828 research outputs found
Guillain-Barré Syndrome-related campylobacter jejuni in Bangladesh: ganglioside mimicry and cross-reactive antibodies
BACKGROUND:
<br/>
Campylobacter jejuni is the predominant antecedent infection in Guillain-Barré syndrome (GBS). Molecular mimicry and cross-reactive immune responses to C. jejuni lipo-oligosaccharides (LOS) precipitate the development of GBS, although this mechanism has not been established in patients from developing countries. We determined the carbohydrate mimicry between C. jejuni LOS and gangliosides, and the cross-reactive antibody response in patients with GBS in Bangladesh.<br/>
METHODOLOGY:<br/>
Sera from 97 GBS patients, and 120 neurological and family controls were tested for antibody reactivity against LOS from C. jejuni isolates from GBS patients in Bangladesh (BD-07, BD-39, BD-10, BD-67 and BD-94) by enzyme-linked immunosorbent assay (ELISA). Cross-reactivity to LOS was determined by ELISA. The LOS outer core structures of C. jejuni strains associated with GBS/MFS were determined by mass spectrometry.<br/>
PRINCIPLE FINDINGS:<br/>
IgG antibodies to LOS from C. jejuni BD-07, BD-39, BD-10, and BD-67 IgG antibodies were found in serum from 56%, 58%, 14% and 15% of GBS patients respectively, as compared to very low frequency (<3%) in controls (p<0.001). Monoclonal antibodies specific for GM1 and GD1a reacted strongly with LOS from the C. jejuni strains (BD-07 and BD-39). Mass spectrometry analysis confirmed the presence of GM1 and GD1a carbohydrate mimics in the LOS from C. jejuni BD-07 and BD-39. Both BD-10 and BD-67 express the same LOS outer core, which appears to be a novel structure displaying GA2 and GD3 mimicry. Up to 90-100% of serum reactivity to gangliosides in two patients (DK-07 and DK-39) was inhibited by 50 µg/ml of LOS from the autologous C. jejuni isolates. However, patient DK-07 developed an anti-GD1a immune response while patient DK-39 developed an anti-GM1 immune response.<br/>
CONCLUSION:<br/>
Carbohydrate mimicry between C. jejuni LOS and gangliosides, and cross-reactive serum antibody precipitate the majority of GBS cases in Bangladesh
A Once and Future Gulf of Mexico Ecosystem: Restoration Recommendations of an Expert Working Group
The Deepwater Horizon (DWH) well blowout released more petroleum hydrocarbons into the marine environment than any previous U.S. oil spill (4.9 million barrels), fouling marine life, damaging deep sea and shoreline habitats and causing closures of economically valuable fisheries in the Gulf of Mexico. A suite of pollutants — liquid and gaseous petroleum compounds plus chemical dispersants — poured into ecosystems that had already been stressed by overfishing, development and global climate change. Beyond the direct effects that were captured in dramatic photographs of oiled birds in the media, it is likely that there are subtle, delayed, indirect and potentially synergistic impacts of these widely dispersed, highly bioavailable and toxic hydrocarbons and chemical dispersants on marine life from pelicans to salt marsh grasses and to deep-sea animals.
As tragic as the DWH blowout was, it has stimulated public interest in protecting this economically, socially and environmentally critical region. The 2010 Mabus Report, commissioned by President Barack Obama and written by the secretary of the Navy, provides a blueprint for restoring the Gulf that is bold, visionary and strategic. It is clear that we need not only to repair the damage left behind by the oil but also to go well beyond that to restore the anthropogenically stressed and declining Gulf ecosystems to prosperity-sustaining levels of historic productivity. For this report, we assembled a team of leading scientists with expertise in coastal and marine ecosystems and with experience in their restoration to identify strategies and specific actions that will revitalize and sustain the Gulf coastal economy.
Because the DWH spill intervened in ecosystems that are intimately interconnected and already under stress, and will remain stressed from global climate change, we argue that restoration of the Gulf must go beyond the traditional “in-place, in-kind” restoration approach that targets specific damaged habitats or species. A sustainable restoration of the Gulf of Mexico after DWH must:
1. Recognize that ecosystem resilience has been compromised by multiple human interventions predating the DWH spill;
2. Acknowledge that significant future environmental change is inevitable and must be factored into restoration plans and actions for them to be durable;
3. Treat the Gulf as a complex and interconnected network of ecosystems from shoreline to deep sea; and
4. Recognize that human and ecosystem productivity in the Gulf are interdependent, and that human needs from and effects on the Gulf must be integral to restoration planning.
With these principles in mind, we provide the scientific basis for a sustainable restoration program along three themes:
1. Assess and repair damage from DWH and other stresses on the Gulf;
2. Protect existing habitats and populations; and
3. Integrate sustainable human use with ecological processes in the Gulf of Mexico.
Under these themes, 15 historically informed, adaptive, ecosystem-based restoration actions are presented to recover Gulf resources and rebuild the resilience of its ecosystem. The vision that guides our recommendations fundamentally imbeds the restoration actions within the context of the changing environment so as to achieve resilience of resources, human communities and the economy into the indefinite future
Nuclear organisation and replication timing are coupled through RIF1-PP1 interaction
Three-dimensional genome organisation and replication timing are known to be correlated, however, it remains unknown whether nuclear architecture overall plays an instructive role in the replication-timing programme and, if so, how. Here we demonstrate that RIF1 is a molecular hub that co-regulates both processes. Both nuclear organisation and replication timing depend upon the interaction between RIF1 and PP1. However, whereas nuclear architecture requires the full complement of RIF1 and its interaction with PP1, replication timing is not sensitive to RIF1 dosage. The role of RIF1 in replication timing also extends beyond its interaction with PP1. Availing of this separation-of-function approach, we have therefore identified in RIF1 dual function the molecular bases of the co-dependency of the replication-timing programme and nuclear architecture
On the structure and evolution of a polar crown prominence/filament system
Polar crown prominences are made of chromospheric plasma partially circling
the Suns poles between 60 and 70 degree latitude. We aim to diagnose the 3D
dynamics of a polar crown prominence using high cadence EUV images from the
Solar Dynamics Observatory (SDO)/AIA at 304 and 171A and the Ahead spacecraft
of the Solar Terrestrial Relations Observatory (STEREO-A)/EUVI at 195A. Using
time series across specific structures we compare flows across the disk in 195A
with the prominence dynamics seen on the limb. The densest prominence material
forms vertical columns which are separated by many tens of Mm and connected by
dynamic bridges of plasma that are clearly visible in 304/171A two-color
images. We also observe intermittent but repetitious flows with velocity 15
km/s in the prominence that appear to be associated with EUV bright points on
the solar disk. The boundary between the prominence and the overlying cavity
appears as a sharp edge. We discuss the structure of the coronal cavity seen
both above and around the prominence. SDO/HMI and GONG magnetograms are used to
infer the underlying magnetic topology. The evolution and structure of the
prominence with respect to the magnetic field seems to agree with the filament
linkage model.Comment: 24 pages, 14 figures, Accepted for publication in Solar Physics
Journal, Movies can be found at http://www2.mps.mpg.de/data/outgoing/panesar
Machine learning-based investigation of the association between CMEs and filaments
YesIn this work we study the association between eruptive filaments/prominences and coronal mass ejections (CMEs) using machine learning-based algorithms that analyse the solar data available between January 1996 and December 2001. The Support Vector Machine (SVM) learning algorithm is used for the purpose of knowledge extraction from the association results. The aim is to identify patterns of associations that can be represented using SVM learning rules for the subsequent use in near real-time and reliable CME prediction systems. Timing and location data in the NGDC filament catalogue and the SOHO/LASCO CME catalogue are processed to associate filaments with CMEs. In the previous studies which classified CMEs into gradual and impulsive CMEs, the associations were refined based on CME speed and acceleration. Then the associated pairs were refined manually to increase the accuracy of the training dataset. In the current study, a data- mining system has been created to process and associate filament and CME data, which are arranged in numerical training vectors. Then the data are fed to SVMs to extract the embedded knowledge and provide the learning rules that could have the potential, in the future, to provide automated predictions of CMEs. The features representing the event time (average of the start and end times), duration, type and extent of the filaments are extracted from all the associated and not-associated filaments and converted to a numerical format that is suitable for SVM use. Several validation and verification methods are used on the extracted dataset to determine if CMEs can be predicted solely and efficiently based on the associated filaments. More than 14000 experiments are carried out to optimise the SVM and determine the input features that provide the best performance
Physics of Solar Prominences: II - Magnetic Structure and Dynamics
Observations and models of solar prominences are reviewed. We focus on
non-eruptive prominences, and describe recent progress in four areas of
prominence research: (1) magnetic structure deduced from observations and
models, (2) the dynamics of prominence plasmas (formation and flows), (3)
Magneto-hydrodynamic (MHD) waves in prominences and (4) the formation and
large-scale patterns of the filament channels in which prominences are located.
Finally, several outstanding issues in prominence research are discussed, along
with observations and models required to resolve them.Comment: 75 pages, 31 pictures, review pape
The Formation and Evolution of Massive Stellar Clusters in IC 4662
We present a multiwavelength study of the formation of massive stellar
clusters, their emergence from cocoons of gas and dust, and their feedback on
surrounding matter. Using data that span from radio to optical wavelengths,
including Spitzer and Hubble ACS observations, we examine the population of
young star clusters in the central starburst region of the irregular Wolf-Rayet
galaxy IC 4662. We model the radio-to-IR spectral energy distributions of
embedded clusters to determine the properties of their HII regions and dust
cocoons (sizes, masses, densities, temperatures), and use near-IR and optical
data with mid-IR spectroscopy to constrain the properties of the embedded
clusters themselves (mass, age, extinction, excitation, abundance). The two
massive star-formation regions in IC 4662 are excited by stellar populations
with ages of ~ 4 million years and masses of ~ 3 x 10^5 M_sun (assuming a
Kroupa IMF). They have high excitation and sub-solar abundances, and they may
actually be comprised of several massive clusters rather than the single
monolithic massive compact objects known as Super Star Clusters (SSCs). Mid-IR
spectra reveal that these clusters have very high extinctions, A_V ~ 20-25 mag,
and that the dust in IC 4662 is well-mixed with the emitting gas, not in a
foreground screen.Comment: 7 pages, 11 figures, to appear in proceedings of the conference
"Young Massive Star Clusters: Initial Conditions and Environments ", held in
Granada, Spain, September 200
Physics of Solar Prominences: I - Spectral Diagnostics and Non-LTE Modelling
This review paper outlines background information and covers recent advances
made via the analysis of spectra and images of prominence plasma and the
increased sophistication of non-LTE (ie when there is a departure from Local
Thermodynamic Equilibrium) radiative transfer models. We first describe the
spectral inversion techniques that have been used to infer the plasma
parameters important for the general properties of the prominence plasma in
both its cool core and the hotter prominence-corona transition region. We also
review studies devoted to the observation of bulk motions of the prominence
plasma and to the determination of prominence mass. However, a simple inversion
of spectroscopic data usually fails when the lines become optically thick at
certain wavelengths. Therefore, complex non-LTE models become necessary. We
thus present the basics of non-LTE radiative transfer theory and the associated
multi-level radiative transfer problems. The main results of one- and
two-dimensional models of the prominences and their fine-structures are
presented. We then discuss the energy balance in various prominence models.
Finally, we outline the outstanding observational and theoretical questions,
and the directions for future progress in our understanding of solar
prominences.Comment: 96 pages, 37 figures, Space Science Reviews. Some figures may have a
better resolution in the published version. New version reflects minor
changes brought after proof editin
Search for a W' boson decaying to a bottom quark and a top quark in pp collisions at sqrt(s) = 7 TeV
Results are presented from a search for a W' boson using a dataset
corresponding to 5.0 inverse femtobarns of integrated luminosity collected
during 2011 by the CMS experiment at the LHC in pp collisions at sqrt(s)=7 TeV.
The W' boson is modeled as a heavy W boson, but different scenarios for the
couplings to fermions are considered, involving both left-handed and
right-handed chiral projections of the fermions, as well as an arbitrary
mixture of the two. The search is performed in the decay channel W' to t b,
leading to a final state signature with a single lepton (e, mu), missing
transverse energy, and jets, at least one of which is tagged as a b-jet. A W'
boson that couples to fermions with the same coupling constant as the W, but to
the right-handed rather than left-handed chiral projections, is excluded for
masses below 1.85 TeV at the 95% confidence level. For the first time using LHC
data, constraints on the W' gauge coupling for a set of left- and right-handed
coupling combinations have been placed. These results represent a significant
improvement over previously published limits.Comment: Submitted to Physics Letters B. Replaced with version publishe
Search for the standard model Higgs boson decaying into two photons in pp collisions at sqrt(s)=7 TeV
A search for a Higgs boson decaying into two photons is described. The
analysis is performed using a dataset recorded by the CMS experiment at the LHC
from pp collisions at a centre-of-mass energy of 7 TeV, which corresponds to an
integrated luminosity of 4.8 inverse femtobarns. Limits are set on the cross
section of the standard model Higgs boson decaying to two photons. The expected
exclusion limit at 95% confidence level is between 1.4 and 2.4 times the
standard model cross section in the mass range between 110 and 150 GeV. The
analysis of the data excludes, at 95% confidence level, the standard model
Higgs boson decaying into two photons in the mass range 128 to 132 GeV. The
largest excess of events above the expected standard model background is
observed for a Higgs boson mass hypothesis of 124 GeV with a local significance
of 3.1 sigma. The global significance of observing an excess with a local
significance greater than 3.1 sigma anywhere in the search range 110-150 GeV is
estimated to be 1.8 sigma. More data are required to ascertain the origin of
this excess.Comment: Submitted to Physics Letters
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