1,862 research outputs found
The potential of the basic research laboratory experience in medical training
La evidencia cientĂfica demuestra, de manera creciente año a año, la importancia de consolidar los conocimientos a partir de experiencias educativas significativas para los estudiantes. Este enfoque pedagĂłgico, enfocado en el aprendizaje como construcciĂłn de significado, representa una experiencia mucho mĂĄs provechosa en el proceso de aprendizaje, ya que implica un rol activo del estudiante, saliendo del espacio de confort de ser un mero receptor de conocimientos. En este sentido, la educaciĂłn en medicina adopta cada vez mĂĄs este pensamiento y se van modificando planes curriculares y formas de trabajo con alumnos en la bĂșsqueda de transformar enfoques tradicionalistas de educaciĂłn en formas educativas que acompañen la era actual del conocimiento, atravesada por las tecnologĂas y el aprendizaje ubicuo y autĂłnomo.Scientific evidence demonstrates, year after year, the importance of consolidating knowledge through meaningful educational experiences for students. This pedagogical approach focused on learning as the construction of meaning represents a much more profitable experience in the learning process, since it implies an active role of the student, leaving the comfort zone of being a mere receiver of knowledge. In this sense, medical education is increasingly adopting this thinking and is modifying curricular plans and ways of working with students in the search for transforming traditionalist approaches to education into educational forms that accompany the current era of knowledge, crossed by technologies and ubiquitous and autonomous learning.Fil: Giraud Billoud, Maximiliano German. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Mendoza. Instituto HistologĂa y EmbriologĂa D/mend Dr.m.burgos; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias MĂ©dicas. Instituto de FisiologĂa; Argentina. Universidad Nacional de Villa Mercedes; Argentin
Tubulointerstitial injury and proximal tubule albumin transport in early diabetic nephropathy induced by type 1 diabetes mellitus
A decrease in the tubular expression of albumin endocytic transporters megalin and cubilin has been associated with diabetic nephropathy (DN), but there are no comprehensive studies to date relating early tubulointerstitial injury and the effect of the disease on both transporters in type 1 diabetes mellitus (T1DM). We used eight-week-old male C57BL/6 mice divided into two groups; one of them received the vehicle (control group), while the other received the vehicle + 200 mg/kg streptozotocin (T1DM). Ten weeks after the injection, we evaluated plasma insulin, enzymuria, urinary vitamin D-binding protein (VDBP), tubulointerstitial fibrosis and proximal tubule histology, markers of autophagy, and megalin and cubilin levels. We found a reduction in tubular protein reabsorption (albumin and VDBP as specific substances carried by both transporters) with increased tubulointerstitial injury, development of fibrosis, thickening of tubular basement membrane, and an increase in tubular cell metalloproteases. This was associated with a decrease in the renal expression of megalin and cubilin. We also observed an increase in the amount of cellular vesicles of the phagocytic system in the tubules, which could be linked to an alteration of normal intracellular trafficking of both receptors, thus affecting the normal function of transporters in early stages of DN. In diabetic animals, the added effects of tubulointerstitial injury, the decreases in megalin and cubilin expression, and an altered intracellular trafficking of these receptors, seriously affect protein reabsorptionFil: Giraud Billoud, Maximiliano German. Universidad del Desarrollo. Facultad de Medicina ClĂnica Alemana; Chile. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Mendoza. Instituto de HistologĂa y EmbriologĂa de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas MĂ©dicas. Instituto de HistologĂa y EmbriologĂa de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Ezquer, Fernando. Universidad del Desarrollo. Facultad de Medicina ClĂnica Alemana; ChileFil: Bahamonde, Javiera. Universidad del Desarrollo. Facultad de Medicina ClĂnica Alemana; ChileFil: Ezquer, Marcelo. Universidad del Desarrollo. Facultad de Medicina ClĂnica Alemana; Chil
Mesenchymal Stem Cell Therapy in Type 1 Diabetes Mellitus and Its Main Complications: From Experimental Findings to Clinical Practice
Type 1 diabetes mellitus (T1DM) is a complex multifactorial disorder which involves a loss of self-tolerance leading to the autoimmune destruction of pancreatic ÎČâcells. Exogenous insulin administration cannot mimic precise pancreatic ÎČ-cell regulation of glucose homeostasis, thereby leading to severe long-term complications. Pancreas or islet transplant only provides partial exogenous insulin independence and induces several adverse effects, including increased morbidity and mortality. The scientific community and diabetic patients are thus, still waiting for an effective therapy which could preserve the remaining ÎČ-cells, replenish islet mass and protect newly-generated ÎČ-cells from autoimmune destruction. Mesenchymal stem cells (MSCs) have been envisioned as a promising tool for T1DM treatment over the past few years, since they could differentiate into glucose-responsive insulin-producing cells. Their immunomodulatory and proangiogenic roles can be used to help arrest ÎČ-cell destruction, preserve residual ÎČ-cell mass, facilitate endogenous ÎČ-cell regeneration and prevent disease recurrence, thereby making them ideal candidates for the comprehensive treatment of diabetic patients. This review focuses on recent pre-clinical data supporting MSC use in regenerating ÎČ-cell mass and also in treating several T1DM-associated complications. Clinical trial results and the ongoing obstacles which must be addressed regarding the widespread use of such therapy are also discussed.Fil: Ezquer, Marcelo. Universidad del Desarrollo. Facultad de Medicina ClĂnica Alemana; ChileFil: Arango Rodriguez, Martha. Universidad del Desarrollo. Facultad de Medicina ClĂnica Alemana; ChileFil: Giraud Billoud, Maximiliano German. Universidad del Desarrollo. Facultad de Medicina ClĂnica Alemana; Chile. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Mendoza. Instituto de HistologĂa y EmbriologĂa de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas MĂ©dicas. Instituto de HistologĂa y EmbriologĂa de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Ezquer, Fernando. Universidad del Desarrollo. Facultad de Medicina ClĂnica Alemana; Chil
Diabetic nephropathy, autophagy and proximal tubule protein endocytic transport: A potentially harmful relationship
Diabetic nephropathy (DN) is the most frequent cause of chronic renal failure. Until now, the pathophysiological mechanisms that determine its development and progression have not yet been elucidated. In the present study, we evaluate the role of autophagy at early stages of DN, induced in type 2 diabetes mellitus (T2DM) mouse, and its association with proximal tubule membrane endocytic receptors, megalin and cubilin. In T2DM animals we observed a tubule-interstitial injury with significantly increased levels of urinary GGT and ALP, but an absence of tubulointerstitial fibrosis. Kidney proximal tubule cells of T2DM animals showed autophagic vesicles larger than those observed in the control group, and an increase in the number of these vesicles marked with LBPA by immunofluorescence. Furthermore, a significant decrease in the ratio of LC3II/LC3I isoforms and in p62 protein expression in DN affected animals is shown. Finally, we observed a marked increase in urinary albumin and vitamin D binding-protein levels in T2DM animals as well as a significant decrease in expression of megalin in the renal cortex. These results indicate an alteration of the tubular endocytic transporters in DN, which could be related to autophagic dysfunction, which would in turn result in impaired organelle recycling, thus contributing to the progression of this disease.Fil: Giraud Billoud, Maximiliano German. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Mendoza. Instituto de HistologĂa y EmbriologĂa de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias MĂ©dicas. Instituto de HistologĂa y EmbriologĂa de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Fader Kaiser, Claudio Marcelo. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Mendoza. Instituto de HistologĂa y EmbriologĂa de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias MĂ©dicas. Instituto de HistologĂa y EmbriologĂa de Mendoza Dr. Mario H. Burgos; ArgentinaFil: AgĂŒero, Rocio. Universidad Nacional de Cuyo. Facultad de Ciencias MĂ©dicas; ArgentinaFil: Ezquer, Fernando. Universidad del Desarrollo; ChileFil: Ezquer, Marcelo. Universidad del Desarrollo; Chil
Uso de lodos residuales de la industria vitivinĂcola como sustrato en la producciĂłn en vivero de plantines de Eucalyptus camaldulensis Dehnh
La presente tesina propone un primer paso en el conocimiento de una alternativa econĂłmicamente viable y ambientalmente sostenible a la disposiciĂłn final de lodos, que se generan en la industria vitivinĂcola, los cuales frecuentemente, son depositados en rellenos sanitarios sin ningĂșn tipo de control ambiental. Su disposiciĂłn en plantaciones forestales con la finalidad de aprovechar sus nutrientes, disminuirĂa el impacto causado al medio ambiente en el uso de vertederos.
Un estudio en un cultivo forestal ya implantado del comportamiento de los forestales frente al agregado de estos lodos demandarĂa un tiempo mucho mĂĄs prolongado que el aconsejable para el desarrollo de una tesina.
Por ello, y como un primer paso, se evaluĂł el uso de lodos provenientes de la industria vitivinĂcola, como abono orgĂĄnico aplicado al sustrato utilizado para la producciĂłn de plantines de Eucalyptus camaldulensis Dehnh en contenedores.
El ensayo fue realizado en el vivero que posee la cĂĄtedra de DasonomĂa, dentro del predio de la Facultad Ciencias Agrarias, Universidad Nacional de Cuyo. Los eucaliptus se desarrollaron en macetas de polietileno de 4l durante 182 dĂas. Se utilizĂł un diseño experimental de bloques completo al azar con 4 tratamientos y 4 repeticiones, dando un total de 16 unidades experimentales.
Los tratamientos incluyen un testigo formado por una mezcla de tierra franco arenosa que contiene solo sustrato base sin ningĂșn tipo de agregado, un segundo tratamiento agregando al sustrato base guano de gallina sin agregado de lodo, un tercer tratamiento con agregado de una dosis que se estima baja de lodo y un cuarto tratamiento con agregado de una dosis que se estima alta de lodo. Todos en sustrato base con textura franco-arenosa.
Las variables altura y diåmetro de las plantas fueron medidas mensualmente y al final del ensayo se midió la biomasa total. Dichas variables fueron sometidas al anålisis de varianza y la comparación de medias por el método de Tukey con 5% de probabilidad.
Los resultados del ensayo experimental aplicado durante el periodo de 182 dĂas evidenciĂł que el sustrato con lodo en dosis alta y guano de gallina presentan un mayor crecimiento para las variables diĂĄmetro y biomasa con respecto al sustrato con lodo en dosis baja y el testigo, poniendo de relieve que el agregado de lodos de bodega, en dosis adecuadas al sustrato constituyen una alternativa tĂ©cnica y ambientalmente recomendable para la deposiciĂłn de lodos provenientes de la industria vitivinĂcola, utilizĂĄndolos como un abono orgĂĄnico.Fil: Giraud Billoud, Juan Francisco. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias
Physiological responses to stress related to hypometabolic situations in an emergent model organism
Los animales utilizan diversas estrategias adaptativas para responder a ambientes estresantes, determinados especialmente por cambios de temperatura, humedad, disponibilidad de agua, alimentos, salinidad, concentraciĂłn de oxĂgeno y radiaciĂłn UV. Una estrategia de respuesta fisiolĂłgica ampliamente estudiada ha sido la denominada: PreparaciĂłn para el estrĂ©s oxidativo (POS). Esta estrategia, observada en diferentes filos de animales, implica que durante distintos estados hipometabĂłlicos (Ej. hibernaciĂłn, estivaciĂłn, hipoxia, etc), los animales ponen en marcha mecanismos de protecciĂłn anticipada contra el estrĂ©s oxidativo, que actuarĂĄn al producirse la re-oxigenaciĂłn y reactivaciĂłn celular durante el incremento de su tasa metabĂłlica. Nuestro equipo de investigaciĂłn ha contribuido cientĂficamente al estudio del metabolismo y del medio interno del organismo modelo emergente Pomacea canaliculata, asĂ como a la caracterizaciĂłn de los modelos de quiescencia (estivaciĂłn e hibernaciĂłn) experimental y la identificaciĂłn de los mecanismos que permiten su tolerancia al estrĂ©s oxidativo inducido por ciclos prolongados de actividad-quiescencia. Con respecto a estos dos estados hipometabĂłlicos, hemos mostrado que este organismo pone en juego la estrategia de POS para tolerar la salida de quiescencia de un largo periodo de tiempo. Es interesante resaltar que esta especie utiliza en perĂodos prolongados la estrategia de POS, mediante el incremento de antioxidantes no enzimĂĄticos como principal defensa. Es por esto que resulta interesante evaluar la respuesta fisiolĂłgica de esta especie en etapas tempranas del ciclo de actividad-estivaciĂłn, dado que es en este momento cuando los fenĂłmenos moleculares presuntamente se estĂĄn produciendo como respuesta al primer aumento de radicales libres y por tanto, proponemos los siguientes objetivos de estudio: a) evidenciar a nivel tisular las respuestas fisiolĂłgicas al estrĂ©s oxidativo, desarrolladas durante un corto perĂodo de hipometabolismo, inducido por ciclos de actividad-estivaciĂłn; b) estudiar los cambios en el medio interno que reflejen las respuestas homeostĂĄticas frente al estrĂ©s del hipometabolismo. La caracterizaciĂłn de este modelo experimental y las estrategias fisiolĂłgicas de defensa que utiliza esta especie frente a situaciones hipometabĂłlicas, puede derivar en aplicaciones prĂĄcticas y traslacionales, como su utilizaciĂłn en el trasplante de Ăłrganos o en patologĂas que presentan hipoxia tisular.Animals use different adaptive strategies to tolerate harsh environmental conditions like changes in temperature, humidity, availability of water, food, salinity, oxygen concentration or UV radiation. A widely studied physiological response strategy has been called "Preparation for oxidative stress" (POS). This strategy, observed in different animal phyla, implies that during hypometabolic states (i.e. hibernation, estivation, hypoxia, etc), animals activate mechanisms of anticipated protection against oxidative stress, which will act upon re-oxygenation and cellular reactivation, during the increase of their metabolic rate. Our research group has contributed scientifically to the study of the metabolism and internal environment of the emerging model organism Pomacea canaliculata, as well as to the characterization of quiescence experimental models (estivation and hibernation) and the identification of the mechanisms that allow its tolerance to oxidative stress induced by prolonged activity-quiescence cycles. Related to these two hypometabolic states, we have shown that this organism uses POS strategy to tolerate the arousal from a long quiescence. It is interesting to note that this species uses non-enzymatic antioxidants as the main defense after prolonged periods of estivation. Is interesting to evaluate the physiological response of this species in early stages of the activity-estivation cycle, because of at this time the molecular phenomena probably occur as a response to the first increase in free radicals. Therefore, we propose the following study objectives: a) to demonstrate at tissue level the physiological responses to oxidative stress, developed during a short period of hypometabolism, induced by cycles of activity-estivation; b) study changes in the internal milieu that reflect homeostatic responses to hypometabolic stress. The characterization of this experimental model and the physiological defense strategies used by this species against hypometabolic situations can lead to practical and translational applications, such as its use in organ transplantation or in pathologies that present tissue hypoxia
Evaluation of female masculinization in Pomacea canaliculata (Caenogastropoda, Ampullariidae) induced by tributyltin, heavy metals, and uranium in culture water
All female Pomacea canaliculata develop a small, male-like copulatory apparatus a few days after birth, which growths slowly until sexual maturity, and even further in older age. Previous studies have found trace elements like mercury (Hg), arsenic (As) and uranium (U) in tap water used for snail culture, and that these elements were accumulated in snail tissues. Here, we test whether the presence of these metals at maximum allowed concentrations (Environmental Protection Agency-EPA) in aquarium water could affect the development of the copulatory apparatus in mature females. Females of different ages were used as controls, grown in reconstituted metal-free water with or without the addition of Hg, As and U, as well as tributyltin (TBT), a compound used as masculinizing agent. Six and seven months old females cultured in tap water showed a longer penis and penile sheath, and a greater overall development of the copulatory apparatus, measured by an index (DI), as compared with same-age females cultured in reconstituted water. Moreover, when females were exposed to Hg, As or U at the maximum contaminant levels for human consumption allowed by EPA regulations, there was no further development of the copulatory apparatus, while there was a clearly positive effect in TBT-exposed females. This study confirms the masculinizing effect of organotin compounds on female copulatory apparatus and discusses the usefulness of the development of these organs as a bioindicator of environmental pollution.Fil: Giraud Billoud, Maximiliano German. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Mendoza. Instituto de HistologĂa y EmbriologĂa de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias MĂ©dicas. Instituto de HistologĂa y EmbriologĂa de Mendoza Dr. Mario H. Burgos; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias MĂ©dicas. Instituto de FisiologĂa; Argentina. Universidad Nacional de Villa Mercedes; ArgentinaFil: Campoy DĂaz, Alejandra Daniela. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Mendoza. Instituto de HistologĂa y EmbriologĂa de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias MĂ©dicas. Instituto de HistologĂa y EmbriologĂa de Mendoza Dr. Mario H. Burgos; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias MĂ©dicas. Instituto de FisiologĂa; Argentina. Universidad Nacional de Villa Mercedes; ArgentinaFil: Mansilla, Emilio. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias; ArgentinaFil: Vega, Israel AnĂbal. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Mendoza. Instituto de HistologĂa y EmbriologĂa de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias MĂ©dicas. Instituto de HistologĂa y EmbriologĂa de Mendoza Dr. Mario H. Burgos; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias MĂ©dicas. Instituto de FisiologĂa; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales. Departamento de BiologĂa; Argentin
Monitoring of SARS-CoV-2 RNA in wastewater as an epidemiological surveillance tool in Mendoza, Argentina
Wastewater-based epidemiology (WBE) is an emerging tool that gives temporal and spatial information on a population's health status. Here, we report the epidemiological dynamics of a population of ~1.2 million residents in the metropolitan region of Mendoza province, Argentina, within the period July 2020 to January 2021. We combined the use of WBE of two wastewater treatment plants with epidemiological surveillance of the corresponding populations. We applied two viral concentration methods (polyethylene glycol precipitation and aluminum-based adsorption-flocculation) and RNA isolation methods in each wastewater sample to increase the possibility of detection and quantification of nucleocapsid markers (N1 and N2) of SARS-CoV-2 by RT-qPCR. Overall, our results allowed us to trace the rise, exponential growth, plateau, and fall of SARS-CoV-2 infections for 26 weeks. Individual analysis for each wastewater treatment plant showed a positive correlation between the viral load of SARS-CoV-2 genetic markers and COVID-19 cases that were diagnosed per week. Our findings indicate that WBE is a useful epidemiological indicator to anticipate the increase in COVID-19 cases and monitor the advance of the pandemic and different waves of infections.Fil: Giraud Billoud, Maximiliano German. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Mendoza. Instituto de HistologĂa y EmbriologĂa de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias MĂ©dicas. Instituto de HistologĂa y EmbriologĂa de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Cuervo, MarĂa Paula. Universidad Nacional de Cuyo; ArgentinaFil: Altamirano, Jorgelina Cecilia. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Mendoza. Instituto Argentino de NivologĂa, GlaciologĂa y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de NivologĂa, GlaciologĂa y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de NivologĂa, GlaciologĂa y Ciencias Ambientales; ArgentinaFil: Pizarro, Marcela. Universidad Nacional de Cuyo; ArgentinaFil: Aranibar, Julieta Nelida. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Mendoza. Instituto Argentino de NivologĂa, GlaciologĂa y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de NivologĂa, GlaciologĂa y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de NivologĂa, GlaciologĂa y Ciencias Ambientales; ArgentinaFil: Catapano, Adolfo. Agua y Saneamientos de Mendoza; ArgentinaFil: Cuello, HĂ©ctor. Gobierno de la Provincia de Mendoza. Hospital Central de Mendoza.; ArgentinaFil: Masachessi, Gisela. Universidad Nacional de CĂłrdoba. Facultad de Medicina. Instituto de VirologĂa Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Vega, Israel AnĂbal. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Mendoza. Instituto de HistologĂa y EmbriologĂa de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias MĂ©dicas. Instituto de HistologĂa y EmbriologĂa de Mendoza Dr. Mario H. Burgos; Argentin
Measurement of the cross-section and charge asymmetry of bosons produced in proton-proton collisions at TeV with the ATLAS detector
This paper presents measurements of the and cross-sections and the associated charge asymmetry as a
function of the absolute pseudorapidity of the decay muon. The data were
collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with
the ATLAS experiment at the LHC and correspond to a total integrated luminosity
of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements
varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the
1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured
with an uncertainty between 0.002 and 0.003. The results are compared with
predictions based on next-to-next-to-leading-order calculations with various
parton distribution functions and have the sensitivity to discriminate between
them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables,
submitted to EPJC. All figures including auxiliary figures are available at
https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at â s = 8 TeV with the ATLAS detector
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fbâ1 of â s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
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