementation of new and improved education programmes, with the overall goal of improving patient care. Integration raises new research questions, all of which contribute to improved clinical care. When and how should palliative care be delivered? What is the optimal model for integrated care? What is the biological and clinical effect of living with advanced cancer for years after diagnosis? Successful integration must challenge the dualistic perspective of either the tumour or the host, and instead focus on a merged approach that places the patient's perspective at the centre. To succeed, integration must be anchored by management and policy makers at all levels of health care, followed by adequate resource allocation, a willingness to prioritise goals and needs, and sustained enthusiasm to help generate support for better integration. This integrated model must be reflected in international and national cancer plans, and be followed by developments of new care models, education and research programmes, all of which should be adapted to the specific cultural contexts within which they are situated. Patient-centred care should be an integrated part of oncology care independent of patient prognosis and treatment intention. To achieve this goal it must be based on changes in professional cultures and priorities in health care

Sustainable supply chain management in city logistics solutions: an experience’s comeback from Cityporto Padua (Italy)

Abstract: The sustainable logistics and transportation studies constitute a primordial research axis in the enterprises ’ governance. In the last years, many reflections and developments in logistics research have studied the economic and the environmental questions related to supply chain management, but only few of them consider sustainability in its totality. Moreover, in practice, city logistics systems conception and planning is currently following a sustainable approach. The aim of this paper is to start a reflection about the three dimensions of sustainable supply chain management (economic, environmental and social), and illustrate these concepts by the results of an experience’s comeback from a city logistics system, Cityporto (Padua, Italy)

A Business Model Assessment and Evaluation Framework for City Logistics Collaborative Strategic Decision Support

Part 15: Collaborative Decision-Making in Value Creation NetworksInternational audienceSeveral City Logistics (CL) initiatives have emerged in the last two decades with the aim to reduce the negative externalities of freight distribution in urban areas. Such initiatives can be public and/or private but need to not break or impeach current operations efficiency so to not hinder their profitability. In order to provide business value to CL initiatives and thus fostering their long-term success, it is necessary to understand the decision-making of private companies operating in the urban freight ecosystem. This paper proposes an ex-ante assessment and evaluation framework built around the concept of an ecosystem business modelling that includes the decision-making by CL stakeholders. A theoretical framework previously developed is extended to evaluate a collaborative business model of an Urban Consolidation Centre (UCC). Cost-Benefit analysis (CBA is used estimate the impact of the business model configuration. Finally, research and practice implications are also addressed